LeishMANIAdb
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Stress-response A/B barrel domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Stress-response A/B barrel domain-containing protein
Gene product:
hypothetical protein, conserved (pseudogene)
Species:
Leishmania mexicana
UniProt:
E9AYX6_LEIMU
TriTrypDb:
LmxM.27.0745
Length:
110

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYX6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYX6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 13 17 PF00082 0.309
CLV_PCSK_SKI1_1 90 94 PF00082 0.365
DEG_Nend_Nbox_1 1 3 PF02207 0.332
DOC_MAPK_MEF2A_6 93 102 PF00069 0.400
DOC_USP7_MATH_1 19 23 PF00917 0.288
DOC_USP7_MATH_1 26 30 PF00917 0.234
DOC_USP7_MATH_1 45 49 PF00917 0.138
DOC_USP7_MATH_1 70 74 PF00917 0.377
DOC_USP7_UBL2_3 8 12 PF12436 0.406
LIG_FHA_1 60 66 PF00498 0.240
LIG_FHA_2 75 81 PF00498 0.327
LIG_LIR_Nem_3 48 54 PF02991 0.237
LIG_Pex14_2 14 18 PF04695 0.357
LIG_SH2_SRC 54 57 PF00017 0.297
LIG_SH2_SRC 78 81 PF00017 0.297
LIG_SH2_STAP1 61 65 PF00017 0.263
LIG_SH2_STAT5 61 64 PF00017 0.269
LIG_SH3_3 92 98 PF00018 0.506
LIG_TRAF2_1 22 25 PF00917 0.406
MOD_CK1_1 68 74 PF00069 0.346
MOD_CK2_1 18 24 PF00069 0.406
MOD_CK2_1 74 80 PF00069 0.318
MOD_GlcNHglycan 70 73 PF01048 0.448
MOD_GSK3_1 55 62 PF00069 0.263
MOD_GSK3_1 64 71 PF00069 0.263
MOD_NEK2_1 65 70 PF00069 0.337
MOD_NEK2_2 26 31 PF00069 0.379
MOD_PIKK_1 55 61 PF00454 0.323
MOD_Plk_1 39 45 PF00069 0.159
TRG_DiLeu_BaLyEn_6 87 92 PF01217 0.236
TRG_PTS1 107 110 PF00515 0.518

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6U1 Leptomonas seymouri 61% 99%
A0A0N0P783 Leptomonas seymouri 32% 86%
A0A0S4JUQ9 Bodo saltans 39% 100%
A0A0S4JVR8 Bodo saltans 40% 75%
A0A1X0P4A0 Trypanosomatidae 30% 98%
A0A3Q8IE23 Leishmania donovani 88% 100%
A0A422NMP7 Trypanosoma rangeli 43% 96%
A4HFJ8 Leishmania braziliensis 68% 100%
D0A5S3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 99%
E9AHE6 Leishmania infantum 88% 100%
V5DA48 Trypanosoma cruzi 38% 96%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS