Autophagy-related protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein APG9, putative

Species:

Leishmania mexicana

UniProt:

E9AYU1_LEIMU

TriTrypDb:

LmxM.27.0390

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0034045	phagophore assembly site membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0000407	phagophore assembly site	2	1
GO:0005737	cytoplasm	2	1
GO:0005773	vacuole	5	1
GO:0005776	autophagosome	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0000502	proteasome complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2

Expansion

Sequence features

E9AYU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYU1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006869	lipid transport	5	12
GO:0006914	autophagy	3	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12
GO:0044237	cellular metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0061919	process utilizing autophagic mechanism	2	12
GO:0071702	organic substance transport	4	12
GO:0000422	autophagy of mitochondrion	4	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0008104	protein localization	4	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0033036	macromolecule localization	2	1
GO:0034497	protein localization to phagophore assembly site	5	1
GO:0044804	autophagy of nucleus	4	1
GO:0044805	late nucleophagy	5	1
GO:0051641	cellular localization	2	1
GO:0061726	mitochondrion disassembly	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1903008	organelle disassembly	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.421
CLV_C14_Caspase3-7	504	508	PF00656	0.476
CLV_C14_Caspase3-7	602	606	PF00656	0.597
CLV_C14_Caspase3-7	667	671	PF00656	0.637
CLV_NRD_NRD_1	371	373	PF00675	0.295
CLV_NRD_NRD_1	653	655	PF00675	0.488
CLV_NRD_NRD_1	716	718	PF00675	0.516
CLV_PCSK_KEX2_1	371	373	PF00082	0.280
CLV_PCSK_KEX2_1	567	569	PF00082	0.326
CLV_PCSK_KEX2_1	653	655	PF00082	0.545
CLV_PCSK_KEX2_1	716	718	PF00082	0.517
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.326
CLV_PCSK_SKI1_1	29	33	PF00082	0.253
CLV_PCSK_SKI1_1	701	705	PF00082	0.493
CLV_Separin_Metazoa	124	128	PF03568	0.459
DEG_SCF_FBW7_2	523	530	PF00400	0.607
DEG_SPOP_SBC_1	681	685	PF00917	0.590
DOC_CKS1_1	151	156	PF01111	0.433
DOC_CYCLIN_yCln2_LP_2	477	483	PF00134	0.277
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.276
DOC_MAPK_gen_1	11	19	PF00069	0.623
DOC_MAPK_gen_1	463	470	PF00069	0.251
DOC_MAPK_gen_1	567	576	PF00069	0.501
DOC_MAPK_MEF2A_6	463	470	PF00069	0.304
DOC_MAPK_MEF2A_6	567	576	PF00069	0.501
DOC_PP2B_LxvP_1	10	13	PF13499	0.620
DOC_PP2B_LxvP_1	477	480	PF13499	0.258
DOC_PP2B_LxvP_1	94	97	PF13499	0.313
DOC_PP4_FxxP_1	151	154	PF00568	0.513
DOC_PP4_FxxP_1	209	212	PF00568	0.513
DOC_PP4_FxxP_1	386	389	PF00568	0.341
DOC_PP4_FxxP_1	655	658	PF00568	0.785
DOC_SPAK_OSR1_1	654	658	PF12202	0.652
DOC_USP7_MATH_1	277	281	PF00917	0.499
DOC_USP7_MATH_1	513	517	PF00917	0.534
DOC_USP7_MATH_1	539	543	PF00917	0.707
DOC_USP7_MATH_1	548	552	PF00917	0.670
DOC_USP7_MATH_1	645	649	PF00917	0.692
DOC_USP7_MATH_1	680	684	PF00917	0.651
DOC_USP7_MATH_1	89	93	PF00917	0.140
DOC_USP7_UBL2_3	303	307	PF12436	0.335
DOC_USP7_UBL2_3	567	571	PF12436	0.631
DOC_WW_Pin1_4	150	155	PF00397	0.409
DOC_WW_Pin1_4	247	252	PF00397	0.453
DOC_WW_Pin1_4	523	528	PF00397	0.713
DOC_WW_Pin1_4	596	601	PF00397	0.655
LIG_14-3-3_CanoR_1	101	105	PF00244	0.297
LIG_14-3-3_CanoR_1	14	18	PF00244	0.616
LIG_14-3-3_CanoR_1	279	283	PF00244	0.513
LIG_14-3-3_CanoR_1	29	38	PF00244	0.513
LIG_14-3-3_CanoR_1	322	332	PF00244	0.242
LIG_14-3-3_CanoR_1	361	367	PF00244	0.285
LIG_14-3-3_CanoR_1	371	380	PF00244	0.255
LIG_14-3-3_CanoR_1	6	10	PF00244	0.665
LIG_14-3-3_CanoR_1	708	714	PF00244	0.700
LIG_Actin_WH2_2	2	20	PF00022	0.627
LIG_Actin_WH2_2	228	244	PF00022	0.499
LIG_Actin_WH2_2	334	349	PF00022	0.299
LIG_Actin_WH2_2	575	591	PF00022	0.588
LIG_APCC_ABBA_1	332	337	PF00400	0.209
LIG_APCC_ABBAyCdc20_2	331	337	PF00400	0.313
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_BRCT_BRCA1_1	205	209	PF00533	0.513
LIG_Clathr_ClatBox_1	225	229	PF01394	0.513
LIG_deltaCOP1_diTrp_1	327	332	PF00928	0.233
LIG_deltaCOP1_diTrp_1	445	453	PF00928	0.206
LIG_eIF4E_1	289	295	PF01652	0.362
LIG_FHA_1	129	135	PF00498	0.396
LIG_FHA_1	147	153	PF00498	0.367
LIG_FHA_1	282	288	PF00498	0.481
LIG_FHA_1	299	305	PF00498	0.166
LIG_FHA_1	30	36	PF00498	0.496
LIG_FHA_1	374	380	PF00498	0.262
LIG_FHA_1	405	411	PF00498	0.313
LIG_FHA_1	469	475	PF00498	0.321
LIG_FHA_1	56	62	PF00498	0.363
LIG_FHA_1	707	713	PF00498	0.610
LIG_FHA_2	254	260	PF00498	0.534
LIG_FHA_2	428	434	PF00498	0.253
LIG_FHA_2	502	508	PF00498	0.513
LIG_FHA_2	593	599	PF00498	0.710
LIG_FHA_2	683	689	PF00498	0.608
LIG_GBD_Chelix_1	379	387	PF00786	0.279
LIG_GBD_Chelix_1	469	477	PF00786	0.260
LIG_LIR_Apic_2	148	154	PF02991	0.420
LIG_LIR_Apic_2	206	212	PF02991	0.513
LIG_LIR_Apic_2	385	389	PF02991	0.342
LIG_LIR_Apic_2	652	658	PF02991	0.784
LIG_LIR_Gen_1	120	129	PF02991	0.227
LIG_LIR_Gen_1	259	268	PF02991	0.442
LIG_LIR_Gen_1	284	293	PF02991	0.421
LIG_LIR_Gen_1	423	432	PF02991	0.263
LIG_LIR_Gen_1	451	462	PF02991	0.246
LIG_LIR_Gen_1	578	583	PF02991	0.443
LIG_LIR_Gen_1	58	67	PF02991	0.430
LIG_LIR_Nem_3	102	108	PF02991	0.276
LIG_LIR_Nem_3	120	126	PF02991	0.152
LIG_LIR_Nem_3	130	136	PF02991	0.445
LIG_LIR_Nem_3	173	177	PF02991	0.509
LIG_LIR_Nem_3	187	193	PF02991	0.363
LIG_LIR_Nem_3	259	265	PF02991	0.429
LIG_LIR_Nem_3	284	288	PF02991	0.476
LIG_LIR_Nem_3	423	429	PF02991	0.245
LIG_LIR_Nem_3	451	457	PF02991	0.246
LIG_LIR_Nem_3	578	582	PF02991	0.443
LIG_LIR_Nem_3	58	62	PF02991	0.414
LIG_PDZ_Class_1	725	730	PF00595	0.559
LIG_Pex14_1	109	113	PF04695	0.369
LIG_Pex14_2	100	104	PF04695	0.253
LIG_Pex14_2	15	19	PF04695	0.589
LIG_Pex14_2	55	59	PF04695	0.323
LIG_Pex14_2	68	72	PF04695	0.198
LIG_Rb_LxCxE_1	73	92	PF01857	0.165
LIG_Rb_pABgroove_1	256	264	PF01858	0.409
LIG_REV1ctd_RIR_1	459	469	PF16727	0.313
LIG_SH2_CRK	285	289	PF00017	0.321
LIG_SH2_CRK	413	417	PF00017	0.306
LIG_SH2_CRK	426	430	PF00017	0.249
LIG_SH2_NCK_1	335	339	PF00017	0.220
LIG_SH2_NCK_1	413	417	PF00017	0.389
LIG_SH2_NCK_1	441	445	PF00017	0.352
LIG_SH2_NCK_1	454	458	PF00017	0.302
LIG_SH2_PTP2	248	251	PF00017	0.453
LIG_SH2_PTP2	299	302	PF00017	0.389
LIG_SH2_SRC	231	234	PF00017	0.484
LIG_SH2_SRC	426	429	PF00017	0.299
LIG_SH2_SRC	454	457	PF00017	0.253
LIG_SH2_STAP1	285	289	PF00017	0.332
LIG_SH2_STAP1	36	40	PF00017	0.413
LIG_SH2_STAT3	132	135	PF00017	0.513
LIG_SH2_STAT3	160	163	PF00017	0.421
LIG_SH2_STAT5	133	136	PF00017	0.465
LIG_SH2_STAT5	231	234	PF00017	0.409
LIG_SH2_STAT5	248	251	PF00017	0.451
LIG_SH2_STAT5	299	302	PF00017	0.321
LIG_SH2_STAT5	36	39	PF00017	0.460
LIG_SH2_STAT5	428	431	PF00017	0.253
LIG_SH2_STAT5	98	101	PF00017	0.313
LIG_SH3_2	215	220	PF14604	0.513
LIG_SH3_3	209	215	PF00018	0.513
LIG_SUMO_SIM_anti_2	407	412	PF11976	0.302
LIG_SUMO_SIM_par_1	231	237	PF11976	0.513
LIG_SUMO_SIM_par_1	465	471	PF11976	0.302
LIG_TYR_ITIM	283	288	PF00017	0.413
LIG_TYR_ITIM	314	319	PF00017	0.313
LIG_UBA3_1	294	303	PF00899	0.192
LIG_WRC_WIRS_1	383	388	PF05994	0.283
LIG_WRC_WIRS_1	56	61	PF05994	0.305
LIG_WRC_WIRS_1	576	581	PF05994	0.439
MOD_CDK_SPxxK_3	150	157	PF00069	0.420
MOD_CK1_1	516	522	PF00069	0.540
MOD_CK1_1	540	546	PF00069	0.758
MOD_CK1_1	575	581	PF00069	0.440
MOD_CK1_1	584	590	PF00069	0.489
MOD_CK1_1	599	605	PF00069	0.719
MOD_CK1_1	629	635	PF00069	0.635
MOD_CK1_1	639	645	PF00069	0.633
MOD_CK1_1	648	654	PF00069	0.573
MOD_CK1_1	695	701	PF00069	0.600
MOD_CK1_1	707	713	PF00069	0.603
MOD_CK2_1	427	433	PF00069	0.346
MOD_CK2_1	592	598	PF00069	0.636
MOD_CK2_1	629	635	PF00069	0.674
MOD_CK2_1	682	688	PF00069	0.621
MOD_CK2_1	76	82	PF00069	0.281
MOD_GlcNHglycan	203	206	PF01048	0.313
MOD_GlcNHglycan	21	24	PF01048	0.366
MOD_GlcNHglycan	448	451	PF01048	0.409
MOD_GlcNHglycan	50	53	PF01048	0.389
MOD_GlcNHglycan	517	521	PF01048	0.302
MOD_GlcNHglycan	539	542	PF01048	0.547
MOD_GlcNHglycan	549	553	PF01048	0.522
MOD_GlcNHglycan	631	634	PF01048	0.407
MOD_GlcNHglycan	647	650	PF01048	0.389
MOD_GlcNHglycan	672	676	PF01048	0.502
MOD_GlcNHglycan	727	730	PF01048	0.430
MOD_GlcNHglycan	91	94	PF01048	0.392
MOD_GSK3_1	113	120	PF00069	0.331
MOD_GSK3_1	146	153	PF00069	0.456
MOD_GSK3_1	249	256	PF00069	0.487
MOD_GSK3_1	277	284	PF00069	0.421
MOD_GSK3_1	360	367	PF00069	0.328
MOD_GSK3_1	378	385	PF00069	0.195
MOD_GSK3_1	519	526	PF00069	0.618
MOD_GSK3_1	592	599	PF00069	0.702
MOD_GSK3_1	622	629	PF00069	0.632
MOD_GSK3_1	639	646	PF00069	0.685
MOD_GSK3_1	692	699	PF00069	0.562
MOD_GSK3_1	721	728	PF00069	0.594
MOD_GSK3_1	76	83	PF00069	0.285
MOD_NEK2_1	100	105	PF00069	0.251
MOD_NEK2_1	113	118	PF00069	0.186
MOD_NEK2_1	128	133	PF00069	0.418
