Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYV4_LEIMU

TriTrypDb:

LmxM.27.0530

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.676
CLV_C14_Caspase3-7	499	503	PF00656	0.704
CLV_NRD_NRD_1	113	115	PF00675	0.531
CLV_NRD_NRD_1	167	169	PF00675	0.499
CLV_NRD_NRD_1	204	206	PF00675	0.581
CLV_NRD_NRD_1	309	311	PF00675	0.620
CLV_NRD_NRD_1	39	41	PF00675	0.511
CLV_NRD_NRD_1	541	543	PF00675	0.508
CLV_NRD_NRD_1	558	560	PF00675	0.535
CLV_NRD_NRD_1	584	586	PF00675	0.521
CLV_NRD_NRD_1	72	74	PF00675	0.368
CLV_PCSK_FUR_1	219	223	PF00082	0.498
CLV_PCSK_KEX2_1	113	115	PF00082	0.537
CLV_PCSK_KEX2_1	157	159	PF00082	0.438
CLV_PCSK_KEX2_1	166	168	PF00082	0.509
CLV_PCSK_KEX2_1	204	206	PF00082	0.581
CLV_PCSK_KEX2_1	221	223	PF00082	0.481
CLV_PCSK_KEX2_1	309	311	PF00082	0.620
CLV_PCSK_KEX2_1	541	543	PF00082	0.508
CLV_PCSK_KEX2_1	558	560	PF00082	0.535
CLV_PCSK_KEX2_1	584	586	PF00082	0.522
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.406
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.506
CLV_PCSK_PC7_1	163	169	PF00082	0.465
CLV_PCSK_SKI1_1	149	153	PF00082	0.406
CLV_PCSK_SKI1_1	350	354	PF00082	0.508
CLV_PCSK_SKI1_1	391	395	PF00082	0.508
CLV_PCSK_SKI1_1	424	428	PF00082	0.616
CLV_PCSK_SKI1_1	548	552	PF00082	0.521
CLV_PCSK_SKI1_1	569	573	PF00082	0.491
CLV_PCSK_SKI1_1	579	583	PF00082	0.507
CLV_PCSK_SKI1_1	82	86	PF00082	0.439
CLV_Separin_Metazoa	70	74	PF03568	0.476
DEG_APCC_DBOX_1	148	156	PF00400	0.404
DEG_APCC_DBOX_1	196	204	PF00400	0.589
DEG_Nend_UBRbox_3	1	3	PF02207	0.585
DEG_SCF_FBW7_1	457	463	PF00400	0.636
DEG_SIAH_1	368	376	PF03145	0.539
DEG_SPOP_SBC_1	249	253	PF00917	0.609
DOC_CKS1_1	457	462	PF01111	0.623
DOC_MAPK_FxFP_2	572	575	PF00069	0.491
DOC_PP1_RVXF_1	329	336	PF00149	0.363
DOC_PP4_FxxP_1	572	575	PF00568	0.491
DOC_USP7_MATH_1	224	228	PF00917	0.735
DOC_USP7_MATH_1	240	244	PF00917	0.549
DOC_USP7_MATH_1	250	254	PF00917	0.569
DOC_USP7_MATH_1	375	379	PF00917	0.622
DOC_USP7_MATH_1	387	391	PF00917	0.572
DOC_USP7_MATH_1	393	397	PF00917	0.612
DOC_USP7_MATH_1	418	422	PF00917	0.592
DOC_USP7_MATH_1	526	530	PF00917	0.779
DOC_USP7_UBL2_3	350	354	PF12436	0.605
DOC_WW_Pin1_4	140	145	PF00397	0.476
DOC_WW_Pin1_4	173	178	PF00397	0.570
DOC_WW_Pin1_4	211	216	PF00397	0.630
DOC_WW_Pin1_4	281	286	PF00397	0.559
DOC_WW_Pin1_4	359	364	PF00397	0.661
DOC_WW_Pin1_4	39	44	PF00397	0.531
DOC_WW_Pin1_4	424	429	PF00397	0.622
DOC_WW_Pin1_4	456	461	PF00397	0.627
DOC_WW_Pin1_4	463	468	PF00397	0.615
DOC_WW_Pin1_4	505	510	PF00397	0.666
LIG_14-3-3_CanoR_1	166	171	PF00244	0.643
LIG_14-3-3_CanoR_1	172	177	PF00244	0.613
