XRN_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

XRN 5'-3' exonuclease N-terminus, putative

Species:

Leishmania mexicana

UniProt:

E9AYZ6_LEIMU

TriTrypDb:

LmxM.27.0940

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYZ6

Function

Biological processes
Term	Name	Level	Count
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0003824	catalytic activity	1	15
GO:0004518	nuclease activity	4	15
GO:0004527	exonuclease activity	5	15
GO:0005488	binding	1	15
GO:0016787	hydrolase activity	2	15
GO:0016788	hydrolase activity, acting on ester bonds	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:1901363	heterocyclic compound binding	2	15
GO:0003723	RNA binding	4	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004534	5'-3' RNA exonuclease activity	7	1
GO:0004540	RNA nuclease activity	4	1
GO:0008409	5'-3' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.571
CLV_C14_Caspase3-7	563	567	PF00656	0.766
CLV_MEL_PAP_1	459	465	PF00089	0.510
CLV_NRD_NRD_1	166	168	PF00675	0.332
CLV_NRD_NRD_1	196	198	PF00675	0.335
CLV_NRD_NRD_1	301	303	PF00675	0.388
CLV_NRD_NRD_1	314	316	PF00675	0.356
CLV_NRD_NRD_1	351	353	PF00675	0.606
CLV_NRD_NRD_1	420	422	PF00675	0.531
CLV_NRD_NRD_1	512	514	PF00675	0.579
CLV_NRD_NRD_1	540	542	PF00675	0.701
CLV_NRD_NRD_1	98	100	PF00675	0.265
CLV_PCSK_FUR_1	349	353	PF00082	0.634
CLV_PCSK_KEX2_1	196	198	PF00082	0.336
CLV_PCSK_KEX2_1	301	303	PF00082	0.359
CLV_PCSK_KEX2_1	314	316	PF00082	0.455
CLV_PCSK_KEX2_1	351	353	PF00082	0.622
CLV_PCSK_KEX2_1	512	514	PF00082	0.582
CLV_PCSK_KEX2_1	549	551	PF00082	0.772
CLV_PCSK_KEX2_1	98	100	PF00082	0.263
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.602
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.711
CLV_PCSK_SKI1_1	314	318	PF00082	0.486
CLV_PCSK_SKI1_1	331	335	PF00082	0.444
CLV_PCSK_SKI1_1	34	38	PF00082	0.361
CLV_PCSK_SKI1_1	353	357	PF00082	0.553
CLV_PCSK_SKI1_1	542	546	PF00082	0.570
DEG_APCC_DBOX_1	33	41	PF00400	0.571
DEG_APCC_DBOX_1	75	83	PF00400	0.555
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.497
DOC_MAPK_gen_1	117	126	PF00069	0.488
DOC_MAPK_gen_1	460	467	PF00069	0.490
DOC_MAPK_gen_1	74	82	PF00069	0.520
DOC_MAPK_gen_1	96	104	PF00069	0.496
DOC_MAPK_MEF2A_6	274	282	PF00069	0.334
DOC_MAPK_MEF2A_6	321	329	PF00069	0.501
DOC_PP1_RVXF_1	272	278	PF00149	0.339
DOC_PP2B_LxvP_1	345	348	PF13499	0.576
DOC_USP7_MATH_1	18	22	PF00917	0.532
DOC_USP7_MATH_1	204	208	PF00917	0.568
DOC_USP7_MATH_1	551	555	PF00917	0.764
DOC_WW_Pin1_4	124	129	PF00397	0.569
DOC_WW_Pin1_4	206	211	PF00397	0.363
LIG_14-3-3_CanoR_1	108	114	PF00244	0.498
LIG_14-3-3_CanoR_1	119	128	PF00244	0.507
LIG_14-3-3_CanoR_1	167	173	PF00244	0.363
LIG_14-3-3_CanoR_1	352	359	PF00244	0.596
LIG_14-3-3_CanoR_1	391	399	PF00244	0.367
LIG_14-3-3_CanoR_1	460	466	PF00244	0.405
LIG_14-3-3_CanoR_1	481	491	PF00244	0.545
LIG_14-3-3_CanoR_1	506	514	PF00244	0.503
LIG_14-3-3_CanoR_1	52	59	PF00244	0.537
LIG_14-3-3_CanoR_1	541	551	PF00244	0.730
LIG_14-3-3_CanoR_1	98	103	PF00244	0.498
LIG_AP2alpha_2	240	242	PF02296	0.505
LIG_APCC_ABBA_1	139	144	PF00400	0.538
LIG_APCC_ABBA_1	397	402	PF00400	0.592
LIG_BRCT_BRCA1_1	385	389	PF00533	0.493
LIG_eIF4E_1	171	177	PF01652	0.571
LIG_eIF4E_1	233	239	PF01652	0.483
LIG_eIF4E_1	312	318	PF01652	0.456
LIG_FHA_1	211	217	PF00498	0.504
LIG_FHA_1	340	346	PF00498	0.649
LIG_FHA_1	372	378	PF00498	0.467
LIG_FHA_1	438	444	PF00498	0.630
LIG_FHA_1	490	496	PF00498	0.475
LIG_FHA_1	502	508	PF00498	0.465
LIG_FHA_1	76	82	PF00498	0.479
LIG_FHA_2	200	206	PF00498	0.534
LIG_FHA_2	235	241	PF00498	0.424
LIG_FHA_2	473	479	PF00498	0.546
LIG_FHA_2	506	512	PF00498	0.423
LIG_FHA_2	543	549	PF00498	0.736
LIG_FHA_2	92	98	PF00498	0.561
LIG_LIR_Gen_1	172	178	PF02991	0.562
LIG_LIR_Gen_1	234	244	PF02991	0.383
LIG_LIR_Gen_1	276	283	PF02991	0.323
LIG_LIR_Nem_3	172	176	PF02991	0.542
LIG_LIR_Nem_3	234	239	PF02991	0.330
LIG_LIR_Nem_3	276	282	PF02991	0.323
LIG_LIR_Nem_3	286	292	PF02991	0.366
LIG_LIR_Nem_3	393	398	PF02991	0.494
LIG_Rb_LxCxE_1	151	172	PF01857	0.571
LIG_SH2_CRK	17	21	PF00017	0.561
LIG_SH2_CRK	83	87	PF00017	0.553
LIG_SH2_NCK_1	236	240	PF00017	0.491
LIG_SH2_SRC	9	12	PF00017	0.525
LIG_SH2_STAT3	163	166	PF00017	0.516
LIG_SH2_STAT5	130	133	PF00017	0.536
LIG_SH2_STAT5	159	162	PF00017	0.560
LIG_SH2_STAT5	163	166	PF00017	0.560
LIG_SH2_STAT5	236	239	PF00017	0.394
LIG_SH2_STAT5	312	315	PF00017	0.468
LIG_SH2_STAT5	387	390	PF00017	0.433
LIG_SH2_STAT5	9	12	PF00017	0.488
LIG_SH3_3	101	107	PF00018	0.535
LIG_SH3_3	226	232	PF00018	0.561
LIG_SH3_3	257	263	PF00018	0.539
LIG_SH3_3	443	449	PF00018	0.409
LIG_SH3_3	47	53	PF00018	0.544
LIG_SUMO_SIM_anti_2	211	218	PF11976	0.450
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.493
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.497
LIG_SUMO_SIM_par_1	77	84	PF11976	0.513
LIG_TRAF2_1	155	158	PF00917	0.535
LIG_TRAF2_1	399	402	PF00917	0.576
LIG_TYR_ITAM	286	306	PF00017	0.520
LIG_TYR_ITIM	81	86	PF00017	0.571
LIG_WW_2	263	266	PF00397	0.574
LIG_WW_3	105	109	PF00397	0.571
MOD_CK1_1	234	240	PF00069	0.482
MOD_CK1_1	245	251	PF00069	0.496
MOD_CK1_1	339	345	PF00069	0.587
MOD_CK1_1	383	389	PF00069	0.452
MOD_CK1_1	406	412	PF00069	0.520
MOD_CK1_1	501	507	PF00069	0.545
MOD_CK2_1	245	251	PF00069	0.438
MOD_CK2_1	5	11	PF00069	0.577
MOD_CK2_1	505	511	PF00069	0.437
MOD_CK2_1	542	548	PF00069	0.580
MOD_CK2_1	562	568	PF00069	0.710
MOD_CK2_1	91	97	PF00069	0.561
MOD_GlcNHglycan	178	181	PF01048	0.298
MOD_GlcNHglycan	191	194	PF01048	0.135
MOD_GlcNHglycan	283	286	PF01048	0.407
MOD_GlcNHglycan	318	321	PF01048	0.499
MOD_GlcNHglycan	336	339	PF01048	0.623
MOD_GlcNHglycan	518	521	PF01048	0.619
MOD_GSK3_1	108	115	PF00069	0.544
MOD_GSK3_1	120	127	PF00069	0.517
MOD_GSK3_1	206	213	PF00069	0.415
MOD_GSK3_1	461	468	PF00069	0.485
MOD_GSK3_1	48	55	PF00069	0.494
MOD_GSK3_1	480	487	PF00069	0.483
MOD_GSK3_1	498	505	PF00069	0.401
MOD_GSK3_1	512	519	PF00069	0.555
MOD_N-GLC_1	120	125	PF02516	0.363
MOD_N-GLC_1	218	223	PF02516	0.269
MOD_N-GLC_1	551	556	PF02516	0.768
MOD_NEK2_1	176	181	PF00069	0.530
MOD_NEK2_1	242	247	PF00069	0.458
MOD_NEK2_1	334	339	PF00069	0.548
MOD_NEK2_1	465	470	PF00069	0.443
MOD_NEK2_1	482	487	PF00069	0.416
MOD_NEK2_1	491	496	PF00069	0.436
MOD_NEK2_2	120	125	PF00069	0.571
MOD_NEK2_2	380	385	PF00069	0.495
MOD_PIKK_1	254	260	PF00454	0.485
MOD_PIKK_1	339	345	PF00454	0.661
MOD_PIKK_1	371	377	PF00454	0.451
MOD_PIKK_1	91	97	PF00454	0.498
MOD_PKA_1	351	357	PF00069	0.619
MOD_PKA_1	512	518	PF00069	0.626
MOD_PKA_1	98	104	PF00069	0.489
MOD_PKA_2	166	172	PF00069	0.363
MOD_PKA_2	351	357	PF00069	0.596
MOD_PKA_2	390	396	PF00069	0.353
MOD_PKA_2	461	467	PF00069	0.392
MOD_PKA_2	471	477	PF00069	0.414
MOD_PKA_2	480	486	PF00069	0.486
MOD_PKA_2	505	511	PF00069	0.551
MOD_PKA_2	51	57	PF00069	0.559
MOD_PKA_2	512	518	PF00069	0.599
MOD_PKA_2	75	81	PF00069	0.518
MOD_PKA_2	98	104	PF00069	0.496
MOD_Plk_1	120	126	PF00069	0.516
MOD_Plk_1	210	216	PF00069	0.482
MOD_Plk_1	242	248	PF00069	0.468
MOD_Plk_1	502	508	PF00069	0.471
MOD_Plk_4	159	165	PF00069	0.550
MOD_Plk_4	212	218	PF00069	0.545
MOD_Plk_4	231	237	PF00069	0.459
MOD_Plk_4	245	251	PF00069	0.462
MOD_Plk_4	75	81	PF00069	0.494
MOD_ProDKin_1	124	130	PF00069	0.569
MOD_ProDKin_1	206	212	PF00069	0.363
MOD_SUMO_rev_2	183	192	PF00179	0.484
TRG_DiLeu_BaEn_1	372	377	PF01217	0.504
TRG_ENDOCYTIC_2	235	238	PF00928	0.361
TRG_ENDOCYTIC_2	289	292	PF00928	0.382
TRG_ENDOCYTIC_2	303	306	PF00928	0.319
TRG_ENDOCYTIC_2	395	398	PF00928	0.525
TRG_ENDOCYTIC_2	83	86	PF00928	0.553
TRG_ER_diArg_1	195	197	PF00400	0.561
TRG_ER_diArg_1	300	302	PF00400	0.402
TRG_ER_diArg_1	313	315	PF00400	0.368
TRG_ER_diArg_1	459	462	PF00400	0.417
TRG_ER_diArg_1	512	514	PF00400	0.580
TRG_ER_diArg_1	73	76	PF00400	0.566
TRG_NLS_MonoExtN_4	348	355	PF00514	0.607
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I835	Leptomonas seymouri	64%	98%
A0A0S4ILZ5	Bodo saltans	33%	99%
A0A0S4JAK8	Bodo saltans	28%	100%
A0A1X0P557	Trypanosomatidae	39%	100%
A0A3R7RG04	Trypanosoma rangeli	28%	70%
A0A3S7X0L0	Leishmania donovani	90%	100%
A0A422N1U3	Trypanosoma rangeli	42%	100%
A4HFL7	Leishmania braziliensis	80%	100%
A4I352	Leishmania infantum	90%	100%
D0A5U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AD71	Leishmania major	89%	100%
V5AT41	Trypanosoma cruzi	38%	100%
V5BDQ7	Trypanosoma cruzi	28%	94%