Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 60, putative

Species:

Leishmania mexicana

UniProt:

E9AYV0_LEIMU

TriTrypDb:

LmxM.27.0480

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.672
CLV_C14_Caspase3-7	33	37	PF00656	0.612
CLV_C14_Caspase3-7	355	359	PF00656	0.732
CLV_C14_Caspase3-7	40	44	PF00656	0.429
CLV_C14_Caspase3-7	460	464	PF00656	0.308
CLV_NRD_NRD_1	130	132	PF00675	0.604
CLV_NRD_NRD_1	172	174	PF00675	0.533
CLV_NRD_NRD_1	196	198	PF00675	0.668
CLV_NRD_NRD_1	273	275	PF00675	0.495
CLV_NRD_NRD_1	487	489	PF00675	0.669
CLV_NRD_NRD_1	568	570	PF00675	0.635
CLV_NRD_NRD_1	88	90	PF00675	0.358
CLV_PCSK_FUR_1	271	275	PF00082	0.534
CLV_PCSK_KEX2_1	130	132	PF00082	0.656
CLV_PCSK_KEX2_1	172	174	PF00082	0.533
CLV_PCSK_KEX2_1	196	198	PF00082	0.668
CLV_PCSK_KEX2_1	273	275	PF00082	0.493
CLV_PCSK_KEX2_1	487	489	PF00082	0.692
CLV_PCSK_KEX2_1	568	570	PF00082	0.538
CLV_PCSK_KEX2_1	87	89	PF00082	0.389
CLV_PCSK_SKI1_1	104	108	PF00082	0.511
CLV_PCSK_SKI1_1	120	124	PF00082	0.538
CLV_PCSK_SKI1_1	470	474	PF00082	0.647
CLV_Separin_Metazoa	536	540	PF03568	0.734
DOC_CKS1_1	401	406	PF01111	0.594
DOC_CKS1_1	83	88	PF01111	0.355
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.564
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.600
DOC_MAPK_gen_1	22	30	PF00069	0.496
DOC_MAPK_gen_1	539	549	PF00069	0.719
DOC_MAPK_gen_1	568	574	PF00069	0.663
DOC_MAPK_gen_1	87	94	PF00069	0.501
DOC_MAPK_MEF2A_6	22	30	PF00069	0.473
DOC_MAPK_MEF2A_6	87	94	PF00069	0.564
DOC_MAPK_RevD_3	117	131	PF00069	0.313
DOC_PP2B_LxvP_1	108	111	PF13499	0.539
DOC_PP2B_LxvP_1	112	115	PF13499	0.534
DOC_PP2B_LxvP_1	443	446	PF13499	0.659
DOC_PP2B_LxvP_1	54	57	PF13499	0.535
DOC_PP4_FxxP_1	401	404	PF00568	0.563
DOC_PP4_FxxP_1	476	479	PF00568	0.567
DOC_USP7_MATH_1	4	8	PF00917	0.525
DOC_USP7_MATH_1	417	421	PF00917	0.566
DOC_USP7_MATH_1	446	450	PF00917	0.718
DOC_USP7_MATH_1	472	476	PF00917	0.648
DOC_USP7_MATH_1	586	590	PF00917	0.636
DOC_WW_Pin1_4	133	138	PF00397	0.656
DOC_WW_Pin1_4	154	159	PF00397	0.595
DOC_WW_Pin1_4	213	218	PF00397	0.707
DOC_WW_Pin1_4	373	378	PF00397	0.735
DOC_WW_Pin1_4	400	405	PF00397	0.587
DOC_WW_Pin1_4	418	423	PF00397	0.498
DOC_WW_Pin1_4	44	49	PF00397	0.595
DOC_WW_Pin1_4	501	506	PF00397	0.541
DOC_WW_Pin1_4	552	557	PF00397	0.473
DOC_WW_Pin1_4	82	87	PF00397	0.557
LIG_14-3-3_CanoR_1	22	27	PF00244	0.521
LIG_14-3-3_CanoR_1	297	301	PF00244	0.588
LIG_14-3-3_CanoR_1	470	479	PF00244	0.596
LIG_14-3-3_CanoR_1	539	549	PF00244	0.770
LIG_14-3-3_CanoR_1	89	95	PF00244	0.613
LIG_AP2alpha_2	300	302	PF02296	0.599
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_BRCT_BRCA1_1	414	418	PF00533	0.322
LIG_FHA_1	13	19	PF00498	0.475
LIG_FHA_1	151	157	PF00498	0.514
