LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYV9_LEIMU

TriTrypDb:

LmxM.27.0580

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071011	precatalytic spliceosome	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AYV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYV9

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	10
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	10
GO:0000398	mRNA splicing, via spliceosome	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006397	mRNA processing	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008380	RNA splicing	7	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016071	mRNA metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	472	476	PF00656	0.418
CLV_C14_Caspase3-7	514	518	PF00656	0.441
CLV_NRD_NRD_1	190	192	PF00675	0.544
CLV_NRD_NRD_1	261	263	PF00675	0.705
CLV_NRD_NRD_1	293	295	PF00675	0.433
CLV_NRD_NRD_1	381	383	PF00675	0.358
CLV_NRD_NRD_1	386	388	PF00675	0.353
CLV_NRD_NRD_1	486	488	PF00675	0.447
CLV_PCSK_KEX2_1	190	192	PF00082	0.418
CLV_PCSK_KEX2_1	263	265	PF00082	0.698
CLV_PCSK_KEX2_1	292	294	PF00082	0.448
CLV_PCSK_KEX2_1	386	388	PF00082	0.341
CLV_PCSK_KEX2_1	486	488	PF00082	0.503
CLV_PCSK_KEX2_1	72	74	PF00082	0.560
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.698
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.560
CLV_PCSK_PC7_1	382	388	PF00082	0.324
CLV_PCSK_PC7_1	482	488	PF00082	0.459
CLV_PCSK_SKI1_1	136	140	PF00082	0.342
CLV_PCSK_SKI1_1	181	185	PF00082	0.489
CLV_PCSK_SKI1_1	293	297	PF00082	0.291
CLV_PCSK_SKI1_1	594	598	PF00082	0.388
CLV_PCSK_SKI1_1	662	666	PF00082	0.500
CLV_Separin_Metazoa	498	502	PF03568	0.430
DEG_SPOP_SBC_1	235	239	PF00917	0.632
DEG_SPOP_SBC_1	252	256	PF00917	0.589
DOC_CKS1_1	150	155	PF01111	0.264
DOC_CYCLIN_RxL_1	289	300	PF00134	0.301
DOC_CYCLIN_yCln2_LP_2	281	287	PF00134	0.521
DOC_MAPK_gen_1	386	396	PF00069	0.428
DOC_MAPK_gen_1	486	493	PF00069	0.359
DOC_MAPK_gen_1	558	567	PF00069	0.443
DOC_MAPK_MEF2A_6	561	569	PF00069	0.386
DOC_PP2B_LxvP_1	107	110	PF13499	0.335
DOC_PP2B_LxvP_1	140	143	PF13499	0.475
DOC_PP2B_LxvP_1	285	288	PF13499	0.463
DOC_PP4_FxxP_1	401	404	PF00568	0.397
DOC_USP7_MATH_1	134	138	PF00917	0.462
DOC_USP7_MATH_1	2	6	PF00917	0.631
DOC_USP7_MATH_1	218	222	PF00917	0.417
DOC_USP7_MATH_1	235	239	PF00917	0.649
DOC_USP7_MATH_1	248	252	PF00917	0.741
DOC_USP7_MATH_1	258	262	PF00917	0.693
DOC_USP7_MATH_1	454	458	PF00917	0.415
DOC_USP7_MATH_1	518	522	PF00917	0.485
DOC_USP7_MATH_1	592	596	PF00917	0.433
DOC_USP7_MATH_1	65	69	PF00917	0.694
DOC_USP7_MATH_1	650	654	PF00917	0.366
DOC_USP7_MATH_1	80	84	PF00917	0.566
DOC_USP7_MATH_1	9	13	PF00917	0.604
DOC_WW_Pin1_4	149	154	PF00397	0.381
DOC_WW_Pin1_4	181	186	PF00397	0.532
LIG_14-3-3_CanoR_1	168	175	PF00244	0.626
LIG_14-3-3_CanoR_1	190	195	PF00244	0.449
LIG_14-3-3_CanoR_1	203	210	PF00244	0.444
LIG_14-3-3_CanoR_1	219	225	PF00244	0.443
LIG_14-3-3_CanoR_1	249	257	PF00244	0.684
LIG_14-3-3_CanoR_1	342	350	PF00244	0.455
LIG_14-3-3_CanoR_1	405	411	PF00244	0.558
LIG_14-3-3_CanoR_1	566	576	PF00244	0.439
