TSNAXIP1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYT5_LEIMU

TriTrypDb:

LmxM.27.0330

Length:

736

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AYT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYT5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.776
CLV_NRD_NRD_1	107	109	PF00675	0.636
CLV_NRD_NRD_1	127	129	PF00675	0.155
CLV_NRD_NRD_1	255	257	PF00675	0.539
CLV_NRD_NRD_1	287	289	PF00675	0.550
CLV_NRD_NRD_1	316	318	PF00675	0.665
CLV_NRD_NRD_1	563	565	PF00675	0.481
CLV_NRD_NRD_1	727	729	PF00675	0.354
CLV_PCSK_FUR_1	104	108	PF00082	0.642
CLV_PCSK_KEX2_1	106	108	PF00082	0.557
CLV_PCSK_KEX2_1	127	129	PF00082	0.343
CLV_PCSK_KEX2_1	255	257	PF00082	0.539
CLV_PCSK_KEX2_1	316	318	PF00082	0.562
CLV_PCSK_KEX2_1	562	564	PF00082	0.489
CLV_PCSK_KEX2_1	663	665	PF00082	0.592
CLV_PCSK_KEX2_1	727	729	PF00082	0.354
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.539
CLV_PCSK_PC1ET2_1	663	665	PF00082	0.592
CLV_PCSK_PC7_1	559	565	PF00082	0.328
CLV_PCSK_SKI1_1	150	154	PF00082	0.273
CLV_PCSK_SKI1_1	164	168	PF00082	0.324
CLV_PCSK_SKI1_1	17	21	PF00082	0.598
CLV_PCSK_SKI1_1	284	288	PF00082	0.641
CLV_PCSK_SKI1_1	543	547	PF00082	0.341
CLV_PCSK_SKI1_1	550	554	PF00082	0.359
CLV_Separin_Metazoa	556	560	PF03568	0.310
CLV_Separin_Metazoa	6	10	PF03568	0.633
DEG_APCC_DBOX_1	542	550	PF00400	0.396
DEG_MDM2_SWIB_1	637	645	PF02201	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.725
DEG_SPOP_SBC_1	99	103	PF00917	0.561
DOC_MAPK_DCC_7	68	76	PF00069	0.525
DOC_MAPK_gen_1	475	483	PF00069	0.425
DOC_MAPK_gen_1	562	570	PF00069	0.498
DOC_MAPK_gen_1	718	725	PF00069	0.381
DOC_MAPK_MEF2A_6	475	483	PF00069	0.460
DOC_MAPK_MEF2A_6	68	76	PF00069	0.522
DOC_PP2B_LxvP_1	76	79	PF13499	0.541
DOC_PP2B_PxIxI_1	697	703	PF00149	0.496
DOC_SPAK_OSR1_1	608	612	PF12202	0.476
DOC_USP7_MATH_1	111	115	PF00917	0.500
DOC_USP7_MATH_1	138	142	PF00917	0.428
DOC_USP7_MATH_1	423	427	PF00917	0.632
DOC_USP7_MATH_1	499	503	PF00917	0.561
DOC_USP7_MATH_1	597	601	PF00917	0.375
DOC_USP7_MATH_1	8	12	PF00917	0.646
DOC_USP7_MATH_1	99	103	PF00917	0.623
DOC_WW_Pin1_4	340	345	PF00397	0.561
DOC_WW_Pin1_4	726	731	PF00397	0.393
LIG_14-3-3_CanoR_1	300	304	PF00244	0.608
LIG_14-3-3_CanoR_1	316	321	PF00244	0.522
LIG_14-3-3_CanoR_1	424	428	PF00244	0.721
LIG_14-3-3_CanoR_1	477	482	PF00244	0.466
LIG_14-3-3_CanoR_1	52	58	PF00244	0.621
LIG_14-3-3_CanoR_1	569	579	PF00244	0.309
LIG_14-3-3_CanoR_1	608	612	PF00244	0.495
LIG_14-3-3_CanoR_1	664	670	PF00244	0.462
LIG_14-3-3_CanoR_1	718	724	PF00244	0.390
LIG_Actin_WH2_2	197	212	PF00022	0.403
LIG_Actin_WH2_2	553	571	PF00022	0.435
LIG_Actin_WH2_2	638	653	PF00022	0.425
LIG_APCC_ABBA_1	146	151	PF00400	0.403
LIG_BRCT_BRCA1_1	361	365	PF00533	0.573
LIG_BRCT_BRCA1_1	69	73	PF00533	0.560
LIG_Clathr_ClatBox_1	247	251	PF01394	0.507
LIG_CtBP_PxDLS_1	554	558	PF00389	0.454
LIG_CtBP_PxDLS_1	730	734	PF00389	0.486
LIG_DLG_GKlike_1	477	485	PF00625	0.274
LIG_EH1_1	363	371	PF00400	0.461
LIG_FHA_1	365	371	PF00498	0.640
LIG_FHA_1	449	455	PF00498	0.627
LIG_FHA_1	469	475	PF00498	0.582
LIG_FHA_1	574	580	PF00498	0.506
LIG_FHA_1	647	653	PF00498	0.358
LIG_FHA_1	671	677	PF00498	0.430
LIG_FHA_1	707	713	PF00498	0.454
LIG_FHA_1	719	725	PF00498	0.351
LIG_FHA_2	195	201	PF00498	0.368
LIG_FHA_2	237	243	PF00498	0.524
LIG_FHA_2	256	262	PF00498	0.634
LIG_FHA_2	612	618	PF00498	0.475
LIG_GBD_Chelix_1	483	491	PF00786	0.250
LIG_LIR_Gen_1	151	160	PF02991	0.303
LIG_LIR_Gen_1	172	181	PF02991	0.243
LIG_LIR_Gen_1	319	326	PF02991	0.635
LIG_LIR_Gen_1	586	597	PF02991	0.393
LIG_LIR_Gen_1	630	637	PF02991	0.334
LIG_LIR_Gen_1	686	694	PF02991	0.422
LIG_LIR_Gen_1	70	81	PF02991	0.550
LIG_LIR_Nem_3	151	156	PF02991	0.301
LIG_LIR_Nem_3	161	166	PF02991	0.286
LIG_LIR_Nem_3	172	177	PF02991	0.315
LIG_LIR_Nem_3	319	323	PF02991	0.592
LIG_LIR_Nem_3	586	592	PF02991	0.452
LIG_LIR_Nem_3	630	636	PF02991	0.398
LIG_LIR_Nem_3	686	691	PF02991	0.421
LIG_LIR_Nem_3	70	76	PF02991	0.559
LIG_NRBOX	622	628	PF00104	0.260
LIG_PDZ_Class_2	731	736	PF00595	0.527
LIG_Pex14_2	149	153	PF04695	0.426
LIG_Pex14_2	156	160	PF04695	0.379
LIG_Pex14_2	507	511	PF04695	0.413
LIG_Pex14_2	585	589	PF04695	0.413
LIG_Pex14_2	633	637	PF04695	0.393
LIG_PTAP_UEV_1	34	39	PF05743	0.555
LIG_SH2_CRK	163	167	PF00017	0.312
LIG_SH2_CRK	174	178	PF00017	0.312
LIG_SH2_CRK	688	692	PF00017	0.439
LIG_SH2_NCK_1	320	324	PF00017	0.622
LIG_SH2_PTP2	690	693	PF00017	0.437
LIG_SH2_SRC	192	195	PF00017	0.393
LIG_SH2_STAP1	174	178	PF00017	0.287
LIG_SH2_STAP1	345	349	PF00017	0.481
LIG_SH2_STAP1	361	365	PF00017	0.550
LIG_SH2_STAT5	133	136	PF00017	0.260
LIG_SH2_STAT5	192	195	PF00017	0.385
LIG_SH2_STAT5	632	635	PF00017	0.453
LIG_SH2_STAT5	688	691	PF00017	0.484
LIG_SH3_2	4	9	PF14604	0.583
LIG_SH3_2	63	68	PF14604	0.466
LIG_SH3_3	1	7	PF00018	0.641
LIG_SH3_3	12	18	PF00018	0.526
LIG_SH3_3	32	38	PF00018	0.749
LIG_SH3_3	450	456	PF00018	0.623
LIG_SH3_3	54	60	PF00018	0.695
LIG_SH3_3	87	93	PF00018	0.701
LIG_SUMO_SIM_par_1	246	251	PF11976	0.541
LIG_SUMO_SIM_par_1	335	341	PF11976	0.450
LIG_SUMO_SIM_par_1	698	703	PF11976	0.535
LIG_TRAF2_1	226	229	PF00917	0.368
LIG_TRAF2_1	729	732	PF00917	0.442
LIG_TRFH_1	45	49	PF08558	0.672
LIG_UBA3_1	206	210	PF00899	0.403
LIG_UBA3_1	247	255	PF00899	0.550
LIG_WRC_WIRS_1	153	158	PF05994	0.345
LIG_WW_3	6	10	PF00397	0.633
MOD_CK1_1	246	252	PF00069	0.478
MOD_CK1_1	277	283	PF00069	0.625
MOD_CK1_1	36	42	PF00069	0.589
MOD_CK1_1	412	418	PF00069	0.734
MOD_CK1_1	490	496	PF00069	0.513
MOD_CK1_1	571	577	PF00069	0.520
MOD_CK1_1	628	634	PF00069	0.442
MOD_CK1_1	668	674	PF00069	0.293
MOD_CK1_1	692	698	PF00069	0.410
MOD_CK2_1	194	200	PF00069	0.452
MOD_CK2_1	236	242	PF00069	0.492
MOD_CK2_1	255	261	PF00069	0.585
MOD_CK2_1	306	312	PF00069	0.460
MOD_CK2_1	611	617	PF00069	0.540
MOD_CK2_1	700	706	PF00069	0.522
MOD_CK2_1	726	732	PF00069	0.435
