Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYZ7_LEIMU

TriTrypDb:

LmxM.27.0950

Length:

913

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.584
CLV_C14_Caspase3-7	516	520	PF00656	0.558
CLV_C14_Caspase3-7	619	623	PF00656	0.616
CLV_NRD_NRD_1	216	218	PF00675	0.662
CLV_NRD_NRD_1	464	466	PF00675	0.654
CLV_NRD_NRD_1	521	523	PF00675	0.607
CLV_NRD_NRD_1	635	637	PF00675	0.514
CLV_NRD_NRD_1	800	802	PF00675	0.475
CLV_NRD_NRD_1	821	823	PF00675	0.579
CLV_PCSK_FUR_1	819	823	PF00082	0.519
CLV_PCSK_KEX2_1	216	218	PF00082	0.660
CLV_PCSK_KEX2_1	434	436	PF00082	0.665
CLV_PCSK_KEX2_1	463	465	PF00082	0.654
CLV_PCSK_KEX2_1	635	637	PF00082	0.514
CLV_PCSK_KEX2_1	800	802	PF00082	0.510
CLV_PCSK_KEX2_1	821	823	PF00082	0.579
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.552
CLV_PCSK_SKI1_1	351	355	PF00082	0.643
CLV_PCSK_SKI1_1	40	44	PF00082	0.572
CLV_PCSK_SKI1_1	45	49	PF00082	0.630
CLV_PCSK_SKI1_1	51	55	PF00082	0.584
CLV_PCSK_SKI1_1	901	905	PF00082	0.408
CLV_Separin_Metazoa	448	452	PF03568	0.544
DEG_SPOP_SBC_1	223	227	PF00917	0.566
DEG_SPOP_SBC_1	481	485	PF00917	0.662
DOC_ANK_TNKS_1	377	384	PF00023	0.595
DOC_CDC14_PxL_1	186	194	PF14671	0.608
DOC_CKS1_1	352	357	PF01111	0.595
DOC_CYCLIN_yCln2_LP_2	642	648	PF00134	0.580
DOC_MAPK_gen_1	541	548	PF00069	0.466
DOC_MAPK_gen_1	699	708	PF00069	0.514
DOC_MAPK_gen_1	756	764	PF00069	0.401
DOC_MAPK_gen_1	846	855	PF00069	0.397
DOC_MAPK_MEF2A_6	699	708	PF00069	0.319
DOC_MAPK_MEF2A_6	846	855	PF00069	0.377
DOC_PP1_SILK_1	333	338	PF00149	0.539
DOC_PP2B_LxvP_1	401	404	PF13499	0.640
DOC_PP2B_LxvP_1	642	645	PF13499	0.600
DOC_PP2B_LxvP_1	733	736	PF13499	0.466
DOC_PP2B_LxvP_1	890	893	PF13499	0.499
DOC_PP4_FxxP_1	582	585	PF00568	0.560
DOC_USP7_MATH_1	27	31	PF00917	0.720
DOC_USP7_MATH_1	295	299	PF00917	0.679
DOC_USP7_MATH_1	370	374	PF00917	0.631
DOC_USP7_MATH_1	427	431	PF00917	0.621
DOC_USP7_MATH_1	455	459	PF00917	0.640
DOC_USP7_MATH_1	479	483	PF00917	0.626
DOC_USP7_MATH_1	49	53	PF00917	0.654
DOC_USP7_MATH_1	505	509	PF00917	0.602
DOC_USP7_MATH_1	513	517	PF00917	0.726
DOC_USP7_MATH_1	649	653	PF00917	0.731
DOC_USP7_MATH_1	68	72	PF00917	0.371
DOC_USP7_MATH_1	802	806	PF00917	0.597
DOC_WW_Pin1_4	351	356	PF00397	0.638
DOC_WW_Pin1_4	366	371	PF00397	0.601
DOC_WW_Pin1_4	403	408	PF00397	0.616
DOC_WW_Pin1_4	576	581	PF00397	0.606
DOC_WW_Pin1_4	743	748	PF00397	0.394
LIG_14-3-3_CanoR_1	123	130	PF00244	0.489
LIG_14-3-3_CanoR_1	137	144	PF00244	0.510
LIG_14-3-3_CanoR_1	172	176	PF00244	0.585
LIG_14-3-3_CanoR_1	26	32	PF00244	0.612
LIG_14-3-3_CanoR_1	463	472	PF00244	0.642
LIG_14-3-3_CanoR_1	554	561	PF00244	0.625
LIG_14-3-3_CanoR_1	635	644	PF00244	0.555
LIG_14-3-3_CanoR_1	876	882	PF00244	0.418
LIG_APCC_ABBA_1	336	341	PF00400	0.584