LIG_Actin_WH2_2	580	596	PF00022	0.433
LIG_APCC_ABBA_1	100	105	PF00400	0.456
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_BIR_III_1	1	5	PF00653	0.522
LIG_BIR_III_2	517	521	PF00653	0.424
LIG_BIR_III_3	1	5	PF00653	0.522
LIG_Clathr_ClatBox_1	147	151	PF01394	0.321
LIG_Clathr_ClatBox_1	452	456	PF01394	0.415
LIG_Clathr_ClatBox_1	655	659	PF01394	0.347
LIG_CSL_BTD_1	672	675	PF09270	0.388
LIG_deltaCOP1_diTrp_1	273	280	PF00928	0.582
LIG_deltaCOP1_diTrp_1	628	637	PF00928	0.472
LIG_eIF4E_1	103	109	PF01652	0.338
LIG_FHA_1	178	184	PF00498	0.610
LIG_FHA_1	190	196	PF00498	0.526
LIG_FHA_1	252	258	PF00498	0.606
LIG_FHA_1	391	397	PF00498	0.368
LIG_FHA_1	475	481	PF00498	0.425
LIG_FHA_1	619	625	PF00498	0.392
LIG_FHA_2	114	120	PF00498	0.426
LIG_FHA_2	167	173	PF00498	0.597
LIG_FHA_2	458	464	PF00498	0.560
LIG_FHA_2	566	572	PF00498	0.303
LIG_FHA_2	614	620	PF00498	0.232
LIG_LIR_Apic_2	521	527	PF02991	0.466
LIG_LIR_Gen_1	116	126	PF02991	0.309
LIG_LIR_Gen_1	327	335	PF02991	0.532
LIG_LIR_Gen_1	363	369	PF02991	0.307
LIG_LIR_Gen_1	371	379	PF02991	0.282
LIG_LIR_Gen_1	634	644	PF02991	0.498
LIG_LIR_Gen_1	93	104	PF02991	0.362
LIG_LIR_Nem_3	116	121	PF02991	0.318
LIG_LIR_Nem_3	278	283	PF02991	0.477
LIG_LIR_Nem_3	327	331	PF02991	0.488
LIG_LIR_Nem_3	363	367	PF02991	0.314
LIG_LIR_Nem_3	371	376	PF02991	0.279
LIG_LIR_Nem_3	464	470	PF02991	0.360
LIG_LIR_Nem_3	595	600	PF02991	0.439
LIG_LIR_Nem_3	634	640	PF02991	0.471
LIG_LIR_Nem_3	93	99	PF02991	0.365
LIG_PCNA_yPIPBox_3	136	148	PF02747	0.455
LIG_Pex14_1	276	280	PF04695	0.581
LIG_Pex14_1	373	377	PF04695	0.346
LIG_SH2_CRK	467	471	PF00017	0.400
LIG_SH2_CRK	48	52	PF00017	0.461
LIG_SH2_CRK	524	528	PF00017	0.488
LIG_SH2_PTP2	156	159	PF00017	0.469
LIG_SH2_SRC	103	106	PF00017	0.371
LIG_SH2_STAP1	118	122	PF00017	0.304
LIG_SH2_STAP1	686	690	PF00017	0.457
LIG_SH2_STAT5	103	106	PF00017	0.371
LIG_SH2_STAT5	156	159	PF00017	0.469
LIG_SH2_STAT5	467	470	PF00017	0.517
LIG_SH2_STAT5	576	579	PF00017	0.451
LIG_SH3_3	147	153	PF00018	0.322
LIG_SH3_3	237	243	PF00018	0.648
LIG_SH3_3	265	271	PF00018	0.611
LIG_SUMO_SIM_anti_2	313	320	PF11976	0.390
LIG_SUMO_SIM_anti_2	653	659	PF11976	0.379
LIG_SUMO_SIM_par_1	653	659	PF11976	0.355
LIG_TRAF2_1	312	315	PF00917	0.518
LIG_TYR_ITIM	46	51	PF00017	0.406
LIG_TYR_ITIM	465	470	PF00017	0.351
LIG_TYR_ITSM	114	121	PF00017	0.423
LIG_UBA3_1	144	149	PF00899	0.233
LIG_UBA3_1	194	199	PF00899	0.428
MOD_CDK_SPxK_1	149	155	PF00069	0.450
MOD_CK1_1	171	177	PF00069	0.584
MOD_CK1_1	251	257	PF00069	0.537
MOD_CK1_1	3	9	PF00069	0.704
MOD_CK1_1	457	463	PF00069	0.379
MOD_CK1_1	540	546	PF00069	0.638
MOD_CK2_1	113	119	PF00069	0.429
MOD_CK2_1	166	172	PF00069	0.574
MOD_CK2_1	308	314	PF00069	0.505
MOD_CK2_1	613	619	PF00069	0.230
MOD_CK2_1	92	98	PF00069	0.423
MOD_Cter_Amidation	70	73	PF01082	0.545
MOD_GlcNHglycan	220	223	PF01048	0.393
MOD_GlcNHglycan	250	253	PF01048	0.797
MOD_GlcNHglycan	310	313	PF01048	0.588
MOD_GlcNHglycan	401	404	PF01048	0.418
MOD_GlcNHglycan	445	448	PF01048	0.496
MOD_GlcNHglycan	471	474	PF01048	0.335
MOD_GlcNHglycan	594	597	PF01048	0.437
MOD_GlcNHglycan	647	650	PF01048	0.459
