UBA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UBA/TS-N domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AYX3_LEIMU

TriTrypDb:

LmxM.27.0720

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYX3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0031593	polyubiquitin modification-dependent protein binding	4	1
GO:0140030	modification-dependent protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.579
CLV_C14_Caspase3-7	212	216	PF00656	0.640
CLV_NRD_NRD_1	176	178	PF00675	0.492
CLV_NRD_NRD_1	75	77	PF00675	0.480
CLV_PCSK_KEX2_1	175	177	PF00082	0.481
CLV_PCSK_SKI1_1	12	16	PF00082	0.592
CLV_PCSK_SKI1_1	155	159	PF00082	0.580
CLV_PCSK_SKI1_1	164	168	PF00082	0.603
CLV_PCSK_SKI1_1	388	392	PF00082	0.409
CLV_PCSK_SKI1_1	49	53	PF00082	0.590
CLV_PCSK_SKI1_1	76	80	PF00082	0.433
CLV_Separin_Metazoa	94	98	PF03568	0.693
DEG_Nend_UBRbox_2	1	3	PF02207	0.557
DEG_SCF_FBW7_1	250	257	PF00400	0.763
DEG_SPOP_SBC_1	290	294	PF00917	0.545
DEG_SPOP_SBC_1	347	351	PF00917	0.494
DOC_CKS1_1	251	256	PF01111	0.765
DOC_CKS1_1	333	338	PF01111	0.635
DOC_CYCLIN_RxL_1	158	170	PF00134	0.628
DOC_CYCLIN_RxL_1	72	83	PF00134	0.480
DOC_MAPK_FxFP_2	283	286	PF00069	0.740
DOC_MAPK_gen_1	113	121	PF00069	0.335
DOC_MAPK_gen_1	9	17	PF00069	0.554
DOC_PP2B_LxvP_1	34	37	PF13499	0.590
DOC_PP4_FxxP_1	279	282	PF00568	0.691
DOC_PP4_FxxP_1	283	286	PF00568	0.670
DOC_USP7_MATH_1	227	231	PF00917	0.685
DOC_USP7_MATH_1	290	294	PF00917	0.680
DOC_USP7_MATH_1	300	304	PF00917	0.608
DOC_USP7_MATH_1	311	315	PF00917	0.600
DOC_USP7_MATH_1	348	352	PF00917	0.644
DOC_USP7_MATH_1	359	363	PF00917	0.724
DOC_USP7_UBL2_3	102	106	PF12436	0.624
DOC_USP7_UBL2_3	111	115	PF12436	0.406
DOC_USP7_UBL2_3	144	148	PF12436	0.585
DOC_WW_Pin1_4	147	152	PF00397	0.600
DOC_WW_Pin1_4	250	255	PF00397	0.754
DOC_WW_Pin1_4	274	279	PF00397	0.725
DOC_WW_Pin1_4	332	337	PF00397	0.666
DOC_WW_Pin1_4	357	362	PF00397	0.689
LIG_14-3-3_CanoR_1	221	229	PF00244	0.727
LIG_14-3-3_CanoR_1	64	74	PF00244	0.686
LIG_BRCT_BRCA1_1	62	66	PF00533	0.344
LIG_FHA_1	224	230	PF00498	0.751
LIG_FHA_1	41	47	PF00498	0.526
LIG_FHA_2	123	129	PF00498	0.526
LIG_FHA_2	20	26	PF00498	0.444
LIG_FHA_2	206	212	PF00498	0.626
LIG_FHA_2	232	238	PF00498	0.750
LIG_FHA_2	373	379	PF00498	0.381
LIG_FHA_2	55	61	PF00498	0.602
LIG_LIR_Apic_2	277	282	PF02991	0.739
LIG_LIR_Nem_3	2	6	PF02991	0.519
LIG_LIR_Nem_3	56	61	PF02991	0.471
LIG_MYND_1	278	282	PF01753	0.441
LIG_NRBOX	162	168	PF00104	0.622
LIG_Pex14_2	279	283	PF04695	0.739
LIG_PTAP_UEV_1	336	341	PF05743	0.722
LIG_PTB_Apo_2	126	133	PF02174	0.526
LIG_SH2_CRK	3	7	PF00017	0.491
LIG_SH2_SRC	3	6	PF00017	0.527
LIG_SH2_STAT3	203	206	PF00017	0.630
LIG_SH2_STAT5	404	407	PF00017	0.536
LIG_SH3_1	334	340	PF00018	0.479
LIG_SH3_3	334	340	PF00018	0.783
LIG_TRAF2_1	101	104	PF00917	0.602
LIG_UBA3_1	136	144	PF00899	0.571
MOD_CK1_1	135	141	PF00069	0.594
MOD_CK1_1	332	338	PF00069	0.694
MOD_CK1_1	349	355	PF00069	0.710
MOD_CK1_1	362	368	PF00069	0.592
MOD_CK2_1	205	211	PF00069	0.633
MOD_CK2_1	222	228	PF00069	0.482
MOD_CK2_1	372	378	PF00069	0.303
MOD_CK2_1	54	60	PF00069	0.596
MOD_CK2_1	98	104	PF00069	0.606
MOD_GlcNHglycan	266	269	PF01048	0.645
MOD_GlcNHglycan	293	296	PF01048	0.531
MOD_GlcNHglycan	308	311	PF01048	0.715
MOD_GlcNHglycan	314	317	PF01048	0.620
MOD_GlcNHglycan	337	340	PF01048	0.721
MOD_GlcNHglycan	357	360	PF01048	0.676
MOD_GlcNHglycan	361	364	PF01048	0.579
MOD_GlcNHglycan	91	94	PF01048	0.592
MOD_GSK3_1	223	230	PF00069	0.698
MOD_GSK3_1	250	257	PF00069	0.675
MOD_GSK3_1	260	267	PF00069	0.602
MOD_GSK3_1	274	281	PF00069	0.548
MOD_GSK3_1	335	342	PF00069	0.706
MOD_GSK3_1	355	362	PF00069	0.703
MOD_N-GLC_1	80	85	PF02516	0.619
MOD_NEK2_1	122	127	PF00069	0.507
MOD_NEK2_1	132	137	PF00069	0.444
MOD_NEK2_1	166	171	PF00069	0.504
MOD_NEK2_1	291	296	PF00069	0.534
MOD_NEK2_1	42	47	PF00069	0.563
MOD_NEK2_1	65	70	PF00069	0.678
MOD_NEK2_2	372	377	PF00069	0.248
MOD_PIKK_1	260	266	PF00454	0.701
MOD_PIKK_1	65	71	PF00454	0.618
MOD_PIKK_1	87	93	PF00454	0.676
MOD_PKA_2	223	229	PF00069	0.736
MOD_Plk_1	19	25	PF00069	0.467
MOD_Plk_2-3	19	25	PF00069	0.492
MOD_Plk_2-3	205	211	PF00069	0.658
MOD_Plk_2-3	54	60	PF00069	0.570
MOD_Plk_4	132	138	PF00069	0.472
MOD_Plk_4	301	307	PF00069	0.724
MOD_ProDKin_1	147	153	PF00069	0.594
MOD_ProDKin_1	250	256	PF00069	0.760
MOD_ProDKin_1	274	280	PF00069	0.724
MOD_ProDKin_1	332	338	PF00069	0.674
MOD_ProDKin_1	357	363	PF00069	0.685
MOD_SUMO_rev_2	101	107	PF00179	0.615
MOD_SUMO_rev_2	19	29	PF00179	0.594
TRG_DiLeu_BaEn_2	274	280	PF01217	0.454
TRG_ENDOCYTIC_2	3	6	PF00928	0.491
TRG_ER_diArg_1	175	177	PF00400	0.550
TRG_ER_diArg_1	61	64	PF00400	0.622
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYN2	Leptomonas seymouri	55%	100%
A0A0S4JV76	Bodo saltans	28%	99%
A0A1X0P4A2	Trypanosomatidae	33%	100%
A0A3R7MIY7	Trypanosoma rangeli	32%	100%
A0A3S7X0H9	Leishmania donovani	90%	100%
A4HFJ5	Leishmania braziliensis	81%	100%
D0A5S0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AD49	Leishmania major	91%	100%
E9AHE3	Leishmania infantum	90%	100%
V5B9I9	Trypanosoma cruzi	35%	100%