LeishMANIAdb
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Chromosome segregation protein SMC

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Chromosome segregation protein SMC
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AYU2_LEIMU
TriTrypDb:
LmxM.27.0400
Length:
140

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYU2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYU2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 111 113 PF00675 0.505
CLV_PCSK_KEX2_1 111 113 PF00082 0.515
CLV_PCSK_KEX2_1 120 122 PF00082 0.476
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.512
CLV_PCSK_SKI1_1 47 51 PF00082 0.531
DEG_MDM2_SWIB_1 9 16 PF02201 0.584
DEG_Nend_UBRbox_3 1 3 PF02207 0.603
DOC_MAPK_gen_1 92 100 PF00069 0.550
DOC_USP7_MATH_1 134 138 PF00917 0.639
DOC_USP7_MATH_1 82 86 PF00917 0.464
DOC_USP7_UBL2_3 83 87 PF12436 0.527
LIG_DLG_GKlike_1 111 118 PF00625 0.342
LIG_FHA_1 26 32 PF00498 0.550
LIG_LIR_Gen_1 10 17 PF02991 0.514
LIG_LIR_Gen_1 59 68 PF02991 0.538
LIG_LIR_Nem_3 10 16 PF02991 0.542
LIG_LIR_Nem_3 59 64 PF02991 0.502
LIG_NRBOX 38 44 PF00104 0.539
LIG_Pex14_2 9 13 PF04695 0.512
LIG_RPA_C_Fungi 106 118 PF08784 0.552
LIG_SUMO_SIM_anti_2 38 43 PF11976 0.540
MOD_CK1_1 25 31 PF00069 0.498
MOD_CK1_1 3 9 PF00069 0.618
MOD_CK2_1 11 17 PF00069 0.404
MOD_GlcNHglycan 134 137 PF01048 0.412
MOD_GlcNHglycan 24 27 PF01048 0.619
MOD_GSK3_1 132 139 PF00069 0.430
MOD_N-GLC_1 1 6 PF02516 0.588
MOD_NEK2_1 1 6 PF00069 0.670
MOD_NEK2_1 132 137 PF00069 0.342
MOD_NEK2_2 82 87 PF00069 0.547
MOD_PKA_1 111 117 PF00069 0.636
MOD_PKA_2 111 117 PF00069 0.636
MOD_Plk_1 100 106 PF00069 0.476
MOD_Plk_2-3 48 54 PF00069 0.552
MOD_Plk_2-3 56 62 PF00069 0.548
TRG_DiLeu_BaEn_1 38 43 PF01217 0.540
TRG_DiLeu_BaEn_1 60 65 PF01217 0.546

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P666 Leptomonas seymouri 72% 99%
A0A1X0P462 Trypanosomatidae 37% 100%
A0A3Q8IE74 Leishmania donovani 93% 100%
A0A422NTD2 Trypanosoma rangeli 32% 100%
A4HFG4 Leishmania braziliensis 84% 100%
A4I2M6 Leishmania infantum 92% 100%
E9AD17 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS