LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AYT4_LEIMU
TriTrypDb:
LmxM.27.0320
Length:
494

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AYT4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYT4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016787 hydrolase activity 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 2 4 PF00675 0.532
CLV_NRD_NRD_1 232 234 PF00675 0.408
CLV_NRD_NRD_1 343 345 PF00675 0.440
CLV_NRD_NRD_1 365 367 PF00675 0.469
CLV_NRD_NRD_1 375 377 PF00675 0.382
CLV_NRD_NRD_1 413 415 PF00675 0.584
CLV_NRD_NRD_1 468 470 PF00675 0.596
CLV_NRD_NRD_1 475 477 PF00675 0.508
CLV_NRD_NRD_1 486 488 PF00675 0.413
CLV_PCSK_KEX2_1 2 4 PF00082 0.532
CLV_PCSK_KEX2_1 232 234 PF00082 0.408
CLV_PCSK_KEX2_1 343 345 PF00082 0.442
CLV_PCSK_KEX2_1 365 367 PF00082 0.442
CLV_PCSK_KEX2_1 375 377 PF00082 0.321
CLV_PCSK_KEX2_1 413 415 PF00082 0.584
CLV_PCSK_KEX2_1 468 470 PF00082 0.596
CLV_PCSK_KEX2_1 475 477 PF00082 0.508
CLV_PCSK_KEX2_1 485 487 PF00082 0.409
CLV_PCSK_PC1ET2_1 485 487 PF00082 0.450
CLV_PCSK_SKI1_1 315 319 PF00082 0.453
CLV_PCSK_SKI1_1 344 348 PF00082 0.362
CLV_PCSK_SKI1_1 375 379 PF00082 0.420
CLV_PCSK_SKI1_1 469 473 PF00082 0.689
DEG_Nend_UBRbox_1 1 4 PF02207 0.583
DEG_SPOP_SBC_1 125 129 PF00917 0.374
DOC_CYCLIN_RxL_1 340 351 PF00134 0.446
DOC_CYCLIN_RxL_1 372 382 PF00134 0.474
DOC_MAPK_gen_1 170 180 PF00069 0.356
DOC_MAPK_gen_1 340 350 PF00069 0.425
DOC_MAPK_gen_1 365 373 PF00069 0.500
DOC_MAPK_gen_1 462 472 PF00069 0.645
DOC_MAPK_gen_1 81 90 PF00069 0.532
DOC_MAPK_MEF2A_6 343 350 PF00069 0.429
DOC_MAPK_NFAT4_5 343 351 PF00069 0.471
DOC_MAPK_RevD_3 217 233 PF00069 0.399
DOC_PP2B_LxvP_1 252 255 PF13499 0.537
DOC_PP4_FxxP_1 441 444 PF00568 0.503
DOC_PP4_FxxP_1 97 100 PF00568 0.484
DOC_USP7_MATH_1 10 14 PF00917 0.620
DOC_USP7_MATH_1 125 129 PF00917 0.447
DOC_USP7_MATH_1 158 162 PF00917 0.486
DOC_USP7_MATH_1 186 190 PF00917 0.560
DOC_USP7_MATH_1 28 32 PF00917 0.487
DOC_USP7_MATH_1 299 303 PF00917 0.267
DOC_USP7_MATH_1 79 83 PF00917 0.564
DOC_USP7_UBL2_3 479 483 PF12436 0.469
DOC_WW_Pin1_4 108 113 PF00397 0.666
DOC_WW_Pin1_4 385 390 PF00397 0.527
DOC_WW_Pin1_4 43 48 PF00397 0.456
DOC_WW_Pin1_4 448 453 PF00397 0.604
DOC_WW_Pin1_4 463 468 PF00397 0.519
DOC_WW_Pin1_4 98 103 PF00397 0.521
LIG_14-3-3_CanoR_1 115 121 PF00244 0.575
LIG_14-3-3_CanoR_1 195 202 PF00244 0.646
LIG_14-3-3_CanoR_1 303 312 PF00244 0.547
LIG_14-3-3_CanoR_1 343 349 PF00244 0.431
LIG_14-3-3_CanoR_1 403 407 PF00244 0.543
LIG_Actin_WH2_2 150 168 PF00022 0.389
LIG_BIR_III_2 250 254 PF00653 0.520
LIG_BRCT_BRCA1_1 127 131 PF00533 0.410
LIG_BRCT_BRCA1_1 308 312 PF00533 0.481
LIG_FHA_1 202 208 PF00498 0.623