LIG_FHA_1	23	29	PF00498	0.441
LIG_FHA_1	242	248	PF00498	0.572
LIG_FHA_1	267	273	PF00498	0.564
LIG_FHA_1	322	328	PF00498	0.560
LIG_FHA_1	343	349	PF00498	0.516
LIG_FHA_1	427	433	PF00498	0.571
LIG_FHA_1	438	444	PF00498	0.569
LIG_FHA_1	45	51	PF00498	0.536
LIG_FHA_1	502	508	PF00498	0.480
LIG_FHA_1	67	73	PF00498	0.546
LIG_FHA_2	196	202	PF00498	0.622
LIG_FHA_2	326	332	PF00498	0.462
LIG_LIR_Apic_2	398	404	PF02991	0.575
LIG_LIR_Apic_2	473	479	PF02991	0.501
LIG_LIR_Gen_1	305	314	PF02991	0.412
LIG_LIR_Gen_1	463	472	PF02991	0.314
LIG_LIR_Nem_3	163	169	PF02991	0.497
LIG_LIR_Nem_3	305	310	PF02991	0.434
LIG_LIR_Nem_3	400	405	PF02991	0.518
LIG_LIR_Nem_3	463	469	PF02991	0.290
LIG_SH2_CRK	402	406	PF00017	0.498
LIG_SH2_CRK	466	470	PF00017	0.518
LIG_SH2_PTP2	307	310	PF00017	0.364
LIG_SH2_SRC	261	264	PF00017	0.567
LIG_SH2_SRC	279	282	PF00017	0.567
LIG_SH2_SRC	311	314	PF00017	0.545
LIG_SH2_STAP1	190	194	PF00017	0.633
LIG_SH2_STAP1	279	283	PF00017	0.561
LIG_SH2_STAP1	68	72	PF00017	0.600
LIG_SH2_STAT3	180	183	PF00017	0.575
LIG_SH2_STAT5	180	183	PF00017	0.570
LIG_SH2_STAT5	307	310	PF00017	0.393
LIG_SH2_STAT5	311	314	PF00017	0.464
LIG_SH2_STAT5	325	328	PF00017	0.406
LIG_SH2_STAT5	329	332	PF00017	0.527
LIG_SH2_STAT5	335	338	PF00017	0.462
LIG_SH2_STAT5	402	405	PF00017	0.460
LIG_SH2_STAT5	49	52	PF00017	0.429
LIG_SH2_STAT5	68	71	PF00017	0.571
LIG_SH3_2	263	268	PF14604	0.566
LIG_SH3_2	83	88	PF14604	0.355
LIG_SH3_3	257	263	PF00018	0.469
LIG_SH3_3	307	313	PF00018	0.548
LIG_SH3_3	362	368	PF00018	0.594
LIG_SH3_3	436	442	PF00018	0.580
LIG_SH3_3	69	75	PF00018	0.537
LIG_SH3_3	80	86	PF00018	0.637
LIG_SUMO_SIM_par_1	25	31	PF11976	0.450
LIG_SUMO_SIM_par_1	348	353	PF11976	0.512
LIG_SUMO_SIM_par_1	409	415	PF11976	0.547
LIG_SUMO_SIM_par_1	506	511	PF11976	0.531
LIG_TRAF2_1	313	316	PF00917	0.585
MOD_CDC14_SPxK_1	376	379	PF00782	0.724
MOD_CDK_SPK_2	82	87	PF00069	0.429
MOD_CDK_SPxK_1	373	379	PF00069	0.724
MOD_CDK_SPxK_1	400	406	PF00069	0.596
MOD_CDK_SPxK_1	82	88	PF00069	0.418
MOD_CDK_SPxxK_3	418	425	PF00069	0.349
MOD_CDK_SPxxK_3	82	89	PF00069	0.578
MOD_CK1_1	100	106	PF00069	0.503
MOD_CK1_1	204	210	PF00069	0.769
MOD_CK1_1	216	222	PF00069	0.668
MOD_CK1_1	340	346	PF00069	0.455
MOD_CK1_1	37	43	PF00069	0.714
MOD_CK1_1	412	418	PF00069	0.493
MOD_CK1_1	522	528	PF00069	0.769
MOD_CK1_1	552	558	PF00069	0.650
MOD_CK1_1	589	595	PF00069	0.648
MOD_CK2_1	148	154	PF00069	0.555
MOD_CK2_1	325	331	PF00069	0.466
MOD_Cter_Amidation	194	197	PF01082	0.747
MOD_GlcNHglycan	104	107	PF01048	0.474
MOD_GlcNHglycan	150	153	PF01048	0.521
MOD_GlcNHglycan	190	193	PF01048	0.726
MOD_GlcNHglycan	207	210	PF01048	0.524
MOD_GlcNHglycan	342	345	PF01048	0.434
MOD_GlcNHglycan	36	40	PF01048	0.663
