Putative isovaleryl-coA dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

isovaleryl-coA dehydrogenase, putative

Species:

Leishmania mexicana

UniProt:

E9AYZ5_LEIMU

TriTrypDb:

LmxM.27.0930

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AYZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYZ5

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006551	leucine metabolic process	5	1
GO:0006552	leucine catabolic process	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009063	amino acid catabolic process	4	1
GO:0009081	branched-chain amino acid metabolic process	4	1
GO:0009083	branched-chain amino acid catabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003995	acyl-CoA dehydrogenase activity	5	12
GO:0005488	binding	1	12
GO:0008470	isovaleryl-CoA dehydrogenase activity	6	3
GO:0016491	oxidoreductase activity	2	12
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.613
CLV_NRD_NRD_1	2	4	PF00675	0.622
CLV_NRD_NRD_1	295	297	PF00675	0.306
CLV_PCSK_KEX2_1	11	13	PF00082	0.613
CLV_PCSK_KEX2_1	2	4	PF00082	0.622
CLV_PCSK_SKI1_1	12	16	PF00082	0.697
CLV_PCSK_SKI1_1	145	149	PF00082	0.361
CLV_PCSK_SKI1_1	2	6	PF00082	0.740
CLV_PCSK_SKI1_1	216	220	PF00082	0.371
CLV_PCSK_SKI1_1	296	300	PF00082	0.321

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXP9	Leptomonas seymouri	32%	99%
A0A0N1I6H4	Leptomonas seymouri	81%	100%
A0A0N1IMF9	Leptomonas seymouri	33%	100%
A0A0S4IM43	Bodo saltans	67%	100%
A0A0S4IY66	Bodo saltans	32%	100%
A0A0S4J7W1	Bodo saltans	27%	100%
A0A0S4JFP0	Bodo saltans	32%	99%
A0A0S4KIH4	Bodo saltans	32%	100%
A0A1X0NL04	Trypanosomatidae	30%	100%
A0A1X0P4C4	Trypanosomatidae	74%	100%

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