MOD_NEK2_1	19	24	PF00069	0.544
MOD_NEK2_1	193	198	PF00069	0.481
MOD_NEK2_1	241	246	PF00069	0.496
MOD_NEK2_1	257	262	PF00069	0.379
MOD_NEK2_1	298	303	PF00069	0.163
MOD_NEK2_1	31	36	PF00069	0.407
MOD_NEK2_1	360	365	PF00069	0.346
MOD_NEK2_1	435	440	PF00069	0.221
MOD_NEK2_1	473	478	PF00069	0.364
MOD_NEK2_1	5	10	PF00069	0.596
MOD_NEK2_1	500	505	PF00069	0.546
MOD_NEK2_1	55	60	PF00069	0.265
MOD_NEK2_1	692	697	PF00069	0.498
MOD_NEK2_1	704	709	PF00069	0.553
MOD_NEK2_2	13	18	PF00069	0.521
MOD_NEK2_2	613	618	PF00069	0.407
MOD_PIKK_1	29	35	PF00454	0.453
MOD_PIKK_1	317	323	PF00454	0.313
MOD_PIKK_1	581	587	PF00454	0.465
MOD_PIKK_1	692	698	PF00454	0.534
MOD_PIKK_1	707	713	PF00454	0.562
MOD_PK_1	203	209	PF00069	0.513
MOD_PKA_2	100	106	PF00069	0.309
MOD_PKA_2	13	19	PF00069	0.620
MOD_PKA_2	241	247	PF00069	0.421
MOD_PKA_2	278	284	PF00069	0.513
MOD_PKA_2	360	366	PF00069	0.289
MOD_PKA_2	5	11	PF00069	0.664
MOD_PKA_2	639	645	PF00069	0.698
MOD_PKA_2	707	713	PF00069	0.705
MOD_PKB_1	345	353	PF00069	0.221
MOD_Plk_4	100	106	PF00069	0.254
MOD_Plk_4	128	134	PF00069	0.468
MOD_Plk_4	249	255	PF00069	0.469
MOD_Plk_4	257	263	PF00069	0.437
MOD_Plk_4	278	284	PF00069	0.444
MOD_Plk_4	31	37	PF00069	0.500
MOD_Plk_4	382	388	PF00069	0.269
MOD_Plk_4	398	404	PF00069	0.277
MOD_Plk_4	457	463	PF00069	0.259
MOD_Plk_4	5	11	PF00069	0.660
MOD_Plk_4	55	61	PF00069	0.258
MOD_Plk_4	550	556	PF00069	0.680
MOD_ProDKin_1	150	156	PF00069	0.409
MOD_ProDKin_1	247	253	PF00069	0.453
MOD_ProDKin_1	523	529	PF00069	0.719
MOD_ProDKin_1	596	602	PF00069	0.649
TRG_DiLeu_BaEn_2	123	129	PF01217	0.420
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.330
TRG_ENDOCYTIC_2	123	126	PF00928	0.381
TRG_ENDOCYTIC_2	285	288	PF00928	0.234
TRG_ENDOCYTIC_2	299	302	PF00928	0.264
TRG_ENDOCYTIC_2	316	319	PF00928	0.196
TRG_ENDOCYTIC_2	335	338	PF00928	0.136
TRG_ENDOCYTIC_2	413	416	PF00928	0.313
TRG_ENDOCYTIC_2	426	429	PF00928	0.249
TRG_ENDOCYTIC_2	454	457	PF00928	0.256
TRG_ER_diArg_1	359	362	PF00400	0.262
TRG_ER_diArg_1	370	372	PF00400	0.265
TRG_ER_diArg_1	617	620	PF00400	0.589
TRG_ER_diArg_1	653	655	PF00400	0.698
TRG_NES_CRM1_1	217	229	PF08389	0.420
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S4	Leptomonas seymouri	70%	100%
A0A0S4JRE4	Bodo saltans	30%	93%
A0A1X0P5B9	Trypanosomatidae	36%	100%
A0A3S5H7H3	Leishmania donovani	96%	100%
A0A422NTE4	Trypanosoma rangeli	36%	100%
A6ZXH8	Saccharomyces cerevisiae (strain YJM789)	21%	73%
D0A5N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AD16	Leishmania major	94%	100%
E9AHC0	Leishmania infantum	96%	100%
E9AIS5	Leishmania braziliensis	82%	100%
P0CM40	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	22%	83%
P0CM41	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	22%	83%
Q12142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	73%
Q8RUS5	Arabidopsis thaliana	21%	84%
V5B7I2	Trypanosoma cruzi	35%	100%