WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AYY8_LEIMU

TriTrypDb:

LmxM.27.0860

Length:

1035

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.588
CLV_C14_Caspase3-7	37	41	PF00656	0.664
CLV_C14_Caspase3-7	574	578	PF00656	0.542
CLV_C14_Caspase3-7	696	700	PF00656	0.492
CLV_NRD_NRD_1	284	286	PF00675	0.633
CLV_NRD_NRD_1	701	703	PF00675	0.463
CLV_NRD_NRD_1	986	988	PF00675	0.485
CLV_NRD_NRD_1	997	999	PF00675	0.377
CLV_PCSK_FUR_1	59	63	PF00082	0.419
CLV_PCSK_KEX2_1	284	286	PF00082	0.633
CLV_PCSK_KEX2_1	581	583	PF00082	0.597
CLV_PCSK_KEX2_1	61	63	PF00082	0.440
CLV_PCSK_KEX2_1	701	703	PF00082	0.463
CLV_PCSK_KEX2_1	848	850	PF00082	0.539
CLV_PCSK_KEX2_1	921	923	PF00082	0.537
CLV_PCSK_KEX2_1	986	988	PF00082	0.485
CLV_PCSK_KEX2_1	997	999	PF00082	0.377
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.633
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.530
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.394
CLV_PCSK_PC1ET2_1	848	850	PF00082	0.508
CLV_PCSK_PC1ET2_1	921	923	PF00082	0.492
CLV_PCSK_SKI1_1	1027	1031	PF00082	0.507
CLV_PCSK_SKI1_1	182	186	PF00082	0.504
CLV_PCSK_SKI1_1	270	274	PF00082	0.380
CLV_PCSK_SKI1_1	848	852	PF00082	0.499
CLV_PCSK_SKI1_1	962	966	PF00082	0.373
CLV_PCSK_SKI1_1	987	991	PF00082	0.408
DEG_APCC_DBOX_1	177	185	PF00400	0.412
DEG_APCC_DBOX_1	269	277	PF00400	0.460
DEG_APCC_DBOX_1	705	713	PF00400	0.403
DEG_APCC_DBOX_1	871	879	PF00400	0.467
DEG_MDM2_SWIB_1	747	755	PF02201	0.537
DEG_Nend_UBRbox_3	1	3	PF02207	0.626
DEG_SPOP_SBC_1	369	373	PF00917	0.299
DEG_SPOP_SBC_1	430	434	PF00917	0.353
DEG_SPOP_SBC_1	451	455	PF00917	0.406
DOC_CKS1_1	53	58	PF01111	0.531
DOC_CKS1_1	796	801	PF01111	0.517
DOC_CYCLIN_RxL_1	1024	1034	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	22	25	PF00134	0.610
DOC_MAPK_gen_1	116	124	PF00069	0.521
DOC_MAPK_gen_1	701	709	PF00069	0.488
DOC_MAPK_gen_1	780	788	PF00069	0.368
DOC_MAPK_MEF2A_6	597	606	PF00069	0.354
DOC_MAPK_MEF2A_6	834	843	PF00069	0.565
DOC_PP1_RVXF_1	119	126	PF00149	0.428
DOC_PP1_RVXF_1	464	471	PF00149	0.386
DOC_PP1_RVXF_1	960	966	PF00149	0.392
DOC_PP2B_LxvP_1	137	140	PF13499	0.397
DOC_PP2B_LxvP_1	22	25	PF13499	0.638
DOC_PP2B_LxvP_1	566	569	PF13499	0.403
DOC_PP2B_LxvP_1	85	88	PF13499	0.474
DOC_PP4_FxxP_1	1022	1025	PF00568	0.408
DOC_USP7_MATH_1	162	166	PF00917	0.620
DOC_USP7_MATH_1	209	213	PF00917	0.378
DOC_USP7_MATH_1	226	230	PF00917	0.574
DOC_USP7_MATH_1	346	350	PF00917	0.634
DOC_USP7_MATH_1	451	455	PF00917	0.479
DOC_USP7_MATH_1	527	531	PF00917	0.454
DOC_USP7_MATH_1	544	548	PF00917	0.660
DOC_USP7_MATH_1	674	678	PF00917	0.501