MOD_GlcNHglycan	224	227	PF01048	0.393
MOD_GlcNHglycan	35	38	PF01048	0.558
MOD_GlcNHglycan	468	471	PF01048	0.431
MOD_GlcNHglycan	665	668	PF01048	0.432
MOD_GlcNHglycan	701	705	PF01048	0.466
MOD_GlcNHglycan	76	79	PF01048	0.476
MOD_GSK3_1	209	216	PF00069	0.305
MOD_GSK3_1	385	392	PF00069	0.557
MOD_GSK3_1	405	412	PF00069	0.638
MOD_GSK3_1	568	575	PF00069	0.525
MOD_GSK3_1	607	614	PF00069	0.503
MOD_GSK3_1	628	635	PF00069	0.445
MOD_GSK3_1	702	709	PF00069	0.539
MOD_LATS_1	403	409	PF00433	0.451
MOD_N-GLC_1	213	218	PF02516	0.403
MOD_N-GLC_1	517	522	PF02516	0.289
MOD_NEK2_1	209	214	PF00069	0.403
MOD_NEK2_1	468	473	PF00069	0.621
MOD_NEK2_1	487	492	PF00069	0.443
MOD_NEK2_1	529	534	PF00069	0.546
MOD_NEK2_1	568	573	PF00069	0.535
MOD_NEK2_1	607	612	PF00069	0.526
MOD_NEK2_1	719	724	PF00069	0.410
MOD_NEK2_2	632	637	PF00069	0.405
MOD_PIKK_1	192	198	PF00454	0.403
MOD_PIKK_1	291	297	PF00454	0.620
MOD_PIKK_1	511	517	PF00454	0.504
MOD_PIKK_1	692	698	PF00454	0.362
MOD_PKA_1	255	261	PF00069	0.535
MOD_PKA_1	316	322	PF00069	0.588
MOD_PKA_1	385	391	PF00069	0.595
MOD_PKA_1	663	669	PF00069	0.453
MOD_PKA_2	255	261	PF00069	0.531
MOD_PKA_2	299	305	PF00069	0.427
MOD_PKA_2	316	322	PF00069	0.614
MOD_PKA_2	423	429	PF00069	0.611
MOD_PKA_2	568	574	PF00069	0.519
MOD_PKA_2	607	613	PF00069	0.412
MOD_PKA_2	663	669	PF00069	0.453
MOD_PKA_2	719	725	PF00069	0.409
MOD_PKA_2	8	14	PF00069	0.776
MOD_Plk_1	213	219	PF00069	0.383
MOD_Plk_1	499	505	PF00069	0.620
MOD_Plk_1	597	603	PF00069	0.411
MOD_Plk_1	628	634	PF00069	0.450
MOD_Plk_2-3	194	200	PF00069	0.380
MOD_Plk_2-3	306	312	PF00069	0.340
MOD_Plk_4	152	158	PF00069	0.374
MOD_Plk_4	165	171	PF00069	0.226
MOD_Plk_4	243	249	PF00069	0.474
MOD_Plk_4	412	418	PF00069	0.466
MOD_Plk_4	487	493	PF00069	0.467
MOD_Plk_4	628	634	PF00069	0.429
MOD_Plk_4	686	692	PF00069	0.511
MOD_Plk_4	719	725	PF00069	0.403
MOD_ProDKin_1	340	346	PF00069	0.561
MOD_ProDKin_1	726	732	PF00069	0.404
MOD_SUMO_rev_2	161	166	PF00179	0.491
MOD_SUMO_rev_2	617	623	PF00179	0.277
TRG_DiLeu_BaEn_2	462	468	PF01217	0.550
TRG_DiLeu_BaEn_2	628	634	PF01217	0.435
TRG_ENDOCYTIC_2	163	166	PF00928	0.288
TRG_ENDOCYTIC_2	174	177	PF00928	0.287
TRG_ENDOCYTIC_2	320	323	PF00928	0.696
TRG_ENDOCYTIC_2	688	691	PF00928	0.441
TRG_ER_diArg_1	104	107	PF00400	0.642
TRG_ER_diArg_1	126	128	PF00400	0.312
TRG_ER_diArg_1	315	317	PF00400	0.681
TRG_ER_diArg_1	562	564	PF00400	0.495
TRG_ER_diArg_1	612	615	PF00400	0.476
TRG_ER_diArg_1	726	728	PF00400	0.421
TRG_NES_CRM1_1	180	194	PF08389	0.422
TRG_NES_CRM1_1	640	654	PF08389	0.328
TRG_Pf-PMV_PEXEL_1	477	482	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY0	Leptomonas seymouri	54%	97%
A0A1X0ND09	Trypanosomatidae	32%	100%
A0A3S7X0D8	Leishmania donovani	91%	100%
A0A422NTD8	Trypanosoma rangeli	32%	98%
A4HFF1	Leishmania braziliensis	78%	99%
A4I2M0	Leishmania infantum	92%	100%
E9AD10	Leishmania major	91%	100%
V5DP68	Trypanosoma cruzi	33%	98%