Pep3_Vps18 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pep3/Vps18/deep orange family/Region in Clathrin and VPS, putative

Species:

Leishmania mexicana

UniProt:

E9AYZ3_LEIMU

TriTrypDb:

LmxM.27.0910

Length:

1091

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005768	endosome	7	1
GO:0030897	HOPS complex	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

E9AYZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0006886	intracellular protein transport	4	9
GO:0006904	vesicle docking involved in exocytosis	3	1
GO:0006996	organelle organization	4	1
GO:0007032	endosome organization	6	1
GO:0007033	vacuole organization	5	1
GO:0008104	protein localization	4	9
GO:0009987	cellular process	1	9
GO:0015031	protein transport	4	9
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	9
GO:0045184	establishment of protein localization	3	9
GO:0046907	intracellular transport	3	9
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	9
GO:0051649	establishment of localization in cell	3	9
GO:0070727	cellular macromolecule localization	3	9
GO:0071702	organic substance transport	4	9
GO:0071705	nitrogen compound transport	4	9
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140029	exocytic process	2	1
GO:0140056	organelle localization by membrane tethering	3	1
GO:0016192	vesicle-mediated transport	4	8

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.608
CLV_C14_Caspase3-7	367	371	PF00656	0.450
CLV_C14_Caspase3-7	418	422	PF00656	0.163
CLV_C14_Caspase3-7	58	62	PF00656	0.506
CLV_C14_Caspase3-7	757	761	PF00656	0.580
CLV_C14_Caspase3-7	91	95	PF00656	0.476
CLV_NRD_NRD_1	1004	1006	PF00675	0.182
CLV_NRD_NRD_1	403	405	PF00675	0.338
CLV_NRD_NRD_1	466	468	PF00675	0.383
CLV_NRD_NRD_1	505	507	PF00675	0.373
CLV_NRD_NRD_1	52	54	PF00675	0.510
CLV_NRD_NRD_1	853	855	PF00675	0.714
CLV_NRD_NRD_1	936	938	PF00675	0.430
CLV_PCSK_FUR_1	851	855	PF00082	0.479
CLV_PCSK_KEX2_1	403	405	PF00082	0.407
CLV_PCSK_KEX2_1	466	468	PF00082	0.420
CLV_PCSK_KEX2_1	507	509	PF00082	0.359
CLV_PCSK_KEX2_1	52	54	PF00082	0.510
CLV_PCSK_KEX2_1	853	855	PF00082	0.714
CLV_PCSK_KEX2_1	963	965	PF00082	0.420
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.389
CLV_PCSK_PC1ET2_1	963	965	PF00082	0.420
CLV_PCSK_SKI1_1	1005	1009	PF00082	0.361
CLV_PCSK_SKI1_1	205	209	PF00082	0.573
CLV_PCSK_SKI1_1	290	294	PF00082	0.539
CLV_PCSK_SKI1_1	332	336	PF00082	0.572
CLV_PCSK_SKI1_1	343	347	PF00082	0.712
CLV_PCSK_SKI1_1	378	382	PF00082	0.402
CLV_PCSK_SKI1_1	466	470	PF00082	0.345
CLV_PCSK_SKI1_1	490	494	PF00082	0.359