DOC_USP7_MATH_1	685	689	PF00917	0.486
DOC_USP7_MATH_1	789	793	PF00917	0.528
DOC_USP7_MATH_1	805	809	PF00917	0.464
DOC_USP7_MATH_1	86	90	PF00917	0.529
DOC_USP7_MATH_1	917	921	PF00917	0.612
DOC_USP7_UBL2_3	621	625	PF12436	0.357
DOC_USP7_UBL2_3	656	660	PF12436	0.514
DOC_WW_Pin1_4	10	15	PF00397	0.598
DOC_WW_Pin1_4	105	110	PF00397	0.647
DOC_WW_Pin1_4	340	345	PF00397	0.654
DOC_WW_Pin1_4	389	394	PF00397	0.481
DOC_WW_Pin1_4	511	516	PF00397	0.508
DOC_WW_Pin1_4	52	57	PF00397	0.531
DOC_WW_Pin1_4	759	764	PF00397	0.747
DOC_WW_Pin1_4	795	800	PF00397	0.523
DOC_WW_Pin1_4	818	823	PF00397	0.527
DOC_WW_Pin1_4	924	929	PF00397	0.593
LIG_14-3-3_CanoR_1	100	105	PF00244	0.486
LIG_14-3-3_CanoR_1	178	182	PF00244	0.443
LIG_14-3-3_CanoR_1	193	201	PF00244	0.412
LIG_14-3-3_CanoR_1	218	226	PF00244	0.417
LIG_14-3-3_CanoR_1	352	359	PF00244	0.615
LIG_14-3-3_CanoR_1	500	509	PF00244	0.465
LIG_14-3-3_CanoR_1	62	66	PF00244	0.568
LIG_14-3-3_CanoR_1	701	709	PF00244	0.467
LIG_14-3-3_CanoR_1	717	721	PF00244	0.470
LIG_14-3-3_CanoR_1	780	788	PF00244	0.481
LIG_14-3-3_CanoR_1	81	86	PF00244	0.444
LIG_14-3-3_CanoR_1	834	841	PF00244	0.513
LIG_14-3-3_CanoR_1	857	865	PF00244	0.538
LIG_14-3-3_CanoR_1	901	909	PF00244	0.508
LIG_14-3-3_CanoR_1	922	927	PF00244	0.569
LIG_14-3-3_CanoR_1	937	943	PF00244	0.702
LIG_14-3-3_CanoR_1	986	995	PF00244	0.434
LIG_BIR_III_2	671	675	PF00653	0.358
LIG_BIR_III_4	27	31	PF00653	0.511
LIG_BIR_III_4	991	995	PF00653	0.515
LIG_BRCT_BRCA1_1	254	258	PF00533	0.456
LIG_BRCT_BRCA1_1	820	824	PF00533	0.632
LIG_Clathr_ClatBox_1	838	842	PF01394	0.542
LIG_FHA_1	106	112	PF00498	0.610
LIG_FHA_1	127	133	PF00498	0.522
LIG_FHA_1	202	208	PF00498	0.495
LIG_FHA_1	214	220	PF00498	0.291
LIG_FHA_1	245	251	PF00498	0.491
LIG_FHA_1	313	319	PF00498	0.403
LIG_FHA_1	332	338	PF00498	0.555
LIG_FHA_1	362	368	PF00498	0.483
LIG_FHA_1	378	384	PF00498	0.326
LIG_FHA_1	447	453	PF00498	0.433
LIG_FHA_1	512	518	PF00498	0.444
LIG_FHA_1	558	564	PF00498	0.315
LIG_FHA_1	607	613	PF00498	0.456
LIG_FHA_1	62	68	PF00498	0.461
LIG_FHA_1	636	642	PF00498	0.476
LIG_FHA_1	796	802	PF00498	0.521
LIG_FHA_1	856	862	PF00498	0.616
LIG_FHA_1	868	874	PF00498	0.397
LIG_FHA_1	925	931	PF00498	0.620
LIG_FHA_1	976	982	PF00498	0.417
LIG_FHA_2	154	160	PF00498	0.482
LIG_FHA_2	35	41	PF00498	0.679
LIG_FHA_2	385	391	PF00498	0.474
LIG_FHA_2	423	429	PF00498	0.371
LIG_FHA_2	893	899	PF00498	0.392
LIG_LIR_Apic_2	1021	1025	PF02991	0.479
LIG_LIR_Gen_1	152	163	PF02991	0.440
LIG_LIR_Gen_1	315	323	PF02991	0.457
LIG_LIR_Gen_1	401	412	PF02991	0.331
LIG_LIR_Gen_1	44	54	PF02991	0.528
LIG_LIR_Gen_1	481	489	PF02991	0.404