LIG_BRCT_BRCA1_1	507	511	PF00533	0.529
LIG_BRCT_BRCA1_1	578	582	PF00533	0.574
LIG_BRCT_BRCA1_1	760	764	PF00533	0.450
LIG_Clathr_ClatBox_1	162	166	PF01394	0.516
LIG_CtBP_PxDLS_1	34	40	PF00389	0.529
LIG_FHA_1	157	163	PF00498	0.489
LIG_FHA_1	200	206	PF00498	0.659
LIG_FHA_1	233	239	PF00498	0.652
LIG_FHA_1	294	300	PF00498	0.559
LIG_FHA_1	358	364	PF00498	0.721
LIG_FHA_1	408	414	PF00498	0.573
LIG_FHA_1	444	450	PF00498	0.541
LIG_FHA_1	493	499	PF00498	0.661
LIG_FHA_1	637	643	PF00498	0.651
LIG_FHA_1	703	709	PF00498	0.385
LIG_FHA_1	743	749	PF00498	0.424
LIG_FHA_1	828	834	PF00498	0.518
LIG_FHA_1	835	841	PF00498	0.402
LIG_FHA_1	867	873	PF00498	0.417
LIG_FHA_2	183	189	PF00498	0.525
LIG_FHA_2	194	200	PF00498	0.614
LIG_FHA_2	224	230	PF00498	0.497
LIG_FHA_2	469	475	PF00498	0.518
LIG_FHA_2	53	59	PF00498	0.601
LIG_FHA_2	531	537	PF00498	0.691
LIG_FHA_2	673	679	PF00498	0.424
LIG_Integrin_isoDGR_2	571	573	PF01839	0.656
LIG_LIR_Apic_2	579	585	PF02991	0.726
LIG_LIR_Gen_1	183	192	PF02991	0.776
LIG_LIR_Gen_1	218	228	PF02991	0.621
LIG_LIR_Gen_1	235	242	PF02991	0.495
LIG_LIR_Gen_1	470	479	PF02991	0.524
LIG_LIR_Gen_1	536	547	PF02991	0.472
LIG_LIR_Gen_1	664	674	PF02991	0.512
LIG_LIR_Gen_1	675	683	PF02991	0.445
LIG_LIR_Gen_1	71	79	PF02991	0.485
LIG_LIR_Gen_1	90	100	PF02991	0.553
LIG_LIR_Nem_3	125	130	PF02991	0.484
LIG_LIR_Nem_3	183	189	PF02991	0.770
LIG_LIR_Nem_3	218	223	PF02991	0.625
LIG_LIR_Nem_3	235	240	PF02991	0.653
LIG_LIR_Nem_3	470	475	PF02991	0.522
LIG_LIR_Nem_3	664	670	PF02991	0.517
LIG_LIR_Nem_3	675	680	PF02991	0.549
LIG_LIR_Nem_3	71	75	PF02991	0.502
LIG_LIR_Nem_3	90	96	PF02991	0.545
LIG_LIR_Nem_3	99	103	PF02991	0.455
LIG_MYND_3	189	193	PF01753	0.611
LIG_NRBOX	707	713	PF00104	0.420
LIG_PCNA_yPIPBox_3	896	907	PF02747	0.434
LIG_PTB_Apo_2	94	101	PF02174	0.492
LIG_PTB_Phospho_1	94	100	PF10480	0.497
LIG_SH2_CRK	72	76	PF00017	0.339
LIG_SH2_NCK_1	198	202	PF00017	0.585
LIG_SH2_NCK_1	265	269	PF00017	0.501
LIG_SH2_NCK_1	472	476	PF00017	0.526
LIG_SH2_NCK_1	677	681	PF00017	0.587
LIG_SH2_SRC	677	680	PF00017	0.683
LIG_SH2_STAP1	677	681	PF00017	0.587
LIG_SH2_STAP1	72	76	PF00017	0.439
LIG_SH2_STAT5	105	108	PF00017	0.493
LIG_SH2_STAT5	301	304	PF00017	0.595
LIG_SH2_STAT5	472	475	PF00017	0.524
LIG_SH2_STAT5	62	65	PF00017	0.501
LIG_SH2_STAT5	789	792	PF00017	0.379
LIG_SH2_STAT5	829	832	PF00017	0.557
LIG_SH3_1	558	564	PF00018	0.547
LIG_SH3_2	561	566	PF14604	0.549
LIG_SH3_3	401	407	PF00018	0.638
LIG_SH3_3	421	427	PF00018	0.556
LIG_SH3_3	558	564	PF00018	0.661
LIG_SH3_3	574	580	PF00018	0.501
LIG_SH3_3	625	631	PF00018	0.696
LIG_SH3_3	677	683	PF00018	0.483
LIG_SUMO_SIM_anti_2	702	708	PF11976	0.311
LIG_SUMO_SIM_par_1	868	874	PF11976	0.410