MOD_GlcNHglycan	389	393	PF01048	0.656
MOD_GlcNHglycan	494	497	PF01048	0.737
MOD_GlcNHglycan	521	524	PF01048	0.774
MOD_GlcNHglycan	590	594	PF01048	0.787
MOD_GSK3_1	150	157	PF00069	0.497
MOD_GSK3_1	201	208	PF00069	0.763
MOD_GSK3_1	213	220	PF00069	0.662
MOD_GSK3_1	296	303	PF00069	0.592
MOD_GSK3_1	317	324	PF00069	0.486
MOD_GSK3_1	508	515	PF00069	0.679
MOD_GSK3_1	518	525	PF00069	0.736
MOD_N-GLC_1	470	475	PF02516	0.644
MOD_N-GLC_2	370	372	PF02516	0.724
MOD_NEK2_1	34	39	PF00069	0.643
MOD_NEK2_1	342	347	PF00069	0.346
MOD_NEK2_1	508	513	PF00069	0.673
MOD_NEK2_1	563	568	PF00069	0.573
MOD_NEK2_2	266	271	PF00069	0.570
MOD_PK_1	409	415	PF00069	0.444
MOD_PKA_1	196	202	PF00069	0.725
MOD_PKA_2	148	154	PF00069	0.555
MOD_PKA_2	195	201	PF00069	0.721
MOD_PKA_2	296	302	PF00069	0.589
MOD_PKA_2	378	384	PF00069	0.775
MOD_PKA_2	518	524	PF00069	0.745
MOD_PKA_2	541	547	PF00069	0.660
MOD_Plk_1	266	272	PF00069	0.561
MOD_Plk_1	549	555	PF00069	0.669
MOD_Plk_4	113	119	PF00069	0.579
MOD_Plk_4	176	182	PF00069	0.516
MOD_Plk_4	321	327	PF00069	0.544
MOD_Plk_4	397	403	PF00069	0.574
MOD_Plk_4	4	10	PF00069	0.464
MOD_Plk_4	464	470	PF00069	0.531
MOD_Plk_4	472	478	PF00069	0.596
MOD_Plk_4	549	555	PF00069	0.629
MOD_ProDKin_1	133	139	PF00069	0.641
MOD_ProDKin_1	154	160	PF00069	0.602
MOD_ProDKin_1	213	219	PF00069	0.701
MOD_ProDKin_1	373	379	PF00069	0.736
MOD_ProDKin_1	400	406	PF00069	0.596
MOD_ProDKin_1	418	424	PF00069	0.499
MOD_ProDKin_1	44	50	PF00069	0.582
MOD_ProDKin_1	501	507	PF00069	0.542
MOD_ProDKin_1	552	558	PF00069	0.467
MOD_ProDKin_1	82	88	PF00069	0.547
MOD_SUMO_rev_2	252	256	PF00179	0.544
MOD_SUMO_rev_2	525	535	PF00179	0.748
TRG_DiLeu_BaEn_1	305	310	PF01217	0.391
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.582
TRG_DiLeu_LyEn_5	165	170	PF01217	0.606
TRG_ENDOCYTIC_2	257	260	PF00928	0.442
TRG_ENDOCYTIC_2	279	282	PF00928	0.567
TRG_ENDOCYTIC_2	307	310	PF00928	0.385
TRG_ENDOCYTIC_2	402	405	PF00928	0.501
TRG_ENDOCYTIC_2	466	469	PF00928	0.505
TRG_ER_diArg_1	129	131	PF00400	0.569
TRG_ER_diArg_1	172	174	PF00400	0.535
TRG_ER_diArg_1	21	24	PF00400	0.586
TRG_ER_diArg_1	270	273	PF00400	0.438
TRG_ER_diArg_1	382	385	PF00400	0.721
TRG_ER_diArg_1	486	488	PF00400	0.683
TRG_ER_diArg_1	491	494	PF00400	0.699
TRG_ER_diArg_1	567	569	PF00400	0.635
TRG_ER_diArg_1	86	89	PF00400	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I592	Leptomonas seymouri	55%	96%
A0A1X0P512	Trypanosomatidae	34%	100%
A0A3S7X0H0	Leishmania donovani	89%	99%
A0A422NTD4	Trypanosoma rangeli	37%	100%
A4HFH4	Leishmania braziliensis	76%	100%
A4I2N4	Leishmania infantum	89%	99%
D0A5Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AD25	Leishmania major	87%	100%
V5BSP9	Trypanosoma cruzi	34%	100%