LIG_LIR_Gen_1	516	527	PF02991	0.444
LIG_LIR_Gen_1	560	570	PF02991	0.319
LIG_LIR_Nem_3	152	158	PF02991	0.406
LIG_LIR_Nem_3	315	320	PF02991	0.446
LIG_LIR_Nem_3	401	407	PF02991	0.487
LIG_LIR_Nem_3	44	50	PF02991	0.515
LIG_LIR_Nem_3	467	473	PF02991	0.478
LIG_LIR_Nem_3	481	485	PF02991	0.312
LIG_LIR_Nem_3	516	522	PF02991	0.410
LIG_LIR_Nem_3	560	565	PF02991	0.301
LIG_MYND_1	459	463	PF01753	0.387
LIG_NRBOX	860	866	PF00104	0.433
LIG_Pex14_2	138	142	PF04695	0.420
LIG_Pex14_2	747	751	PF04695	0.509
LIG_Pex14_2	984	988	PF04695	0.401
LIG_SH2_CRK	47	51	PF00017	0.590
LIG_SH2_CRK	54	58	PF00017	0.572
LIG_SH2_GRB2like	404	407	PF00017	0.364
LIG_SH2_NCK_1	155	159	PF00017	0.479
LIG_SH2_PTP2	404	407	PF00017	0.497
LIG_SH2_SRC	404	407	PF00017	0.497
LIG_SH2_SRC	968	971	PF00017	0.448
LIG_SH2_STAP1	47	51	PF00017	0.514
LIG_SH2_STAP1	482	486	PF00017	0.388
LIG_SH2_STAT5	153	156	PF00017	0.400
LIG_SH2_STAT5	174	177	PF00017	0.584
LIG_SH2_STAT5	366	369	PF00017	0.396
LIG_SH2_STAT5	375	378	PF00017	0.306
LIG_SH2_STAT5	404	407	PF00017	0.497
LIG_SH2_STAT5	54	57	PF00017	0.490
LIG_SH2_STAT5	926	929	PF00017	0.592
LIG_SH2_STAT5	982	985	PF00017	0.464
LIG_SH3_2	279	284	PF14604	0.618
LIG_SH3_3	273	279	PF00018	0.458
LIG_SH3_3	457	463	PF00018	0.382
LIG_SH3_3	728	734	PF00018	0.310
LIG_SH3_3	847	853	PF00018	0.461
LIG_SH3_4	656	663	PF00018	0.492
LIG_SUMO_SIM_anti_2	1007	1013	PF11976	0.376
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.393
LIG_SUMO_SIM_anti_2	800	808	PF11976	0.570
LIG_SUMO_SIM_par_1	329	335	PF11976	0.568
LIG_SUMO_SIM_par_1	378	384	PF11976	0.394
LIG_SUMO_SIM_par_1	600	605	PF11976	0.394
LIG_SUMO_SIM_par_1	690	696	PF11976	0.460
LIG_TRAF2_1	167	170	PF00917	0.513
LIG_UBA3_1	650	656	PF00899	0.357
LIG_WRC_WIRS_1	1019	1024	PF05994	0.460
LIG_WW_3	1024	1028	PF00397	0.450
MOD_CDK_SPK_2	389	394	PF00069	0.481
MOD_CDK_SPK_2	759	764	PF00069	0.590
MOD_CDK_SPK_2	924	929	PF00069	0.669
MOD_CDK_SPxxK_3	511	518	PF00069	0.466
MOD_CDK_SPxxK_3	52	59	PF00069	0.533
MOD_CK1_1	103	109	PF00069	0.501
MOD_CK1_1	161	167	PF00069	0.454
MOD_CK1_1	177	183	PF00069	0.565
MOD_CK1_1	252	258	PF00069	0.435
MOD_CK1_1	290	296	PF00069	0.658
MOD_CK1_1	340	346	PF00069	0.609
MOD_CK1_1	347	353	PF00069	0.653
MOD_CK1_1	36	42	PF00069	0.678
MOD_CK1_1	360	366	PF00069	0.349
MOD_CK1_1	446	452	PF00069	0.486
MOD_CK1_1	478	484	PF00069	0.383
MOD_CK1_1	774	780	PF00069	0.491
MOD_CK1_1	833	839	PF00069	0.689
MOD_CK1_1	915	921	PF00069	0.688
MOD_CK1_1	938	944	PF00069	0.486
MOD_CK2_1	112	118	PF00069	0.529
MOD_CK2_1	153	159	PF00069	0.477
MOD_CK2_1	162	168	PF00069	0.526
MOD_CK2_1	384	390	PF00069	0.530
MOD_CK2_1	484	490	PF00069	0.395
MOD_CK2_1	722	728	PF00069	0.519
MOD_CK2_1	738	744	PF00069	0.401
MOD_CK2_1	892	898	PF00069	0.363
MOD_Cter_Amidation	579	582	PF01082	0.634
MOD_GlcNHglycan	1006	1009	PF01048	0.513
MOD_GlcNHglycan	105	108	PF01048	0.508
MOD_GlcNHglycan	159	163	PF01048	0.565
MOD_GlcNHglycan	164	167	PF01048	0.566
MOD_GlcNHglycan	190	193	PF01048	0.447
MOD_GlcNHglycan	230	233	PF01048	0.486
MOD_GlcNHglycan	326	329	PF01048	0.568
MOD_GlcNHglycan	353	356	PF01048	0.614
MOD_GlcNHglycan	372	375	PF01048	0.300
MOD_GlcNHglycan	387	390	PF01048	0.580
MOD_GlcNHglycan	398	401	PF01048	0.660
MOD_GlcNHglycan	416	419	PF01048	0.320
MOD_GlcNHglycan	445	448	PF01048	0.419
MOD_GlcNHglycan	486	489	PF01048	0.411
MOD_GlcNHglycan	546	549	PF01048	0.557
MOD_GlcNHglycan	633	636	PF01048	0.409
MOD_GlcNHglycan	67	70	PF01048	0.534
MOD_GlcNHglycan	709	712	PF01048	0.462
MOD_GlcNHglycan	807	810	PF01048	0.650
MOD_GlcNHglycan	81	84	PF01048	0.491
MOD_GlcNHglycan	824	827	PF01048	0.432
MOD_GlcNHglycan	913	917	PF01048	0.679
MOD_GlcNHglycan	938	941	PF01048	0.577
MOD_GSK3_1	149	156	PF00069	0.439
MOD_GSK3_1	158	165	PF00069	0.460
MOD_GSK3_1	176	183	PF00069	0.325
MOD_GSK3_1	188	195	PF00069	0.400
MOD_GSK3_1	203	210	PF00069	0.354
MOD_GSK3_1	340	347	PF00069	0.609
MOD_GSK3_1	357	364	PF00069	0.457
MOD_GSK3_1	385	392	PF00069	0.669
MOD_GSK3_1	442	449	PF00069	0.464
MOD_GSK3_1	61	68	PF00069	0.561
MOD_GSK3_1	631	638	PF00069	0.579
MOD_GSK3_1	697	704	PF00069	0.434
MOD_GSK3_1	743	750	PF00069	0.626
MOD_GSK3_1	77	84	PF00069	0.423
MOD_GSK3_1	770	777	PF00069	0.325
MOD_GSK3_1	818	825	PF00069	0.586
MOD_GSK3_1	851	858	PF00069	0.563
MOD_GSK3_1	908	915	PF00069	0.625
MOD_GSK3_1	931	938	PF00069	0.619
MOD_GSK3_1	942	949	PF00069	0.699
MOD_N-GLC_1	323	328	PF02516	0.554
MOD_N-GLC_1	384	389	PF02516	0.446
MOD_N-GLC_1	635	640	PF02516	0.326
MOD_N-GLC_1	674	679	PF02516	0.498
MOD_N-GLC_1	950	955	PF02516	0.443
MOD_NEK2_1	1	6	PF00069	0.557
MOD_NEK2_1	202	207	PF00069	0.567
MOD_NEK2_1	213	218	PF00069	0.322
MOD_NEK2_1	337	342	PF00069	0.581
MOD_NEK2_1	351	356	PF00069	0.555
MOD_NEK2_1	359	364	PF00069	0.427
MOD_NEK2_1	368	373	PF00069	0.412
MOD_NEK2_1	495	500	PF00069	0.496
MOD_NEK2_1	590	595	PF00069	0.649
MOD_NEK2_1	631	636	PF00069	0.320
MOD_NEK2_1	707	712	PF00069	0.465
MOD_NEK2_1	747	752	PF00069	0.510
MOD_NEK2_1	782	787	PF00069	0.516
MOD_NEK2_1	804	809	PF00069	0.448
MOD_NEK2_1	824	829	PF00069	0.581
MOD_NEK2_1	844	849	PF00069	0.526
MOD_NEK2_1	892	897	PF00069	0.367
MOD_NEK2_1	935	940	PF00069	0.665
MOD_PIKK_1	701	707	PF00454	0.512
MOD_PIKK_1	722	728	PF00454	0.324
MOD_PIKK_1	856	862	PF00454	0.598
