Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYW7_LEIMU

TriTrypDb:

LmxM.27.0660

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 3
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AYW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.363
CLV_C14_Caspase3-7	84	88	PF00656	0.333
CLV_NRD_NRD_1	20	22	PF00675	0.356
CLV_NRD_NRD_1	329	331	PF00675	0.326
CLV_NRD_NRD_1	367	369	PF00675	0.492
CLV_NRD_NRD_1	402	404	PF00675	0.638
CLV_NRD_NRD_1	499	501	PF00675	0.546
CLV_PCSK_FUR_1	18	22	PF00082	0.422
CLV_PCSK_FUR_1	327	331	PF00082	0.315
CLV_PCSK_FUR_1	497	501	PF00082	0.550
CLV_PCSK_KEX2_1	189	191	PF00082	0.417
CLV_PCSK_KEX2_1	20	22	PF00082	0.437
CLV_PCSK_KEX2_1	329	331	PF00082	0.326
CLV_PCSK_KEX2_1	367	369	PF00082	0.484
CLV_PCSK_KEX2_1	402	404	PF00082	0.633
CLV_PCSK_KEX2_1	499	501	PF00082	0.546
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.417
CLV_PCSK_PC7_1	16	22	PF00082	0.455
CLV_PCSK_PC7_1	495	501	PF00082	0.516
CLV_PCSK_SKI1_1	20	24	PF00082	0.406
CLV_PCSK_SKI1_1	25	29	PF00082	0.329
CLV_PCSK_SKI1_1	403	407	PF00082	0.556
DEG_Nend_UBRbox_1	1	4	PF02207	0.630
DEG_SPOP_SBC_1	199	203	PF00917	0.262
DEG_SPOP_SBC_1	233	237	PF00917	0.477
DEG_SPOP_SBC_1	268	272	PF00917	0.475
DEG_SPOP_SBC_1	277	281	PF00917	0.493
DEG_SPOP_SBC_1	284	288	PF00917	0.477
DOC_CYCLIN_RxL_1	20	29	PF00134	0.587
DOC_MAPK_gen_1	188	198	PF00069	0.331
DOC_MAPK_gen_1	497	507	PF00069	0.739
DOC_PP1_SILK_1	403	408	PF00149	0.757
DOC_PP2B_LxvP_1	196	199	PF13499	0.298
DOC_PP2B_LxvP_1	352	355	PF13499	0.693
DOC_USP7_MATH_1	155	159	PF00917	0.298
DOC_USP7_MATH_1	199	203	PF00917	0.262
DOC_USP7_MATH_1	285	289	PF00917	0.509
DOC_USP7_MATH_1	343	347	PF00917	0.655
DOC_USP7_MATH_1	355	359	PF00917	0.697
DOC_USP7_MATH_1	363	367	PF00917	0.657
DOC_USP7_MATH_1	372	376	PF00917	0.624
DOC_WW_Pin1_4	257	262	PF00397	0.426
DOC_WW_Pin1_4	273	278	PF00397	0.471
DOC_WW_Pin1_4	391	396	PF00397	0.740
DOC_WW_Pin1_4	413	418	PF00397	0.636
DOC_WW_Pin1_4	442	447	PF00397	0.630
DOC_WW_Pin1_4	490	495	PF00397	0.758
LIG_14-3-3_CanoR_1	2	8	PF00244	0.570
LIG_14-3-3_CanoR_1	25	31	PF00244	0.498
LIG_14-3-3_CanoR_1	367	372	PF00244	0.653
LIG_14-3-3_CanoR_1	448	455	PF00244	0.707
LIG_14-3-3_CanoR_1	489	496	PF00244	0.706
LIG_14-3-3_CanoR_1	497	507	PF00244	0.698
LIG_14-3-3_CanoR_1	67	73	PF00244	0.482
LIG_Actin_WH2_2	51	69	PF00022	0.355
LIG_BRCT_BRCA1_1	37	41	PF00533	0.224
LIG_BRCT_BRCA1_1	502	506	PF00533	0.732
LIG_CtBP_PxDLS_1	441	445	PF00389	0.671
LIG_CtBP_PxDLS_1	459	463	PF00389	0.653
