WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4470)/Domain of unknown function (DUF4471), putative

Species:

Leishmania mexicana

UniProt:

E9AYW0_LEIMU

TriTrypDb:

LmxM.27.0590

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AYW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYW0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0070286	axonemal dynein complex assembly	6	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0006996	organelle organization	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044458	motile cilium assembly	7	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.501
CLV_C14_Caspase3-7	299	303	PF00656	0.464
CLV_C14_Caspase3-7	567	571	PF00656	0.617
CLV_NRD_NRD_1	238	240	PF00675	0.476
CLV_NRD_NRD_1	343	345	PF00675	0.264
CLV_NRD_NRD_1	40	42	PF00675	0.531
CLV_NRD_NRD_1	58	60	PF00675	0.720
CLV_NRD_NRD_1	95	97	PF00675	0.605
CLV_PCSK_FUR_1	38	42	PF00082	0.601
CLV_PCSK_KEX2_1	343	345	PF00082	0.264
CLV_PCSK_KEX2_1	37	39	PF00082	0.500
CLV_PCSK_KEX2_1	40	42	PF00082	0.565
CLV_PCSK_KEX2_1	58	60	PF00082	0.692
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.573
CLV_PCSK_PC7_1	54	60	PF00082	0.599
CLV_PCSK_SKI1_1	150	154	PF00082	0.292
CLV_PCSK_SKI1_1	189	193	PF00082	0.264
CLV_PCSK_SKI1_1	224	228	PF00082	0.395
CLV_PCSK_SKI1_1	239	243	PF00082	0.425
CLV_PCSK_SKI1_1	469	473	PF00082	0.238
CLV_PCSK_SKI1_1	96	100	PF00082	0.613
DEG_APCC_DBOX_1	149	157	PF00400	0.529
DEG_APCC_DBOX_1	410	418	PF00400	0.464
DEG_SCF_FBW7_1	106	111	PF00400	0.564
DEG_SPOP_SBC_1	121	125	PF00917	0.786
DOC_CKS1_1	443	448	PF01111	0.504
DOC_CYCLIN_RxL_1	351	362	PF00134	0.534
DOC_MAPK_gen_1	326	335	PF00069	0.464
DOC_MAPK_gen_1	457	465	PF00069	0.504
DOC_MAPK_MEF2A_6	210	217	PF00069	0.481
DOC_MAPK_NFAT4_5	210	218	PF00069	0.481
DOC_PIKK_1	82	89	PF02985	0.716
DOC_PP1_RVXF_1	187	194	PF00149	0.464
DOC_PP1_RVXF_1	208	215	PF00149	0.464
DOC_PP1_RVXF_1	353	360	PF00149	0.535
DOC_PP1_RVXF_1	457	463	PF00149	0.527
DOC_USP7_MATH_1	108	112	PF00917	0.761
DOC_USP7_MATH_1	121	125	PF00917	0.712
DOC_USP7_MATH_1	144	148	PF00917	0.526
DOC_USP7_MATH_1	161	165	PF00917	0.442
DOC_USP7_MATH_1	39	43	PF00917	0.700
DOC_USP7_UBL2_3	351	355	PF12436	0.522
DOC_WW_Pin1_4	104	109	PF00397	0.731
DOC_WW_Pin1_4	116	121	PF00397	0.742
DOC_WW_Pin1_4	125	130	PF00397	0.722
DOC_WW_Pin1_4	23	28	PF00397	0.366
DOC_WW_Pin1_4	442	447	PF00397	0.481
DOC_WW_Pin1_4	493	498	PF00397	0.463
DOC_WW_Pin1_4	64	69	PF00397	0.763
DOC_WW_Pin1_4	72	77	PF00397	0.644
LIG_14-3-3_CanoR_1	154	160	PF00244	0.464
LIG_14-3-3_CanoR_1	251	256	PF00244	0.462
LIG_14-3-3_CanoR_1	343	349	PF00244	0.456
LIG_Actin_WH2_2	145	162	PF00022	0.535
LIG_Actin_WH2_2	235	253	PF00022	0.429
LIG_APCC_ABBA_1	211	216	PF00400	0.464
LIG_APCC_ABBAyCdc20_2	210	216	PF00400	0.464
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_Clathr_ClatBox_1	212	216	PF01394	0.473
LIG_deltaCOP1_diTrp_1	20	25	PF00928	0.408
LIG_deltaCOP1_diTrp_1	306	311	PF00928	0.464
LIG_deltaCOP1_diTrp_1	466	470	PF00928	0.518
LIG_EH1_1	49	57	PF00400	0.482
LIG_eIF4E_1	579	585	PF01652	0.475
LIG_FHA_1	285	291	PF00498	0.455
LIG_FHA_1	315	321	PF00498	0.464
LIG_FHA_1	450	456	PF00498	0.544
LIG_FHA_1	494	500	PF00498	0.492
LIG_FHA_1	549	555	PF00498	0.443
LIG_FHA_2	105	111	PF00498	0.777
LIG_FHA_2	565	571	PF00498	0.636
LIG_GBD_Chelix_1	234	242	PF00786	0.437
LIG_LIR_Apic_2	347	353	PF02991	0.462
LIG_LIR_Apic_2	577	582	PF02991	0.426
LIG_LIR_Gen_1	254	262	PF02991	0.464
LIG_LIR_Gen_1	30	39	PF02991	0.421
LIG_LIR_Gen_1	306	313	PF02991	0.481
LIG_LIR_Gen_1	314	323	PF02991	0.446
LIG_LIR_Gen_1	466	472	PF02991	0.466
LIG_LIR_Nem_3	174	180	PF02991	0.468
LIG_LIR_Nem_3	30	34	PF02991	0.388
LIG_LIR_Nem_3	306	310	PF02991	0.473
LIG_LIR_Nem_3	314	319	PF02991	0.453
LIG_LIR_Nem_3	379	383	PF02991	0.535
LIG_LIR_Nem_3	466	470	PF02991	0.474
LIG_NRBOX	193	199	PF00104	0.464
LIG_PCNA_yPIPBox_3	189	202	PF02747	0.481
LIG_PCNA_yPIPBox_3	578	588	PF02747	0.474
LIG_Pex14_1	307	311	PF04695	0.464
LIG_Pex14_2	192	196	PF04695	0.464
LIG_PTB_Apo_2	371	378	PF02174	0.464
LIG_Rb_LxCxE_1	468	489	PF01857	0.492
LIG_SH2_CRK	316	320	PF00017	0.464
LIG_SH2_CRK	350	354	PF00017	0.464
LIG_SH2_CRK	438	442	PF00017	0.535
LIG_SH2_GRB2like	298	301	PF00017	0.499
LIG_SH2_GRB2like	316	319	PF00017	0.373
LIG_SH2_PTP2	579	582	PF00017	0.245
LIG_SH2_SRC	440	443	PF00017	0.535
LIG_SH2_STAP1	316	320	PF00017	0.464
LIG_SH2_STAP1	348	352	PF00017	0.464
LIG_SH2_STAP1	451	455	PF00017	0.535
LIG_SH2_STAT5	178	181	PF00017	0.450
LIG_SH2_STAT5	316	319	PF00017	0.467
LIG_SH2_STAT5	415	418	PF00017	0.535
LIG_SH2_STAT5	440	443	PF00017	0.535
LIG_SH2_STAT5	451	454	PF00017	0.535
LIG_SH2_STAT5	5	8	PF00017	0.573
LIG_SH2_STAT5	531	534	PF00017	0.535
LIG_SH2_STAT5	579	582	PF00017	0.475
LIG_SH2_STAT5	587	590	PF00017	0.530
LIG_SH3_1	440	446	PF00018	0.563
LIG_SH3_2	592	597	PF14604	0.422
LIG_SH3_3	176	182	PF00018	0.522
LIG_SH3_3	440	446	PF00018	0.504
LIG_SH3_3	589	595	PF00018	0.417
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.540
LIG_TRAF2_1	203	206	PF00917	0.535
LIG_TRAF2_1	254	257	PF00917	0.535
LIG_UBA3_1	89	97	PF00899	0.551
LIG_WRC_WIRS_1	252	257	PF05994	0.304
LIG_WRC_WIRS_1	377	382	PF05994	0.398
MOD_CDK_SPxxK_3	72	79	PF00069	0.701
MOD_CK1_1	111	117	PF00069	0.783
MOD_CK1_1	123	129	PF00069	0.685
MOD_CK1_1	16	22	PF00069	0.572
MOD_CK1_1	67	73	PF00069	0.697
MOD_CK1_1	77	83	PF00069	0.631
MOD_CK2_1	104	110	PF00069	0.611
MOD_CK2_1	251	257	PF00069	0.298
MOD_CK2_1	77	83	PF00069	0.661
MOD_Cter_Amidation	35	38	PF01082	0.295
MOD_GlcNHglycan	163	166	PF01048	0.428
MOD_GlcNHglycan	276	280	PF01048	0.282
MOD_GlcNHglycan	361	364	PF01048	0.435
MOD_GlcNHglycan	41	44	PF01048	0.653
MOD_GlcNHglycan	446	449	PF01048	0.381
MOD_GlcNHglycan	64	67	PF01048	0.721
MOD_GlcNHglycan	69	72	PF01048	0.770
