Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYY5_LEIMU

TriTrypDb:

LmxM.27.0830

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	50	54	PF00656	0.648
CLV_NRD_NRD_1	174	176	PF00675	0.667
CLV_NRD_NRD_1	19	21	PF00675	0.789
CLV_NRD_NRD_1	298	300	PF00675	0.636
CLV_NRD_NRD_1	314	316	PF00675	0.627
CLV_NRD_NRD_1	396	398	PF00675	0.499
CLV_NRD_NRD_1	399	401	PF00675	0.519
CLV_NRD_NRD_1	465	467	PF00675	0.641
CLV_PCSK_FUR_1	397	401	PF00082	0.557
CLV_PCSK_KEX2_1	122	124	PF00082	0.746
CLV_PCSK_KEX2_1	174	176	PF00082	0.678
CLV_PCSK_KEX2_1	19	21	PF00082	0.789
CLV_PCSK_KEX2_1	300	302	PF00082	0.644
CLV_PCSK_KEX2_1	313	315	PF00082	0.626
CLV_PCSK_KEX2_1	398	400	PF00082	0.560
CLV_PCSK_KEX2_1	464	466	PF00082	0.584
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.711
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.644
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.560
CLV_PCSK_SKI1_1	399	403	PF00082	0.540
CLV_PCSK_SKI1_1	441	445	PF00082	0.510
DOC_CKS1_1	56	61	PF01111	0.732
DOC_MAPK_gen_1	216	224	PF00069	0.720
DOC_MAPK_gen_1	325	332	PF00069	0.581
DOC_PP2B_LxvP_1	110	113	PF13499	0.656
DOC_PP2B_LxvP_1	205	208	PF13499	0.756
DOC_PP4_FxxP_1	328	331	PF00568	0.584
DOC_SPAK_OSR1_1	327	331	PF12202	0.571
DOC_USP7_MATH_1	114	118	PF00917	0.750
DOC_USP7_MATH_1	233	237	PF00917	0.741
DOC_USP7_MATH_1	261	265	PF00917	0.664
DOC_USP7_MATH_1	366	370	PF00917	0.754
DOC_WW_Pin1_4	126	131	PF00397	0.770
DOC_WW_Pin1_4	169	174	PF00397	0.705
DOC_WW_Pin1_4	229	234	PF00397	0.704
DOC_WW_Pin1_4	333	338	PF00397	0.692
DOC_WW_Pin1_4	55	60	PF00397	0.633
LIG_14-3-3_CanoR_1	115	119	PF00244	0.758
LIG_14-3-3_CanoR_1	189	193	PF00244	0.714
LIG_14-3-3_CanoR_1	199	207	PF00244	0.555
LIG_14-3-3_CanoR_1	447	455	PF00244	0.548
LIG_APCC_ABBA_1	302	307	PF00400	0.759
LIG_APCC_ABBA_1	329	334	PF00400	0.599
LIG_BRCT_BRCA1_1	127	131	PF00533	0.752
LIG_BRCT_BRCA1_1	285	289	PF00533	0.590
LIG_BRCT_BRCA1_2	285	291	PF00533	0.589
LIG_deltaCOP1_diTrp_1	176	182	PF00928	0.445
LIG_EVH1_1	110	114	PF00568	0.785
LIG_FHA_1	105	111	PF00498	0.684
LIG_FHA_1	306	312	PF00498	0.764
LIG_FHA_1	378	384	PF00498	0.619
LIG_FHA_1	400	406	PF00498	0.546
LIG_FHA_1	432	438	PF00498	0.608
LIG_FHA_1	440	446	PF00498	0.519
LIG_FHA_2	66	72	PF00498	0.606
LIG_LIR_Apic_2	204	209	PF02991	0.759
LIG_LIR_Apic_2	326	331	PF02991	0.600
LIG_LIR_Gen_1	176	185	PF02991	0.621
LIG_LIR_Gen_1	47	56	PF02991	0.605
LIG_LIR_Nem_3	176	181	PF02991	0.451
LIG_LIR_Nem_3	264	268	PF02991	0.671
LIG_LIR_Nem_3	47	51	PF02991	0.604
LIG_Pex14_2	213	217	PF04695	0.656
LIG_Pex14_2	328	332	PF04695	0.581
LIG_Pex14_2	345	349	PF04695	0.464
LIG_SH2_CRK	268	272	PF00017	0.732
LIG_SH2_GRB2like	348	351	PF00017	0.456
LIG_SH2_NCK_1	306	310	PF00017	0.522
LIG_SH2_SRC	206	209	PF00017	0.759
LIG_SH2_STAP1	389	393	PF00017	0.529
LIG_SH2_STAT5	206	209	PF00017	0.759
LIG_SH2_STAT5	268	271	PF00017	0.690
LIG_SH2_STAT5	348	351	PF00017	0.456
LIG_SH2_STAT5	57	60	PF00017	0.769
LIG_SH3_1	206	212	PF00018	0.763
LIG_SH3_2	170	175	PF14604	0.672
LIG_SH3_3	108	114	PF00018	0.652
LIG_SH3_3	167	173	PF00018	0.726
LIG_SH3_3	206	212	PF00018	0.639
LIG_SH3_3	53	59	PF00018	0.691
LIG_SH3_3	96	102	PF00018	0.733
LIG_SUMO_SIM_par_1	100	109	PF11976	0.669
LIG_SUMO_SIM_par_1	220	227	PF11976	0.798
LIG_TRAF2_1	14	17	PF00917	0.767
LIG_TYR_ITSM	264	271	PF00017	0.740
LIG_WW_3	112	116	PF00397	0.705
LIG_WW_3	207	211	PF00397	0.763
MOD_CDC14_SPxK_1	172	175	PF00782	0.667
MOD_CDK_SPK_2	169	174	PF00069	0.705
MOD_CDK_SPK_2	333	338	PF00069	0.692
MOD_CDK_SPK_2	55	60	PF00069	0.458
MOD_CDK_SPxK_1	169	175	PF00069	0.676
MOD_CK1_1	11	17	PF00069	0.770
MOD_CK1_1	129	135	PF00069	0.774
MOD_CK1_1	201	207	PF00069	0.759
MOD_CK1_1	21	27	PF00069	0.579
MOD_CK1_1	439	445	PF00069	0.535
MOD_CK2_1	11	17	PF00069	0.771
MOD_CK2_1	220	226	PF00069	0.796
MOD_CK2_1	366	372	PF00069	0.612
MOD_CK2_1	44	50	PF00069	0.698
MOD_Cter_Amidation	311	314	PF01082	0.687
MOD_DYRK1A_RPxSP_1	169	173	PF00069	0.681
MOD_GlcNHglycan	10	13	PF01048	0.716
MOD_GlcNHglycan	142	145	PF01048	0.672
MOD_GlcNHglycan	2	5	PF01048	0.700
MOD_GlcNHglycan	248	251	PF01048	0.776
MOD_GlcNHglycan	285	288	PF01048	0.612
MOD_GlcNHglycan	316	319	PF01048	0.686
MOD_GlcNHglycan	35	38	PF01048	0.619
MOD_GlcNHglycan	377	380	PF01048	0.464
MOD_GSK3_1	101	108	PF00069	0.511
MOD_GSK3_1	11	18	PF00069	0.732
MOD_GSK3_1	121	128	PF00069	0.640
MOD_GSK3_1	129	136	PF00069	0.729
MOD_GSK3_1	229	236	PF00069	0.813
MOD_GSK3_1	362	369	PF00069	0.587
MOD_GSK3_1	414	421	PF00069	0.578
MOD_GSK3_1	61	68	PF00069	0.657
MOD_N-GLC_1	229	234	PF02516	0.761
MOD_N-GLC_1	69	74	PF02516	0.602
MOD_NEK2_1	121	126	PF00069	0.570
MOD_NEK2_1	188	193	PF00069	0.662
MOD_NEK2_1	332	337	PF00069	0.639
MOD_NEK2_1	436	441	PF00069	0.520
MOD_NEK2_1	8	13	PF00069	0.789
MOD_NEK2_2	263	268	PF00069	0.744
MOD_OFUCOSY	260	267	PF10250	0.753
MOD_PIKK_1	233	239	PF00454	0.805
MOD_PIKK_1	61	67	PF00454	0.570
MOD_PKA_1	314	320	PF00069	0.669
MOD_PKA_1	399	405	PF00069	0.580
MOD_PKA_2	114	120	PF00069	0.765
MOD_PKA_2	18	24	PF00069	0.763
MOD_PKA_2	188	194	PF00069	0.679
MOD_PKA_2	198	204	PF00069	0.633
MOD_PKA_2	314	320	PF00069	0.785
MOD_PKA_2	359	365	PF00069	0.510
MOD_PKA_2	399	405	PF00069	0.545
MOD_PKA_2	417	423	PF00069	0.651
MOD_PKA_2	446	452	PF00069	0.532
MOD_PKA_2	77	83	PF00069	0.746
MOD_PKB_1	397	405	PF00069	0.571
MOD_Plk_1	201	207	PF00069	0.643
MOD_Plk_4	177	183	PF00069	0.623
MOD_Plk_4	201	207	PF00069	0.648
MOD_Plk_4	44	50	PF00069	0.671
MOD_ProDKin_1	126	132	PF00069	0.768
MOD_ProDKin_1	169	175	PF00069	0.698
MOD_ProDKin_1	229	235	PF00069	0.706
MOD_ProDKin_1	333	339	PF00069	0.689
MOD_ProDKin_1	55	61	PF00069	0.640
TRG_ENDOCYTIC_2	268	271	PF00928	0.632
TRG_ER_diArg_1	173	175	PF00400	0.759
TRG_ER_diArg_1	298	301	PF00400	0.660
TRG_ER_diArg_1	313	315	PF00400	0.624
TRG_ER_diArg_1	397	400	PF00400	0.528
TRG_ER_diArg_1	464	466	PF00400	0.651
TRG_NLS_MonoExtC_3	298	303	PF00514	0.692
TRG_NLS_MonoExtN_4	119	126	PF00514	0.626
TRG_NLS_MonoExtN_4	297	304	PF00514	0.691
TRG_NLS_MonoExtN_4	397	402	PF00514	0.559
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D2	Leptomonas seymouri	40%	84%
A0A3S7X0I5	Leishmania donovani	88%	100%
A4HFK5	Leishmania braziliensis	73%	100%
D0A5T1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AD60	Leishmania major	89%	100%
E9AHF5	Leishmania infantum	88%	100%