Kinetoplast-associated protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AYS6_LEIMU

TriTrypDb:

LmxM.27.0240

Length:

1346

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AYS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	1284	1286	PF00675	0.418
CLV_NRD_NRD_1	1289	1291	PF00675	0.358
CLV_PCSK_KEX2_1	1283	1285	PF00082	0.428
CLV_PCSK_KEX2_1	1289	1291	PF00082	0.357
CLV_PCSK_KEX2_1	1300	1302	PF00082	0.299
CLV_PCSK_PC1ET2_1	1283	1285	PF00082	0.355
CLV_PCSK_PC1ET2_1	1300	1302	PF00082	0.288
CLV_PCSK_PC7_1	1285	1291	PF00082	0.352
CLV_PCSK_SKI1_1	11	15	PF00082	0.401
CLV_PCSK_SKI1_1	1324	1328	PF00082	0.264
DOC_MAPK_gen_1	1287	1297	PF00069	0.532
DOC_USP7_MATH_1	37	41	PF00917	0.674
DOC_USP7_UBL2_3	1283	1287	PF12436	0.551
DOC_WW_Pin1_4	47	52	PF00397	0.658
LIG_14-3-3_CanoR_1	1303	1312	PF00244	0.515
LIG_Actin_WH2_2	1240	1256	PF00022	0.498
LIG_BRCT_BRCA1_1	1328	1332	PF00533	0.226
LIG_CaM_IQ_9	1295	1311	PF13499	0.508
LIG_FHA_1	1312	1318	PF00498	0.564
LIG_LIR_Gen_1	1329	1340	PF02991	0.226
LIG_LIR_Nem_3	1328	1334	PF02991	0.226
LIG_MLH1_MIPbox_1	1328	1332	PF16413	0.226
LIG_Pex14_2	1293	1297	PF04695	0.627
LIG_Pex14_2	1326	1330	PF04695	0.264
LIG_Pex14_2	1334	1338	PF04695	0.243
LIG_SUMO_SIM_par_1	1313	1321	PF11976	0.536
LIG_TRAF2_1	33	36	PF00917	0.644
LIG_WRC_WIRS_1	1327	1332	PF05994	0.226
MOD_CK1_1	1264	1270	PF00069	0.509
MOD_CK1_1	1271	1277	PF00069	0.515
MOD_CK2_1	1271	1277	PF00069	0.616
MOD_CK2_1	1313	1319	PF00069	0.529
MOD_CK2_1	16	22	PF00069	0.614
MOD_CK2_1	30	36	PF00069	0.625
MOD_Cter_Amidation	1321	1324	PF01082	0.254
MOD_GlcNHglycan	1262	1266	PF01048	0.297
MOD_GlcNHglycan	1273	1276	PF01048	0.419
MOD_GlcNHglycan	1306	1309	PF01048	0.313
MOD_GSK3_1	1264	1271	PF00069	0.574
MOD_GSK3_1	1313	1320	PF00069	0.578
MOD_N-GLC_1	28	33	PF02516	0.434
MOD_NEK2_1	1326	1331	PF00069	0.244
MOD_PIKK_1	30	36	PF00454	0.648
MOD_PK_1	1313	1319	PF00069	0.519
MOD_PKA_1	1289	1295	PF00069	0.552
MOD_PKA_2	1289	1295	PF00069	0.552
MOD_PKA_2	44	50	PF00069	0.656
MOD_PKB_1	1301	1309	PF00069	0.510
MOD_PKB_1	5	13	PF00069	0.612
MOD_Plk_1	1261	1267	PF00069	0.505
MOD_Plk_1	28	34	PF00069	0.640
MOD_Plk_4	1326	1332	PF00069	0.266
MOD_ProDKin_1	47	53	PF00069	0.658
MOD_SUMO_rev_2	1316	1325	PF00179	0.498
TRG_ER_diArg_1	4	7	PF00400	0.623
TRG_NLS_Bipartite_1	1283	1304	PF00514	0.521
TRG_NLS_MonoExtC_3	1282	1287	PF00514	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X0C7	Leishmania donovani	95%	83%
A4HFE2	Leishmania braziliensis	81%	98%
E9AKC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
Q4QJH9	Leishmania major	47%	100%