Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYS4_LEIMU

TriTrypDb:

LmxM.27.0220

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.477
CLV_NRD_NRD_1	178	180	PF00675	0.355
CLV_NRD_NRD_1	281	283	PF00675	0.574
CLV_NRD_NRD_1	293	295	PF00675	0.395
CLV_NRD_NRD_1	74	76	PF00675	0.459
CLV_NRD_NRD_1	83	85	PF00675	0.405
CLV_PCSK_KEX2_1	159	161	PF00082	0.448
CLV_PCSK_KEX2_1	177	179	PF00082	0.382
CLV_PCSK_KEX2_1	20	22	PF00082	0.472
CLV_PCSK_KEX2_1	280	282	PF00082	0.589
CLV_PCSK_KEX2_1	293	295	PF00082	0.345
CLV_PCSK_KEX2_1	83	85	PF00082	0.446
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.541
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.486
CLV_PCSK_PC7_1	173	179	PF00082	0.467
CLV_PCSK_SKI1_1	116	120	PF00082	0.590
CLV_PCSK_SKI1_1	189	193	PF00082	0.539
CLV_PCSK_SKI1_1	202	206	PF00082	0.432
CLV_PCSK_SKI1_1	301	305	PF00082	0.454
CLV_PCSK_SKI1_1	75	79	PF00082	0.515
DEG_APCC_DBOX_1	115	123	PF00400	0.595
DEG_APCC_DBOX_1	74	82	PF00400	0.486
DOC_CDC14_PxL_1	128	136	PF14671	0.492
DOC_CYCLIN_RxL_1	73	82	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.436
DOC_MAPK_gen_1	159	167	PF00069	0.514
DOC_MAPK_gen_1	184	193	PF00069	0.537
DOC_MAPK_gen_1	75	81	PF00069	0.460
DOC_MAPK_gen_1	83	89	PF00069	0.421
DOC_MAPK_MEF2A_6	43	51	PF00069	0.495
DOC_PP1_RVXF_1	74	81	PF00149	0.515
DOC_PP2B_LxvP_1	204	207	PF13499	0.485
DOC_PP4_FxxP_1	141	144	PF00568	0.594
DOC_USP7_MATH_1	10	14	PF00917	0.482
DOC_USP7_MATH_1	142	146	PF00917	0.515
DOC_USP7_MATH_1	245	249	PF00917	0.594
DOC_USP7_MATH_1	258	262	PF00917	0.579
DOC_USP7_MATH_1	38	42	PF00917	0.348
DOC_USP7_MATH_1	52	56	PF00917	0.509
DOC_USP7_MATH_1	70	74	PF00917	0.187
DOC_WW_Pin1_4	222	227	PF00397	0.505
DOC_WW_Pin1_4	29	34	PF00397	0.586
DOC_WW_Pin1_4	43	48	PF00397	0.327
LIG_14-3-3_CanoR_1	147	156	PF00244	0.522
LIG_14-3-3_CanoR_1	178	187	PF00244	0.543
LIG_BRCT_BRCA1_1	137	141	PF00533	0.398
LIG_Clathr_ClatBox_1	310	314	PF01394	0.591
LIG_EVH1_1	128	132	PF00568	0.478
LIG_FHA_1	285	291	PF00498	0.526
LIG_FHA_1	298	304	PF00498	0.433
LIG_FHA_1	305	311	PF00498	0.476
LIG_FHA_2	222	228	PF00498	0.574
LIG_Integrin_RGD_1	63	65	PF01839	0.497
LIG_LIR_Apic_2	138	144	PF02991	0.288
LIG_LIR_Gen_1	166	176	PF02991	0.501
LIG_LIR_Gen_1	50	57	PF02991	0.308
LIG_LIR_Nem_3	125	131	PF02991	0.488
LIG_LIR_Nem_3	166	172	PF02991	0.495
LIG_LIR_Nem_3	50	56	PF02991	0.311
LIG_LYPXL_S_1	127	131	PF13949	0.519
