RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9AYT7_LEIMU

TriTrypDb:

LmxM.27.0350

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AYT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYT7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.560
CLV_NRD_NRD_1	165	167	PF00675	0.557
CLV_NRD_NRD_1	318	320	PF00675	0.522
CLV_NRD_NRD_1	377	379	PF00675	0.506
CLV_PCSK_KEX2_1	165	167	PF00082	0.578
CLV_PCSK_KEX2_1	318	320	PF00082	0.522
CLV_PCSK_KEX2_1	376	378	PF00082	0.537
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.576
CLV_PCSK_SKI1_1	145	149	PF00082	0.471
CLV_PCSK_SKI1_1	215	219	PF00082	0.382
CLV_PCSK_SKI1_1	246	250	PF00082	0.504
CLV_PCSK_SKI1_1	5	9	PF00082	0.717
CLV_PCSK_SKI1_1	75	79	PF00082	0.433
DEG_COP1_1	332	342	PF00400	0.531
DOC_CYCLIN_RxL_1	212	220	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.513
DOC_MAPK_gen_1	142	150	PF00069	0.519
DOC_MAPK_gen_1	165	173	PF00069	0.570
DOC_MAPK_gen_1	376	382	PF00069	0.530
DOC_MAPK_gen_1	5	15	PF00069	0.654
DOC_MAPK_gen_1	53	62	PF00069	0.512
DOC_PP4_FxxP_1	101	104	PF00568	0.521
DOC_USP7_MATH_1	307	311	PF00917	0.460
DOC_USP7_MATH_1	340	344	PF00917	0.608
DOC_USP7_UBL2_3	53	57	PF12436	0.612
DOC_WW_Pin1_4	100	105	PF00397	0.520
DOC_WW_Pin1_4	140	145	PF00397	0.574
DOC_WW_Pin1_4	166	171	PF00397	0.512
DOC_WW_Pin1_4	182	187	PF00397	0.547
DOC_WW_Pin1_4	197	202	PF00397	0.544
DOC_WW_Pin1_4	338	343	PF00397	0.708
DOC_WW_Pin1_4	363	368	PF00397	0.736
LIG_14-3-3_CanoR_1	290	294	PF00244	0.499
LIG_14-3-3_CanoR_1	319	327	PF00244	0.569
LIG_14-3-3_CanoR_1	447	455	PF00244	0.487
LIG_AP2alpha_2	48	50	PF02296	0.427
LIG_BIR_III_4	466	470	PF00653	0.530
LIG_BRCT_BRCA1_1	38	42	PF00533	0.692
LIG_eIF4E_1	254	260	PF01652	0.506
LIG_FHA_1	155	161	PF00498	0.420
LIG_FHA_1	208	214	PF00498	0.456
LIG_FHA_1	330	336	PF00498	0.681
LIG_FHA_1	377	383	PF00498	0.343
LIG_FHA_1	94	100	PF00498	0.480
LIG_FHA_2	130	136	PF00498	0.538
LIG_FHA_2	303	309	PF00498	0.553
LIG_FHA_2	66	72	PF00498	0.439
LIG_FHA_2	86	92	PF00498	0.206
LIG_LIR_Gen_1	292	301	PF02991	0.394
LIG_LIR_Gen_1	343	353	PF02991	0.710
LIG_LIR_Gen_1	417	427	PF02991	0.491
LIG_LIR_Nem_3	200	206	PF02991	0.446
LIG_LIR_Nem_3	292	297	PF02991	0.407
LIG_LIR_Nem_3	39	45	PF02991	0.728
LIG_LIR_Nem_3	417	422	PF02991	0.491
LIG_LIR_Nem_3	76	81	PF02991	0.497
LIG_LIR_Nem_3	96	101	PF02991	0.182
LIG_LYPXL_SIV_4	252	260	PF13949	0.498
LIG_MYND_1	386	390	PF01753	0.534
LIG_NRBOX	213	219	PF00104	0.493
LIG_NRBOX	393	399	PF00104	0.513
LIG_SH2_CRK	415	419	PF00017	0.482
LIG_SH2_NCK_1	350	354	PF00017	0.462
LIG_SH2_SRC	350	353	PF00017	0.460
LIG_SH2_STAP1	152	156	PF00017	0.503
LIG_SH2_STAT5	254	257	PF00017	0.453
LIG_SH2_STAT5	320	323	PF00017	0.561
LIG_SH2_STAT5	381	384	PF00017	0.496
LIG_SH2_STAT5	415	418	PF00017	0.480
LIG_SH3_3	301	307	PF00018	0.558
LIG_SH3_3	336	342	PF00018	0.680
LIG_SH3_3	346	352	PF00018	0.664
LIG_SH3_3	364	370	PF00018	0.662
LIG_SUMO_SIM_anti_2	146	154	PF11976	0.508
LIG_SUMO_SIM_par_1	392	400	PF11976	0.562
LIG_TRAF2_1	132	135	PF00917	0.504
LIG_UBA3_1	242	246	PF00899	0.463
LIG_UBA3_1	313	322	PF00899	0.539
LIG_WRC_WIRS_1	206	211	PF05994	0.513
LIG_WRC_WIRS_1	37	42	PF05994	0.654
