LeishMANIAdb
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LRAT domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
LRAT domain-containing protein
Gene product:
Protein of unknown function (DUF778), putative
Species:
Leishmania mexicana
UniProt:
E9AYZ2_LEIMU
TriTrypDb:
LmxM.27.0900
Length:
195

Annotations

LeishMANIAdb annotations

A small, compact tail-anchored protein related to animal TMEM222 and plant RTE1. Function unknown.. Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11
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Expansion

Sequence features

E9AYZ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYZ2

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_PCSK_KEX2_1 105 107 PF00082 0.296
CLV_PCSK_PC1ET2_1 105 107 PF00082 0.295
CLV_PCSK_SKI1_1 173 177 PF00082 0.249
CLV_PCSK_SKI1_1 70 74 PF00082 0.323
DEG_Nend_UBRbox_2 1 3 PF02207 0.720
DOC_MAPK_DCC_7 176 184 PF00069 0.283
DOC_MAPK_gen_1 149 155 PF00069 0.508
DOC_MAPK_gen_1 6 15 PF00069 0.684
DOC_MAPK_MEF2A_6 176 184 PF00069 0.283
DOC_PP1_RVXF_1 165 172 PF00149 0.691
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I138 Leptomonas seymouri 64% 99%
A0A0S4IX94 Bodo saltans 53% 100%
A0A1X0P8A2 Trypanosomatidae 54% 96%
A0A3S7X0K2 Leishmania donovani 91% 99%
A0A422NWL7 Trypanosoma rangeli 52% 97%
A4HFL3 Leishmania braziliensis 68% 100%
A4I2P7 Leishmania infantum 91% 99%
D0A2W6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9AD67 Leishmania major 88% 100%
F4ITL6 Arabidopsis thaliana 33% 78%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS