Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYX2_LEIMU

TriTrypDb:

LmxM.27.0710

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.520
CLV_NRD_NRD_1	191	193	PF00675	0.558
CLV_NRD_NRD_1	256	258	PF00675	0.503
CLV_NRD_NRD_1	287	289	PF00675	0.528
CLV_NRD_NRD_1	4	6	PF00675	0.560
CLV_NRD_NRD_1	63	65	PF00675	0.597
CLV_NRD_NRD_1	83	85	PF00675	0.568
CLV_PCSK_FUR_1	2	6	PF00082	0.440
CLV_PCSK_KEX2_1	191	193	PF00082	0.559
CLV_PCSK_KEX2_1	203	205	PF00082	0.479
CLV_PCSK_KEX2_1	256	258	PF00082	0.503
CLV_PCSK_KEX2_1	287	289	PF00082	0.528
CLV_PCSK_KEX2_1	4	6	PF00082	0.517
CLV_PCSK_KEX2_1	63	65	PF00082	0.593
CLV_PCSK_KEX2_1	83	85	PF00082	0.601
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.417
CLV_PCSK_PC7_1	79	85	PF00082	0.532
CLV_PCSK_SKI1_1	204	208	PF00082	0.340
CLV_PCSK_SKI1_1	345	349	PF00082	0.583
CLV_PCSK_SKI1_1	370	374	PF00082	0.524
CLV_PCSK_SKI1_1	63	67	PF00082	0.675
CLV_PCSK_SKI1_1	84	88	PF00082	0.481
DEG_Nend_UBRbox_1	1	4	PF02207	0.718
DOC_CYCLIN_RxL_1	367	378	PF00134	0.462
DOC_MAPK_gen_1	231	238	PF00069	0.398
DOC_MAPK_gen_1	63	72	PF00069	0.687
DOC_MAPK_MEF2A_6	208	217	PF00069	0.482
DOC_MAPK_MEF2A_6	231	238	PF00069	0.453
DOC_MAPK_RevD_3	70	84	PF00069	0.548
DOC_PP1_RVXF_1	190	197	PF00149	0.578
DOC_PP1_RVXF_1	368	375	PF00149	0.425
DOC_PP2B_LxvP_1	217	220	PF13499	0.438
DOC_PP4_FxxP_1	266	269	PF00568	0.552
DOC_USP7_MATH_1	120	124	PF00917	0.710
DOC_USP7_MATH_1	298	302	PF00917	0.499
DOC_USP7_MATH_1	416	420	PF00917	0.565
DOC_USP7_MATH_1	88	92	PF00917	0.633
DOC_USP7_MATH_1	94	98	PF00917	0.563
DOC_WW_Pin1_4	108	113	PF00397	0.620
DOC_WW_Pin1_4	318	323	PF00397	0.589
DOC_WW_Pin1_4	384	389	PF00397	0.528
DOC_WW_Pin1_4	440	445	PF00397	0.509
LIG_14-3-3_CanoR_1	170	174	PF00244	0.623
LIG_14-3-3_CanoR_1	261	265	PF00244	0.546
LIG_14-3-3_CanoR_1	383	388	PF00244	0.414
LIG_14-3-3_CanoR_1	48	54	PF00244	0.644
LIG_14-3-3_CanoR_1	67	73	PF00244	0.640
LIG_BIR_III_4	73	77	PF00653	0.406
LIG_BRCT_BRCA1_1	262	266	PF00533	0.461
LIG_BRCT_BRCA1_1	49	53	PF00533	0.483
LIG_deltaCOP1_diTrp_1	195	200	PF00928	0.453
LIG_deltaCOP1_diTrp_1	390	398	PF00928	0.487
LIG_FHA_1	150	156	PF00498	0.589
LIG_FHA_1	367	373	PF00498	0.437
LIG_FHA_1	375	381	PF00498	0.350
LIG_FHA_1	384	390	PF00498	0.394
LIG_FHA_1	424	430	PF00498	0.651
LIG_FHA_2	156	162	PF00498	0.510
LIG_FHA_2	242	248	PF00498	0.613
LIG_FHA_2	406	412	PF00498	0.519
LIG_LIR_Apic_2	263	269	PF02991	0.565
LIG_LIR_Apic_2	395	400	PF02991	0.538
LIG_LIR_Gen_1	195	201	PF02991	0.302
LIG_LIR_Gen_1	29	40	PF02991	0.512
LIG_LIR_Gen_1	426	434	PF02991	0.374
LIG_LIR_Gen_1	97	108	PF02991	0.460
LIG_LIR_Nem_3	195	199	PF02991	0.453
LIG_LIR_Nem_3	29	35	PF02991	0.466
LIG_LIR_Nem_3	426	430	PF02991	0.519
LIG_LIR_Nem_3	97	103	PF02991	0.389
LIG_NRBOX	371	377	PF00104	0.491
LIG_Pex14_1	100	104	PF04695	0.457