MOD_PKA_1	61	67	PF00069	0.387
MOD_PKA_1	701	707	PF00069	0.416
MOD_PKA_2	177	183	PF00069	0.440
MOD_PKA_2	192	198	PF00069	0.395
MOD_PKA_2	287	293	PF00069	0.698
MOD_PKA_2	324	330	PF00069	0.515
MOD_PKA_2	351	357	PF00069	0.619
MOD_PKA_2	443	449	PF00069	0.394
MOD_PKA_2	590	596	PF00069	0.367
MOD_PKA_2	61	67	PF00069	0.548
MOD_PKA_2	701	707	PF00069	0.537
MOD_PKA_2	716	722	PF00069	0.427
MOD_PKA_2	782	788	PF00069	0.524
MOD_PKA_2	833	839	PF00069	0.587
MOD_PKA_2	856	862	PF00069	0.559
MOD_PKA_2	900	906	PF00069	0.495
MOD_PKA_2	936	942	PF00069	0.768
MOD_Plk_1	202	208	PF00069	0.444
MOD_Plk_1	360	366	PF00069	0.486
MOD_Plk_1	377	383	PF00069	0.287
MOD_Plk_1	743	749	PF00069	0.564
MOD_Plk_1	950	956	PF00069	0.487
MOD_Plk_4	1	7	PF00069	0.554
MOD_Plk_4	149	155	PF00069	0.495
MOD_Plk_4	182	188	PF00069	0.423
MOD_Plk_4	203	209	PF00069	0.434
MOD_Plk_4	260	266	PF00069	0.433
MOD_Plk_4	287	293	PF00069	0.672
MOD_Plk_4	304	310	PF00069	0.318
MOD_Plk_4	313	319	PF00069	0.468
MOD_Plk_4	361	367	PF00069	0.460
MOD_Plk_4	431	437	PF00069	0.387
MOD_Plk_4	637	643	PF00069	0.457
MOD_Plk_4	685	691	PF00069	0.426
MOD_Plk_4	719	725	PF00069	0.554
MOD_Plk_4	733	739	PF00069	0.383
MOD_Plk_4	747	753	PF00069	0.478
MOD_Plk_4	774	780	PF00069	0.551
MOD_Plk_4	87	93	PF00069	0.582
MOD_ProDKin_1	10	16	PF00069	0.605
MOD_ProDKin_1	105	111	PF00069	0.631
MOD_ProDKin_1	340	346	PF00069	0.653
MOD_ProDKin_1	389	395	PF00069	0.480
MOD_ProDKin_1	511	517	PF00069	0.510
MOD_ProDKin_1	52	58	PF00069	0.532
MOD_ProDKin_1	759	765	PF00069	0.745
MOD_ProDKin_1	795	801	PF00069	0.524
MOD_ProDKin_1	818	824	PF00069	0.524
MOD_ProDKin_1	924	930	PF00069	0.592
MOD_SUMO_for_1	550	553	PF00179	0.549
MOD_SUMO_rev_2	36	44	PF00179	0.616
MOD_SUMO_rev_2	574	583	PF00179	0.568
TRG_DiLeu_BaEn_1	118	123	PF01217	0.529
TRG_DiLeu_BaEn_1	203	208	PF01217	0.489
TRG_DiLeu_BaLyEn_6	554	559	PF01217	0.537
TRG_DiLeu_LyEn_5	118	123	PF01217	0.529
TRG_ENDOCYTIC_2	155	158	PF00928	0.391
TRG_ENDOCYTIC_2	404	407	PF00928	0.497
TRG_ENDOCYTIC_2	47	50	PF00928	0.516
TRG_ENDOCYTIC_2	482	485	PF00928	0.390
TRG_ENDOCYTIC_2	54	57	PF00928	0.567
TRG_ER_diArg_1	872	875	PF00400	0.471
TRG_ER_diArg_1	986	988	PF00400	0.485
TRG_ER_diArg_1	997	999	PF00400	0.377
TRG_NLS_MonoExtC_3	283	288	PF00514	0.628
TRG_NLS_MonoExtN_4	282	289	PF00514	0.620
TRG_Pf-PMV_PEXEL_1	1027	1031	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	997	1001	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ23	Leptomonas seymouri	38%	96%
A0A3S7X0K8	Leishmania donovani	86%	100%
A4HFK8	Leishmania braziliensis	70%	100%
A4I2P0	Leishmania infantum	86%	100%
E9AD63	Leishmania major	85%	100%