LIG_14-3-3_CanoR_1	226	233	PF00244	0.514
LIG_14-3-3_CanoR_1	334	342	PF00244	0.533
LIG_14-3-3_CanoR_1	584	591	PF00244	0.511
LIG_APCC_ABBA_1	100	105	PF00400	0.435
LIG_BRCT_BRCA1_1	377	381	PF00533	0.473
LIG_CtBP_PxDLS_1	382	386	PF00389	0.473
LIG_FHA_1	173	179	PF00498	0.564
LIG_FHA_1	395	401	PF00498	0.585
LIG_FHA_1	409	415	PF00498	0.587
LIG_FHA_1	457	463	PF00498	0.648
LIG_FHA_1	464	470	PF00498	0.592
LIG_FHA_1	476	482	PF00498	0.531
LIG_FHA_1	5	11	PF00498	0.488
LIG_FHA_1	530	536	PF00498	0.618
LIG_FHA_1	586	592	PF00498	0.441
LIG_FHA_2	25	31	PF00498	0.463
LIG_FHA_2	276	282	PF00498	0.459
LIG_FHA_2	494	500	PF00498	0.569
LIG_LIR_Apic_2	193	199	PF02991	0.470
LIG_LIR_Apic_2	429	434	PF02991	0.528
LIG_LIR_Apic_2	570	575	PF02991	0.488
LIG_LYPXL_yS_3	260	263	PF13949	0.523
LIG_MYND_3	535	539	PF01753	0.593
LIG_PCNA_yPIPBox_3	541	551	PF02747	0.492
LIG_RPA_C_Fungi	537	549	PF08784	0.516
LIG_SH2_CRK	431	435	PF00017	0.525
LIG_SH2_NCK_1	431	435	PF00017	0.638
LIG_SH2_PTP2	68	71	PF00017	0.397
LIG_SH2_SRC	303	306	PF00017	0.396
LIG_SH2_SRC	68	71	PF00017	0.463
LIG_SH2_STAP1	298	302	PF00017	0.475
LIG_SH2_STAT5	103	106	PF00017	0.466
LIG_SH2_STAT5	58	61	PF00017	0.384
LIG_SH2_STAT5	68	71	PF00017	0.417
LIG_SH3_1	40	46	PF00018	0.504
LIG_SH3_3	183	189	PF00018	0.566
LIG_SH3_3	360	366	PF00018	0.658
LIG_SH3_3	377	383	PF00018	0.494
LIG_SH3_3	40	46	PF00018	0.504
LIG_SUMO_SIM_anti_2	150	156	PF11976	0.394
LIG_SUMO_SIM_par_1	18	23	PF11976	0.404
LIG_TRAF2_1	131	134	PF00917	0.466
LIG_UBA3_1	151	157	PF00899	0.371
LIG_UBA3_1	84	90	PF00899	0.502
MOD_CDC14_SPxK_1	470	473	PF00782	0.608
MOD_CDK_SPK_2	456	461	PF00069	0.604
MOD_CDK_SPK_2	505	510	PF00069	0.654
MOD_CDK_SPxK_1	173	179	PF00069	0.564
MOD_CDK_SPxK_1	359	365	PF00069	0.663
MOD_CDK_SPxK_1	424	430	PF00069	0.644
MOD_CDK_SPxK_1	467	473	PF00069	0.612
MOD_CDK_SPxxK_3	42	49	PF00069	0.430
MOD_CDK_SPxxK_3	505	512	PF00069	0.617
MOD_CK1_1	214	220	PF00069	0.556
MOD_CK1_1	242	248	PF00069	0.618
MOD_CK1_1	251	257	PF00069	0.508
MOD_CK1_1	36	42	PF00069	0.487
MOD_CK1_1	4	10	PF00069	0.404
MOD_CK1_1	463	469	PF00069	0.601
MOD_CK1_1	476	482	PF00069	0.630
MOD_CK1_1	514	520	PF00069	0.630
MOD_CK1_1	529	535	PF00069	0.528
MOD_CK2_1	128	134	PF00069	0.413
MOD_CK2_1	24	30	PF00069	0.464
MOD_CK2_1	270	276	PF00069	0.583
MOD_CK2_1	480	486	PF00069	0.664
MOD_CK2_1	493	499	PF00069	0.546
MOD_GlcNHglycan	130	133	PF01048	0.503
MOD_GlcNHglycan	228	231	PF01048	0.666
MOD_GlcNHglycan	254	257	PF01048	0.747
MOD_GlcNHglycan	272	275	PF01048	0.410
MOD_GlcNHglycan	342	345	PF01048	0.506
MOD_GlcNHglycan	35	38	PF01048	0.575
MOD_GlcNHglycan	385	388	PF01048	0.490
MOD_GlcNHglycan	414	417	PF01048	0.566
MOD_GlcNHglycan	420	423	PF01048	0.569
MOD_GlcNHglycan	446	449	PF01048	0.649
MOD_GlcNHglycan	478	481	PF01048	0.599
MOD_GlcNHglycan	513	516	PF01048	0.739
MOD_GlcNHglycan	518	521	PF01048	0.587
MOD_GlcNHglycan	576	579	PF01048	0.489
MOD_GSK3_1	173	180	PF00069	0.518
MOD_GSK3_1	239	246	PF00069	0.516
MOD_GSK3_1	248	255	PF00069	0.592
MOD_GSK3_1	323	330	PF00069	0.542
MOD_GSK3_1	381	388	PF00069	0.573
MOD_GSK3_1	408	415	PF00069	0.615
MOD_GSK3_1	418	425	PF00069	0.575
MOD_GSK3_1	456	463	PF00069	0.615
MOD_GSK3_1	476	483	PF00069	0.491
MOD_N-GLC_1	467	472	PF02516	0.612
MOD_N-GLC_2	63	65	PF02516	0.410
MOD_NEK2_1	1	6	PF00069	0.480
MOD_NEK2_1	126	131	PF00069	0.410
MOD_NEK2_1	275	280	PF00069	0.467
MOD_NEK2_1	333	338	PF00069	0.370
MOD_NEK2_1	385	390	PF00069	0.616
MOD_NEK2_1	410	415	PF00069	0.492
MOD_NEK2_1	475	480	PF00069	0.612
MOD_NEK2_1	567	572	PF00069	0.494
MOD_NEK2_2	369	374	PF00069	0.480
MOD_PIKK_1	585	591	PF00454	0.439
MOD_PKA_1	166	172	PF00069	0.465
MOD_PKA_2	166	172	PF00069	0.453
MOD_PKA_2	225	231	PF00069	0.561
MOD_PKA_2	270	276	PF00069	0.494
MOD_PKA_2	333	339	PF00069	0.531
MOD_PKA_2	429	435	PF00069	0.689
MOD_PKA_2	460	466	PF00069	0.775
MOD_PKA_2	583	589	PF00069	0.507
MOD_Plk_1	147	153	PF00069	0.411
MOD_Plk_1	275	281	PF00069	0.468
MOD_Plk_1	436	442	PF00069	0.625
MOD_Plk_1	567	573	PF00069	0.493
MOD_Plk_4	369	375	PF00069	0.537
MOD_ProDKin_1	140	146	PF00069	0.468
MOD_ProDKin_1	173	179	PF00069	0.576
MOD_ProDKin_1	211	217	PF00069	0.631
MOD_ProDKin_1	281	287	PF00069	0.551
MOD_ProDKin_1	359	365	PF00069	0.663
MOD_ProDKin_1	39	45	PF00069	0.518
MOD_ProDKin_1	424	430	PF00069	0.626
MOD_ProDKin_1	456	462	PF00069	0.625
MOD_ProDKin_1	463	469	PF00069	0.616
MOD_ProDKin_1	505	511	PF00069	0.667
MOD_SUMO_rev_2	343	352	PF00179	0.562
TRG_DiLeu_BaEn_2	133	139	PF01217	0.457
TRG_DiLeu_BaEn_2	140	146	PF01217	0.422
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.355
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.369
TRG_ENDOCYTIC_2	103	106	PF00928	0.450
TRG_ENDOCYTIC_2	260	263	PF00928	0.523
TRG_ER_diArg_1	112	114	PF00400	0.519
TRG_ER_diArg_1	166	168	PF00400	0.478
TRG_ER_diArg_1	203	205	PF00400	0.579
TRG_ER_diArg_1	449	452	PF00400	0.629
TRG_ER_diArg_1	540	542	PF00400	0.510
TRG_ER_diArg_1	583	585	PF00400	0.518
TRG_NES_CRM1_1	198	211	PF08389	0.464
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5K9	Leptomonas seymouri	50%	96%
A0A3S7X0F9	Leishmania donovani	86%	100%
A4HFH9	Leishmania braziliensis	68%	98%
E9AD30	Leishmania major	88%	100%
E9AHC3	Leishmania infantum	87%	100%