CLV_PCSK_SKI1_1	515	519	PF00082	0.453
CLV_PCSK_SKI1_1	570	574	PF00082	0.366
CLV_PCSK_SKI1_1	579	583	PF00082	0.331
CLV_PCSK_SKI1_1	626	630	PF00082	0.489
CLV_PCSK_SKI1_1	66	70	PF00082	0.503
CLV_PCSK_SKI1_1	725	729	PF00082	0.468
CLV_PCSK_SKI1_1	874	878	PF00082	0.568
DEG_APCC_DBOX_1	472	480	PF00400	0.454
DEG_APCC_DBOX_1	578	586	PF00400	0.365
DEG_APCC_DBOX_1	65	73	PF00400	0.571
DEG_SPOP_SBC_1	248	252	PF00917	0.540
DOC_CYCLIN_RxL_1	576	583	PF00134	0.334
DOC_CYCLIN_RxL_1	623	633	PF00134	0.531
DOC_CYCLIN_RxL_1	729	742	PF00134	0.568
DOC_CYCLIN_RxL_1	999	1011	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.584
DOC_MAPK_DCC_7	732	741	PF00069	0.577
DOC_MAPK_FxFP_2	1015	1018	PF00069	0.392
DOC_MAPK_gen_1	269	277	PF00069	0.542
DOC_MAPK_gen_1	52	59	PF00069	0.508
DOC_MAPK_gen_1	640	649	PF00069	0.549
DOC_MAPK_gen_1	729	739	PF00069	0.547
DOC_MAPK_gen_1	937	944	PF00069	0.454
DOC_MAPK_HePTP_8	639	651	PF00069	0.441
DOC_MAPK_MEF2A_6	642	651	PF00069	0.520
DOC_MAPK_MEF2A_6	732	741	PF00069	0.577
DOC_PP1_RVXF_1	330	336	PF00149	0.570
DOC_PP1_RVXF_1	438	444	PF00149	0.307
DOC_PP1_RVXF_1	513	519	PF00149	0.480
DOC_PP4_FxxP_1	1015	1018	PF00568	0.392
DOC_PP4_FxxP_1	429	432	PF00568	0.428
DOC_PP4_FxxP_1	80	83	PF00568	0.383
DOC_USP7_MATH_1	123	127	PF00917	0.478
DOC_USP7_MATH_1	139	143	PF00917	0.537
DOC_USP7_MATH_1	151	155	PF00917	0.606
DOC_USP7_MATH_1	221	225	PF00917	0.424
DOC_USP7_MATH_1	248	252	PF00917	0.538
DOC_USP7_MATH_1	262	266	PF00917	0.538
DOC_USP7_MATH_1	371	375	PF00917	0.601
DOC_USP7_MATH_1	412	416	PF00917	0.440
DOC_USP7_MATH_1	6	10	PF00917	0.526
DOC_USP7_MATH_1	868	872	PF00917	0.737
DOC_USP7_MATH_1	910	914	PF00917	0.586
DOC_WW_Pin1_4	211	216	PF00397	0.489
DOC_WW_Pin1_4	447	452	PF00397	0.406
LIG_14-3-3_CanoR_1	271	276	PF00244	0.549
LIG_14-3-3_CanoR_1	336	341	PF00244	0.643
LIG_14-3-3_CanoR_1	343	349	PF00244	0.716
LIG_14-3-3_CanoR_1	447	451	PF00244	0.163
LIG_14-3-3_CanoR_1	579	588	PF00244	0.400
LIG_AP2alpha_2	444	446	PF02296	0.323
LIG_APCC_ABBA_1	20	25	PF00400	0.544
LIG_APCC_ABBA_1	836	841	PF00400	0.410
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BIR_III_3	1	5	PF00653	0.677
LIG_BRCT_BRCA1_1	184	188	PF00533	0.515
LIG_BRCT_BRCA1_1	216	220	PF00533	0.585
LIG_BRCT_BRCA1_1	223	227	PF00533	0.360
LIG_DLG_GKlike_1	1032	1039	PF00625	0.444
LIG_EH1_1	763	771	PF00400	0.496
LIG_FHA_1	108	114	PF00498	0.539
LIG_FHA_1	26	32	PF00498	0.438
LIG_FHA_1	265	271	PF00498	0.489
LIG_FHA_1	272	278	PF00498	0.495
LIG_FHA_1	322	328	PF00498	0.537
LIG_FHA_1	335	341	PF00498	0.574
LIG_FHA_1	569	575	PF00498	0.447
