RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AYV8_LEIMU

TriTrypDb:

LmxM.27.0570

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYV8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.482
CLV_NRD_NRD_1	159	161	PF00675	0.400
CLV_NRD_NRD_1	19	21	PF00675	0.559
CLV_NRD_NRD_1	343	345	PF00675	0.635
CLV_NRD_NRD_1	395	397	PF00675	0.415
CLV_NRD_NRD_1	422	424	PF00675	0.577
CLV_NRD_NRD_1	451	453	PF00675	0.457
CLV_NRD_NRD_1	459	461	PF00675	0.402
CLV_NRD_NRD_1	473	475	PF00675	0.413
CLV_NRD_NRD_1	513	515	PF00675	0.617
CLV_PCSK_FUR_1	471	475	PF00082	0.426
CLV_PCSK_FUR_1	511	515	PF00082	0.447
CLV_PCSK_KEX2_1	112	114	PF00082	0.512
CLV_PCSK_KEX2_1	159	161	PF00082	0.400
CLV_PCSK_KEX2_1	19	21	PF00082	0.559
CLV_PCSK_KEX2_1	343	345	PF00082	0.635
CLV_PCSK_KEX2_1	395	397	PF00082	0.422
CLV_PCSK_KEX2_1	424	426	PF00082	0.559
CLV_PCSK_KEX2_1	451	453	PF00082	0.457
CLV_PCSK_KEX2_1	471	473	PF00082	0.503
CLV_PCSK_KEX2_1	511	513	PF00082	0.450
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.573
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.559
CLV_PCSK_SKI1_1	153	157	PF00082	0.356
CLV_PCSK_SKI1_1	176	180	PF00082	0.405
CLV_PCSK_SKI1_1	20	24	PF00082	0.555
DEG_ODPH_VHL_1	368	381	PF01847	0.516
DEG_SCF_FBW7_1	32	38	PF00400	0.481
DEG_SCF_FBW7_1	334	340	PF00400	0.624
DEG_SPOP_SBC_1	308	312	PF00917	0.532
DEG_SPOP_SBC_1	337	341	PF00917	0.632
DOC_CKS1_1	218	223	PF01111	0.642
DOC_CKS1_1	32	37	PF01111	0.479
DOC_CKS1_1	334	339	PF01111	0.625
DOC_PP1_RVXF_1	174	181	PF00149	0.406
DOC_PP2B_LxvP_1	14	17	PF13499	0.511
DOC_PP2B_LxvP_1	215	218	PF13499	0.475
DOC_PP4_FxxP_1	327	330	PF00568	0.733
DOC_PP4_FxxP_1	367	370	PF00568	0.490
DOC_USP7_MATH_1	10	14	PF00917	0.580
DOC_USP7_MATH_1	209	213	PF00917	0.601
DOC_USP7_MATH_1	233	237	PF00917	0.575
DOC_USP7_MATH_1	282	286	PF00917	0.552
DOC_USP7_MATH_1	308	312	PF00917	0.585
DOC_USP7_MATH_1	35	39	PF00917	0.612
DOC_USP7_MATH_1	426	430	PF00917	0.517
DOC_USP7_UBL2_3	502	506	PF12436	0.423
DOC_USP7_UBL2_3	76	80	PF12436	0.295
DOC_WW_Pin1_4	217	222	PF00397	0.575
DOC_WW_Pin1_4	237	242	PF00397	0.633
DOC_WW_Pin1_4	244	249	PF00397	0.557
DOC_WW_Pin1_4	28	33	PF00397	0.572
DOC_WW_Pin1_4	333	338	PF00397	0.656
DOC_WW_Pin1_4	346	351	PF00397	0.580
LIG_14-3-3_CanoR_1	176	181	PF00244	0.401
LIG_14-3-3_CanoR_1	19	28	PF00244	0.604
LIG_14-3-3_CanoR_1	232	241	PF00244	0.549
LIG_14-3-3_CanoR_1	303	313	PF00244	0.601
LIG_14-3-3_CanoR_1	343	350	PF00244	0.591
LIG_14-3-3_CanoR_1	425	431	PF00244	0.517
LIG_14-3-3_CanoR_1	62	70	PF00244	0.305
LIG_14-3-3_CanoR_1	94	99	PF00244	0.365
LIG_BIR_II_1	1	5	PF00653	0.807
LIG_EVH1_1	215	219	PF00568	0.472
LIG_FHA_1	163	169	PF00498	0.374
LIG_FHA_1	238	244	PF00498	0.583
LIG_FHA_2	118	124	PF00498	0.595
LIG_FHA_2	32	38	PF00498	0.522
LIG_FHA_2	481	487	PF00498	0.439
LIG_LIR_Apic_2	326	330	PF02991	0.754
LIG_LIR_Apic_2	364	370	PF02991	0.482
LIG_LIR_Gen_1	291	301	PF02991	0.508
LIG_LIR_Gen_1	378	389	PF02991	0.419
LIG_LIR_Gen_1	40	50	PF02991	0.302
LIG_LIR_Nem_3	362	368	PF02991	0.523
LIG_LIR_Nem_3	378	384	PF02991	0.445
LIG_LIR_Nem_3	40	45	PF02991	0.513
LIG_Pex14_1	118	122	PF04695	0.524
LIG_SH2_GRB2like	42	45	PF00017	0.449
LIG_SH2_SRC	42	45	PF00017	0.449
LIG_SH2_SRC	475	478	PF00017	0.448
LIG_SH2_STAP1	164	168	PF00017	0.314
LIG_SH2_STAP1	96	100	PF00017	0.479
LIG_SH2_STAT5	115	118	PF00017	0.502
LIG_SH2_STAT5	164	167	PF00017	0.404
LIG_SH2_STAT5	301	304	PF00017	0.523
LIG_SH2_STAT5	366	369	PF00017	0.550
LIG_SH2_STAT5	475	478	PF00017	0.464
LIG_SH2_STAT5	73	76	PF00017	0.282
LIG_SH2_STAT5	96	99	PF00017	0.401
LIG_SH3_3	213	219	PF00018	0.616
LIG_SH3_3	29	35	PF00018	0.492
LIG_SH3_3	318	324	PF00018	0.579
LIG_SH3_3	53	59	PF00018	0.370
LIG_SUMO_SIM_par_1	220	225	PF11976	0.496
LIG_TRAF2_1	131	134	PF00917	0.541
LIG_TRAF2_1	440	443	PF00917	0.480
LIG_TRFH_1	366	370	PF08558	0.497
LIG_WRC_WIRS_1	95	100	PF05994	0.371
MOD_CK1_1	2	8	PF00069	0.798
MOD_CK1_1	204	210	PF00069	0.563
MOD_CK1_1	259	265	PF00069	0.600
MOD_CK1_1	268	274	PF00069	0.672
MOD_CK1_1	275	281	PF00069	0.572
MOD_CK1_1	304	310	PF00069	0.630
MOD_CK1_1	31	37	PF00069	0.538
MOD_CK1_1	312	318	PF00069	0.626
MOD_CK1_1	342	348	PF00069	0.676
MOD_CK2_1	128	134	PF00069	0.441
MOD_CK2_1	268	274	PF00069	0.508
MOD_CK2_1	31	37	PF00069	0.515
MOD_CK2_1	437	443	PF00069	0.495
MOD_CK2_1	9	15	PF00069	0.549
MOD_GlcNHglycan	101	104	PF01048	0.558
MOD_GlcNHglycan	203	206	PF01048	0.632
MOD_GlcNHglycan	211	214	PF01048	0.575
MOD_GlcNHglycan	235	238	PF01048	0.490
MOD_GlcNHglycan	25	28	PF01048	0.672
MOD_GlcNHglycan	261	264	PF01048	0.609
MOD_GlcNHglycan	293	296	PF01048	0.789
MOD_GlcNHglycan	306	309	PF01048	0.580
MOD_GlcNHglycan	358	361	PF01048	0.575
MOD_GlcNHglycan	37	40	PF01048	0.546
MOD_GlcNHglycan	419	422	PF01048	0.658
MOD_GlcNHglycan	439	442	PF01048	0.511
MOD_GSK3_1	23	30	PF00069	0.542
MOD_GSK3_1	233	240	PF00069	0.496
MOD_GSK3_1	253	260	PF00069	0.644
MOD_GSK3_1	264	271	PF00069	0.600
MOD_GSK3_1	273	280	PF00069	0.580
MOD_GSK3_1	299	306	PF00069	0.572
MOD_GSK3_1	308	315	PF00069	0.645
MOD_GSK3_1	31	38	PF00069	0.537
MOD_GSK3_1	333	340	PF00069	0.675
MOD_GSK3_1	342	349	PF00069	0.607
MOD_GSK3_1	352	359	PF00069	0.473
MOD_GSK3_1	490	497	PF00069	0.444
MOD_GSK3_1	90	97	PF00069	0.370
MOD_N-GLC_1	291	296	PF02516	0.621
MOD_N-GLC_1	299	304	PF02516	0.726
MOD_N-GLC_1	506	511	PF02516	0.337
MOD_N-GLC_2	44	46	PF02516	0.305
MOD_N-GLC_2	64	66	PF02516	0.183
MOD_N-GLC_2	83	85	PF02516	0.305
MOD_NEK2_1	1	6	PF00069	0.618
MOD_NEK2_1	136	141	PF00069	0.530
MOD_NEK2_1	181	186	PF00069	0.315
MOD_NEK2_1	199	204	PF00069	0.609
MOD_NEK2_1	273	278	PF00069	0.596
MOD_NEK2_1	417	422	PF00069	0.559
MOD_NEK2_1	69	74	PF00069	0.305
MOD_PIKK_1	257	263	PF00454	0.508
MOD_PIKK_1	490	496	PF00454	0.426
MOD_PKA_1	343	349	PF00069	0.569
MOD_PKA_2	231	237	PF00069	0.602
MOD_PKA_2	288	294	PF00069	0.656
MOD_PKA_2	302	308	PF00069	0.656
MOD_PKA_2	342	348	PF00069	0.639
MOD_PKA_2	90	96	PF00069	0.373
MOD_PKB_1	60	68	PF00069	0.305
MOD_Plk_1	118	124	PF00069	0.537
MOD_Plk_1	291	297	PF00069	0.739
MOD_Plk_1	315	321	PF00069	0.607
MOD_Plk_1	506	512	PF00069	0.346
MOD_Plk_1	540	546	PF00069	0.357
MOD_Plk_4	136	142	PF00069	0.462
MOD_ProDKin_1	217	223	PF00069	0.578
MOD_ProDKin_1	237	243	PF00069	0.634
MOD_ProDKin_1	244	250	PF00069	0.558
MOD_ProDKin_1	28	34	PF00069	0.573
MOD_ProDKin_1	333	339	PF00069	0.658
MOD_ProDKin_1	346	352	PF00069	0.578
MOD_SUMO_for_1	401	404	PF00179	0.506
MOD_SUMO_for_1	505	508	PF00179	0.456
MOD_SUMO_rev_2	101	110	PF00179	0.458
TRG_ENDOCYTIC_2	293	296	PF00928	0.516
TRG_ENDOCYTIC_2	365	368	PF00928	0.566
TRG_ENDOCYTIC_2	42	45	PF00928	0.488
TRG_ER_diArg_1	110	113	PF00400	0.476
TRG_ER_diArg_1	284	287	PF00400	0.545
TRG_ER_diArg_1	395	398	PF00400	0.416
TRG_ER_diArg_1	451	453	PF00400	0.461
TRG_ER_diArg_1	470	473	PF00400	0.292
TRG_ER_diArg_1	510	513	PF00400	0.436
TRG_ER_diArg_1	518	521	PF00400	0.441
TRG_ER_diArg_1	59	62	PF00400	0.333
TRG_NLS_MonoExtN_4	109	115	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6U0	Leptomonas seymouri	52%	98%
A0A3S7X0G9	Leishmania donovani	84%	100%
A4HFI3	Leishmania braziliensis	70%	99%
E9AD34	Leishmania major	86%	100%
E9AHC7	Leishmania infantum	84%	100%