RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYX1_LEIMU

TriTrypDb:

LmxM.27.0700

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.484
CLV_NRD_NRD_1	160	162	PF00675	0.710
CLV_NRD_NRD_1	368	370	PF00675	0.688
CLV_NRD_NRD_1	385	387	PF00675	0.677
CLV_PCSK_KEX2_1	160	162	PF00082	0.710
CLV_PCSK_KEX2_1	310	312	PF00082	0.462
CLV_PCSK_KEX2_1	368	370	PF00082	0.688
CLV_PCSK_KEX2_1	373	375	PF00082	0.691
CLV_PCSK_KEX2_1	385	387	PF00082	0.715
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.462
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.669
CLV_PCSK_PC7_1	306	312	PF00082	0.471
CLV_PCSK_PC7_1	369	375	PF00082	0.616
CLV_PCSK_SKI1_1	201	205	PF00082	0.508
CLV_PCSK_SKI1_1	310	314	PF00082	0.403
DEG_Nend_UBRbox_3	1	3	PF02207	0.836
DEG_SCF_FBW7_1	140	146	PF00400	0.810
DEG_SCF_FBW7_1	25	31	PF00400	0.693
DEG_SPOP_SBC_1	58	62	PF00917	0.681
DOC_CKS1_1	140	145	PF01111	0.709
DOC_CKS1_1	25	30	PF01111	0.702
DOC_CYCLIN_RxL_1	306	315	PF00134	0.458
DOC_MAPK_gen_1	204	212	PF00069	0.487
DOC_MAPK_gen_1	347	355	PF00069	0.498
DOC_PP1_RVXF_1	206	213	PF00149	0.423
DOC_PP1_RVXF_1	308	315	PF00149	0.448
DOC_PP2B_LxvP_1	337	340	PF13499	0.566
DOC_PP4_FxxP_1	192	195	PF00568	0.529
DOC_USP7_MATH_1	109	113	PF00917	0.728
DOC_USP7_MATH_1	118	122	PF00917	0.665
DOC_USP7_MATH_1	147	151	PF00917	0.736
DOC_USP7_MATH_1	156	160	PF00917	0.614
DOC_USP7_MATH_1	279	283	PF00917	0.481
DOC_USP7_MATH_1	349	353	PF00917	0.497
DOC_USP7_MATH_1	362	366	PF00917	0.626
DOC_USP7_MATH_1	394	398	PF00917	0.823
DOC_WW_Pin1_4	101	106	PF00397	0.689
DOC_WW_Pin1_4	133	138	PF00397	0.691
DOC_WW_Pin1_4	139	144	PF00397	0.707
DOC_WW_Pin1_4	223	228	PF00397	0.483
DOC_WW_Pin1_4	24	29	PF00397	0.712
DOC_WW_Pin1_4	37	42	PF00397	0.534
DOC_WW_Pin1_4	48	53	PF00397	0.590
DOC_WW_Pin1_4	87	92	PF00397	0.672
LIG_14-3-3_CanoR_1	374	381	PF00244	0.700
LIG_14-3-3_CanoR_1	390	399	PF00244	0.555
LIG_Clathr_ClatBox_1	84	88	PF01394	0.794
LIG_EVH1_2	441	445	PF00568	0.704
LIG_FHA_1	189	195	PF00498	0.613
LIG_FHA_1	37	43	PF00498	0.653
LIG_FHA_2	263	269	PF00498	0.460
LIG_FHA_2	322	328	PF00498	0.481
LIG_FHA_2	427	433	PF00498	0.736
LIG_FHA_2	81	87	PF00498	0.703
LIG_GSK3_LRP6_1	37	42	PF00069	0.703
LIG_IBAR_NPY_1	125	127	PF08397	0.676
LIG_LIR_Apic_2	104	109	PF02991	0.684
LIG_LIR_Apic_2	189	195	PF02991	0.560
LIG_LIR_Apic_2	61	67	PF02991	0.675
LIG_LIR_Gen_1	333	342	PF02991	0.607
LIG_LIR_Nem_3	333	337	PF02991	0.599
LIG_Pex14_2	44	48	PF04695	0.553
LIG_SH2_CRK	106	110	PF00017	0.801
LIG_SH2_CRK	72	76	PF00017	0.682
LIG_SH2_PTP2	334	337	PF00017	0.595
LIG_SH2_SRC	430	433	PF00017	0.809
LIG_SH2_STAP1	127	131	PF00017	0.692
LIG_SH2_STAP1	430	434	PF00017	0.802
LIG_SH2_STAT3	32	35	PF00017	0.697
LIG_SH2_STAT3	440	443	PF00017	0.701
LIG_SH2_STAT3	8	11	PF00017	0.731
LIG_SH2_STAT5	127	130	PF00017	0.713
LIG_SH2_STAT5	209	212	PF00017	0.417
LIG_SH2_STAT5	292	295	PF00017	0.441
LIG_SH2_STAT5	334	337	PF00017	0.493
LIG_SH3_3	137	143	PF00018	0.630
LIG_SH3_3	214	220	PF00018	0.540
LIG_SH3_3	35	41	PF00018	0.669
LIG_SH3_3	432	438	PF00018	0.681
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.469
LIG_SUMO_SIM_par_1	83	90	PF11976	0.689
LIG_TRAF2_1	429	432	PF00917	0.817
LIG_TRAF2_2	52	57	PF00917	0.706
LIG_TRFH_1	192	196	PF08558	0.513
MOD_CDC14_SPxK_1	90	93	PF00782	0.773
MOD_CDK_SPxK_1	87	93	PF00069	0.776
MOD_CK1_1	132	138	PF00069	0.691
MOD_CK1_1	141	147	PF00069	0.707
MOD_CK1_1	154	160	PF00069	0.709
MOD_CK1_1	237	243	PF00069	0.803
MOD_CK1_1	246	252	PF00069	0.525
MOD_CK1_1	30	36	PF00069	0.729
MOD_CK1_1	377	383	PF00069	0.724
MOD_CK1_1	4	10	PF00069	0.776
MOD_CK1_1	62	68	PF00069	0.698
MOD_CK2_1	147	153	PF00069	0.601
MOD_CK2_1	262	268	PF00069	0.471
MOD_CK2_1	279	285	PF00069	0.475
MOD_CK2_1	321	327	PF00069	0.479
MOD_CK2_1	426	432	PF00069	0.819
MOD_CK2_1	441	447	PF00069	0.532
MOD_CK2_1	80	86	PF00069	0.708
MOD_Cter_Amidation	366	369	PF01082	0.777
MOD_GlcNHglycan	119	123	PF01048	0.718
MOD_GlcNHglycan	131	134	PF01048	0.465
MOD_GlcNHglycan	149	152	PF01048	0.738
MOD_GlcNHglycan	153	157	PF01048	0.688
MOD_GlcNHglycan	164	167	PF01048	0.586
MOD_GlcNHglycan	227	230	PF01048	0.688
MOD_GlcNHglycan	242	245	PF01048	0.695
MOD_GlcNHglycan	364	367	PF01048	0.720
MOD_GlcNHglycan	381	384	PF01048	0.702
MOD_GlcNHglycan	392	395	PF01048	0.677
MOD_GlcNHglycan	396	399	PF01048	0.574
MOD_GlcNHglycan	406	409	PF01048	0.658
MOD_GlcNHglycan	431	435	PF01048	0.696
MOD_GSK3_1	125	132	PF00069	0.774
MOD_GSK3_1	139	146	PF00069	0.716
MOD_GSK3_1	147	154	PF00069	0.703
MOD_GSK3_1	20	27	PF00069	0.724
MOD_GSK3_1	221	228	PF00069	0.619
MOD_GSK3_1	233	240	PF00069	0.748
MOD_GSK3_1	243	250	PF00069	0.569
MOD_GSK3_1	279	286	PF00069	0.457
MOD_GSK3_1	3	10	PF00069	0.695
MOD_GSK3_1	300	307	PF00069	0.430
MOD_GSK3_1	390	397	PF00069	0.823
MOD_GSK3_1	400	407	PF00069	0.497
MOD_GSK3_1	426	433	PF00069	0.816
MOD_GSK3_1	58	65	PF00069	0.585
MOD_N-GLC_1	20	25	PF02516	0.577
MOD_N-GLC_1	232	237	PF02516	0.802
MOD_N-GLC_1	4	9	PF02516	0.796
MOD_NEK2_1	1	6	PF00069	0.740
MOD_NEK2_1	129	134	PF00069	0.657
MOD_NEK2_1	138	143	PF00069	0.715
MOD_NEK2_1	152	157	PF00069	0.644
MOD_NEK2_1	162	167	PF00069	0.687
MOD_NEK2_1	188	193	PF00069	0.670
MOD_NEK2_1	262	267	PF00069	0.497
MOD_NEK2_1	304	309	PF00069	0.418
MOD_NEK2_1	402	407	PF00069	0.750
MOD_NEK2_1	42	47	PF00069	0.624
MOD_NEK2_1	59	64	PF00069	0.779
MOD_PIKK_1	30	36	PF00454	0.699
MOD_PIKK_1	400	406	PF00454	0.794
MOD_PIKK_1	7	13	PF00454	0.687
MOD_PKA_2	349	355	PF00069	0.493
MOD_Plk_1	188	194	PF00069	0.593
MOD_Plk_1	247	253	PF00069	0.608
MOD_Plk_1	300	306	PF00069	0.469
MOD_Plk_1	377	383	PF00069	0.724
MOD_Plk_1	4	10	PF00069	0.738
MOD_Plk_2-3	327	333	PF00069	0.290
MOD_Plk_4	300	306	PF00069	0.436
MOD_Plk_4	349	355	PF00069	0.493
MOD_Plk_4	59	65	PF00069	0.724
MOD_ProDKin_1	101	107	PF00069	0.693
MOD_ProDKin_1	133	139	PF00069	0.693
MOD_ProDKin_1	143	149	PF00069	0.713
MOD_ProDKin_1	223	229	PF00069	0.485
MOD_ProDKin_1	24	30	PF00069	0.712
MOD_ProDKin_1	37	43	PF00069	0.536
MOD_ProDKin_1	48	54	PF00069	0.590
MOD_ProDKin_1	87	93	PF00069	0.674
MOD_SUMO_rev_2	351	360	PF00179	0.518
TRG_DiLeu_BaEn_1	268	273	PF01217	0.446
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.617
TRG_ENDOCYTIC_2	209	212	PF00928	0.417
TRG_ENDOCYTIC_2	334	337	PF00928	0.595
TRG_ER_diArg_1	160	162	PF00400	0.706
TRG_ER_diArg_1	206	209	PF00400	0.473
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.730

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5L6	Leptomonas seymouri	58%	100%
A0A3S7X0I2	Leishmania donovani	94%	100%
A4HFJ4	Leishmania braziliensis	73%	100%
E9AD47	Leishmania major	91%	100%
E9AHE1	Leishmania infantum	92%	100%