Conserved plasma membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYS8_LEIMU

TriTrypDb:

LmxM.27.0260

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AYS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	290	292	PF00675	0.565
CLV_NRD_NRD_1	93	95	PF00675	0.501
CLV_PCSK_KEX2_1	106	108	PF00082	0.372
CLV_PCSK_KEX2_1	93	95	PF00082	0.510
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.371
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.489
CLV_PCSK_SKI1_1	136	140	PF00082	0.443
CLV_PCSK_SKI1_1	213	217	PF00082	0.481
CLV_PCSK_SKI1_1	281	285	PF00082	0.539
DEG_APCC_DBOX_1	93	101	PF00400	0.570
DEG_Nend_Nbox_1	1	3	PF02207	0.445
DEG_SPOP_SBC_1	172	176	PF00917	0.765
DEG_SPOP_SBC_1	186	190	PF00917	0.590
DOC_MAPK_gen_1	93	102	PF00069	0.572
DOC_MAPK_MEF2A_6	93	102	PF00069	0.597
DOC_PP1_RVXF_1	214	220	PF00149	0.508
DOC_PP4_FxxP_1	116	119	PF00568	0.631
DOC_PP4_FxxP_1	286	289	PF00568	0.592
DOC_USP7_MATH_1	173	177	PF00917	0.743
DOC_USP7_MATH_1	186	190	PF00917	0.599
DOC_USP7_MATH_1	218	222	PF00917	0.714
DOC_USP7_MATH_1	248	252	PF00917	0.719
DOC_USP7_MATH_1	81	85	PF00917	0.447
DOC_WW_Pin1_4	301	306	PF00397	0.735
LIG_14-3-3_CanoR_1	3	11	PF00244	0.440
LIG_BIR_III_4	269	273	PF00653	0.670
LIG_FHA_1	143	149	PF00498	0.717
LIG_FHA_1	182	188	PF00498	0.694
LIG_FHA_1	221	227	PF00498	0.635
LIG_FHA_1	250	256	PF00498	0.667
LIG_FHA_1	37	43	PF00498	0.380
LIG_FHA_1	77	83	PF00498	0.419
LIG_FHA_2	252	258	PF00498	0.701
LIG_Integrin_RGD_1	277	279	PF01839	0.501
LIG_IRF3_LxIS_1	146	151	PF10401	0.637
LIG_LIR_Gen_1	205	215	PF02991	0.659
LIG_LIR_Nem_3	163	168	PF02991	0.714
LIG_LIR_Nem_3	205	211	PF02991	0.633
LIG_MYND_1	285	289	PF01753	0.669
LIG_SH2_CRK	165	169	PF00017	0.730
LIG_SH2_STAP1	208	212	PF00017	0.677
LIG_SH2_STAT5	238	241	PF00017	0.631
LIG_SH2_STAT5	46	49	PF00017	0.388
LIG_SH3_3	193	199	PF00018	0.642
LIG_SH3_3	8	14	PF00018	0.465
LIG_SH3_3	97	103	PF00018	0.606
LIG_SH3_4	284	291	PF00018	0.739
LIG_SUMO_SIM_anti_2	15	23	PF11976	0.439
LIG_SUMO_SIM_anti_2	174	184	PF11976	0.688
LIG_SUMO_SIM_anti_2	96	102	PF11976	0.559
LIG_SUMO_SIM_par_1	143	151	PF11976	0.687
LIG_SUMO_SIM_par_1	194	200	PF11976	0.621
LIG_SUMO_SIM_par_1	223	231	PF11976	0.620
LIG_UBA3_1	211	216	PF00899	0.678
MOD_CK1_1	174	180	PF00069	0.702
MOD_CK1_1	200	206	PF00069	0.680
MOD_CK1_1	221	227	PF00069	0.645
MOD_CK1_1	251	257	PF00069	0.695
MOD_CK1_1	27	33	PF00069	0.445
MOD_CK1_1	293	299	PF00069	0.749
MOD_CK2_1	174	180	PF00069	0.728
MOD_CK2_1	251	257	PF00069	0.699
MOD_CK2_1	29	35	PF00069	0.477
MOD_CK2_1	293	299	PF00069	0.752
MOD_CK2_1	50	56	PF00069	0.412
MOD_Cter_Amidation	104	107	PF01082	0.485
MOD_GlcNHglycan	202	205	PF01048	0.438
MOD_GlcNHglycan	294	298	PF01048	0.523
MOD_GSK3_1	138	145	PF00069	0.651
MOD_GSK3_1	181	188	PF00069	0.563
MOD_GSK3_1	217	224	PF00069	0.617
MOD_GSK3_1	24	31	PF00069	0.456
MOD_GSK3_1	249	256	PF00069	0.690
MOD_GSK3_1	76	83	PF00069	0.334
MOD_NEK2_1	148	153	PF00069	0.608
MOD_NEK2_1	181	186	PF00069	0.678
MOD_NEK2_1	202	207	PF00069	0.670
MOD_NEK2_1	4	9	PF00069	0.378
MOD_OFUCOSY	137	142	PF10250	0.310
MOD_PKA_2	221	227	PF00069	0.587
MOD_PKA_2	273	279	PF00069	0.684
MOD_PKA_2	290	296	PF00069	0.745
MOD_Plk_1	142	148	PF00069	0.683
MOD_Plk_2-3	253	259	PF00069	0.683
MOD_Plk_2-3	50	56	PF00069	0.412
MOD_Plk_4	17	23	PF00069	0.385
MOD_Plk_4	197	203	PF00069	0.693
MOD_Plk_4	207	213	PF00069	0.599
MOD_ProDKin_1	301	307	PF00069	0.731
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.680
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.677
TRG_ENDOCYTIC_2	165	168	PF00928	0.731
TRG_ENDOCYTIC_2	208	211	PF00928	0.599
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX16	Leptomonas seymouri	46%	95%
A0A3Q8IE36	Leishmania donovani	89%	100%
A4HFE5	Leishmania braziliensis	73%	100%
A4I2L5	Leishmania infantum	89%	100%
C9ZKW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	84%
E9AD03	Leishmania major	90%	100%