Vasohibin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Vasohibin

Gene product:

Vasohibin, putative

Species:

Leishmania mexicana

UniProt:

E9AYU8_LEIMU

TriTrypDb:

LmxM.27.0460

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AYU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYU8

Function

Biological processes
Term	Name	Level	Count
GO:0022603	regulation of anatomical structure morphogenesis	4	7
GO:0045765	regulation of angiogenesis	5	7
GO:0050789	regulation of biological process	2	7
GO:0050793	regulation of developmental process	3	7
GO:0051239	regulation of multicellular organismal process	3	7
GO:0065007	biological regulation	1	7
GO:1901342	regulation of vasculature development	5	7
GO:2000026	regulation of multicellular organismal development	4	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.718
CLV_NRD_NRD_1	147	149	PF00675	0.346
CLV_NRD_NRD_1	400	402	PF00675	0.523
CLV_NRD_NRD_1	422	424	PF00675	0.615
CLV_NRD_NRD_1	598	600	PF00675	0.809
CLV_PCSK_KEX2_1	400	402	PF00082	0.523
CLV_PCSK_KEX2_1	417	419	PF00082	0.577
CLV_PCSK_KEX2_1	429	431	PF00082	0.726
CLV_PCSK_KEX2_1	464	466	PF00082	0.782
CLV_PCSK_KEX2_1	480	482	PF00082	0.718
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.679
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.629
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.785
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.718
CLV_PCSK_SKI1_1	218	222	PF00082	0.409
CLV_PCSK_SKI1_1	287	291	PF00082	0.728
CLV_PCSK_SKI1_1	378	382	PF00082	0.526
CLV_PCSK_SKI1_1	423	427	PF00082	0.691
CLV_PCSK_SKI1_1	62	66	PF00082	0.318
CLV_PCSK_SKI1_1	81	85	PF00082	0.212
DEG_SIAH_1	483	491	PF03145	0.616
DEG_SPOP_SBC_1	334	338	PF00917	0.666
DOC_CKS1_1	233	238	PF01111	0.541
DOC_CKS1_1	512	517	PF01111	0.584
DOC_CKS1_1	590	595	PF01111	0.701
DOC_CKS1_1	619	624	PF01111	0.784
DOC_CYCLIN_yCln2_LP_2	468	474	PF00134	0.505
DOC_MAPK_gen_1	378	387	PF00069	0.507
DOC_MAPK_gen_1	461	470	PF00069	0.790
DOC_MAPK_gen_1	492	502	PF00069	0.562
DOC_MAPK_gen_1	69	78	PF00069	0.619
DOC_MAPK_MEF2A_6	107	116	PF00069	0.530
DOC_MAPK_MEF2A_6	464	472	PF00069	0.523
DOC_MAPK_MEF2A_6	495	502	PF00069	0.545
DOC_MAPK_NFAT4_5	465	473	PF00069	0.504
DOC_PP1_RVXF_1	379	385	PF00149	0.612
DOC_PP2B_LxvP_1	318	321	PF13499	0.642
DOC_PP2B_LxvP_1	425	428	PF13499	0.798
DOC_PP2B_LxvP_1	468	471	PF13499	0.696
DOC_PP2B_LxvP_1	500	503	PF13499	0.732
DOC_PP2B_LxvP_1	526	529	PF13499	0.514
DOC_PP4_FxxP_1	586	589	PF00568	0.796
DOC_PP4_FxxP_1	619	622	PF00568	0.667
DOC_USP7_MATH_1	158	162	PF00917	0.619
DOC_USP7_MATH_1	248	252	PF00917	0.784
DOC_USP7_MATH_1	28	32	PF00917	0.546
DOC_USP7_MATH_1	294	298	PF00917	0.723
DOC_USP7_MATH_1	323	327	PF00917	0.726
DOC_USP7_MATH_1	438	442	PF00917	0.741
DOC_USP7_MATH_1	508	512	PF00917	0.717
DOC_USP7_MATH_1	539	543	PF00917	0.536
DOC_USP7_MATH_1	559	563	PF00917	0.770
DOC_WW_Pin1_4	134	139	PF00397	0.500
DOC_WW_Pin1_4	229	234	PF00397	0.707
DOC_WW_Pin1_4	263	268	PF00397	0.705
DOC_WW_Pin1_4	316	321	PF00397	0.707
DOC_WW_Pin1_4	325	330	PF00397	0.745
DOC_WW_Pin1_4	407	412	PF00397	0.523
DOC_WW_Pin1_4	490	495	PF00397	0.700
DOC_WW_Pin1_4	511	516	PF00397	0.643
DOC_WW_Pin1_4	555	560	PF00397	0.733
DOC_WW_Pin1_4	569	574	PF00397	0.650
DOC_WW_Pin1_4	589	594	PF00397	0.697
DOC_WW_Pin1_4	618	623	PF00397	0.791
DOC_WW_Pin1_4	629	634	PF00397	0.630
LIG_14-3-3_CanoR_1	111	117	PF00244	0.538
LIG_14-3-3_CanoR_1	133	138	PF00244	0.604
LIG_14-3-3_CanoR_1	449	457	PF00244	0.578
LIG_14-3-3_CanoR_1	465	469	PF00244	0.767
LIG_14-3-3_CanoR_1	522	527	PF00244	0.624
LIG_14-3-3_CanoR_1	538	544	PF00244	0.489
LIG_14-3-3_CanoR_1	599	609	PF00244	0.817
LIG_14-3-3_CanoR_1	610	619	PF00244	0.625
LIG_14-3-3_CanoR_1	62	68	PF00244	0.511
LIG_Actin_WH2_2	93	109	PF00022	0.530
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_BIR_III_2	575	579	PF00653	0.741
LIG_BRCT_BRCA1_1	304	308	PF00533	0.720
LIG_BRCT_BRCA1_1	615	619	PF00533	0.691
LIG_BRCT_BRCA1_1	74	78	PF00533	0.619
LIG_deltaCOP1_diTrp_1	198	203	PF00928	0.546
LIG_EH_1	15	19	PF12763	0.546
LIG_eIF4E_1	125	131	PF01652	0.546
LIG_EVH1_1	24	28	PF00568	0.619
LIG_FHA_1	101	107	PF00498	0.513
LIG_FHA_1	135	141	PF00498	0.506
LIG_FHA_1	551	557	PF00498	0.573
LIG_FHA_2	103	109	PF00498	0.619
LIG_FHA_2	188	194	PF00498	0.546
LIG_FHA_2	359	365	PF00498	0.591
LIG_FHA_2	77	83	PF00498	0.516
LIG_GBD_Chelix_1	348	356	PF00786	0.574
LIG_LIR_Apic_2	567	573	PF02991	0.620
LIG_LIR_Apic_2	583	589	PF02991	0.706
LIG_LIR_Apic_2	616	622	PF02991	0.671
LIG_LIR_Gen_1	161	169	PF02991	0.546
LIG_LIR_Gen_1	172	181	PF02991	0.501
LIG_LIR_Gen_1	353	362	PF02991	0.480
LIG_LIR_Gen_1	542	550	PF02991	0.500
LIG_LIR_Gen_1	56	65	PF02991	0.546
LIG_LIR_Gen_1	82	93	PF02991	0.555
LIG_LIR_Gen_1	94	102	PF02991	0.529
LIG_LIR_LC3C_4	499	502	PF02991	0.528
LIG_LIR_Nem_3	151	157	PF02991	0.526
LIG_LIR_Nem_3	161	166	PF02991	0.546
LIG_LIR_Nem_3	172	176	PF02991	0.501
LIG_LIR_Nem_3	198	204	PF02991	0.536
LIG_LIR_Nem_3	305	311	PF02991	0.711
LIG_LIR_Nem_3	343	348	PF02991	0.518
LIG_LIR_Nem_3	353	358	PF02991	0.476
LIG_LIR_Nem_3	364	370	PF02991	0.504
LIG_LIR_Nem_3	542	546	PF02991	0.504
LIG_LIR_Nem_3	56	60	PF02991	0.546
LIG_LIR_Nem_3	63	67	PF02991	0.546
LIG_LIR_Nem_3	82	88	PF02991	0.546
LIG_LIR_Nem_3	94	100	PF02991	0.529
LIG_MYND_1	263	267	PF01753	0.726
LIG_MYND_1	589	593	PF01753	0.696
LIG_NRP_CendR_1	634	635	PF00754	0.693
LIG_Pex14_2	619	623	PF04695	0.714
LIG_PTB_Apo_2	246	253	PF02174	0.727
LIG_Rb_LxCxE_1	86	108	PF01857	0.546
LIG_SH2_CRK	141	145	PF00017	0.546
LIG_SH2_CRK	154	158	PF00017	0.546
LIG_SH2_CRK	159	163	PF00017	0.546
LIG_SH2_CRK	345	349	PF00017	0.544
LIG_SH2_CRK	355	359	PF00017	0.411
LIG_SH2_CRK	367	371	PF00017	0.516
LIG_SH2_CRK	570	574	PF00017	0.590
LIG_SH2_SRC	605	608	PF00017	0.738
LIG_SH2_STAP1	102	106	PF00017	0.619
LIG_SH2_STAP1	304	308	PF00017	0.720
LIG_SH2_STAT5	102	105	PF00017	0.619
LIG_SH3_3	22	28	PF00018	0.552
LIG_SH3_3	227	233	PF00018	0.643
LIG_SH3_3	261	267	PF00018	0.755
LIG_SH3_3	317	323	PF00018	0.700
LIG_SH3_3	326	332	PF00018	0.768
LIG_SH3_3	587	593	PF00018	0.713
LIG_SH3_4	600	607	PF00018	0.528
LIG_SUMO_SIM_par_1	128	134	PF11976	0.546
LIG_SUMO_SIM_par_1	2	11	PF11976	0.553
LIG_TYR_ITIM	152	157	PF00017	0.588
LIG_TYR_ITIM	55	60	PF00017	0.546
LIG_TYR_ITIM	83	88	PF00017	0.411
LIG_UBA3_1	180	184	PF00899	0.619
LIG_WW_3	26	30	PF00397	0.546
LIG_WW_3	268	272	PF00397	0.720
MOD_CDC14_SPxK_1	319	322	PF00782	0.623
MOD_CDC14_SPxK_1	632	635	PF00782	0.763
MOD_CDK_SPK_2	490	495	PF00069	0.641
MOD_CDK_SPK_2	589	594	PF00069	0.697
MOD_CDK_SPK_2	629	634	PF00069	0.691
MOD_CDK_SPxK_1	316	322	PF00069	0.625
MOD_CDK_SPxK_1	629	635	PF00069	0.770
MOD_CK1_1	115	121	PF00069	0.546
MOD_CK1_1	232	238	PF00069	0.704
MOD_CK1_1	251	257	PF00069	0.480
MOD_CK1_1	316	322	PF00069	0.709
MOD_CK1_1	325	331	PF00069	0.742
MOD_CK1_1	410	416	PF00069	0.529
MOD_CK1_1	506	512	PF00069	0.767
MOD_CK1_1	517	523	PF00069	0.705
MOD_CK1_1	53	59	PF00069	0.626
MOD_CK1_1	534	540	PF00069	0.711
MOD_CK1_1	555	561	PF00069	0.724
MOD_CK1_1	608	614	PF00069	0.728
MOD_CK1_1	72	78	PF00069	0.404
MOD_CK2_1	187	193	PF00069	0.546
MOD_CK2_1	220	226	PF00069	0.773
MOD_CK2_1	292	298	PF00069	0.803
MOD_CK2_1	358	364	PF00069	0.587
MOD_CK2_1	391	397	PF00069	0.653
MOD_CK2_1	577	583	PF00069	0.712
MOD_CK2_1	600	606	PF00069	0.821
MOD_CK2_1	76	82	PF00069	0.516
MOD_Cter_Amidation	478	481	PF01082	0.696
MOD_GlcNHglycan	287	290	PF01048	0.653
MOD_GlcNHglycan	325	328	PF01048	0.564
MOD_GlcNHglycan	393	396	PF01048	0.649
MOD_GlcNHglycan	412	415	PF01048	0.401
MOD_GlcNHglycan	438	441	PF01048	0.797
MOD_GlcNHglycan	442	445	PF01048	0.691
MOD_GlcNHglycan	453	456	PF01048	0.590
MOD_GlcNHglycan	484	487	PF01048	0.670
MOD_GlcNHglycan	508	511	PF01048	0.775
MOD_GlcNHglycan	516	519	PF01048	0.810
MOD_GlcNHglycan	526	529	PF01048	0.595
MOD_GlcNHglycan	561	564	PF01048	0.746
MOD_GlcNHglycan	613	616	PF01048	0.731
MOD_GSK3_1	144	151	PF00069	0.546
MOD_GSK3_1	216	223	PF00069	0.605
MOD_GSK3_1	228	235	PF00069	0.751
MOD_GSK3_1	248	255	PF00069	0.475
MOD_GSK3_1	281	288	PF00069	0.658
MOD_GSK3_1	292	299	PF00069	0.760
MOD_GSK3_1	309	316	PF00069	0.623
MOD_GSK3_1	323	330	PF00069	0.777
MOD_GSK3_1	334	341	PF00069	0.458
MOD_GSK3_1	436	443	PF00069	0.727
MOD_GSK3_1	524	531	PF00069	0.536
MOD_GSK3_1	555	562	PF00069	0.733
MOD_GSK3_1	605	612	PF00069	0.727
MOD_GSK3_1	613	620	PF00069	0.682
MOD_GSK3_1	621	628	PF00069	0.634
MOD_GSK3_1	72	79	PF00069	0.507
MOD_N-GLC_1	248	253	PF02516	0.804
MOD_N-GLC_1	436	441	PF02516	0.768