LIG_FHA_1	669	675	PF00498	0.449
LIG_FHA_1	706	712	PF00498	0.446
LIG_FHA_1	718	724	PF00498	0.344
LIG_FHA_1	825	831	PF00498	0.545
LIG_FHA_1	84	90	PF00498	0.496
LIG_FHA_1	842	848	PF00498	0.390
LIG_FHA_1	930	936	PF00498	0.428
LIG_FHA_2	89	95	PF00498	0.473
LIG_FHA_2	956	962	PF00498	0.433
LIG_FHA_2	967	973	PF00498	0.425
LIG_FHA_2	974	980	PF00498	0.423
LIG_Integrin_isoDGR_2	288	290	PF01839	0.541
LIG_LIR_Apic_2	427	432	PF02991	0.458
LIG_LIR_Gen_1	174	181	PF02991	0.481
LIG_LIR_Gen_1	224	233	PF02991	0.388
LIG_LIR_Gen_1	393	402	PF02991	0.307
LIG_LIR_Gen_1	474	485	PF02991	0.392
LIG_LIR_Gen_1	552	561	PF02991	0.376
LIG_LIR_Gen_1	596	607	PF02991	0.483
LIG_LIR_Gen_1	621	632	PF02991	0.530
LIG_LIR_Gen_1	706	712	PF02991	0.484
LIG_LIR_Gen_1	86	92	PF02991	0.439
LIG_LIR_Nem_3	1011	1017	PF02991	0.307
LIG_LIR_Nem_3	174	178	PF02991	0.498
LIG_LIR_Nem_3	393	398	PF02991	0.307
LIG_LIR_Nem_3	474	480	PF02991	0.375
LIG_LIR_Nem_3	552	557	PF02991	0.360
LIG_LIR_Nem_3	575	581	PF02991	0.389
LIG_LIR_Nem_3	596	602	PF02991	0.477
LIG_LIR_Nem_3	621	627	PF02991	0.542
LIG_LIR_Nem_3	706	710	PF02991	0.381
LIG_LIR_Nem_3	747	751	PF02991	0.471
LIG_LIR_Nem_3	86	90	PF02991	0.481
LIG_LIR_Nem_3	946	951	PF02991	0.421
LIG_LIR_Nem_3	954	959	PF02991	0.373
LIG_LIR_Nem_3	989	994	PF02991	0.394
LIG_PCNA_PIPBox_1	1036	1045	PF02747	0.521
LIG_PCNA_yPIPBox_3	44	56	PF02747	0.437
LIG_SH2_CRK	558	562	PF00017	0.372
LIG_SH2_NCK_1	298	302	PF00017	0.473
LIG_SH2_PTP2	788	791	PF00017	0.474
LIG_SH2_PTP2	87	90	PF00017	0.436
LIG_SH2_STAP1	645	649	PF00017	0.460
LIG_SH2_STAP1	751	755	PF00017	0.557
LIG_SH2_STAP1	815	819	PF00017	0.406
LIG_SH2_STAT3	959	962	PF00017	0.454
LIG_SH2_STAT5	1014	1017	PF00017	0.356
LIG_SH2_STAT5	305	308	PF00017	0.486
LIG_SH2_STAT5	673	676	PF00017	0.375
LIG_SH2_STAT5	788	791	PF00017	0.339
LIG_SH2_STAT5	87	90	PF00017	0.470
LIG_SH2_STAT5	955	958	PF00017	0.380
LIG_SH2_STAT5	993	996	PF00017	0.307
LIG_SH3_1	428	434	PF00018	0.454
LIG_SH3_3	1075	1081	PF00018	0.542
LIG_SH3_3	16	22	PF00018	0.588
LIG_SH3_3	24	30	PF00018	0.537
LIG_SH3_3	396	402	PF00018	0.440
LIG_SH3_3	428	434	PF00018	0.428
LIG_SH3_3	70	76	PF00018	0.481
LIG_SUMO_SIM_par_1	1074	1079	PF11976	0.428
LIG_SUMO_SIM_par_1	235	241	PF11976	0.461
LIG_SUMO_SIM_par_1	344	351	PF11976	0.529
LIG_SUMO_SIM_par_1	715	721	PF11976	0.490
LIG_SUMO_SIM_par_1	765	771	PF11976	0.485
LIG_UBA3_1	259	264	PF00899	0.250
LIG_UBA3_1	598	606	PF00899	0.481
LIG_UBA3_1	723	729	PF00899	0.544
LIG_WRC_WIRS_1	1039	1044	PF05994	0.499
LIG_WRC_WIRS_1	745	750	PF05994	0.526
LIG_WW_2	431	434	PF00397	0.454
MOD_CK1_1	211	217	PF00069	0.523
MOD_CK1_1	338	344	PF00069	0.609
MOD_CK1_1	415	421	PF00069	0.404
MOD_CK1_1	450	456	PF00069	0.240
MOD_CK1_1	660	666	PF00069	0.519
MOD_CK1_1	858	864	PF00069	0.578
MOD_CK2_1	1028	1034	PF00069	0.436
MOD_CK2_1	280	286	PF00069	0.594
MOD_CK2_1	336	342	PF00069	0.631
MOD_CK2_1	344	350	PF00069	0.695
MOD_CK2_1	627	633	PF00069	0.414
MOD_CK2_1	751	757	PF00069	0.494
MOD_CK2_1	8	14	PF00069	0.658
MOD_CK2_1	857	863	PF00069	0.646
MOD_CK2_1	90	96	PF00069	0.446
MOD_CK2_1	966	972	PF00069	0.416
MOD_DYRK1A_RPxSP_1	447	451	PF00069	0.163
MOD_GlcNHglycan	1010	1013	PF01048	0.222
MOD_GlcNHglycan	152	156	PF01048	0.659
MOD_GlcNHglycan	159	162	PF01048	0.717
MOD_GlcNHglycan	184	187	PF01048	0.478
MOD_GlcNHglycan	264	267	PF01048	0.550
MOD_GlcNHglycan	280	283	PF01048	0.424
MOD_GlcNHglycan	308	311	PF01048	0.457
MOD_GlcNHglycan	373	376	PF01048	0.545
MOD_GlcNHglycan	383	386	PF01048	0.388
MOD_GlcNHglycan	418	421	PF01048	0.373
MOD_GlcNHglycan	53	56	PF01048	0.502
MOD_GlcNHglycan	616	619	PF01048	0.567
MOD_GlcNHglycan	659	662	PF01048	0.547
MOD_GlcNHglycan	780	783	PF01048	0.521
MOD_GlcNHglycan	855	858	PF01048	0.618
MOD_GlcNHglycan	925	928	PF01048	0.363
MOD_GSK3_1	1028	1035	PF00069	0.533
MOD_GSK3_1	157	164	PF00069	0.761
MOD_GSK3_1	25	32	PF00069	0.568
MOD_GSK3_1	334	341	PF00069	0.649
MOD_GSK3_1	412	419	PF00069	0.310
MOD_GSK3_1	446	453	PF00069	0.398
MOD_GSK3_1	564	571	PF00069	0.460
MOD_GSK3_1	580	587	PF00069	0.277
MOD_GSK3_1	610	617	PF00069	0.498
MOD_GSK3_1	853	860	PF00069	0.496
MOD_GSK3_1	95	102	PF00069	0.454
MOD_N-GLC_2	525	527	PF02516	0.407
MOD_NEK2_1	1007	1012	PF00069	0.345
MOD_NEK2_1	107	112	PF00069	0.555
MOD_NEK2_1	159	164	PF00069	0.725
MOD_NEK2_1	208	213	PF00069	0.537
MOD_NEK2_1	237	242	PF00069	0.359
MOD_NEK2_1	334	339	PF00069	0.565
MOD_NEK2_1	446	451	PF00069	0.277
MOD_NEK2_1	469	474	PF00069	0.422
MOD_NEK2_1	51	56	PF00069	0.447
MOD_NEK2_1	580	585	PF00069	0.244
MOD_NEK2_1	627	632	PF00069	0.415
MOD_NEK2_1	668	673	PF00069	0.535
MOD_NEK2_1	68	73	PF00069	0.484
MOD_NEK2_1	804	809	PF00069	0.427
MOD_NEK2_1	810	815	PF00069	0.415
MOD_NEK2_1	99	104	PF00069	0.485
MOD_NEK2_2	559	564	PF00069	0.243
MOD_NEK2_2	883	888	PF00069	0.534
MOD_PIKK_1	123	129	PF00454	0.656
MOD_PIKK_1	161	167	PF00454	0.669
MOD_PIKK_1	269	275	PF00454	0.569
MOD_PIKK_1	31	37	PF00454	0.591
MOD_PIKK_1	496	502	PF00454	0.302
MOD_PIKK_1	519	525	PF00454	0.520
MOD_PIKK_1	966	972	PF00454	0.372
MOD_PIKK_1	994	1000	PF00454	0.412
MOD_PK_1	336	342	PF00069	0.602
MOD_PKA_1	853	859	PF00069	0.599
MOD_PKA_2	294	300	PF00069	0.518
MOD_PKA_2	335	341	PF00069	0.577
