LRAT domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF778), putative

Species:

Leishmania mexicana

UniProt:

E9AYZ2_LEIMU

TriTrypDb:

LmxM.27.0900

Length:

195

Annotations

LeishMANIAdb annotations

A small, compact tail-anchored protein related to animal TMEM222 and plant RTE1. Function unknown.. Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AYZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYZ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	105	107	PF00082	0.296
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.295
CLV_PCSK_SKI1_1	173	177	PF00082	0.249
CLV_PCSK_SKI1_1	70	74	PF00082	0.323
DEG_Nend_UBRbox_2	1	3	PF02207	0.720
DOC_MAPK_DCC_7	176	184	PF00069	0.283
DOC_MAPK_gen_1	149	155	PF00069	0.508
DOC_MAPK_gen_1	6	15	PF00069	0.684
DOC_MAPK_MEF2A_6	176	184	PF00069	0.283
DOC_PP1_RVXF_1	165	172	PF00149	0.691
DOC_PP4_FxxP_1	73	76	PF00568	0.482
DOC_USP7_MATH_1	114	118	PF00917	0.557
DOC_WW_Pin1_4	30	35	PF00397	0.635
DOC_WW_Pin1_4	8	13	PF00397	0.679
LIG_14-3-3_CanoR_1	123	131	PF00244	0.444
LIG_14-3-3_CanoR_1	167	172	PF00244	0.628
LIG_CaM_IQ_9	57	72	PF13499	0.550
LIG_CSL_BTD_1	31	34	PF09270	0.631
LIG_LIR_Apic_2	39	43	PF02991	0.445
LIG_LIR_Gen_1	170	179	PF02991	0.567
LIG_LIR_Nem_3	125	131	PF02991	0.443
LIG_LIR_Nem_3	170	174	PF02991	0.570
LIG_PCNA_PIPBox_1	124	133	PF02747	0.495
LIG_PCNA_yPIPBox_3	123	131	PF02747	0.495
LIG_PDZ_Class_2	190	195	PF00595	0.363
LIG_Pex14_1	40	44	PF04695	0.470
LIG_Pex14_2	28	32	PF04695	0.591
LIG_SH2_SRC	86	89	PF00017	0.660
LIG_SH2_SRC	91	94	PF00017	0.675
LIG_SH2_STAP1	111	115	PF00017	0.456
LIG_SH2_STAT3	58	61	PF00017	0.531
LIG_SH2_STAT5	168	171	PF00017	0.600
LIG_SH2_STAT5	86	89	PF00017	0.625
LIG_SH2_STAT5	91	94	PF00017	0.632
LIG_SH3_3	10	16	PF00018	0.646
LIG_SUMO_SIM_anti_2	181	186	PF11976	0.428
LIG_TYR_ITIM	77	82	PF00017	0.442
LIG_WRC_WIRS_1	168	173	PF05994	0.577
LIG_WRC_WIRS_1	87	92	PF05994	0.657
MOD_CK2_1	139	145	PF00069	0.523
MOD_GlcNHglycan	96	99	PF01048	0.323
MOD_LATS_1	165	171	PF00433	0.466
MOD_N-GLC_2	133	135	PF02516	0.245
MOD_NEK2_1	115	120	PF00069	0.466
MOD_PIKK_1	50	56	PF00454	0.506
MOD_PKA_2	122	128	PF00069	0.439
MOD_Plk_4	134	140	PF00069	0.438
MOD_Plk_4	178	184	PF00069	0.408
MOD_Plk_4	36	42	PF00069	0.445
MOD_Plk_4	86	92	PF00069	0.665
MOD_ProDKin_1	30	36	PF00069	0.636
MOD_ProDKin_1	8	14	PF00069	0.681
MOD_SUMO_for_1	104	107	PF00179	0.495
TRG_ENDOCYTIC_2	128	131	PF00928	0.445
TRG_ENDOCYTIC_2	168	171	PF00928	0.709
TRG_ENDOCYTIC_2	79	82	PF00928	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I138	Leptomonas seymouri	64%	99%
A0A0S4IX94	Bodo saltans	53%	100%
A0A1X0P8A2	Trypanosomatidae	54%	96%
A0A3S7X0K2	Leishmania donovani	91%	99%
A0A422NWL7	Trypanosoma rangeli	52%	97%
A4HFL3	Leishmania braziliensis	68%	100%
A4I2P7	Leishmania infantum	91%	99%
D0A2W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AD67	Leishmania major	88%	100%
F4ITL6	Arabidopsis thaliana	33%	78%
Q8BVA2	Mus musculus	32%	94%
Q9H0R3	Homo sapiens	32%	94%
Q9SD42	Arabidopsis thaliana	31%	84%
V5DL06	Trypanosoma cruzi	55%	98%