MOD_GSK3_1	104	111	PF00069	0.766
MOD_GSK3_1	116	123	PF00069	0.740
MOD_GSK3_1	271	278	PF00069	0.394
MOD_GSK3_1	324	331	PF00069	0.313
MOD_GSK3_1	390	397	PF00069	0.348
MOD_GSK3_1	489	496	PF00069	0.302
MOD_GSK3_1	67	74	PF00069	0.684
MOD_GSK3_1	92	99	PF00069	0.667
MOD_LATS_1	388	394	PF00433	0.342
MOD_N-GLC_1	353	358	PF02516	0.317
MOD_NEK2_1	13	18	PF00069	0.577
MOD_NEK2_1	152	157	PF00069	0.457
MOD_NEK2_1	197	202	PF00069	0.317
MOD_NEK2_1	265	270	PF00069	0.365
MOD_NEK2_1	335	340	PF00069	0.315
MOD_NEK2_1	359	364	PF00069	0.342
MOD_NEK2_1	486	491	PF00069	0.315
MOD_NEK2_2	403	408	PF00069	0.317
MOD_PIKK_1	111	117	PF00454	0.710
MOD_PIKK_1	265	271	PF00454	0.372
MOD_PIKK_1	284	290	PF00454	0.206
MOD_PIKK_1	381	387	PF00454	0.369
MOD_PIKK_1	45	51	PF00454	0.762
MOD_PIKK_1	489	495	PF00454	0.317
MOD_PIKK_1	572	578	PF00454	0.536
MOD_PKA_1	96	102	PF00069	0.538
MOD_PKA_2	274	280	PF00069	0.173
MOD_PKA_2	328	334	PF00069	0.342
MOD_PKA_2	39	45	PF00069	0.621
MOD_PKA_2	391	397	PF00069	0.417
MOD_Plk_1	244	250	PF00069	0.447
MOD_Plk_1	335	341	PF00069	0.314
MOD_Plk_1	353	359	PF00069	0.321
MOD_Plk_4	197	203	PF00069	0.341
MOD_Plk_4	244	250	PF00069	0.476
MOD_Plk_4	30	36	PF00069	0.501
MOD_Plk_4	413	419	PF00069	0.417
MOD_Plk_4	495	501	PF00069	0.385
MOD_Plk_4	580	586	PF00069	0.497
MOD_ProDKin_1	104	110	PF00069	0.734
MOD_ProDKin_1	116	122	PF00069	0.742
MOD_ProDKin_1	125	131	PF00069	0.717
MOD_ProDKin_1	23	29	PF00069	0.364
MOD_ProDKin_1	442	448	PF00069	0.342
MOD_ProDKin_1	493	499	PF00069	0.316
MOD_ProDKin_1	64	70	PF00069	0.765
MOD_ProDKin_1	72	78	PF00069	0.639
MOD_SUMO_rev_2	254	260	PF00179	0.380
MOD_SUMO_rev_2	347	353	PF00179	0.357
MOD_SUMO_rev_2	553	559	PF00179	0.564
TRG_DiLeu_BaEn_1	138	143	PF01217	0.457
TRG_DiLeu_BaEn_1	208	213	PF01217	0.317
TRG_DiLeu_BaEn_1	315	320	PF01217	0.417
TRG_DiLeu_BaEn_1	85	90	PF01217	0.668
TRG_DiLeu_BaEn_1	9	14	PF01217	0.628
TRG_DiLeu_BaEn_2	465	471	PF01217	0.348
TRG_DiLeu_BaEn_2	514	520	PF01217	0.317
TRG_ENDOCYTIC_2	316	319	PF00928	0.317
TRG_ENDOCYTIC_2	415	418	PF00928	0.317
TRG_ENDOCYTIC_2	438	441	PF00928	0.317
TRG_ER_diArg_1	342	344	PF00400	0.317
TRG_ER_diArg_1	38	41	PF00400	0.586
TRG_ER_diArg_1	389	392	PF00400	0.342
TRG_NLS_MonoCore_2	36	41	PF00514	0.541
TRG_NLS_MonoExtC_3	36	41	PF00514	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILC1	Leptomonas seymouri	70%	100%
A0A1X0P5D9	Trypanosomatidae	50%	100%
A0A3R7RLZ6	Trypanosoma rangeli	53%	100%
A0A3S7X0G7	Leishmania donovani	94%	100%
A4HFI5	Leishmania braziliensis	85%	100%
D0A5R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D3ZCM9	Rattus norvegicus	28%	100%
E9AD36	Leishmania major	93%	100%
E9AHC9	Leishmania infantum	94%	100%
F1MLB4	Bos taurus	31%	100%
F6S9E6	Xenopus tropicalis	26%	100%
Q32NQ7	Xenopus laevis	27%	100%
Q3UYV8	Mus musculus	28%	100%
Q8N9W5	Homo sapiens	30%	100%
Q95K25	Macaca fascicularis	28%	100%