Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AYW5_LEIMU

TriTrypDb:

LmxM.27.0640

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.644
CLV_NRD_NRD_1	211	213	PF00675	0.592
CLV_NRD_NRD_1	283	285	PF00675	0.576
CLV_NRD_NRD_1	30	32	PF00675	0.638
CLV_NRD_NRD_1	54	56	PF00675	0.607
CLV_PCSK_FUR_1	28	32	PF00082	0.716
CLV_PCSK_FUR_1	52	56	PF00082	0.640
CLV_PCSK_KEX2_1	108	110	PF00082	0.658
CLV_PCSK_KEX2_1	122	124	PF00082	0.585
CLV_PCSK_KEX2_1	210	212	PF00082	0.598
CLV_PCSK_KEX2_1	283	285	PF00082	0.680
CLV_PCSK_KEX2_1	30	32	PF00082	0.633
CLV_PCSK_KEX2_1	54	56	PF00082	0.603
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.658
CLV_PCSK_PC7_1	207	213	PF00082	0.583
CLV_PCSK_SKI1_1	161	165	PF00082	0.660
CLV_PCSK_SKI1_1	37	41	PF00082	0.595
DEG_APCC_DBOX_1	289	297	PF00400	0.520
DEG_Nend_Nbox_1	1	3	PF02207	0.688
DEG_SCF_FBW7_1	130	136	PF00400	0.503
DEG_SPOP_SBC_1	144	148	PF00917	0.503
DEG_SPOP_SBC_1	155	159	PF00917	0.588
DEG_SPOP_SBC_1	4	8	PF00917	0.696
DOC_CKS1_1	130	135	PF01111	0.502
DOC_CYCLIN_RxL_1	161	172	PF00134	0.644
DOC_MAPK_DCC_7	161	169	PF00069	0.657
DOC_MAPK_gen_1	108	119	PF00069	0.623
DOC_MAPK_gen_1	52	59	PF00069	0.727
DOC_MAPK_MEF2A_6	112	119	PF00069	0.473
DOC_MAPK_MEF2A_6	161	170	PF00069	0.743
DOC_MIT_MIM_1	243	252	PF04212	0.436
DOC_USP7_MATH_1	154	158	PF00917	0.696
DOC_USP7_MATH_1	216	220	PF00917	0.463
DOC_USP7_MATH_1	231	235	PF00917	0.738
DOC_USP7_MATH_1	238	242	PF00917	0.623
DOC_USP7_MATH_1	4	8	PF00917	0.784
DOC_WW_Pin1_4	129	134	PF00397	0.740
DOC_WW_Pin1_4	214	219	PF00397	0.605
LIG_14-3-3_CanoR_1	112	118	PF00244	0.641
LIG_14-3-3_CanoR_1	225	235	PF00244	0.634
LIG_14-3-3_CanoR_1	239	245	PF00244	0.602
LIG_14-3-3_CanoR_1	290	294	PF00244	0.509
LIG_14-3-3_CterR_2	310	314	PF00244	0.572
LIG_Actin_WH2_2	242	260	PF00022	0.523
LIG_Actin_WH2_2	69	87	PF00022	0.626
LIG_APCC_ABBA_1	186	191	PF00400	0.717
LIG_APCC_ABBAyCdc20_2	185	191	PF00400	0.717
LIG_BRCT_BRCA1_1	265	269	PF00533	0.664
LIG_BRCT_BRCA1_1	301	305	PF00533	0.711
LIG_FHA_1	136	142	PF00498	0.786
LIG_FHA_1	215	221	PF00498	0.717
LIG_FHA_1	63	69	PF00498	0.623
LIG_FHA_2	238	244	PF00498	0.453
LIG_FHA_2	7	13	PF00498	0.583
LIG_FHA_2	81	87	PF00498	0.711
LIG_FHA_2	94	100	PF00498	0.664
LIG_LIR_Gen_1	176	181	PF02991	0.561
LIG_LIR_Gen_1	23	34	PF02991	0.434
LIG_LIR_Nem_3	176	180	PF02991	0.564
LIG_LIR_Nem_3	23	29	PF02991	0.572
LIG_NRBOX	113	119	PF00104	0.728
LIG_Pex14_1	173	177	PF04695	0.636
LIG_RPA_C_Fungi	279	291	PF08784	0.507
LIG_SH2_CRK	177	181	PF00017	0.604
LIG_SH2_STAP1	177	181	PF00017	0.616
LIG_SH2_STAT5	38	41	PF00017	0.719
LIG_SH3_3	127	133	PF00018	0.593
LIG_SH3_3	210	216	PF00018	0.648
LIG_SUMO_SIM_par_1	166	172	PF11976	0.665
LIG_TRAF2_1	240	243	PF00917	0.517
LIG_TYR_ITIM	175	180	PF00017	0.613
LIG_TYR_ITIM	24	29	PF00017	0.724
MOD_CK1_1	146	152	PF00069	0.670
MOD_CK1_1	241	247	PF00069	0.590
MOD_CK1_1	3	9	PF00069	0.657
MOD_CK1_1	93	99	PF00069	0.716
MOD_CK2_1	154	160	PF00069	0.581
MOD_CK2_1	237	243	PF00069	0.696
MOD_CK2_1	4	10	PF00069	0.774
MOD_CK2_1	80	86	PF00069	0.621
MOD_CK2_1	93	99	PF00069	0.716
MOD_GlcNHglycan	2	5	PF01048	0.694
MOD_GlcNHglycan	258	261	PF01048	0.661
MOD_GlcNHglycan	265	268	PF01048	0.559
MOD_GlcNHglycan	301	304	PF01048	0.625
MOD_GSK3_1	125	132	PF00069	0.650
MOD_GSK3_1	2	9	PF00069	0.696
MOD_GSK3_1	237	244	PF00069	0.528
MOD_GSK3_1	58	65	PF00069	0.622
MOD_GSK3_1	86	93	PF00069	0.720
MOD_N-GLC_1	200	205	PF02516	0.554
MOD_N-GLC_1	299	304	PF02516	0.602
MOD_N-GLC_1	62	67	PF02516	0.720
MOD_NEK2_1	101	106	PF00069	0.559
MOD_NEK2_1	145	150	PF00069	0.760
MOD_NEK2_1	2	7	PF00069	0.663
MOD_NEK2_1	256	261	PF00069	0.639
MOD_PIKK_1	125	131	PF00454	0.492
MOD_PIKK_1	238	244	PF00454	0.628
MOD_PKA_2	231	237	PF00069	0.738
MOD_PKA_2	238	244	PF00069	0.622
MOD_PKA_2	289	295	PF00069	0.520
MOD_PKA_2	90	96	PF00069	0.729
MOD_Plk_1	125	131	PF00069	0.541
MOD_Plk_1	136	142	PF00069	0.666
MOD_Plk_1	62	68	PF00069	0.721
MOD_Plk_1	80	86	PF00069	0.427
MOD_Plk_1	91	97	PF00069	0.621
MOD_Plk_2-3	86	92	PF00069	0.664
MOD_Plk_4	113	119	PF00069	0.682
MOD_Plk_4	136	142	PF00069	0.590
MOD_Plk_4	176	182	PF00069	0.618
MOD_Plk_4	216	222	PF00069	0.685
MOD_Plk_4	289	295	PF00069	0.539
MOD_ProDKin_1	129	135	PF00069	0.739
MOD_ProDKin_1	214	220	PF00069	0.603
MOD_SUMO_rev_2	70	79	PF00179	0.508
TRG_DiLeu_BaEn_2	264	270	PF01217	0.657
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.640
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.675
TRG_ENDOCYTIC_2	177	180	PF00928	0.607
TRG_ENDOCYTIC_2	26	29	PF00928	0.685
TRG_ER_diArg_1	183	186	PF00400	0.601
TRG_ER_diArg_1	210	212	PF00400	0.707
TRG_ER_diArg_1	28	31	PF00400	0.688
TRG_ER_diArg_1	282	284	PF00400	0.592
TRG_ER_diArg_1	308	311	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T8	Leptomonas seymouri	31%	100%
A0A3Q8IE11	Leishmania donovani	87%	100%
A4HFJ0	Leishmania braziliensis	63%	100%
E9AD41	Leishmania major	84%	100%
E9AHD4	Leishmania infantum	87%	100%