Calcium uniporter protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcium uniporter protein, mitochondrial

Species:

Leishmania mexicana

UniProt:

E9AYY0_LEIMU

TriTrypDb:

LmxM.27.0780

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	12
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	12
GO:0031966	mitochondrial membrane	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990246	uniplex complex	4	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

E9AYY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYY0

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	12
GO:0006874	intracellular calcium ion homeostasis	7	12
GO:0006875	obsolete intracellular metal ion homeostasis	6	12
GO:0009987	cellular process	1	12
GO:0019725	cellular homeostasis	2	12
GO:0030003	intracellular monoatomic cation homeostasis	5	12
GO:0042592	homeostatic process	3	12
GO:0048878	chemical homeostasis	4	12
GO:0050801	monoatomic ion homeostasis	5	12
GO:0051560	mitochondrial calcium ion homeostasis	8	12
GO:0055065	obsolete metal ion homeostasis	7	12
GO:0055074	calcium ion homeostasis	8	12
GO:0055080	monoatomic cation homeostasis	6	12
GO:0055082	intracellular chemical homeostasis	3	12
GO:0065007	biological regulation	1	12
GO:0065008	regulation of biological quality	2	12
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	12
GO:0072507	obsolete divalent inorganic cation homeostasis	7	12
GO:0098771	inorganic ion homeostasis	6	12
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006816	calcium ion transport	7	1
GO:0006851	mitochondrial calcium ion transmembrane transport	4	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0036444	calcium import into the mitochondrion	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0070588	calcium ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0005261	monoatomic cation channel activity	5	12
GO:0005262	calcium channel activity	6	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015085	calcium ion transmembrane transporter activity	6	12
GO:0015267	channel activity	4	12
GO:0015291	secondary active transmembrane transporter activity	4	12
GO:0015292	uniporter activity	5	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0022803	passive transmembrane transporter activity	3	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0046873	metal ion transmembrane transporter activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.501
CLV_C14_Caspase3-7	77	81	PF00656	0.692
CLV_NRD_NRD_1	10	12	PF00675	0.523
CLV_NRD_NRD_1	184	186	PF00675	0.313
CLV_NRD_NRD_1	196	198	PF00675	0.302
CLV_NRD_NRD_1	211	213	PF00675	0.245
CLV_NRD_NRD_1	279	281	PF00675	0.292
CLV_NRD_NRD_1	30	32	PF00675	0.542
CLV_NRD_NRD_1	37	39	PF00675	0.545
CLV_PCSK_FUR_1	209	213	PF00082	0.338
CLV_PCSK_KEX2_1	10	12	PF00082	0.523
CLV_PCSK_KEX2_1	184	186	PF00082	0.293
CLV_PCSK_KEX2_1	198	200	PF00082	0.121
CLV_PCSK_KEX2_1	211	213	PF00082	0.265
CLV_PCSK_KEX2_1	30	32	PF00082	0.541
CLV_PCSK_KEX2_1	37	39	PF00082	0.531
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.273
CLV_PCSK_SKI1_1	139	143	PF00082	0.338
CLV_PCSK_SKI1_1	306	310	PF00082	0.359
CLV_PCSK_SKI1_1	37	41	PF00082	0.417
CLV_PCSK_SKI1_1	70	74	PF00082	0.380
DEG_APCC_DBOX_1	305	313	PF00400	0.551
DEG_Nend_UBRbox_3	1	3	PF02207	0.690
DEG_SPOP_SBC_1	19	23	PF00917	0.697
DOC_PP1_RVXF_1	97	103	PF00149	0.516
DOC_PP1_SILK_1	310	315	PF00149	0.433
DOC_USP7_MATH_1	154	158	PF00917	0.522
DOC_USP7_MATH_1	173	177	PF00917	0.549
DOC_USP7_MATH_1	45	49	PF00917	0.696
DOC_USP7_MATH_1	50	54	PF00917	0.685
DOC_USP7_UBL2_3	194	198	PF12436	0.486
DOC_USP7_UBL2_3	314	318	PF12436	0.617
DOC_WW_Pin1_4	46	51	PF00397	0.622
DOC_WW_Pin1_4	61	66	PF00397	0.643
LIG_14-3-3_CanoR_1	162	170	PF00244	0.380
LIG_14-3-3_CanoR_1	209	215	PF00244	0.541
LIG_14-3-3_CanoR_1	231	235	PF00244	0.320
LIG_14-3-3_CanoR_1	30	36	PF00244	0.700
LIG_Actin_WH2_2	123	141	PF00022	0.493
LIG_APCC_ABBAyCdc20_2	139	145	PF00400	0.538
LIG_FHA_1	20	26	PF00498	0.743
LIG_FHA_1	250	256	PF00498	0.234
LIG_FHA_1	3	9	PF00498	0.648
LIG_FHA_1	62	68	PF00498	0.639
LIG_FHA_2	117	123	PF00498	0.473
LIG_FHA_2	188	194	PF00498	0.565
LIG_FHA_2	231	237	PF00498	0.305
LIG_FHA_2	75	81	PF00498	0.644
LIG_HCF-1_HBM_1	267	270	PF13415	0.513
LIG_LIR_Gen_1	236	247	PF02991	0.255
LIG_LIR_Gen_1	267	278	PF02991	0.473
LIG_LIR_Gen_1	59	68	PF02991	0.573
LIG_LIR_Nem_3	233	237	PF02991	0.244
LIG_LIR_Nem_3	267	273	PF02991	0.460
LIG_LIR_Nem_3	289	295	PF02991	0.455
LIG_LIR_Nem_3	59	63	PF02991	0.585
LIG_LYPXL_SIV_4	294	302	PF13949	0.557
LIG_Pex14_2	235	239	PF04695	0.277
LIG_Pex14_2	273	277	PF04695	0.482
LIG_SH2_SRC	295	298	PF00017	0.557
LIG_SH2_STAT5	143	146	PF00017	0.556
LIG_SH2_STAT5	234	237	PF00017	0.287
LIG_SH2_STAT5	247	250	PF00017	0.242
LIG_SH2_STAT5	261	264	PF00017	0.373
LIG_SH3_3	108	114	PF00018	0.613
LIG_SH3_3	150	156	PF00018	0.511
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.648
LIG_SUMO_SIM_par_1	125	131	PF11976	0.466
LIG_TYR_ITIM	232	237	PF00017	0.362
LIG_UBA3_1	308	314	PF00899	0.591
LIG_WRC_WIRS_1	174	179	PF05994	0.530
MOD_CK1_1	168	174	PF00069	0.488
MOD_CK1_1	18	24	PF00069	0.730
MOD_CK1_1	230	236	PF00069	0.305
MOD_CK1_1	48	54	PF00069	0.676
MOD_CK2_1	106	112	PF00069	0.552
MOD_CK2_1	116	122	PF00069	0.451
MOD_CK2_1	187	193	PF00069	0.537
MOD_Cter_Amidation	35	38	PF01082	0.417
MOD_GlcNHglycan	11	14	PF01048	0.473
MOD_GlcNHglycan	158	161	PF01048	0.361
MOD_GlcNHglycan	17	20	PF01048	0.411
MOD_GlcNHglycan	270	273	PF01048	0.149
MOD_GlcNHglycan	315	318	PF01048	0.442
MOD_GlcNHglycan	52	55	PF01048	0.482
MOD_GSK3_1	15	22	PF00069	0.694
MOD_GSK3_1	156	163	PF00069	0.507
MOD_GSK3_1	168	175	PF00069	0.395
MOD_GSK3_1	243	250	PF00069	0.349
MOD_GSK3_1	45	52	PF00069	0.668
MOD_LATS_1	29	35	PF00433	0.537
MOD_N-GLC_1	160	165	PF02516	0.332
MOD_NEK2_1	249	254	PF00069	0.161
MOD_NEK2_1	308	313	PF00069	0.604
MOD_NEK2_1	4	9	PF00069	0.706
MOD_PIKK_1	74	80	PF00454	0.685
MOD_PKA_1	30	36	PF00069	0.752
MOD_PKA_1	37	43	PF00069	0.737
MOD_PKA_2	154	160	PF00069	0.502
MOD_PKA_2	161	167	PF00069	0.438
MOD_PKA_2	210	216	PF00069	0.513
MOD_PKA_2	230	236	PF00069	0.121
MOD_PKA_2	30	36	PF00069	0.710
MOD_PKA_2	37	43	PF00069	0.696
MOD_PKA_2	9	15	PF00069	0.746
MOD_Plk_1	266	272	PF00069	0.477
MOD_Plk_4	131	137	PF00069	0.520
MOD_Plk_4	173	179	PF00069	0.444
MOD_Plk_4	230	236	PF00069	0.317
MOD_Plk_4	243	249	PF00069	0.263
MOD_Plk_4	308	314	PF00069	0.496
MOD_Plk_4	4	10	PF00069	0.746
MOD_ProDKin_1	46	52	PF00069	0.620
MOD_ProDKin_1	61	67	PF00069	0.643
TRG_DiLeu_BaEn_4	304	310	PF01217	0.575
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.629
TRG_ENDOCYTIC_2	234	237	PF00928	0.293
TRG_ENDOCYTIC_2	261	264	PF00928	0.425
TRG_ENDOCYTIC_2	270	273	PF00928	0.479
TRG_ENDOCYTIC_2	295	298	PF00928	0.461
TRG_ER_diArg_1	184	186	PF00400	0.513
TRG_ER_diArg_1	196	199	PF00400	0.484
TRG_ER_diArg_1	210	212	PF00400	0.427
TRG_ER_diArg_1	30	32	PF00400	0.741
TRG_ER_diArg_1	37	39	PF00400	0.743
TRG_ER_diArg_1	9	11	PF00400	0.758
TRG_NLS_Bipartite_1	184	201	PF00514	0.349
TRG_NLS_MonoExtN_4	194	201	PF00514	0.349
TRG_NLS_MonoExtN_4	279	284	PF00514	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8M7	Leptomonas seymouri	61%	96%
A0A0S4JRI1	Bodo saltans	39%	100%
A0A1X0P3Z9	Trypanosomatidae	39%	100%
A0A3Q8IHI0	Leishmania donovani	90%	100%
A0A422NMN9	Trypanosoma rangeli	46%	100%
A4HFK2	Leishmania braziliensis	75%	100%
D0A5S5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AD55	Leishmania major	85%	100%
E9AHF0	Leishmania infantum	90%	100%
Q9NWR8	Homo sapiens	24%	95%
V5DA35	Trypanosoma cruzi	44%	100%