Putative heat shock protein DNAJ

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein DNAJ, putative

Species:

Leishmania mexicana

UniProt:

E9AYU3_LEIMU

TriTrypDb:

LmxM.27.0410

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AYU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYU3

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0009987	cellular process	1	1
GO:0042026	protein refolding	3	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.639
CLV_C14_Caspase3-7	258	262	PF00656	0.583
CLV_NRD_NRD_1	130	132	PF00675	0.266
CLV_NRD_NRD_1	2	4	PF00675	0.457
CLV_NRD_NRD_1	270	272	PF00675	0.432
CLV_NRD_NRD_1	42	44	PF00675	0.436
CLV_NRD_NRD_1	62	64	PF00675	0.474
CLV_PCSK_FUR_1	127	131	PF00082	0.274
CLV_PCSK_FUR_1	263	267	PF00082	0.422
CLV_PCSK_KEX2_1	129	131	PF00082	0.266
CLV_PCSK_KEX2_1	2	4	PF00082	0.473
CLV_PCSK_KEX2_1	265	267	PF00082	0.486
CLV_PCSK_KEX2_1	270	272	PF00082	0.470
CLV_PCSK_KEX2_1	42	44	PF00082	0.439
CLV_PCSK_KEX2_1	62	64	PF00082	0.432
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.318
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.414
CLV_PCSK_PC7_1	266	272	PF00082	0.461
CLV_PCSK_SKI1_1	188	192	PF00082	0.340
CLV_PCSK_SKI1_1	2	6	PF00082	0.470
CLV_PCSK_SKI1_1	233	237	PF00082	0.415
CLV_PCSK_SKI1_1	265	269	PF00082	0.426
CLV_PCSK_SKI1_1	95	99	PF00082	0.238
DEG_Nend_UBRbox_1	1	4	PF02207	0.675
DEG_SPOP_SBC_1	238	242	PF00917	0.562
DOC_CYCLIN_RxL_1	90	99	PF00134	0.450
DOC_PP4_FxxP_1	309	312	PF00568	0.690
DOC_SPAK_OSR1_1	266	270	PF12202	0.670
DOC_USP7_MATH_1	20	24	PF00917	0.700
DOC_USP7_MATH_1	277	281	PF00917	0.617
DOC_USP7_UBL2_3	90	94	PF12436	0.430
DOC_WW_Pin1_4	326	331	PF00397	0.647
DOC_WW_Pin1_4	78	83	PF00397	0.360
LIG_14-3-3_CanoR_1	233	239	PF00244	0.752
LIG_14-3-3_CanoR_1	266	270	PF00244	0.590
LIG_14-3-3_CanoR_1	271	277	PF00244	0.610
LIG_14-3-3_CanoR_1	28	34	PF00244	0.659
LIG_14-3-3_CanoR_1	50	58	PF00244	0.720
LIG_14-3-3_CanoR_1	7	16	PF00244	0.567
LIG_BRCT_BRCA1_1	160	164	PF00533	0.703
LIG_BRCT_BRCA1_1	22	26	PF00533	0.728
LIG_BRCT_BRCA1_1	305	309	PF00533	0.662
LIG_BRCT_BRCA1_1	53	57	PF00533	0.630
LIG_FHA_1	240	246	PF00498	0.683
LIG_FHA_1	339	345	PF00498	0.296
LIG_FHA_2	256	262	PF00498	0.599
LIG_FHA_2	282	288	PF00498	0.631
LIG_FHA_2	83	89	PF00498	0.534
LIG_LIR_Apic_2	306	312	PF02991	0.684
LIG_LIR_Gen_1	118	128	PF02991	0.464
LIG_LIR_Gen_1	73	82	PF02991	0.455
LIG_LIR_Nem_3	111	117	PF02991	0.439
LIG_LIR_Nem_3	118	124	PF02991	0.447
LIG_LIR_Nem_3	184	190	PF02991	0.530
LIG_LIR_Nem_3	197	203	PF02991	0.549
LIG_LIR_Nem_3	229	235	PF02991	0.644
LIG_LIR_Nem_3	73	78	PF02991	0.431
LIG_NRBOX	343	349	PF00104	0.357
LIG_Pex14_2	187	191	PF04695	0.526
LIG_Pex14_2	232	236	PF04695	0.625
LIG_Pex14_2	40	44	PF04695	0.779
LIG_REV1ctd_RIR_1	38	46	PF16727	0.576
LIG_SH2_CRK	121	125	PF00017	0.430
LIG_SH2_CRK	75	79	PF00017	0.407
LIG_SH2_CRK	93	97	PF00017	0.390
LIG_SH2_NCK_1	121	125	PF00017	0.472
LIG_SH2_SRC	173	176	PF00017	0.695
LIG_SH2_STAT3	133	136	PF00017	0.603
LIG_SH2_STAT5	259	262	PF00017	0.624
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.362
LIG_SUMO_SIM_par_1	340	346	PF11976	0.409
LIG_TRAF2_1	179	182	PF00917	0.549
LIG_WRPW_2	232	235	PF00400	0.550
MOD_CK1_1	147	153	PF00069	0.569
MOD_CK1_1	158	164	PF00069	0.628
MOD_CK1_1	228	234	PF00069	0.567
MOD_CK1_1	237	243	PF00069	0.568
MOD_CK1_1	8	14	PF00069	0.491
MOD_CK2_1	176	182	PF00069	0.442
MOD_CK2_1	281	287	PF00069	0.610
MOD_CK2_1	82	88	PF00069	0.264
MOD_Cter_Amidation	263	266	PF01082	0.541
MOD_GlcNHglycan	117	120	PF01048	0.400
MOD_GlcNHglycan	149	152	PF01048	0.575
MOD_GlcNHglycan	157	160	PF01048	0.583
MOD_GlcNHglycan	161	164	PF01048	0.428
MOD_GlcNHglycan	34	37	PF01048	0.598
MOD_GlcNHglycan	53	56	PF01048	0.556
MOD_GlcNHglycan	67	70	PF01048	0.553
MOD_GSK3_1	115	122	PF00069	0.367
MOD_GSK3_1	147	154	PF00069	0.521
MOD_GSK3_1	155	162	PF00069	0.532
MOD_GSK3_1	221	228	PF00069	0.609
MOD_GSK3_1	234	241	PF00069	0.465
MOD_GSK3_1	255	262	PF00069	0.602
MOD_GSK3_1	277	284	PF00069	0.553
MOD_GSK3_1	322	329	PF00069	0.570
MOD_GSK3_1	45	52	PF00069	0.581
MOD_GSK3_1	78	85	PF00069	0.245
MOD_N-GLC_1	277	282	PF02516	0.523
MOD_N-GLC_1	303	308	PF02516	0.509
MOD_NEK2_1	254	259	PF00069	0.488
MOD_NEK2_1	27	32	PF00069	0.673
MOD_NEK2_1	361	366	PF00069	0.304
MOD_NEK2_1	5	10	PF00069	0.584
MOD_NEK2_1	51	56	PF00069	0.568
MOD_NEK2_2	20	25	PF00069	0.507
MOD_PIKK_1	314	320	PF00454	0.568
MOD_PIKK_1	82	88	PF00454	0.357
MOD_PK_1	113	119	PF00069	0.344
MOD_PK_1	271	277	PF00069	0.391
MOD_PKA_1	265	271	PF00069	0.575
MOD_PKA_2	265	271	PF00069	0.502
MOD_PKA_2	27	33	PF00069	0.664
MOD_PKA_2	49	55	PF00069	0.648
MOD_Plk_1	228	234	PF00069	0.524
MOD_Plk_1	254	260	PF00069	0.498
MOD_Plk_1	277	283	PF00069	0.580
MOD_Plk_2-3	255	261	PF00069	0.494
MOD_Plk_4	119	125	PF00069	0.357
MOD_Plk_4	343	349	PF00069	0.264
MOD_Plk_4	361	367	PF00069	0.264
MOD_ProDKin_1	326	332	PF00069	0.558
MOD_ProDKin_1	78	84	PF00069	0.166
MOD_SUMO_rev_2	83	92	PF00179	0.264
TRG_ENDOCYTIC_2	121	124	PF00928	0.264
TRG_ENDOCYTIC_2	175	178	PF00928	0.477
TRG_ENDOCYTIC_2	75	78	PF00928	0.266
TRG_ENDOCYTIC_2	93	96	PF00928	0.145
TRG_ER_diArg_1	1	3	PF00400	0.616
TRG_ER_diArg_1	269	271	PF00400	0.584
TRG_ER_diArg_1	289	292	PF00400	0.438
TRG_ER_diArg_1	41	43	PF00400	0.590
TRG_ER_diArg_1	62	64	PF00400	0.607
TRG_NES_CRM1_1	184	197	PF08389	0.437
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD75	Leptomonas seymouri	69%	100%
A0A0S4JV26	Bodo saltans	41%	100%
A0A1X0P3X0	Trypanosomatidae	56%	100%
A0A3S5IRT6	Trypanosoma rangeli	53%	100%
A0A3S7X0F2	Leishmania donovani	93%	79%
A4HFG5	Leishmania braziliensis	81%	100%
A4I2M7	Leishmania infantum	93%	100%
D0A5P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AD18	Leishmania major	92%	100%
V5BN28	Trypanosoma cruzi	52%	92%