LIG_TRAF2_1	133	136	PF00917	0.486
LIG_TRAF2_1	369	372	PF00917	0.597
LIG_TRAF2_1	414	417	PF00917	0.591
LIG_TRAF2_1	662	665	PF00917	0.509
LIG_TRAF2_1	676	679	PF00917	0.529
LIG_TYR_ITSM	673	680	PF00017	0.424
LIG_WRC_WIRS_1	872	877	PF05994	0.468
LIG_WW_3	306	310	PF00397	0.653
MOD_CDC14_SPxK_1	746	749	PF00782	0.402
MOD_CDK_SPxK_1	743	749	PF00069	0.397
MOD_CK1_1	20	26	PF00069	0.699
MOD_CK1_1	227	233	PF00069	0.616
MOD_CK1_1	406	412	PF00069	0.572
MOD_CK1_1	482	488	PF00069	0.622
MOD_CK1_1	52	58	PF00069	0.527
MOD_CK1_1	553	559	PF00069	0.618
MOD_CK1_1	638	644	PF00069	0.567
MOD_CK1_1	871	877	PF00069	0.435
MOD_CK2_1	130	136	PF00069	0.556
MOD_CK2_1	193	199	PF00069	0.623
MOD_CK2_1	366	372	PF00069	0.670
MOD_CK2_1	411	417	PF00069	0.599
MOD_CK2_1	468	474	PF00069	0.531
MOD_CK2_1	52	58	PF00069	0.527
MOD_CK2_1	530	536	PF00069	0.770
MOD_CK2_1	672	678	PF00069	0.521
MOD_CK2_1	751	757	PF00069	0.534
MOD_CK2_1	81	87	PF00069	0.429
MOD_CK2_1	821	827	PF00069	0.499
MOD_GlcNHglycan	119	122	PF01048	0.523
MOD_GlcNHglycan	139	142	PF01048	0.389
MOD_GlcNHglycan	253	256	PF01048	0.618
MOD_GlcNHglycan	257	260	PF01048	0.608
MOD_GlcNHglycan	285	288	PF01048	0.641
MOD_GlcNHglycan	293	296	PF01048	0.593
MOD_GlcNHglycan	372	375	PF01048	0.621
MOD_GlcNHglycan	398	401	PF01048	0.798
MOD_GlcNHglycan	429	432	PF01048	0.688
MOD_GlcNHglycan	45	48	PF01048	0.650
MOD_GlcNHglycan	455	458	PF01048	0.572
MOD_GlcNHglycan	498	501	PF01048	0.654
MOD_GlcNHglycan	83	86	PF01048	0.547
MOD_GlcNHglycan	857	860	PF01048	0.636
MOD_GlcNHglycan	908	911	PF01048	0.499
MOD_GSK3_1	16	23	PF00069	0.812
MOD_GSK3_1	218	225	PF00069	0.639
MOD_GSK3_1	228	235	PF00069	0.577
MOD_GSK3_1	247	254	PF00069	0.588
MOD_GSK3_1	263	270	PF00069	0.642
MOD_GSK3_1	291	298	PF00069	0.635
MOD_GSK3_1	366	373	PF00069	0.654
MOD_GSK3_1	403	410	PF00069	0.643
MOD_GSK3_1	43	50	PF00069	0.647
MOD_GSK3_1	453	460	PF00069	0.677
MOD_GSK3_1	477	484	PF00069	0.662
MOD_GSK3_1	488	495	PF00069	0.607
MOD_GSK3_1	530	537	PF00069	0.752
MOD_GSK3_1	550	557	PF00069	0.504
MOD_GSK3_1	596	603	PF00069	0.624
MOD_GSK3_1	630	637	PF00069	0.591
MOD_GSK3_1	669	676	PF00069	0.415
MOD_GSK3_1	737	744	PF00069	0.353
MOD_GSK3_1	817	824	PF00069	0.598
MOD_GSK3_1	827	834	PF00069	0.446
MOD_GSK3_1	871	878	PF00069	0.408
MOD_LATS_1	461	467	PF00433	0.694
MOD_N-GLC_1	148	153	PF02516	0.524
MOD_N-GLC_1	232	237	PF02516	0.602
MOD_N-GLC_1	492	497	PF02516	0.667
MOD_N-GLC_1	596	601	PF02516	0.656
MOD_N-GLC_1	702	707	PF02516	0.477
MOD_N-GLC_2	611	613	PF02516	0.594
MOD_NEK2_1	1	6	PF00069	0.633
MOD_NEK2_1	130	135	PF00069	0.431
MOD_NEK2_1	21	26	PF00069	0.571
MOD_NEK2_1	228	233	PF00069	0.590
MOD_NEK2_1	737	742	PF00069	0.464
MOD_NEK2_1	855	860	PF00069	0.480
MOD_NEK2_1	865	870	PF00069	0.412