LIG_eIF4E_1	225	231	PF01652	0.411
LIG_FHA_1	278	284	PF00498	0.493
LIG_FHA_1	302	308	PF00498	0.397
LIG_FHA_1	431	437	PF00498	0.637
LIG_FHA_1	455	461	PF00498	0.714
LIG_FHA_1	499	505	PF00498	0.740
LIG_FHA_2	287	293	PF00498	0.513
LIG_GBD_Chelix_1	315	323	PF00786	0.387
LIG_LIR_Gen_1	310	320	PF02991	0.387
LIG_LIR_Gen_1	6	13	PF02991	0.567
LIG_LIR_Nem_3	104	108	PF02991	0.329
LIG_LIR_Nem_3	142	148	PF02991	0.318
LIG_LIR_Nem_3	310	315	PF02991	0.469
LIG_LIR_Nem_3	6	12	PF02991	0.602
LIG_REV1ctd_RIR_1	10	20	PF16727	0.563
LIG_SH2_CRK	19	23	PF00017	0.592
LIG_SH2_CRK	193	197	PF00017	0.333
LIG_SH2_NCK_1	43	47	PF00017	0.389
LIG_SH2_STAP1	193	197	PF00017	0.298
LIG_SH2_STAP1	226	230	PF00017	0.375
LIG_SH2_STAP1	449	453	PF00017	0.665
LIG_SH2_STAP1	9	13	PF00017	0.634
LIG_SH2_STAT3	132	135	PF00017	0.289
LIG_SH2_STAT3	449	452	PF00017	0.665
LIG_SH2_STAT5	105	108	PF00017	0.378
LIG_SH2_STAT5	152	155	PF00017	0.298
LIG_SH2_STAT5	9	12	PF00017	0.616
LIG_SH3_3	389	395	PF00018	0.672
LIG_SH3_3	435	441	PF00018	0.660
LIG_TRAF2_1	294	297	PF00917	0.534
LIG_TRAF2_1	432	435	PF00917	0.623
LIG_WRC_WIRS_1	387	392	PF05994	0.692
LIG_WW_1	465	468	PF00397	0.615
MOD_CDC14_SPxK_1	394	397	PF00782	0.609
MOD_CDC14_SPxK_1	416	419	PF00782	0.523
MOD_CDK_SPK_2	490	495	PF00069	0.652
MOD_CDK_SPxK_1	391	397	PF00069	0.674
MOD_CDK_SPxK_1	413	419	PF00069	0.531
MOD_CDK_SPxK_1	442	448	PF00069	0.523
MOD_CDK_SPxxK_3	490	497	PF00069	0.700
MOD_CK1_1	118	124	PF00069	0.368
MOD_CK1_1	169	175	PF00069	0.387
MOD_CK1_1	210	216	PF00069	0.359
MOD_CK1_1	278	284	PF00069	0.587
MOD_CK1_1	288	294	PF00069	0.671
MOD_CK1_1	346	352	PF00069	0.660
MOD_CK1_1	366	372	PF00069	0.483
MOD_CK1_1	373	379	PF00069	0.623
MOD_CK1_1	383	389	PF00069	0.529
MOD_CK1_1	447	453	PF00069	0.523
MOD_CK1_1	480	486	PF00069	0.661
MOD_CK2_1	113	119	PF00069	0.224
MOD_CK2_1	136	142	PF00069	0.337
MOD_CK2_1	286	292	PF00069	0.638
MOD_CK2_1	355	361	PF00069	0.602
MOD_CK2_1	379	385	PF00069	0.503
MOD_Cter_Amidation	186	189	PF01082	0.337
MOD_Cter_Amidation	400	403	PF01082	0.687
MOD_GlcNHglycan	138	141	PF01048	0.344
MOD_GlcNHglycan	155	158	PF01048	0.270
MOD_GlcNHglycan	348	351	PF01048	0.647
MOD_GlcNHglycan	398	402	PF01048	0.536
MOD_GlcNHglycan	423	426	PF01048	0.691
MOD_GlcNHglycan	44	47	PF01048	0.526
MOD_GSK3_1	109	116	PF00069	0.422
MOD_GSK3_1	119	126	PF00069	0.333
MOD_GSK3_1	166	173	PF00069	0.344
MOD_GSK3_1	207	214	PF00069	0.264
MOD_GSK3_1	232	239	PF00069	0.588
MOD_GSK3_1	240	247	PF00069	0.522
MOD_GSK3_1	248	255	PF00069	0.503
