Trichohyalin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Trichohyalin

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYW2_LEIMU

TriTrypDb:

LmxM.27.0610

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AYW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.500
CLV_NRD_NRD_1	169	171	PF00675	0.561
CLV_NRD_NRD_1	182	184	PF00675	0.552
CLV_NRD_NRD_1	207	209	PF00675	0.644
CLV_NRD_NRD_1	239	241	PF00675	0.573
CLV_NRD_NRD_1	268	270	PF00675	0.637
CLV_NRD_NRD_1	304	306	PF00675	0.526
CLV_NRD_NRD_1	373	375	PF00675	0.466
CLV_NRD_NRD_1	379	381	PF00675	0.478
CLV_NRD_NRD_1	390	392	PF00675	0.374
CLV_NRD_NRD_1	447	449	PF00675	0.656
CLV_PCSK_KEX2_1	100	102	PF00082	0.487
CLV_PCSK_KEX2_1	111	113	PF00082	0.484
CLV_PCSK_KEX2_1	169	171	PF00082	0.477
CLV_PCSK_KEX2_1	239	241	PF00082	0.629
CLV_PCSK_KEX2_1	304	306	PF00082	0.572
CLV_PCSK_KEX2_1	325	327	PF00082	0.470
CLV_PCSK_KEX2_1	379	381	PF00082	0.484
CLV_PCSK_KEX2_1	390	392	PF00082	0.509
CLV_PCSK_KEX2_1	446	448	PF00082	0.645
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.566
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.489
CLV_PCSK_SKI1_1	350	354	PF00082	0.550
CLV_PCSK_SKI1_1	42	46	PF00082	0.544
CLV_PCSK_SKI1_1	64	68	PF00082	0.383
DEG_APCC_DBOX_1	216	224	PF00400	0.585
DEG_APCC_DBOX_1	315	323	PF00400	0.389
DEG_SPOP_SBC_1	8	12	PF00917	0.477
DOC_CYCLIN_RxL_1	37	49	PF00134	0.540
DOC_MAPK_gen_1	314	322	PF00069	0.451
DOC_MAPK_gen_1	325	333	PF00069	0.532
DOC_MAPK_gen_1	446	455	PF00069	0.551
DOC_MAPK_MEF2A_6	446	455	PF00069	0.551
DOC_USP7_MATH_1	381	385	PF00917	0.484
DOC_USP7_MATH_1	420	424	PF00917	0.592
DOC_USP7_MATH_1	451	455	PF00917	0.682
DOC_USP7_MATH_1	8	12	PF00917	0.498
DOC_USP7_UBL2_3	18	22	PF12436	0.627
DOC_USP7_UBL2_3	209	213	PF12436	0.752
DOC_USP7_UBL2_3	242	246	PF12436	0.705
DOC_USP7_UBL2_3	321	325	PF12436	0.565
DOC_WW_Pin1_4	454	459	PF00397	0.682
LIG_14-3-3_CanoR_1	251	256	PF00244	0.616
LIG_14-3-3_CanoR_1	435	441	PF00244	0.655
LIG_14-3-3_CanoR_1	77	84	PF00244	0.471
LIG_FHA_1	351	357	PF00498	0.521
LIG_FHA_1	56	62	PF00498	0.555
LIG_FHA_2	334	340	PF00498	0.415
LIG_FHA_2	410	416	PF00498	0.400
LIG_FHA_2	46	52	PF00498	0.364
LIG_HP1_1	451	455	PF01393	0.553
LIG_Integrin_isoDGR_2	138	140	PF01839	0.409
LIG_LIR_Apic_2	3	7	PF02991	0.482
LIG_NRBOX	40	46	PF00104	0.532
LIG_PDZ_Class_2	458	463	PF00595	0.691
LIG_RPA_C_Fungi	365	377	PF08784	0.570
LIG_SH2_CRK	4	8	PF00017	0.482
LIG_SH2_SRC	355	358	PF00017	0.487
LIG_SH2_STAP1	34	38	PF00017	0.447
LIG_SH2_STAP1	98	102	PF00017	0.580
LIG_SH2_STAT3	190	193	PF00017	0.591
LIG_SH2_STAT3	300	303	PF00017	0.476
LIG_SH2_STAT5	198	201	PF00017	0.424
LIG_SH2_STAT5	300	303	PF00017	0.580
LIG_SH2_STAT5	355	358	PF00017	0.557
LIG_SH2_STAT5	436	439	PF00017	0.463
LIG_SH3_3	450	456	PF00018	0.552
LIG_SUMO_SIM_par_1	451	457	PF11976	0.617
LIG_TRAF2_1	194	197	PF00917	0.538
LIG_TRAF2_1	310	313	PF00917	0.428
LIG_TRAF2_1	336	339	PF00917	0.552
LIG_TRFH_1	4	8	PF08558	0.412
LIG_UBA3_1	319	325	PF00899	0.403
LIG_ULM_U2AF65_1	239	244	PF00076	0.698
MOD_CK1_1	238	244	PF00069	0.724
MOD_CK1_1	454	460	PF00069	0.754
MOD_CK2_1	333	339	PF00069	0.550
MOD_CK2_1	409	415	PF00069	0.359
MOD_CK2_1	45	51	PF00069	0.411
MOD_CK2_1	454	460	PF00069	0.749
MOD_GlcNHglycan	232	235	PF01048	0.706
MOD_GlcNHglycan	69	72	PF01048	0.517
MOD_GlcNHglycan	78	81	PF01048	0.511
MOD_GSK3_1	247	254	PF00069	0.610
MOD_GSK3_1	420	427	PF00069	0.629
MOD_N-GLC_1	381	386	PF02516	0.545
MOD_NEK2_1	403	408	PF00069	0.456
MOD_NEK2_1	45	50	PF00069	0.598
MOD_NEK2_1	67	72	PF00069	0.515
MOD_PIKK_1	264	270	PF00454	0.608
MOD_PIKK_1	350	356	PF00454	0.523
MOD_PIKK_1	420	426	PF00454	0.653
MOD_PK_1	251	257	PF00069	0.682
MOD_PKA_1	22	28	PF00069	0.599
MOD_PKA_2	235	241	PF00069	0.616
MOD_PKA_2	403	409	PF00069	0.532
MOD_PKA_2	424	430	PF00069	0.665
MOD_PKA_2	76	82	PF00069	0.481
MOD_Plk_1	156	162	PF00069	0.614
MOD_Plk_4	156	162	PF00069	0.593
MOD_ProDKin_1	454	460	PF00069	0.681
MOD_SUMO_for_1	194	197	PF00179	0.613
MOD_SUMO_for_1	245	248	PF00179	0.698
MOD_SUMO_for_1	408	411	PF00179	0.528
MOD_SUMO_rev_2	11	20	PF00179	0.550
MOD_SUMO_rev_2	136	145	PF00179	0.514
MOD_SUMO_rev_2	227	233	PF00179	0.724
MOD_SUMO_rev_2	288	295	PF00179	0.587
TRG_DiLeu_BaEn_1	357	362	PF01217	0.479
TRG_ER_diArg_1	100	103	PF00400	0.491
TRG_ER_diArg_1	169	172	PF00400	0.557
TRG_ER_diArg_1	217	220	PF00400	0.669
TRG_ER_diArg_1	389	391	PF00400	0.502
TRG_ER_diArg_1	433	436	PF00400	0.489
TRG_ER_diArg_1	446	448	PF00400	0.466
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN1	Leptomonas seymouri	56%	100%
A0A1X0P3Z6	Trypanosomatidae	31%	100%
A0A3Q8IE88	Leishmania donovani	87%	100%
A0A3R7MQZ8	Trypanosoma rangeli	33%	100%
A4HFI7	Leishmania braziliensis	71%	100%
D0A5R3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AD38	Leishmania major	86%	100%
E9AHD1	Leishmania infantum	87%	100%
V5BE50	Trypanosoma cruzi	28%	100%