Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYW1_LEIMU

TriTrypDb:

LmxM.27.0600

Length:

954

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYW1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.585
CLV_C14_Caspase3-7	4	8	PF00656	0.741
CLV_NRD_NRD_1	291	293	PF00675	0.596
CLV_NRD_NRD_1	308	310	PF00675	0.583
CLV_NRD_NRD_1	325	327	PF00675	0.465
CLV_NRD_NRD_1	382	384	PF00675	0.553
CLV_NRD_NRD_1	401	403	PF00675	0.731
CLV_NRD_NRD_1	526	528	PF00675	0.452
CLV_NRD_NRD_1	681	683	PF00675	0.541
CLV_NRD_NRD_1	689	691	PF00675	0.447
CLV_NRD_NRD_1	717	719	PF00675	0.516
CLV_NRD_NRD_1	741	743	PF00675	0.456
CLV_NRD_NRD_1	849	851	PF00675	0.669
CLV_NRD_NRD_1	894	896	PF00675	0.663
CLV_NRD_NRD_1	948	950	PF00675	0.613
CLV_PCSK_FUR_1	289	293	PF00082	0.582
CLV_PCSK_FUR_1	306	310	PF00082	0.512
CLV_PCSK_FUR_1	664	668	PF00082	0.732
CLV_PCSK_FUR_1	679	683	PF00082	0.419
CLV_PCSK_KEX2_1	289	291	PF00082	0.542
CLV_PCSK_KEX2_1	308	310	PF00082	0.569
CLV_PCSK_KEX2_1	325	327	PF00082	0.541
CLV_PCSK_KEX2_1	382	384	PF00082	0.553
CLV_PCSK_KEX2_1	400	402	PF00082	0.751
CLV_PCSK_KEX2_1	504	506	PF00082	0.498
CLV_PCSK_KEX2_1	528	530	PF00082	0.421
CLV_PCSK_KEX2_1	643	645	PF00082	0.659
CLV_PCSK_KEX2_1	666	668	PF00082	0.576
CLV_PCSK_KEX2_1	681	683	PF00082	0.406
CLV_PCSK_KEX2_1	717	719	PF00082	0.516
CLV_PCSK_KEX2_1	741	743	PF00082	0.456
CLV_PCSK_KEX2_1	894	896	PF00082	0.663
CLV_PCSK_KEX2_1	948	950	PF00082	0.609
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.498
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.469
CLV_PCSK_PC1ET2_1	643	645	PF00082	0.670
CLV_PCSK_PC1ET2_1	666	668	PF00082	0.617
CLV_PCSK_PC7_1	500	506	PF00082	0.451
CLV_PCSK_PC7_1	944	950	PF00082	0.549
CLV_PCSK_SKI1_1	10	14	PF00082	0.575
CLV_PCSK_SKI1_1	268	272	PF00082	0.526
CLV_PCSK_SKI1_1	348	352	PF00082	0.459
CLV_PCSK_SKI1_1	366	370	PF00082	0.498
CLV_PCSK_SKI1_1	382	386	PF00082	0.397
CLV_PCSK_SKI1_1	387	391	PF00082	0.477
CLV_PCSK_SKI1_1	536	540	PF00082	0.458
CLV_PCSK_SKI1_1	571	575	PF00082	0.555
CLV_PCSK_SKI1_1	741	745	PF00082	0.364
CLV_PCSK_SKI1_1	778	782	PF00082	0.542
CLV_PCSK_SKI1_1	894	898	PF00082	0.525
CLV_PCSK_SKI1_1	936	940	PF00082	0.526
DEG_APCC_DBOX_1	570	578	PF00400	0.455
DEG_SPOP_SBC_1	77	81	PF00917	0.636
DEG_SPOP_SBC_1	789	793	PF00917	0.539
DOC_CKS1_1	156	161	PF01111	0.632
DOC_CKS1_1	804	809	PF01111	0.603
DOC_CKS1_1	816	821	PF01111	0.512
DOC_CYCLIN_RxL_1	345	354	PF00134	0.538
DOC_CYCLIN_RxL_1	774	785	PF00134	0.640
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	226	232	PF00134	0.509
DOC_MAPK_gen_1	268	277	PF00069	0.539
DOC_MAPK_gen_1	513	523	PF00069	0.529
DOC_MAPK_gen_1	931	940	PF00069	0.465
DOC_MAPK_MEF2A_6	725	732	PF00069	0.596
DOC_PP4_FxxP_1	25	28	PF00568	0.558
DOC_USP7_MATH_1	104	108	PF00917	0.778
DOC_USP7_MATH_1	194	198	PF00917	0.676
DOC_USP7_MATH_1	208	212	PF00917	0.576
DOC_USP7_MATH_1	249	253	PF00917	0.675
DOC_USP7_MATH_1	52	56	PF00917	0.732
DOC_USP7_MATH_1	617	621	PF00917	0.536
DOC_USP7_MATH_1	635	639	PF00917	0.484
DOC_USP7_MATH_1	731	735	PF00917	0.524
DOC_USP7_MATH_1	757	761	PF00917	0.561
DOC_USP7_MATH_1	763	767	PF00917	0.585
DOC_USP7_MATH_1	77	81	PF00917	0.763
DOC_USP7_MATH_1	886	890	PF00917	0.751
DOC_WW_Pin1_4	11	16	PF00397	0.615
DOC_WW_Pin1_4	155	160	PF00397	0.707
DOC_WW_Pin1_4	162	167	PF00397	0.639
DOC_WW_Pin1_4	202	207	PF00397	0.498
DOC_WW_Pin1_4	225	230	PF00397	0.668
DOC_WW_Pin1_4	298	303	PF00397	0.518
DOC_WW_Pin1_4	401	406	PF00397	0.650
DOC_WW_Pin1_4	45	50	PF00397	0.784
DOC_WW_Pin1_4	5	10	PF00397	0.679
DOC_WW_Pin1_4	613	618	PF00397	0.523
DOC_WW_Pin1_4	655	660	PF00397	0.613
DOC_WW_Pin1_4	803	808	PF00397	0.663
DOC_WW_Pin1_4	815	820	PF00397	0.562
DOC_WW_Pin1_4	824	829	PF00397	0.589
DOC_WW_Pin1_4	83	88	PF00397	0.780
DOC_WW_Pin1_4	831	836	PF00397	0.583
DOC_WW_Pin1_4	913	918	PF00397	0.512
DOC_WW_Pin1_4	924	929	PF00397	0.489
DOC_WW_Pin1_4	98	103	PF00397	0.656
LIG_14-3-3_CanoR_1	149	155	PF00244	0.638
LIG_14-3-3_CanoR_1	227	233	PF00244	0.505
LIG_14-3-3_CanoR_1	308	314	PF00244	0.617
LIG_14-3-3_CanoR_1	318	324	PF00244	0.413
LIG_14-3-3_CanoR_1	348	353	PF00244	0.459
LIG_14-3-3_CanoR_1	366	372	PF00244	0.490
LIG_14-3-3_CanoR_1	559	563	PF00244	0.507
LIG_14-3-3_CanoR_1	634	642	PF00244	0.735
LIG_14-3-3_CanoR_1	742	752	PF00244	0.482
LIG_14-3-3_CanoR_1	783	790	PF00244	0.753
LIG_14-3-3_CanoR_1	796	804	PF00244	0.676
LIG_14-3-3_CanoR_1	894	901	PF00244	0.653
LIG_Actin_WH2_2	608	626	PF00022	0.317
LIG_eIF4E_1	534	540	PF01652	0.421
LIG_FHA_1	11	17	PF00498	0.651
LIG_FHA_1	140	146	PF00498	0.611
LIG_FHA_1	149	155	PF00498	0.591
LIG_FHA_1	318	324	PF00498	0.392
LIG_FHA_1	32	38	PF00498	0.636
LIG_FHA_1	352	358	PF00498	0.585
LIG_FHA_1	462	468	PF00498	0.608
LIG_FHA_1	727	733	PF00498	0.568
LIG_FHA_1	783	789	PF00498	0.559
LIG_FHA_2	476	482	PF00498	0.441
LIG_FHA_2	596	602	PF00498	0.429
LIG_FHA_2	733	739	PF00498	0.561
LIG_FHA_2	79	85	PF00498	0.688
LIG_FHA_2	925	931	PF00498	0.582
LIG_KLC1_Yacidic_2	259	263	PF13176	0.568
LIG_LIR_Apic_2	24	28	PF02991	0.512
LIG_LIR_Gen_1	369	379	PF02991	0.487
LIG_LIR_Gen_1	599	610	PF02991	0.386
LIG_LIR_Nem_3	128	133	PF02991	0.513
LIG_LIR_Nem_3	346	350	PF02991	0.500
LIG_LIR_Nem_3	369	375	PF02991	0.500
LIG_LIR_Nem_3	533	538	PF02991	0.448
LIG_LIR_Nem_3	599	605	PF02991	0.388
LIG_SH2_CRK	535	539	PF00017	0.446
LIG_SH2_GRB2like	444	447	PF00017	0.467
LIG_SH2_NCK_1	109	113	PF00017	0.611
LIG_SH2_NCK_1	376	380	PF00017	0.539
LIG_SH2_SRC	261	264	PF00017	0.502
LIG_SH2_SRC	376	379	PF00017	0.404
LIG_SH2_STAP1	209	213	PF00017	0.625
LIG_SH2_STAP1	303	307	PF00017	0.488
LIG_SH2_STAP1	319	323	PF00017	0.370
LIG_SH2_STAP1	444	448	PF00017	0.581
LIG_SH2_STAT3	710	713	PF00017	0.581
LIG_SH2_STAT5	261	264	PF00017	0.676
LIG_SH2_STAT5	319	322	PF00017	0.367
LIG_SH2_STAT5	609	612	PF00017	0.471
LIG_SH2_STAT5	710	713	PF00017	0.581
LIG_SH3_1	292	298	PF00018	0.506
LIG_SH3_1	624	630	PF00018	0.531
LIG_SH3_1	850	856	PF00018	0.620
LIG_SH3_2	853	858	PF14604	0.625
LIG_SH3_3	134	140	PF00018	0.701
LIG_SH3_3	151	157	PF00018	0.606
LIG_SH3_3	292	298	PF00018	0.506
LIG_SH3_3	358	364	PF00018	0.417
LIG_SH3_3	43	49	PF00018	0.676
LIG_SH3_3	624	630	PF00018	0.587
LIG_SH3_3	725	731	PF00018	0.495
LIG_SH3_3	801	807	PF00018	0.657
LIG_SH3_3	813	819	PF00018	0.539
LIG_SH3_3	850	856	PF00018	0.620
LIG_SH3_3	879	885	PF00018	0.652
LIG_SUMO_SIM_anti_2	601	607	PF11976	0.433
LIG_SUMO_SIM_par_1	348	354	PF11976	0.552
LIG_SUMO_SIM_par_1	463	469	PF11976	0.596
LIG_TRAF2_1	280	283	PF00917	0.575
LIG_TYR_ITIM	607	612	PF00017	0.273
LIG_WW_3	363	367	PF00397	0.420
MOD_CDC14_SPxK_1	404	407	PF00782	0.627
MOD_CDK_SPK_2	5	10	PF00069	0.629
MOD_CDK_SPxK_1	401	407	PF00069	0.620
MOD_CDK_SPxxK_3	803	810	PF00069	0.769
MOD_CDK_SPxxK_3	815	822	PF00069	0.581
MOD_CDK_SPxxK_3	924	931	PF00069	0.552
MOD_CK1_1	107	113	PF00069	0.700
MOD_CK1_1	14	20	PF00069	0.699
MOD_CK1_1	147	153	PF00069	0.685
MOD_CK1_1	177	183	PF00069	0.567
MOD_CK1_1	228	234	PF00069	0.573
MOD_CK1_1	466	472	PF00069	0.491
