LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AYW3_LEIMU
TriTrypDb:
LmxM.27.0620
Length:
479

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8
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Expansion

Sequence features

E9AYW3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYW3

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 314 318 PF00656 0.644
CLV_NRD_NRD_1 230 232 PF00675 0.412
CLV_NRD_NRD_1 271 273 PF00675 0.574
CLV_NRD_NRD_1 91 93 PF00675 0.464
CLV_PCSK_KEX2_1 230 232 PF00082 0.418
CLV_PCSK_KEX2_1 271 273 PF00082 0.574
CLV_PCSK_KEX2_1 91 93 PF00082 0.474
CLV_PCSK_SKI1_1 235 239 PF00082 0.364
CLV_PCSK_SKI1_1 251 255 PF00082 0.372
CLV_PCSK_SKI1_1 413 417 PF00082 0.301
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I8L9 Leptomonas seymouri 63% 100%
A0A3S7X0H3 Leishmania donovani 88% 100%
A4HFI8 Leishmania braziliensis 74% 100%
D0A5R4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AD39 Leishmania major 87% 100%
E9AHD2 Leishmania infantum 89% 100%
V5BIJ3 Trypanosoma cruzi 34% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS