Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYU6_LEIMU

TriTrypDb:

LmxM.27.0440

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.488
CLV_C14_Caspase3-7	241	245	PF00656	0.634
CLV_C14_Caspase3-7	526	530	PF00656	0.475
CLV_NRD_NRD_1	141	143	PF00675	0.646
CLV_NRD_NRD_1	169	171	PF00675	0.641
CLV_NRD_NRD_1	248	250	PF00675	0.541
CLV_NRD_NRD_1	324	326	PF00675	0.620
CLV_NRD_NRD_1	399	401	PF00675	0.276
CLV_NRD_NRD_1	549	551	PF00675	0.517
CLV_PCSK_KEX2_1	128	130	PF00082	0.547
CLV_PCSK_KEX2_1	141	143	PF00082	0.610
CLV_PCSK_KEX2_1	171	173	PF00082	0.645
CLV_PCSK_KEX2_1	399	401	PF00082	0.276
CLV_PCSK_KEX2_1	485	487	PF00082	0.467
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.547
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.666
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.504
CLV_PCSK_SKI1_1	142	146	PF00082	0.510
CLV_PCSK_SKI1_1	253	257	PF00082	0.618
CLV_PCSK_SKI1_1	376	380	PF00082	0.489
CLV_PCSK_SKI1_1	38	42	PF00082	0.516
CLV_PCSK_SKI1_1	399	403	PF00082	0.396
CLV_PCSK_SKI1_1	445	449	PF00082	0.516
CLV_PCSK_SKI1_1	49	53	PF00082	0.462
CLV_PCSK_SKI1_1	538	542	PF00082	0.442
CLV_PCSK_SKI1_1	78	82	PF00082	0.428
DEG_APCC_DBOX_1	312	320	PF00400	0.439
DEG_SPOP_SBC_1	2	6	PF00917	0.454
DOC_CKS1_1	379	384	PF01111	0.433
DOC_CYCLIN_RxL_1	107	120	PF00134	0.437
DOC_CYCLIN_RxL_1	249	257	PF00134	0.538
DOC_CYCLIN_RxL_1	370	381	PF00134	0.498
DOC_MAPK_gen_1	128	135	PF00069	0.401
DOC_MAPK_gen_1	33	43	PF00069	0.540
DOC_MAPK_gen_1	399	407	PF00069	0.262
DOC_MAPK_gen_1	485	491	PF00069	0.603
DOC_MAPK_MEF2A_6	313	320	PF00069	0.429
DOC_PP1_RVXF_1	76	83	PF00149	0.450
DOC_PP1_SILK_1	137	142	PF00149	0.426
DOC_PP2B_LxvP_1	12	15	PF13499	0.515
DOC_PP4_FxxP_1	379	382	PF00568	0.400
DOC_USP7_MATH_1	101	105	PF00917	0.517
DOC_USP7_MATH_1	192	196	PF00917	0.582
DOC_USP7_MATH_1	2	6	PF00917	0.612
DOC_USP7_MATH_1	238	242	PF00917	0.573
DOC_USP7_MATH_1	293	297	PF00917	0.550
DOC_USP7_MATH_1	343	347	PF00917	0.586
DOC_USP7_MATH_1	471	475	PF00917	0.603
DOC_USP7_MATH_1	478	482	PF00917	0.562
DOC_USP7_MATH_1	495	499	PF00917	0.474
DOC_USP7_UBL2_3	538	542	PF12436	0.396
DOC_WW_Pin1_4	217	222	PF00397	0.629
DOC_WW_Pin1_4	232	237	PF00397	0.672
DOC_WW_Pin1_4	318	323	PF00397	0.359
DOC_WW_Pin1_4	364	369	PF00397	0.526
DOC_WW_Pin1_4	378	383	PF00397	0.388
DOC_WW_Pin1_4	508	513	PF00397	0.429
LIG_14-3-3_CanoR_1	399	408	PF00244	0.506
LIG_14-3-3_CanoR_1	502	512	PF00244	0.464
LIG_14-3-3_CanoR_1	69	76	PF00244	0.458
LIG_Actin_WH2_2	287	305	PF00022	0.604
LIG_APCC_ABBA_1	41	46	PF00400	0.564
LIG_BRCT_BRCA1_1	320	324	PF00533	0.421
LIG_BRCT_BRCA1_1	425	429	PF00533	0.658
LIG_BRCT_BRCA1_2	320	326	PF00533	0.395
LIG_Clathr_ClatBox_1	185	189	PF01394	0.594
LIG_CtBP_PxDLS_1	15	19	PF00389	0.549
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.379
LIG_EH_1	414	418	PF12763	0.456
LIG_EH1_1	206	214	PF00400	0.621
LIG_FHA_1	217	223	PF00498	0.538
LIG_FHA_1	379	385	PF00498	0.554
LIG_FHA_1	400	406	PF00498	0.376
LIG_FHA_2	153	159	PF00498	0.619
LIG_FHA_2	206	212	PF00498	0.551
LIG_FHA_2	392	398	PF00498	0.528
LIG_LIR_Gen_1	264	272	PF02991	0.572
LIG_LIR_Nem_3	264	268	PF02991	0.598
LIG_LIR_Nem_3	321	327	PF02991	0.404
LIG_LIR_Nem_3	412	417	PF02991	0.548
LIG_MYND_1	11	15	PF01753	0.578
LIG_MYND_1	147	151	PF01753	0.643
LIG_NBox_RRM_1	500	510	PF00076	0.429
LIG_NRBOX	224	230	PF00104	0.632
LIG_NRBOX	315	321	PF00104	0.455
LIG_SH2_CRK	265	269	PF00017	0.650
LIG_SH2_SRC	93	96	PF00017	0.515
LIG_SH2_STAP1	533	537	PF00017	0.425
LIG_SH2_STAP1	93	97	PF00017	0.533
LIG_SH2_STAT3	164	167	PF00017	0.604
LIG_SH2_STAT5	207	210	PF00017	0.448
LIG_SH2_STAT5	435	438	PF00017	0.618
LIG_SH3_3	356	362	PF00018	0.541
LIG_SH3_3	472	478	PF00018	0.726
LIG_SUMO_SIM_par_1	10	17	PF11976	0.667
LIG_SUMO_SIM_par_1	223	230	PF11976	0.679
LIG_TRAF2_1	45	48	PF00917	0.519
LIG_TYR_ITIM	531	536	PF00017	0.332
LIG_WRC_WIRS_1	327	332	PF05994	0.398
LIG_WRC_WIRS_1	411	416	PF05994	0.346
LIG_WRC_WIRS_1	497	502	PF05994	0.275
MOD_CDK_SPK_2	318	323	PF00069	0.359
MOD_CDK_SPxK_1	364	370	PF00069	0.476
MOD_CDK_SPxxK_3	217	224	PF00069	0.624
MOD_CDK_SPxxK_3	318	325	PF00069	0.374
MOD_CDK_SPxxK_3	508	515	PF00069	0.428
MOD_CK1_1	296	302	PF00069	0.553
MOD_CK1_1	423	429	PF00069	0.633
MOD_CK1_1	464	470	PF00069	0.686
MOD_CK1_1	476	482	PF00069	0.610
MOD_CK1_1	5	11	PF00069	0.567
MOD_CK1_1	511	517	PF00069	0.539
MOD_CK2_1	152	158	PF00069	0.541
MOD_CK2_1	343	349	PF00069	0.589
MOD_CK2_1	391	397	PF00069	0.538
MOD_CK2_1	42	48	PF00069	0.541
MOD_CK2_1	511	517	PF00069	0.497
MOD_Cter_Amidation	548	551	PF01082	0.489
MOD_GlcNHglycan	23	26	PF01048	0.651
MOD_GlcNHglycan	240	243	PF01048	0.627
MOD_GlcNHglycan	244	248	PF01048	0.556
MOD_GlcNHglycan	295	298	PF01048	0.582
MOD_GlcNHglycan	338	341	PF01048	0.376
MOD_GlcNHglycan	426	429	PF01048	0.611
MOD_GlcNHglycan	467	470	PF01048	0.730
MOD_GlcNHglycan	505	508	PF01048	0.459
MOD_GSK3_1	1	8	PF00069	0.628
MOD_GSK3_1	203	210	PF00069	0.536
MOD_GSK3_1	216	223	PF00069	0.587
MOD_GSK3_1	227	234	PF00069	0.641
MOD_GSK3_1	292	299	PF00069	0.692
MOD_GSK3_1	420	427	PF00069	0.590
MOD_GSK3_1	461	468	PF00069	0.648
MOD_GSK3_1	473	480	PF00069	0.563
MOD_LATS_1	67	73	PF00433	0.495
MOD_N-GLC_1	122	127	PF02516	0.430
MOD_N-GLC_2	37	39	PF02516	0.580
MOD_NEK2_1	152	157	PF00069	0.596
MOD_NEK2_1	243	248	PF00069	0.463
MOD_NEK2_1	3	8	PF00069	0.594
MOD_PIKK_1	227	233	PF00454	0.578
MOD_PIKK_1	478	484	PF00454	0.576
MOD_PIKK_1	5	11	PF00454	0.611
MOD_PKA_1	170	176	PF00069	0.706
MOD_PKA_1	399	405	PF00069	0.271
MOD_PKA_2	32	38	PF00069	0.717
MOD_PKA_2	399	405	PF00069	0.438
MOD_PKA_2	423	429	PF00069	0.600
MOD_PKA_2	464	470	PF00069	0.707
MOD_PKA_2	489	495	PF00069	0.506
MOD_PKB_1	443	451	PF00069	0.512
MOD_Plk_1	122	128	PF00069	0.552
MOD_Plk_1	142	148	PF00069	0.434
MOD_Plk_4	122	128	PF00069	0.364
MOD_Plk_4	180	186	PF00069	0.611
MOD_Plk_4	264	270	PF00069	0.621
MOD_Plk_4	306	312	PF00069	0.542
MOD_Plk_4	370	376	PF00069	0.402
MOD_ProDKin_1	217	223	PF00069	0.627
MOD_ProDKin_1	232	238	PF00069	0.673
MOD_ProDKin_1	318	324	PF00069	0.370
MOD_ProDKin_1	364	370	PF00069	0.525
MOD_ProDKin_1	378	384	PF00069	0.387
MOD_ProDKin_1	508	514	PF00069	0.426
MOD_SUMO_for_1	51	54	PF00179	0.536
MOD_SUMO_rev_2	195	205	PF00179	0.603
TRG_DiLeu_BaEn_1	315	320	PF01217	0.346
TRG_DiLeu_BaEn_1	442	447	PF01217	0.548
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.589
TRG_ENDOCYTIC_2	102	105	PF00928	0.403
TRG_ENDOCYTIC_2	265	268	PF00928	0.560
TRG_ENDOCYTIC_2	533	536	PF00928	0.434
TRG_ER_diArg_1	140	142	PF00400	0.634
TRG_ER_diArg_1	169	172	PF00400	0.677
TRG_ER_diArg_1	399	401	PF00400	0.276
TRG_NLS_MonoExtC_3	169	174	PF00514	0.741
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	437	442	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKI5	Leptomonas seymouri	55%	99%
A0A1X0P429	Trypanosomatidae	25%	100%
A0A3R7MVK8	Trypanosoma rangeli	27%	100%
A0A3S7X0E6	Leishmania donovani	92%	100%
A4HFG8	Leishmania braziliensis	81%	100%
A4I2N0	Leishmania infantum	92%	100%
D0A5P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
E9AD21	Leishmania major	92%	99%
V5DP58	Trypanosoma cruzi	27%	100%