MOD_GlcNHglycan	651	655	PF01048	0.404
MOD_GlcNHglycan	686	689	PF01048	0.424
MOD_GlcNHglycan	69	72	PF01048	0.586
MOD_GlcNHglycan	74	77	PF01048	0.444
MOD_GSK3_1	173	180	PF00069	0.659
MOD_GSK3_1	247	254	PF00069	0.805
MOD_GSK3_1	3	10	PF00069	0.704
MOD_GSK3_1	390	397	PF00069	0.337
MOD_GSK3_1	412	419	PF00069	0.398
MOD_GSK3_1	432	439	PF00069	0.214
MOD_GSK3_1	457	464	PF00069	0.563
MOD_GSK3_1	536	543	PF00069	0.717
MOD_GSK3_1	609	616	PF00069	0.204
MOD_NEK2_1	394	399	PF00069	0.405
MOD_NEK2_1	416	421	PF00069	0.443
MOD_NEK2_1	422	427	PF00069	0.419
MOD_NEK2_1	469	474	PF00069	0.391
MOD_NEK2_1	554	559	PF00069	0.348
MOD_NEK2_1	577	582	PF00069	0.451
MOD_NEK2_1	644	649	PF00069	0.443
MOD_NEK2_1	667	672	PF00069	0.395
MOD_NEK2_1	92	97	PF00069	0.428
MOD_NEK2_2	609	614	PF00069	0.301
MOD_NEK2_2	620	625	PF00069	0.313
MOD_PIKK_1	518	524	PF00454	0.411
MOD_PIKK_1	547	553	PF00454	0.463
MOD_PIKK_1	673	679	PF00454	0.511
MOD_PKA_1	190	196	PF00069	0.330
MOD_PKA_1	72	78	PF00069	0.572
MOD_PKA_2	189	195	PF00069	0.447
MOD_PKA_2	202	208	PF00069	0.344
MOD_PKA_2	218	224	PF00069	0.380
MOD_PKA_2	248	254	PF00069	0.618
MOD_PKA_2	341	347	PF00069	0.478
MOD_PKA_2	351	357	PF00069	0.526
MOD_PKA_2	457	463	PF00069	0.404
MOD_PKA_2	565	571	PF00069	0.391
MOD_PKA_2	644	650	PF00069	0.540
MOD_PKA_2	72	78	PF00069	0.666
MOD_Plk_1	540	546	PF00069	0.556
MOD_Plk_1	650	656	PF00069	0.366
MOD_Plk_4	113	119	PF00069	0.393
MOD_Plk_4	190	196	PF00069	0.339
MOD_Plk_4	236	242	PF00069	0.599
MOD_Plk_4	276	282	PF00069	0.483
MOD_Plk_4	406	412	PF00069	0.439
MOD_Plk_4	432	438	PF00069	0.241
MOD_Plk_4	457	463	PF00069	0.565
MOD_Plk_4	476	482	PF00069	0.255
MOD_Plk_4	599	605	PF00069	0.470
MOD_Plk_4	609	615	PF00069	0.250
MOD_Plk_4	679	685	PF00069	0.413
MOD_ProDKin_1	149	155	PF00069	0.377
MOD_ProDKin_1	181	187	PF00069	0.519
MOD_SUMO_rev_2	111	116	PF00179	0.443
MOD_SUMO_rev_2	229	235	PF00179	0.592
TRG_DiLeu_BaEn_4	123	129	PF01217	0.356
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.286
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.419
TRG_DiLeu_BaLyEn_6	606	611	PF01217	0.359
TRG_ENDOCYTIC_2	118	121	PF00928	0.307
TRG_ENDOCYTIC_2	156	159	PF00928	0.353
TRG_ENDOCYTIC_2	25	28	PF00928	0.341
TRG_ENDOCYTIC_2	467	470	PF00928	0.405
TRG_ENDOCYTIC_2	48	51	PF00928	0.433
TRG_ER_diArg_1	291	294	PF00400	0.411
TRG_ER_diArg_1	385	387	PF00400	0.355
TRG_NES_CRM1_1	98	112	PF08389	0.416
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM3	Leptomonas seymouri	63%	100%
A0A3R7KHV4	Trypanosoma rangeli	35%	100%
A0A3S5H7H4	Leishmania donovani	91%	100%
A4HFI4	Leishmania braziliensis	79%	100%
D0A5R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AD35	Leishmania major	92%	100%
E9AHC8	Leishmania infantum	92%	100%
G5EEG7	Caenorhabditis elegans	24%	100%
Q2TAY7	Homo sapiens	25%	100%
Q2TBS9	Bos taurus	25%	100%
Q3UKJ7	Mus musculus	25%	100%
Q5ZME8	Gallus gallus	25%	100%
Q6NRT3	Xenopus laevis	25%	100%
Q6P4J8	Xenopus tropicalis	25%	100%
Q76B40	Cricetulus griseus	25%	100%
Q7ZVA0	Danio rerio	24%	100%
Q99M63	Rattus norvegicus	25%	100%
V5B9I2	Trypanosoma cruzi	34%	100%