MOD_CDK_SPK_2	140	145	PF00069	0.522
MOD_CK1_1	143	149	PF00069	0.460
MOD_CK1_1	169	175	PF00069	0.431
MOD_CK1_1	18	24	PF00069	0.606
MOD_CK1_1	197	203	PF00069	0.448
MOD_CK1_1	207	213	PF00069	0.385
MOD_CK1_1	25	31	PF00069	0.563
MOD_CK1_1	289	295	PF00069	0.393
MOD_CK1_1	333	339	PF00069	0.655
MOD_CK1_1	343	349	PF00069	0.636
MOD_CK1_1	51	57	PF00069	0.657
MOD_CK1_1	66	72	PF00069	0.394
MOD_CK2_1	129	135	PF00069	0.466
MOD_CK2_1	205	211	PF00069	0.427
MOD_CK2_1	217	223	PF00069	0.415
MOD_CK2_1	24	30	PF00069	0.588
MOD_CK2_1	302	308	PF00069	0.526
MOD_CK2_1	67	73	PF00069	0.516
MOD_CK2_1	85	91	PF00069	0.535
MOD_DYRK1A_RPxSP_1	140	144	PF00069	0.399
MOD_DYRK1A_RPxSP_1	166	170	PF00069	0.483
MOD_GlcNHglycan	160	163	PF01048	0.516
MOD_GlcNHglycan	24	27	PF01048	0.628
MOD_GlcNHglycan	262	265	PF01048	0.558
MOD_GlcNHglycan	323	326	PF01048	0.557
MOD_GSK3_1	11	18	PF00069	0.616
MOD_GSK3_1	134	141	PF00069	0.378
MOD_GSK3_1	150	157	PF00069	0.449
MOD_GSK3_1	20	27	PF00069	0.553
MOD_GSK3_1	213	220	PF00069	0.461
MOD_GSK3_1	302	309	PF00069	0.526
MOD_GSK3_1	326	333	PF00069	0.606
MOD_GSK3_1	334	341	PF00069	0.641
MOD_GSK3_1	376	383	PF00069	0.455
MOD_GSK3_1	63	70	PF00069	0.289
MOD_LATS_1	316	322	PF00433	0.544
MOD_NEK2_1	120	125	PF00069	0.346
MOD_NEK2_1	15	20	PF00069	0.714
MOD_NEK2_1	213	218	PF00069	0.430
MOD_NEK2_1	260	265	PF00069	0.475
MOD_NEK2_1	276	281	PF00069	0.464
MOD_NEK2_1	327	332	PF00069	0.664
MOD_NEK2_1	334	339	PF00069	0.696
MOD_NEK2_1	397	402	PF00069	0.501
MOD_NEK2_1	477	482	PF00069	0.528
MOD_NEK2_1	65	70	PF00069	0.523
MOD_NEK2_2	414	419	PF00069	0.482
MOD_OFUCOSY	274	280	PF10250	0.474
MOD_PIKK_1	120	126	PF00454	0.456
MOD_PIKK_1	134	140	PF00454	0.460
MOD_PIKK_1	154	160	PF00454	0.493
MOD_PKA_1	318	324	PF00069	0.570
MOD_PKA_1	376	382	PF00069	0.530
MOD_PKA_2	164	170	PF00069	0.584
MOD_PKA_2	289	295	PF00069	0.505
MOD_PKA_2	318	324	PF00069	0.548
MOD_PKA_2	376	382	PF00069	0.506
MOD_Plk_1	11	17	PF00069	0.705
MOD_Plk_1	35	41	PF00069	0.567
MOD_Plk_2-3	423	429	PF00069	0.553
MOD_Plk_4	143	149	PF00069	0.460
MOD_Plk_4	213	219	PF00069	0.456
MOD_Plk_4	234	240	PF00069	0.261
MOD_Plk_4	289	295	PF00069	0.393
MOD_Plk_4	330	336	PF00069	0.694
MOD_Plk_4	340	346	PF00069	0.648
MOD_Plk_4	36	42	PF00069	0.646
MOD_Plk_4	389	395	PF00069	0.501
MOD_Plk_4	414	420	PF00069	0.482
MOD_Plk_4	73	79	PF00069	0.519
MOD_ProDKin_1	100	106	PF00069	0.521
MOD_ProDKin_1	140	146	PF00069	0.572
MOD_ProDKin_1	166	172	PF00069	0.512
MOD_ProDKin_1	182	188	PF00069	0.540
MOD_ProDKin_1	197	203	PF00069	0.540
MOD_ProDKin_1	338	344	PF00069	0.709
MOD_ProDKin_1	363	369	PF00069	0.733
MOD_SUMO_rev_2	71	77	PF00179	0.524
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.454
TRG_ENDOCYTIC_2	415	418	PF00928	0.482
TRG_ER_diArg_1	164	166	PF00400	0.557
TRG_ER_diArg_1	317	319	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I589	Leptomonas seymouri	68%	97%
A0A1X0P421	Trypanosomatidae	38%	100%
A0A3Q8IG64	Leishmania donovani	92%	100%
A0A3R7NWC3	Trypanosoma rangeli	43%	100%
A4HFG0	Leishmania braziliensis	76%	100%
A4I2M2	Leishmania infantum	92%	100%
D0A5N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AD12	Leishmania major	93%	100%
V5BXF1	Trypanosoma cruzi	42%	100%