Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYW3_LEIMU

TriTrypDb:

LmxM.27.0620

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AYW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.644
CLV_NRD_NRD_1	230	232	PF00675	0.412
CLV_NRD_NRD_1	271	273	PF00675	0.574
CLV_NRD_NRD_1	91	93	PF00675	0.464
CLV_PCSK_KEX2_1	230	232	PF00082	0.418
CLV_PCSK_KEX2_1	271	273	PF00082	0.574
CLV_PCSK_KEX2_1	91	93	PF00082	0.474
CLV_PCSK_SKI1_1	235	239	PF00082	0.364
CLV_PCSK_SKI1_1	251	255	PF00082	0.372
CLV_PCSK_SKI1_1	413	417	PF00082	0.301
CLV_PCSK_SKI1_1	418	422	PF00082	0.249
CLV_PCSK_SKI1_1	91	95	PF00082	0.377
DEG_SPOP_SBC_1	125	129	PF00917	0.659
DEG_SPOP_SBC_1	154	158	PF00917	0.571
DEG_SPOP_SBC_1	38	42	PF00917	0.385
DOC_MAPK_gen_1	230	238	PF00069	0.580
DOC_MAPK_MEF2A_6	251	259	PF00069	0.293
DOC_MAPK_MEF2A_6	367	375	PF00069	0.372
DOC_MAPK_MEF2A_6	399	407	PF00069	0.497
DOC_MAPK_MEF2A_6	418	426	PF00069	0.493
DOC_PP1_RVXF_1	233	239	PF00149	0.562
DOC_PP1_RVXF_1	89	96	PF00149	0.640
DOC_SPAK_OSR1_1	272	276	PF12202	0.280
DOC_USP7_MATH_1	130	134	PF00917	0.705
DOC_USP7_MATH_1	153	157	PF00917	0.707
DOC_USP7_MATH_1	160	164	PF00917	0.722
DOC_USP7_MATH_1	28	32	PF00917	0.479
DOC_USP7_MATH_1	359	363	PF00917	0.190
DOC_USP7_MATH_1	38	42	PF00917	0.457
DOC_USP7_MATH_1	463	467	PF00917	0.451
DOC_USP7_UBL2_3	311	315	PF12436	0.682
DOC_WW_Pin1_4	126	131	PF00397	0.710
DOC_WW_Pin1_4	14	19	PF00397	0.533
DOC_WW_Pin1_4	177	182	PF00397	0.673
DOC_WW_Pin1_4	186	191	PF00397	0.726
DOC_WW_Pin1_4	303	308	PF00397	0.657
DOC_WW_Pin1_4	392	397	PF00397	0.628
LIG_14-3-3_CanoR_1	113	123	PF00244	0.704
LIG_14-3-3_CanoR_1	126	130	PF00244	0.706
LIG_14-3-3_CanoR_1	327	333	PF00244	0.643
LIG_BRCT_BRCA1_1	139	143	PF00533	0.602
LIG_CaM_IQ_9	84	100	PF13499	0.626
LIG_Clathr_ClatBox_1	297	301	PF01394	0.495
LIG_Dynein_DLC8_1	111	117	PF01221	0.640
LIG_EH1_1	291	299	PF00400	0.569
LIG_EH1_1	319	327	PF00400	0.636
LIG_eIF4E_1	292	298	PF01652	0.515
LIG_eIF4E_1	372	378	PF01652	0.372
LIG_EVH1_2	19	23	PF00568	0.429
LIG_FHA_1	115	121	PF00498	0.637
LIG_FHA_1	126	132	PF00498	0.598
LIG_FHA_1	164	170	PF00498	0.700
LIG_FHA_1	178	184	PF00498	0.672
LIG_FHA_1	252	258	PF00498	0.328
LIG_FHA_1	304	310	PF00498	0.675
LIG_FHA_1	342	348	PF00498	0.491
LIG_FHA_1	38	44	PF00498	0.460
LIG_FHA_1	419	425	PF00498	0.312
LIG_FHA_1	53	59	PF00498	0.279
LIG_GBD_Chelix_1	218	226	PF00786	0.442
LIG_IRF3_LxIS_1	322	329	PF10401	0.634
LIG_LIR_Gen_1	291	300	PF02991	0.594
LIG_LIR_Gen_1	344	354	PF02991	0.294
LIG_LIR_Gen_1	421	429	PF02991	0.370
LIG_LIR_Gen_1	466	474	PF02991	0.329
LIG_LIR_Gen_1	71	78	PF02991	0.384
LIG_LIR_Nem_3	239	243	PF02991	0.684
LIG_LIR_Nem_3	344	349	PF02991	0.294
LIG_LIR_Nem_3	421	426	PF02991	0.349
LIG_LIR_Nem_3	466	471	PF02991	0.348
LIG_LIR_Nem_3	71	76	PF02991	0.377
LIG_OCRL_FandH_1	379	391	PF00620	0.285
LIG_PCNA_yPIPBox_3	409	418	PF02747	0.519
LIG_PDZ_Class_2	474	479	PF00595	0.348
LIG_Pex14_1	376	380	PF04695	0.246
LIG_Pex14_2	423	427	PF04695	0.301
LIG_Pex14_2	464	468	PF04695	0.390
LIG_PTB_Apo_2	472	479	PF02174	0.247
LIG_REV1ctd_RIR_1	141	149	PF16727	0.612
LIG_SH2_NCK_1	138	142	PF00017	0.647
LIG_SH2_PTP2	244	247	PF00017	0.372
LIG_SH2_PTP2	372	375	PF00017	0.361
LIG_SH2_SRC	445	448	PF00017	0.375
LIG_SH2_STAP1	138	142	PF00017	0.515
LIG_SH2_STAP1	292	296	PF00017	0.579
LIG_SH2_STAT5	244	247	PF00017	0.387
LIG_SH2_STAT5	258	261	PF00017	0.474
LIG_SH2_STAT5	372	375	PF00017	0.352
LIG_SH2_STAT5	379	382	PF00017	0.373
LIG_SH3_3	100	106	PF00018	0.669
LIG_SH3_3	12	18	PF00018	0.555
LIG_SH3_3	147	153	PF00018	0.596
LIG_SH3_3	210	216	PF00018	0.654
LIG_SH3_3	293	299	PF00018	0.536
LIG_SH3_3	349	355	PF00018	0.328
LIG_SH3_3	48	54	PF00018	0.368
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.694
LIG_SUMO_SIM_anti_2	55	63	PF11976	0.359
LIG_SUMO_SIM_par_1	298	303	PF11976	0.582
LIG_SUMO_SIM_par_1	306	314	PF11976	0.692
LIG_SUMO_SIM_par_1	55	63	PF11976	0.337
LIG_TYR_ITIM	366	371	PF00017	0.502
LIG_TYR_ITIM	377	382	PF00017	0.363
LIG_WRC_WIRS_1	84	89	PF05994	0.665
LIG_WW_3	1	5	PF00397	0.368
MOD_CDK_SPxxK_3	392	399	PF00069	0.642
MOD_CK1_1	163	169	PF00069	0.690
MOD_CK1_1	175	181	PF00069	0.615
MOD_CK1_1	182	188	PF00069	0.674
MOD_CK1_1	31	37	PF00069	0.467
MOD_CK1_1	392	398	PF00069	0.607
MOD_CK1_1	62	68	PF00069	0.490
MOD_CK1_1	9	15	PF00069	0.538
MOD_CK2_1	130	136	PF00069	0.681
MOD_CK2_1	285	291	PF00069	0.316
MOD_CK2_1	326	332	PF00069	0.648
MOD_CK2_1	441	447	PF00069	0.388
MOD_GlcNHglycan	106	109	PF01048	0.469
MOD_GlcNHglycan	139	142	PF01048	0.430
MOD_GlcNHglycan	174	177	PF01048	0.430
MOD_GlcNHglycan	282	285	PF01048	0.302
MOD_GlcNHglycan	328	331	PF01048	0.299
MOD_GlcNHglycan	362	365	PF01048	0.614
MOD_GlcNHglycan	8	11	PF01048	0.634
MOD_GSK3_1	121	128	PF00069	0.682
MOD_GSK3_1	175	182	PF00069	0.719
MOD_GSK3_1	27	34	PF00069	0.532
MOD_GSK3_1	280	287	PF00069	0.320
MOD_GSK3_1	425	432	PF00069	0.302
MOD_GSK3_1	437	444	PF00069	0.421
MOD_GSK3_1	6	13	PF00069	0.567
MOD_GSK3_1	60	67	PF00069	0.374
MOD_N-GLC_1	31	36	PF02516	0.693
MOD_N-GLC_1	38	43	PF02516	0.612
MOD_NEK2_1	114	119	PF00069	0.538
MOD_NEK2_1	137	142	PF00069	0.604
MOD_NEK2_1	183	188	PF00069	0.594
MOD_NEK2_1	21	26	PF00069	0.480
MOD_NEK2_1	285	290	PF00069	0.316
MOD_NEK2_1	326	331	PF00069	0.643
MOD_NEK2_1	341	346	PF00069	0.523
MOD_NEK2_1	360	365	PF00069	0.226
MOD_NEK2_1	425	430	PF00069	0.321
MOD_NEK2_1	464	469	PF00069	0.394
MOD_NEK2_1	59	64	PF00069	0.321
MOD_NEK2_1	94	99	PF00069	0.607
MOD_NEK2_2	68	73	PF00069	0.190
MOD_PIKK_1	10	16	PF00454	0.448
MOD_PIKK_1	112	118	PF00454	0.686
MOD_PIKK_1	230	236	PF00454	0.586
MOD_PK_1	315	321	PF00069	0.653
MOD_PKA_1	230	236	PF00069	0.575
MOD_PKA_2	112	118	PF00069	0.691
MOD_PKA_2	125	131	PF00069	0.705
MOD_PKA_2	230	236	PF00069	0.629
MOD_PKA_2	326	332	PF00069	0.646
MOD_Plk_1	31	37	PF00069	0.479
MOD_Plk_1	38	44	PF00069	0.416
MOD_Plk_2-3	441	447	PF00069	0.381
MOD_Plk_4	285	291	PF00069	0.446
MOD_Plk_4	315	321	PF00069	0.611
MOD_Plk_4	335	341	PF00069	0.464
MOD_Plk_4	342	348	PF00069	0.456
MOD_Plk_4	39	45	PF00069	0.430
MOD_Plk_4	418	424	PF00069	0.468
MOD_Plk_4	429	435	PF00069	0.266
MOD_Plk_4	52	58	PF00069	0.259
MOD_Plk_4	68	74	PF00069	0.233
MOD_ProDKin_1	126	132	PF00069	0.705
MOD_ProDKin_1	14	20	PF00069	0.535
MOD_ProDKin_1	177	183	PF00069	0.675
MOD_ProDKin_1	186	192	PF00069	0.724
MOD_ProDKin_1	303	309	PF00069	0.660
MOD_ProDKin_1	392	398	PF00069	0.626
MOD_SUMO_for_1	310	313	PF00179	0.676
MOD_SUMO_rev_2	312	316	PF00179	0.673
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.387
TRG_ENDOCYTIC_2	243	246	PF00928	0.330
TRG_ENDOCYTIC_2	292	295	PF00928	0.584
TRG_ENDOCYTIC_2	368	371	PF00928	0.353
TRG_ENDOCYTIC_2	372	375	PF00928	0.322
TRG_ENDOCYTIC_2	379	382	PF00928	0.325
TRG_ENDOCYTIC_2	451	454	PF00928	0.318
TRG_ER_diArg_1	229	231	PF00400	0.601
TRG_ER_diArg_1	270	272	PF00400	0.379
TRG_ER_diArg_1	90	92	PF00400	0.648
TRG_NES_CRM1_1	323	335	PF08389	0.602
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8L9	Leptomonas seymouri	63%	100%
A0A3S7X0H3	Leishmania donovani	88%	100%
A4HFI8	Leishmania braziliensis	74%	100%
D0A5R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AD39	Leishmania major	87%	100%
E9AHD2	Leishmania infantum	89%	100%
V5BIJ3	Trypanosoma cruzi	34%	100%