LIG_SH2_STAP1	104	108	PF00017	0.455
LIG_SH2_STAT5	142	145	PF00017	0.440
LIG_SH2_STAT5	189	192	PF00017	0.559
LIG_SH2_STAT5	397	400	PF00017	0.529
LIG_SH3_3	111	117	PF00018	0.602
LIG_SH3_3	151	157	PF00018	0.472
LIG_SH3_3	163	169	PF00018	0.541
LIG_SH3_3	359	365	PF00018	0.543
LIG_SH3_3	69	75	PF00018	0.589
LIG_SH3_CIN85_PxpxPR_1	113	118	PF14604	0.478
LIG_SUMO_SIM_par_1	211	216	PF11976	0.409
LIG_WRC_WIRS_1	371	376	PF05994	0.420
MOD_CK1_1	321	327	PF00069	0.467
MOD_CK1_1	42	48	PF00069	0.608
MOD_CK1_1	428	434	PF00069	0.495
MOD_CK1_1	443	449	PF00069	0.497
MOD_CK2_1	155	161	PF00069	0.489
MOD_CK2_1	384	390	PF00069	0.534
MOD_CK2_1	405	411	PF00069	0.520
MOD_CK2_1	434	440	PF00069	0.663
MOD_Cter_Amidation	254	257	PF01082	0.468
MOD_GlcNHglycan	176	179	PF01048	0.639
MOD_GlcNHglycan	26	29	PF01048	0.456
MOD_GlcNHglycan	41	44	PF01048	0.521
MOD_GlcNHglycan	418	421	PF01048	0.613
MOD_GSK3_1	120	127	PF00069	0.656
MOD_GSK3_1	20	27	PF00069	0.427
MOD_GSK3_1	260	267	PF00069	0.536
MOD_GSK3_1	366	373	PF00069	0.468
MOD_GSK3_1	38	45	PF00069	0.556
MOD_GSK3_1	416	423	PF00069	0.610
MOD_GSK3_1	425	432	PF00069	0.532
MOD_N-GLC_1	392	397	PF02516	0.518
MOD_NEK2_1	20	25	PF00069	0.346
MOD_NEK2_1	213	218	PF00069	0.415
MOD_NEK2_1	234	239	PF00069	0.395
MOD_NEK2_1	260	265	PF00069	0.489
MOD_NEK2_1	303	308	PF00069	0.378
MOD_NEK2_1	31	36	PF00069	0.509
MOD_NEK2_1	311	316	PF00069	0.467
MOD_NEK2_1	374	379	PF00069	0.376
MOD_NEK2_1	425	430	PF00069	0.461
MOD_NEK2_2	298	303	PF00069	0.364
MOD_PIKK_1	118	124	PF00454	0.549
MOD_PIKK_1	149	155	PF00454	0.464
MOD_PIKK_1	321	327	PF00454	0.467
MOD_PIKK_1	357	363	PF00454	0.419
MOD_PIKK_1	443	449	PF00454	0.708
MOD_PKA_2	169	175	PF00069	0.565
MOD_PKA_2	260	266	PF00069	0.512
MOD_PKA_2	47	53	PF00069	0.565
MOD_Plk_1	149	155	PF00069	0.535
MOD_Plk_1	194	200	PF00069	0.568
MOD_Plk_1	213	219	PF00069	0.386
MOD_Plk_1	241	247	PF00069	0.532
MOD_Plk_1	312	318	PF00069	0.584
MOD_Plk_2-3	405	411	PF00069	0.520
MOD_Plk_4	155	161	PF00069	0.351
MOD_Plk_4	195	201	PF00069	0.456
MOD_Plk_4	26	32	PF00069	0.454
MOD_Plk_4	298	304	PF00069	0.358
MOD_Plk_4	370	376	PF00069	0.414
MOD_Plk_4	429	435	PF00069	0.527
MOD_Plk_4	95	101	PF00069	0.602
MOD_ProDKin_1	108	114	PF00069	0.630
MOD_ProDKin_1	318	324	PF00069	0.583
MOD_ProDKin_1	384	390	PF00069	0.534
MOD_ProDKin_1	440	446	PF00069	0.512
TRG_ER_diArg_1	1	4	PF00400	0.637
TRG_ER_diArg_1	191	193	PF00400	0.552
TRG_ER_diArg_1	286	288	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU3	Leptomonas seymouri	39%	100%
A0A0S4JRJ3	Bodo saltans	24%	100%
A0A3Q8IPT0	Leishmania donovani	86%	100%
A0A3R7KFH1	Trypanosoma rangeli	28%	100%
D0A5R9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AD48	Leishmania major	87%	100%
E9AHE2	Leishmania infantum	86%	91%
V5BIJ6	Trypanosoma cruzi	27%	100%