MOD_NEK2_1	100	105	PF00069	0.521
MOD_NEK2_1	144	149	PF00069	0.543
MOD_NEK2_1	220	225	PF00069	0.743
MOD_NEK2_1	252	257	PF00069	0.736
MOD_NEK2_1	285	290	PF00069	0.798
MOD_NEK2_1	292	297	PF00069	0.752
MOD_NEK2_1	451	456	PF00069	0.539
MOD_NEK2_1	609	614	PF00069	0.800
MOD_NEK2_1	625	630	PF00069	0.548
MOD_NEK2_1	93	98	PF00069	0.546
MOD_NEK2_2	102	107	PF00069	0.619
MOD_NEK2_2	158	163	PF00069	0.619
MOD_OFUCOSY	574	581	PF10250	0.617
MOD_PIKK_1	10	16	PF00454	0.565
MOD_PIKK_1	100	106	PF00454	0.546
MOD_PIKK_1	600	606	PF00454	0.607
MOD_PK_1	50	56	PF00069	0.619
MOD_PKA_1	148	154	PF00069	0.546
MOD_PKA_1	464	470	PF00069	0.782
MOD_PKA_2	28	34	PF00069	0.546
MOD_PKA_2	38	44	PF00069	0.546
MOD_PKA_2	391	397	PF00069	0.576
MOD_PKA_2	464	470	PF00069	0.782
MOD_PKA_2	609	615	PF00069	0.769
MOD_PKB_1	447	455	PF00069	0.539
MOD_Plk_1	192	198	PF00069	0.546
MOD_Plk_1	216	222	PF00069	0.563
MOD_Plk_1	248	254	PF00069	0.727
MOD_Plk_1	272	278	PF00069	0.646
MOD_Plk_1	281	287	PF00069	0.613
MOD_Plk_1	338	344	PF00069	0.515
MOD_Plk_1	503	509	PF00069	0.727
MOD_Plk_1	93	99	PF00069	0.543
MOD_Plk_2-3	38	44	PF00069	0.428
MOD_Plk_2-3	579	585	PF00069	0.713
MOD_Plk_4	148	154	PF00069	0.589
MOD_Plk_4	158	164	PF00069	0.546
MOD_Plk_4	281	287	PF00069	0.495
MOD_Plk_4	496	502	PF00069	0.743
MOD_Plk_4	72	78	PF00069	0.526
MOD_Plk_4	93	99	PF00069	0.546
MOD_ProDKin_1	134	140	PF00069	0.500
MOD_ProDKin_1	229	235	PF00069	0.707
MOD_ProDKin_1	263	269	PF00069	0.700
MOD_ProDKin_1	316	322	PF00069	0.709
MOD_ProDKin_1	325	331	PF00069	0.742
MOD_ProDKin_1	407	413	PF00069	0.527
MOD_ProDKin_1	490	496	PF00069	0.702
MOD_ProDKin_1	511	517	PF00069	0.647
MOD_ProDKin_1	555	561	PF00069	0.733
MOD_ProDKin_1	569	575	PF00069	0.652
MOD_ProDKin_1	589	595	PF00069	0.700
MOD_ProDKin_1	618	624	PF00069	0.787
MOD_ProDKin_1	629	635	PF00069	0.631
MOD_SUMO_for_1	116	119	PF00179	0.546
MOD_SUMO_rev_2	179	185	PF00179	0.619
MOD_SUMO_rev_2	410	419	PF00179	0.645
TRG_DiLeu_BaEn_2	42	48	PF01217	0.619
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.468
TRG_ENDOCYTIC_2	125	128	PF00928	0.533
TRG_ENDOCYTIC_2	141	144	PF00928	0.443
TRG_ENDOCYTIC_2	154	157	PF00928	0.504
TRG_ENDOCYTIC_2	159	162	PF00928	0.504
TRG_ENDOCYTIC_2	173	176	PF00928	0.522
TRG_ENDOCYTIC_2	345	348	PF00928	0.499
TRG_ENDOCYTIC_2	355	358	PF00928	0.475
TRG_ENDOCYTIC_2	367	370	PF00928	0.507
TRG_ENDOCYTIC_2	57	60	PF00928	0.546
TRG_ENDOCYTIC_2	85	88	PF00928	0.411
TRG_ER_diArg_1	132	135	PF00400	0.546
TRG_ER_diArg_1	400	402	PF00400	0.523
TRG_ER_diArg_1	633	635	PF00400	0.680
TRG_NLS_MonoExtC_3	422	427	PF00514	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY3	Leptomonas seymouri	49%	96%
A0A3Q8IE45	Leishmania donovani	88%	100%
A4HFH0	Leishmania braziliensis	74%	99%
A4I2N2	Leishmania infantum	88%	100%
E9AD23	Leishmania major	86%	98%