MOD_CK1_1	638	644	PF00069	0.768
MOD_CK1_1	654	660	PF00069	0.528
MOD_CK1_1	734	740	PF00069	0.516
MOD_CK1_1	836	842	PF00069	0.522
MOD_CK1_1	902	908	PF00069	0.654
MOD_CK2_1	162	168	PF00069	0.627
MOD_CK2_1	215	221	PF00069	0.562
MOD_CK2_1	475	481	PF00069	0.436
MOD_CK2_1	595	601	PF00069	0.535
MOD_CK2_1	732	738	PF00069	0.571
MOD_CK2_1	78	84	PF00069	0.689
MOD_CK2_1	789	795	PF00069	0.605
MOD_CK2_1	915	921	PF00069	0.611
MOD_CK2_1	923	929	PF00069	0.593
MOD_Cter_Amidation	72	75	PF01082	0.644
MOD_Cter_Amidation	848	851	PF01082	0.624
MOD_DYRK1A_RPxSP_1	803	807	PF00069	0.625
MOD_GlcNHglycan	146	149	PF01048	0.624
MOD_GlcNHglycan	210	213	PF01048	0.616
MOD_GlcNHglycan	239	242	PF01048	0.735
MOD_GlcNHglycan	427	430	PF01048	0.707
MOD_GlcNHglycan	478	481	PF01048	0.633
MOD_GlcNHglycan	560	563	PF01048	0.601
MOD_GlcNHglycan	619	622	PF01048	0.552
MOD_GlcNHglycan	637	640	PF01048	0.535
MOD_GlcNHglycan	646	649	PF01048	0.745
MOD_GlcNHglycan	653	656	PF01048	0.533
MOD_GlcNHglycan	69	72	PF01048	0.703
MOD_GlcNHglycan	745	748	PF01048	0.584
MOD_GlcNHglycan	765	768	PF01048	0.651
MOD_GlcNHglycan	798	801	PF01048	0.706
MOD_GlcNHglycan	835	838	PF01048	0.635
MOD_GlcNHglycan	870	873	PF01048	0.653
MOD_GlcNHglycan	879	882	PF01048	0.579
MOD_GlcNHglycan	901	904	PF01048	0.743
MOD_GlcNHglycan	949	952	PF01048	0.596
MOD_GSK3_1	10	17	PF00069	0.692
MOD_GSK3_1	129	136	PF00069	0.757
MOD_GSK3_1	140	147	PF00069	0.566
MOD_GSK3_1	179	186	PF00069	0.637
MOD_GSK3_1	200	207	PF00069	0.602
MOD_GSK3_1	237	244	PF00069	0.569
MOD_GSK3_1	26	33	PF00069	0.541
MOD_GSK3_1	613	620	PF00069	0.594
MOD_GSK3_1	630	637	PF00069	0.520
MOD_GSK3_1	651	658	PF00069	0.637
MOD_GSK3_1	757	764	PF00069	0.619
MOD_GSK3_1	790	797	PF00069	0.719
MOD_GSK3_1	94	101	PF00069	0.740
MOD_LATS_1	892	898	PF00433	0.521
MOD_N-GLC_1	5	10	PF02516	0.566
MOD_N-GLC_1	770	775	PF02516	0.538
MOD_N-GLC_2	59	61	PF02516	0.668
MOD_NEK2_1	167	172	PF00069	0.641
MOD_NEK2_1	200	205	PF00069	0.468
MOD_NEK2_1	31	36	PF00069	0.679
MOD_NEK2_1	770	775	PF00069	0.646
MOD_PIKK_1	140	146	PF00454	0.534
MOD_PIKK_1	174	180	PF00454	0.606
MOD_PIKK_1	200	206	PF00454	0.517
MOD_PIKK_1	231	237	PF00454	0.629
MOD_PIKK_1	26	32	PF00454	0.560
MOD_PIKK_1	466	472	PF00454	0.491
MOD_PIKK_1	690	696	PF00454	0.573
MOD_PKA_1	332	338	PF00069	0.476
MOD_PKA_1	690	696	PF00069	0.461
MOD_PKA_1	894	900	PF00069	0.518
MOD_PKA_2	148	154	PF00069	0.722
MOD_PKA_2	317	323	PF00069	0.427
MOD_PKA_2	558	564	PF00069	0.469
MOD_PKA_2	732	738	PF00069	0.492
MOD_PKA_2	782	788	PF00069	0.703
MOD_PKA_2	894	900	PF00069	0.636
MOD_PKA_2	947	953	PF00069	0.538
MOD_PKB_1	794	802	PF00069	0.759
MOD_Plk_1	188	194	PF00069	0.569
MOD_Plk_1	708	714	PF00069	0.724
MOD_Plk_1	726	732	PF00069	0.435
MOD_Plk_1	94	100	PF00069	0.707
MOD_Plk_2-3	447	453	PF00069	0.539
MOD_Plk_2-3	915	921	PF00069	0.533
MOD_Plk_4	367	373	PF00069	0.551
MOD_Plk_4	757	763	PF00069	0.491
MOD_Plk_4	915	921	PF00069	0.584
MOD_ProDKin_1	155	161	PF00069	0.707
MOD_ProDKin_1	162	168	PF00069	0.641
MOD_ProDKin_1	202	208	PF00069	0.495
MOD_ProDKin_1	225	231	PF00069	0.670
MOD_ProDKin_1	298	304	PF00069	0.511
MOD_ProDKin_1	401	407	PF00069	0.646
MOD_ProDKin_1	45	51	PF00069	0.784
MOD_ProDKin_1	5	11	PF00069	0.674
MOD_ProDKin_1	613	619	PF00069	0.529
MOD_ProDKin_1	655	661	PF00069	0.614
MOD_ProDKin_1	803	809	PF00069	0.660
MOD_ProDKin_1	815	821	PF00069	0.561
MOD_ProDKin_1	824	830	PF00069	0.592
MOD_ProDKin_1	83	89	PF00069	0.781
MOD_ProDKin_1	831	837	PF00069	0.579
MOD_ProDKin_1	913	919	PF00069	0.507
MOD_ProDKin_1	924	930	PF00069	0.485
MOD_ProDKin_1	98	104	PF00069	0.654
MOD_SUMO_for_1	503	506	PF00179	0.498
MOD_SUMO_for_1	665	668	PF00179	0.639
MOD_SUMO_rev_2	386	391	PF00179	0.505
MOD_SUMO_rev_2	522	530	PF00179	0.569
TRG_DiLeu_BaEn_1	581	586	PF01217	0.470
TRG_DiLeu_BaEn_1	915	920	PF01217	0.535
TRG_DiLeu_BaLyEn_6	715	720	PF01217	0.607
TRG_ENDOCYTIC_2	535	538	PF00928	0.455
TRG_ENDOCYTIC_2	609	612	PF00928	0.269
TRG_ER_diArg_1	289	292	PF00400	0.583
TRG_ER_diArg_1	306	309	PF00400	0.571
TRG_ER_diArg_1	324	326	PF00400	0.577
TRG_ER_diArg_1	400	402	PF00400	0.763
TRG_ER_diArg_1	527	530	PF00400	0.457
TRG_ER_diArg_1	678	681	PF00400	0.539
TRG_ER_diArg_1	716	718	PF00400	0.522
TRG_ER_diArg_1	740	742	PF00400	0.462
TRG_ER_diArg_1	893	895	PF00400	0.601
TRG_ER_diArg_1	931	934	PF00400	0.624
TRG_Pf-PMV_PEXEL_1	505	510	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC69	Leptomonas seymouri	54%	92%
A0A1X0P481	Trypanosomatidae	29%	100%
A0A3R7NHW7	Trypanosoma rangeli	30%	100%
A0A3S7X0G5	Leishmania donovani	82%	96%
A4HFI6	Leishmania braziliensis	67%	99%
E9AD37	Leishmania major	81%	100%
E9AHD0	Leishmania infantum	83%	96%