MOD_PKA_2	416	422	PF00069	0.277
MOD_PKA_2	446	452	PF00069	0.212
MOD_PKA_2	496	502	PF00069	0.249
MOD_PKA_2	51	57	PF00069	0.459
MOD_PKA_2	564	570	PF00069	0.486
MOD_PKA_2	853	859	PF00069	0.599
MOD_PKB_1	851	859	PF00069	0.493
MOD_Plk_1	1085	1091	PF00069	0.516
MOD_Plk_1	173	179	PF00069	0.537
MOD_Plk_1	341	347	PF00069	0.696
MOD_Plk_1	356	362	PF00069	0.511
MOD_Plk_1	705	711	PF00069	0.465
MOD_Plk_1	751	757	PF00069	0.551
MOD_Plk_1	863	869	PF00069	0.683
MOD_Plk_1	883	889	PF00069	0.535
MOD_Plk_1	95	101	PF00069	0.521
MOD_Plk_4	1038	1044	PF00069	0.492
MOD_Plk_4	301	307	PF00069	0.457
MOD_Plk_4	559	565	PF00069	0.524
MOD_Plk_4	594	600	PF00069	0.446
MOD_Plk_4	706	712	PF00069	0.460
MOD_Plk_4	744	750	PF00069	0.488
MOD_Plk_4	805	811	PF00069	0.521
MOD_Plk_4	83	89	PF00069	0.478
MOD_ProDKin_1	211	217	PF00069	0.484
MOD_ProDKin_1	447	453	PF00069	0.406
MOD_SUMO_rev_2	866	876	PF00179	0.652
TRG_DiLeu_BaEn_1	174	179	PF01217	0.442
TRG_DiLeu_BaEn_1	329	334	PF01217	0.562
TRG_DiLeu_BaEn_1	64	69	PF01217	0.575
TRG_DiLeu_BaEn_1	940	945	PF01217	0.376
TRG_DiLeu_BaLyEn_6	647	652	PF01217	0.409
TRG_DiLeu_BaLyEn_6	787	792	PF01217	0.435
TRG_DiLeu_LyEn_5	329	334	PF01217	0.562
TRG_ENDOCYTIC_2	558	561	PF00928	0.366
TRG_ENDOCYTIC_2	645	648	PF00928	0.396
TRG_ENDOCYTIC_2	788	791	PF00928	0.365
TRG_ENDOCYTIC_2	833	836	PF00928	0.409
TRG_ENDOCYTIC_2	87	90	PF00928	0.433
TRG_ER_diArg_1	402	404	PF00400	0.338
TRG_ER_diArg_1	440	443	PF00400	0.342
TRG_ER_diArg_1	466	468	PF00400	0.428
TRG_ER_diArg_1	505	508	PF00400	0.356
TRG_ER_diArg_1	51	53	PF00400	0.501
TRG_NES_CRM1_1	594	608	PF08389	0.426
TRG_NES_CRM1_1	934	947	PF08389	0.368
TRG_NLS_MonoExtC_3	505	511	PF00514	0.478
TRG_Pf-PMV_PEXEL_1	1005	1009	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	650	654	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	725	730	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	735	740	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	790	794	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	937	941	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX5	Leptomonas seymouri	63%	99%
A0A0S4JVP2	Bodo saltans	30%	100%
A0A1X0P439	Trypanosomatidae	35%	98%
A0A3R7NS00	Trypanosoma rangeli	36%	100%
A0A3S7X0J6	Leishmania donovani	93%	100%
A4HFL4	Leishmania braziliensis	82%	99%
A4I2P5	Leishmania infantum	94%	100%
D0A5Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9AD68	Leishmania major	93%	100%
F4IDS7	Arabidopsis thaliana	22%	100%
P59015	Danio rerio	21%	100%
Q9P253	Homo sapiens	24%	100%
V5BE49	Trypanosoma cruzi	38%	100%