Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYS5_LEIMU

TriTrypDb:

LmxM.27.0230

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYS5

PDB structure(s): 7aih_Aw , 7am2_Aw , 7ane_Aw

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.285
CLV_NRD_NRD_1	165	167	PF00675	0.410
CLV_NRD_NRD_1	21	23	PF00675	0.486
CLV_PCSK_FUR_1	163	167	PF00082	0.433
CLV_PCSK_KEX2_1	165	167	PF00082	0.406
CLV_PCSK_KEX2_1	21	23	PF00082	0.457
CLV_PCSK_KEX2_1	74	76	PF00082	0.417
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.512
CLV_PCSK_PC7_1	161	167	PF00082	0.512
CLV_PCSK_SKI1_1	41	45	PF00082	0.517
CLV_PCSK_SKI1_1	81	85	PF00082	0.543
DOC_CKS1_1	126	131	PF01111	0.416
DOC_CKS1_1	180	185	PF01111	0.564
DOC_USP7_MATH_1	59	63	PF00917	0.448
DOC_WW_Pin1_4	113	118	PF00397	0.527
DOC_WW_Pin1_4	125	130	PF00397	0.425
DOC_WW_Pin1_4	133	138	PF00397	0.441
DOC_WW_Pin1_4	179	184	PF00397	0.567
LIG_14-3-3_CanoR_1	123	127	PF00244	0.532
LIG_BIR_II_1	1	5	PF00653	0.444
LIG_FHA_1	110	116	PF00498	0.410
LIG_FHA_1	78	84	PF00498	0.554
LIG_FHA_2	104	110	PF00498	0.279
LIG_LIR_Apic_2	125	129	PF02991	0.426
LIG_LIR_Gen_1	10	18	PF02991	0.496
LIG_LIR_Gen_1	29	39	PF02991	0.424
LIG_LIR_Nem_3	10	14	PF02991	0.403
LIG_LIR_Nem_3	29	34	PF02991	0.427
LIG_Pex14_2	54	58	PF04695	0.384
LIG_PTB_Apo_2	25	32	PF02174	0.417
LIG_PTB_Apo_2	62	69	PF02174	0.378
LIG_PTB_Phospho_1	25	31	PF10480	0.422
LIG_SH2_GRB2like	26	29	PF00017	0.411
LIG_SH2_NCK_1	140	144	PF00017	0.523
LIG_SH2_NCK_1	27	31	PF00017	0.399
LIG_SH2_STAT5	134	137	PF00017	0.395
LIG_SH2_STAT5	140	143	PF00017	0.395
LIG_SH3_3	111	117	PF00018	0.412
LIG_SH3_3	156	162	PF00018	0.455
LIG_SH3_3	177	183	PF00018	0.455
LIG_SH3_5	183	187	PF00018	0.466
LIG_TRAF2_1	136	139	PF00917	0.465
LIG_TRAF2_2	117	122	PF00917	0.466
LIG_UBA3_1	67	74	PF00899	0.519
MOD_CK1_1	10	16	PF00069	0.394
MOD_CK1_1	125	131	PF00069	0.449
MOD_CK2_1	133	139	PF00069	0.460
MOD_CK2_1	26	32	PF00069	0.417
MOD_GlcNHglycan	2	5	PF01048	0.423
MOD_GlcNHglycan	28	31	PF01048	0.458
MOD_GSK3_1	109	116	PF00069	0.411
MOD_GSK3_1	22	29	PF00069	0.426
MOD_GSK3_1	77	84	PF00069	0.558
MOD_GSK3_1	99	106	PF00069	0.388
MOD_LATS_1	79	85	PF00433	0.445
MOD_N-GLC_1	103	108	PF02516	0.270
MOD_N-GLC_1	109	114	PF02516	0.294
MOD_NEK2_1	83	88	PF00069	0.461
MOD_NEK2_2	7	12	PF00069	0.575
MOD_PKA_2	122	128	PF00069	0.546
MOD_PKA_2	7	13	PF00069	0.418
MOD_Plk_1	103	109	PF00069	0.273
MOD_Plk_1	138	144	PF00069	0.299
MOD_Plk_4	10	16	PF00069	0.540
MOD_Plk_4	103	109	PF00069	0.281
MOD_Plk_4	22	28	PF00069	0.360
MOD_ProDKin_1	113	119	PF00069	0.528
MOD_ProDKin_1	125	131	PF00069	0.417
MOD_ProDKin_1	133	139	PF00069	0.444
MOD_ProDKin_1	179	185	PF00069	0.568
MOD_SUMO_rev_2	51	59	PF00179	0.366
TRG_ENDOCYTIC_2	31	34	PF00928	0.374
TRG_ER_diArg_1	160	163	PF00400	0.461
TRG_ER_diArg_1	164	166	PF00400	0.430
TRG_ER_diArg_1	20	22	PF00400	0.489
TRG_ER_diArg_1	87	90	PF00400	0.432
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUR0	Leptomonas seymouri	80%	100%
A0A0S4ISI6	Bodo saltans	49%	94%
A0A1X0NMF2	Trypanosomatidae	58%	99%
A0A381MKM9	Leishmania infantum	96%	100%
A0A3S7X0C8	Leishmania donovani	96%	100%
A0A422NXI0	Trypanosoma rangeli	58%	99%
A4HFE1	Leishmania braziliensis	90%	100%
C9ZKW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	99%
E9AD00	Leishmania major	94%	100%