LIG_FHA_1 256 262 PF00498 0.688
LIG_FHA_1 345 351 PF00498 0.356
LIG_FHA_1 395 401 PF00498 0.474
LIG_FHA_1 472 478 PF00498 0.562
LIG_FHA_1 52 58 PF00498 0.462
LIG_FHA_2 101 107 PF00498 0.607
LIG_FHA_2 195 201 PF00498 0.606
LIG_FHA_2 319 325 PF00498 0.458
LIG_FHA_2 330 336 PF00498 0.502
LIG_FHA_2 43 49 PF00498 0.361
LIG_Integrin_isoDGR_2 463 465 PF01839 0.620
LIG_LIR_Apic_2 438 444 PF02991 0.500
LIG_LIR_Apic_2 448 452 PF02991 0.517
LIG_LIR_Apic_2 95 100 PF02991 0.474
LIG_LIR_Gen_1 128 139 PF02991 0.391
LIG_LIR_Gen_1 318 327 PF02991 0.285
LIG_LIR_Gen_1 390 400 PF02991 0.489
LIG_LIR_Gen_1 82 93 PF02991 0.353
LIG_LIR_Nem_3 167 172 PF02991 0.305
LIG_LIR_Nem_3 318 322 PF02991 0.272
LIG_LIR_Nem_3 390 395 PF02991 0.412
LIG_LIR_Nem_3 82 88 PF02991 0.529
LIG_LRP6_Inhibitor_1 477 483 PF00058 0.513
LIG_MYND_1 385 389 PF01753 0.400
LIG_NBox_RRM_1 313 323 PF00076 0.377
LIG_PCNA_yPIPBox_3 214 223 PF02747 0.419
LIG_REV1ctd_RIR_1 310 319 PF16727 0.375
LIG_SH2_CRK 169 173 PF00017 0.453
LIG_SH2_CRK 319 323 PF00017 0.225
LIG_SH2_NCK_1 202 206 PF00017 0.498
LIG_SH2_SRC 333 336 PF00017 0.476
LIG_SH2_SRC 85 88 PF00017 0.315
LIG_SH2_STAP1 126 130 PF00017 0.449
LIG_SH2_STAP1 319 323 PF00017 0.218
LIG_SH2_STAP1 333 337 PF00017 0.474
LIG_SH2_STAP1 424 428 PF00017 0.544
LIG_SH2_STAP1 85 89 PF00017 0.357
LIG_SH2_STAT3 304 307 PF00017 0.431
LIG_SH2_STAT5 126 129 PF00017 0.414
LIG_SH2_STAT5 304 307 PF00017 0.516
LIG_SH2_STAT5 363 366 PF00017 0.535
LIG_SH2_STAT5 481 484 PF00017 0.492
LIG_SH3_3 106 112 PF00018 0.433
LIG_SH3_3 239 245 PF00018 0.350
LIG_SH3_3 324 330 PF00018 0.529
LIG_SUMO_SIM_anti_2 281 287 PF11976 0.393
LIG_SUMO_SIM_anti_2 370 375 PF11976 0.469
LIG_SUMO_SIM_par_1 429 434 PF11976 0.635
LIG_TRAF2_1 208 211 PF00917 0.687
LIG_TRAF2_1 332 335 PF00917 0.498
LIG_TYR_ITIM 157 162 PF00017 0.398
LIG_TYR_ITIM 317 322 PF00017 0.216
LIG_TYR_ITIM 83 88 PF00017 0.316
LIG_UBA3_1 419 427 PF00899 0.519
LIG_UBA3_1 89 98 PF00899 0.363
MOD_CDK_SPK_2 108 113 PF00069 0.437
MOD_CDK_SPK_2 463 468 PF00069 0.626
MOD_CDK_SPxK_1 463 469 PF00069 0.473
MOD_CDK_SPxxK_3 108 115 PF00069 0.425
MOD_CK1_1 108 114 PF00069 0.677
MOD_CK1_1 121 127 PF00069 0.411
MOD_CK1_1 190 196 PF00069 0.681
MOD_CK1_1 29 35 PF00069 0.467
MOD_CK1_1 409 415 PF00069 0.713
MOD_CK2_1 116 122 PF00069 0.521
MOD_CK2_1 178 184 PF00069 0.398
MOD_CK2_1 194 200 PF00069 0.497
MOD_CK2_1 318 324 PF00069 0.482
MOD_CK2_1 329 335 PF00069 0.509
MOD_CK2_1 42 48 PF00069 0.296
MOD_GlcNHglycan 12 15 PF01048 0.690
MOD_GlcNHglycan 122 126 PF01048 0.465
MOD_GlcNHglycan 128 131 PF01048 0.430
MOD_GlcNHglycan 166 169 PF01048 0.448
MOD_GlcNHglycan 264 267 PF01048 0.631
MOD_GlcNHglycan 308 311 PF01048 0.500
MOD_GlcNHglycan 334 338 PF01048 0.467
MOD_GlcNHglycan 350 353 PF01048 0.459
MOD_GSK3_1 121 128 PF00069 0.370
MOD_GSK3_1 186 193 PF00069 0.608
MOD_GSK3_1 26 33 PF00069 0.546
MOD_GSK3_1 295 302 PF00069 0.421
MOD_GSK3_1 329 336 PF00069 0.634
MOD_GSK3_1 344 351 PF00069 0.442
MOD_GSK3_1 379 386 PF00069 0.495
MOD_GSK3_1 402 409 PF00069 0.612
MOD_GSK3_1 448 455 PF00069 0.664
MOD_GSK3_1 471 478 PF00069 0.575
MOD_NEK2_1 178 183 PF00069 0.461
MOD_NEK2_1 26 31 PF00069 0.536
MOD_NEK2_1 261 266 PF00069 0.663
MOD_NEK2_1 348 353 PF00069 0.462
MOD_NEK2_1 74 79 PF00069 0.411
MOD_NEK2_2 394 399 PF00069 0.488
MOD_NEK2_2 79 84 PF00069 0.371
MOD_NEK2_2 92 97 PF00069 0.251
MOD_PIKK_1 303 309 PF00454 0.422
MOD_PIKK_1 406 412 PF00454 0.566
MOD_PK_1 429 435 PF00069 0.612
MOD_PKA_1 475 481 PF00069 0.492
MOD_PKA_2 194 200 PF00069 0.463
MOD_PKA_2 267 273 PF00069 0.470
MOD_PKA_2 379 385 PF00069 0.634
MOD_PKA_2 402 408 PF00069 0.547
MOD_PKA_2 475 481 PF00069 0.500
MOD_Plk_1 105 111 PF00069 0.735
MOD_Plk_1 121 127 PF00069 0.289
MOD_Plk_1 209 215 PF00069 0.678
MOD_Plk_1 26 32 PF00069 0.441
MOD_Plk_2-3 105 111 PF00069 0.701
MOD_Plk_2-3 329 335 PF00069 0.509
MOD_Plk_4 281 287 PF00069 0.420
MOD_Plk_4 318 324 PF00069 0.421
MOD_ProDKin_1 108 114 PF00069 0.659
MOD_ProDKin_1 385 391 PF00069 0.519
MOD_ProDKin_1 43 49 PF00069 0.456
MOD_ProDKin_1 448 454 PF00069 0.605
MOD_ProDKin_1 463 469 PF00069 0.520
MOD_ProDKin_1 98 104 PF00069 0.532
MOD_SUMO_rev_2 439 448 PF00179 0.547
TRG_DiLeu_BaEn_2 271 277 PF01217 0.407
TRG_DiLeu_BaEn_2 436 442 PF01217 0.504
TRG_ENDOCYTIC_2 159 162 PF00928 0.445
TRG_ENDOCYTIC_2 169 172 PF00928 0.237
TRG_ENDOCYTIC_2 319 322 PF00928 0.230
TRG_ENDOCYTIC_2 85 88 PF00928 0.315
TRG_ER_diArg_1 1 3 PF00400 0.530
TRG_ER_diArg_1 231 233 PF00400 0.412
TRG_ER_diArg_1 364 366 PF00400 0.416
TRG_ER_diArg_1 374 376 PF00400 0.312
TRG_ER_diArg_1 413 415 PF00400 0.584
TRG_ER_diArg_1 467 469 PF00400 0.597
TRG_ER_diArg_1 475 477 PF00400 0.497
TRG_NLS_Bipartite_1 468 489 PF00514 0.563
TRG_NLS_MonoCore_2 484 489 PF00514 0.469
TRG_NLS_MonoExtN_4 483 489 PF00514 0.471
TRG_Pf-PMV_PEXEL_1 138 142 PF00026 0.404
TRG_Pf-PMV_PEXEL_1 232 236 PF00026 0.410
TRG_Pf-PMV_PEXEL_1 375 379 PF00026 0.428

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5S3 Leptomonas seymouri 60% 100%
A0A1X0P4N9 Trypanosomatidae 34% 100%
A0A3R7KSE1 Trypanosoma rangeli 36% 100%
A0A3S7X0E2 Leishmania donovani 91% 100%
A4HFF0 Leishmania braziliensis 82% 100%
A4I2L9 Leishmania infantum 91% 100%
D0A5N1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AD09 Leishmania major 91% 100%
V5BSR3 Trypanosoma cruzi 35% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS