Putative calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calpain-like cysteine peptidase, putative

Species:

Leishmania mexicana

UniProt:

E9AYV1_LEIMU

TriTrypDb:

LmxM.27.0490

Length:

2355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0019538	protein metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004175	endopeptidase activity	4	7
GO:0004197	cysteine-type endopeptidase activity	5	7
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	7
GO:0008233	peptidase activity	3	7
GO:0008234	cysteine-type peptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0140096	catalytic activity, acting on a protein	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1563	1567	PF00656	0.566
CLV_C14_Caspase3-7	1577	1581	PF00656	0.548
CLV_C14_Caspase3-7	1772	1776	PF00656	0.699
CLV_C14_Caspase3-7	1929	1933	PF00656	0.580
CLV_C14_Caspase3-7	506	510	PF00656	0.516
CLV_C14_Caspase3-7	597	601	PF00656	0.534
CLV_C14_Caspase3-7	625	629	PF00656	0.538
CLV_C14_Caspase3-7	641	645	PF00656	0.526
CLV_C14_Caspase3-7	8	12	PF00656	0.559
CLV_C14_Caspase3-7	930	934	PF00656	0.631

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZW3	Leptomonas seymouri	56%	79%
A0A0S4JUM4	Bodo saltans	37%	69%
A0A1X0P5C8	Trypanosomatidae	48%	93%
A0A422MYY1	Trypanosoma rangeli	42%	100%
D0A5Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%

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