MOD_GSK3_1	257	264	PF00069	0.558
MOD_GSK3_1	267	274	PF00069	0.568
MOD_GSK3_1	275	282	PF00069	0.556
MOD_GSK3_1	283	290	PF00069	0.549
MOD_GSK3_1	3	10	PF00069	0.496
MOD_GSK3_1	35	42	PF00069	0.224
MOD_GSK3_1	363	370	PF00069	0.654
MOD_GSK3_1	372	379	PF00069	0.606
MOD_GSK3_1	397	404	PF00069	0.619
MOD_GSK3_1	421	428	PF00069	0.636
MOD_GSK3_1	447	454	PF00069	0.608
MOD_GSK3_1	473	480	PF00069	0.673
MOD_GSK3_1	58	65	PF00069	0.536
MOD_N-GLC_1	301	306	PF02516	0.434
MOD_N-GLC_1	379	384	PF02516	0.638
MOD_N-GLC_2	421	423	PF02516	0.524
MOD_NEK2_1	109	114	PF00069	0.422
MOD_NEK2_1	11	16	PF00069	0.600
MOD_NEK2_1	35	40	PF00069	0.224
MOD_NEK2_1	453	458	PF00069	0.629
MOD_NEK2_1	473	478	PF00069	0.528
MOD_NEK2_1	498	503	PF00069	0.643
MOD_NEK2_1	62	67	PF00069	0.569
MOD_PIKK_1	425	431	PF00454	0.579
MOD_PK_1	500	506	PF00069	0.669
MOD_PKA_1	367	373	PF00069	0.599
MOD_PKA_1	499	505	PF00069	0.675
MOD_PKA_2	136	142	PF00069	0.337
MOD_PKA_2	363	369	PF00069	0.670
MOD_PKA_2	401	407	PF00069	0.695
MOD_PKA_2	447	453	PF00069	0.623
MOD_PKA_2	480	486	PF00069	0.651
MOD_PKA_2	488	494	PF00069	0.623
MOD_PKA_2	498	504	PF00069	0.555
MOD_PKA_2	66	72	PF00069	0.520
MOD_PKB_1	497	505	PF00069	0.681
MOD_Plk_1	211	217	PF00069	0.274
MOD_Plk_1	301	307	PF00069	0.274
MOD_Plk_1	58	64	PF00069	0.506
MOD_Plk_4	110	116	PF00069	0.446
MOD_Plk_4	301	307	PF00069	0.476
MOD_Plk_4	35	41	PF00069	0.224
MOD_Plk_4	473	479	PF00069	0.638
MOD_Plk_4	500	506	PF00069	0.653
MOD_Plk_4	7	13	PF00069	0.435
MOD_ProDKin_1	257	263	PF00069	0.516
MOD_ProDKin_1	273	279	PF00069	0.582
MOD_ProDKin_1	391	397	PF00069	0.674
MOD_ProDKin_1	413	419	PF00069	0.531
MOD_ProDKin_1	442	448	PF00069	0.523
MOD_ProDKin_1	490	496	PF00069	0.699
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.427
TRG_ENDOCYTIC_2	138	141	PF00928	0.387
TRG_ENDOCYTIC_2	19	22	PF00928	0.403
TRG_ENDOCYTIC_2	193	196	PF00928	0.387
TRG_ENDOCYTIC_2	225	228	PF00928	0.480
TRG_ENDOCYTIC_2	9	12	PF00928	0.490
TRG_ER_diArg_1	16	19	PF00400	0.566
TRG_ER_diArg_1	190	193	PF00400	0.224
TRG_ER_diArg_1	20	22	PF00400	0.504
TRG_ER_diArg_1	327	330	PF00400	0.356
TRG_ER_diArg_1	494	497	PF00400	0.692
TRG_ER_diArg_1	498	500	PF00400	0.656
TRG_NLS_Bipartite_1	178	193	PF00514	0.224
TRG_NLS_MonoExtC_3	187	192	PF00514	0.224
TRG_NLS_MonoExtN_4	186	193	PF00514	0.224
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICK3	Leishmania donovani	85%	99%
A4HJ08	Leishmania braziliensis	58%	97%
E9AD43	Leishmania major	83%	99%
E9AHD6	Leishmania infantum	85%	99%