MOD_NEK2_1	875	880	PF00069	0.290
MOD_NEK2_2	27	32	PF00069	0.706
MOD_NEK2_2	513	518	PF00069	0.573
MOD_NEK2_2	836	841	PF00069	0.440
MOD_PIKK_1	148	154	PF00454	0.517
MOD_PIKK_1	21	27	PF00454	0.669
MOD_PIKK_1	218	224	PF00454	0.730
MOD_PIKK_1	802	808	PF00454	0.575
MOD_PKA_1	463	469	PF00069	0.643
MOD_PKA_1	566	572	PF00069	0.604
MOD_PKA_1	635	641	PF00069	0.506
MOD_PKA_1	821	827	PF00069	0.525
MOD_PKA_2	122	128	PF00069	0.490
MOD_PKA_2	130	136	PF00069	0.483
MOD_PKA_2	171	177	PF00069	0.580
MOD_PKA_2	329	335	PF00069	0.472
MOD_PKA_2	463	469	PF00069	0.643
MOD_PKA_2	553	559	PF00069	0.648
MOD_PKA_2	634	640	PF00069	0.618
MOD_PKA_2	802	808	PF00069	0.504
MOD_PKA_2	821	827	PF00069	0.566
MOD_PKA_2	834	840	PF00069	0.331
MOD_PKA_2	875	881	PF00069	0.407
MOD_PKA_2	9	15	PF00069	0.662
MOD_PKB_1	819	827	PF00069	0.521
MOD_Plk_1	148	154	PF00069	0.549
MOD_Plk_1	182	188	PF00069	0.486
MOD_Plk_1	340	346	PF00069	0.568
MOD_Plk_1	702	708	PF00069	0.473
MOD_Plk_1	751	757	PF00069	0.451
MOD_Plk_2-3	443	449	PF00069	0.541
MOD_Plk_2-3	470	476	PF00069	0.524
MOD_Plk_2-3	726	732	PF00069	0.525
MOD_Plk_2-3	758	764	PF00069	0.464
MOD_Plk_4	171	177	PF00069	0.619
MOD_Plk_4	182	188	PF00069	0.449
MOD_Plk_4	295	301	PF00069	0.618
MOD_Plk_4	340	346	PF00069	0.544
MOD_Plk_4	534	540	PF00069	0.549
MOD_Plk_4	591	597	PF00069	0.746
MOD_Plk_4	669	675	PF00069	0.484
MOD_Plk_4	702	708	PF00069	0.475
MOD_Plk_4	737	743	PF00069	0.365
MOD_Plk_4	809	815	PF00069	0.561
MOD_ProDKin_1	351	357	PF00069	0.639
MOD_ProDKin_1	366	372	PF00069	0.602
MOD_ProDKin_1	403	409	PF00069	0.621
MOD_ProDKin_1	576	582	PF00069	0.607
MOD_ProDKin_1	743	749	PF00069	0.397
MOD_SUMO_for_1	660	663	PF00179	0.412
MOD_SUMO_rev_2	752	761	PF00179	0.464
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.609
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.600
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.457
TRG_DiLeu_BaLyEn_6	733	738	PF01217	0.538
TRG_ENDOCYTIC_2	100	103	PF00928	0.483
TRG_ENDOCYTIC_2	472	475	PF00928	0.524
TRG_ENDOCYTIC_2	677	680	PF00928	0.588
TRG_ENDOCYTIC_2	72	75	PF00928	0.448
TRG_ENDOCYTIC_2	93	96	PF00928	0.480
TRG_ER_diArg_1	215	217	PF00400	0.655
TRG_ER_diArg_1	463	465	PF00400	0.675
TRG_ER_diArg_1	542	545	PF00400	0.653
TRG_ER_diArg_1	800	803	PF00400	0.514
TRG_ER_diArg_1	819	822	PF00400	0.534
TRG_NES_CRM1_1	180	193	PF08389	0.634
TRG_NLS_MonoExtN_4	564	570	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	722	726	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	901	905	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J7	Leptomonas seymouri	40%	96%
A0A3S7X0M1	Leishmania donovani	79%	100%
A4HFL8	Leishmania braziliensis	59%	99%
A4I2P1	Leishmania infantum	79%	100%
E9AD72	Leishmania major	75%	97%