LIG_LYPXL_yS_3	128	131	PF13949	0.508
LIG_MAD2	294	302	PF02301	0.510
LIG_MYND_1	232	236	PF01753	0.376
LIG_Pex14_1	96	100	PF04695	0.421
LIG_PTAP_UEV_1	211	216	PF05743	0.534
LIG_SH2_CRK	169	173	PF00017	0.517
LIG_SH2_CRK	53	57	PF00017	0.531
LIG_SH2_NCK_1	53	57	PF00017	0.531
LIG_SH2_STAT3	104	107	PF00017	0.515
LIG_SH3_3	124	130	PF00018	0.435
LIG_SH3_3	209	215	PF00018	0.472
LIG_SH3_3	223	229	PF00018	0.462
LIG_SH3_4	301	308	PF00018	0.285
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.559
LIG_TYR_ITIM	167	172	PF00017	0.535
LIG_TYR_ITIM	51	56	PF00017	0.532
LIG_WW_2	129	132	PF00397	0.484
MOD_CK1_1	276	282	PF00069	0.559
MOD_CK2_1	147	153	PF00069	0.478
MOD_CK2_1	245	251	PF00069	0.630
MOD_GlcNHglycan	12	15	PF01048	0.499
MOD_GlcNHglycan	149	152	PF01048	0.514
MOD_GlcNHglycan	211	215	PF01048	0.509
MOD_GlcNHglycan	260	263	PF01048	0.514
MOD_GlcNHglycan	40	43	PF01048	0.409
MOD_GSK3_1	142	149	PF00069	0.492
MOD_GSK3_1	16	23	PF00069	0.432
MOD_GSK3_1	265	272	PF00069	0.414
MOD_GSK3_1	43	50	PF00069	0.427
MOD_NEK2_1	1	6	PF00069	0.503
MOD_NEK2_1	122	127	PF00069	0.453
MOD_NEK2_1	135	140	PF00069	0.381
MOD_NEK2_1	146	151	PF00069	0.479
MOD_NEK2_1	165	170	PF00069	0.437
MOD_NEK2_1	221	226	PF00069	0.568
MOD_NEK2_1	274	279	PF00069	0.565
MOD_NEK2_1	79	84	PF00069	0.507
MOD_NEK2_2	52	57	PF00069	0.531
MOD_OFUCOSY	264	269	PF10250	0.386
MOD_PK_1	20	26	PF00069	0.519
MOD_PKA_1	20	26	PF00069	0.472
MOD_PKA_2	146	152	PF00069	0.482
MOD_PKA_2	185	191	PF00069	0.574
MOD_PKA_2	20	26	PF00069	0.454
MOD_Plk_1	165	171	PF00069	0.525
MOD_Plk_4	123	129	PF00069	0.459
MOD_Plk_4	167	173	PF00069	0.493
MOD_Plk_4	230	236	PF00069	0.360
MOD_Plk_4	52	58	PF00069	0.516
MOD_Plk_4	91	97	PF00069	0.408
MOD_ProDKin_1	222	228	PF00069	0.496
MOD_ProDKin_1	29	35	PF00069	0.575
MOD_ProDKin_1	43	49	PF00069	0.318
TRG_DiLeu_BaEn_1	217	222	PF01217	0.538
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.457
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.510
TRG_ENDOCYTIC_2	128	131	PF00928	0.469
TRG_ENDOCYTIC_2	169	172	PF00928	0.509
TRG_ENDOCYTIC_2	53	56	PF00928	0.536
TRG_ER_diArg_1	159	161	PF00400	0.480
TRG_ER_diArg_1	280	282	PF00400	0.588
TRG_ER_diArg_1	293	295	PF00400	0.343
TRG_ER_diArg_1	83	86	PF00400	0.474
TRG_NLS_Bipartite_1	159	181	PF00514	0.484
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E8	Leptomonas seymouri	62%	100%
A0A0S4IST0	Bodo saltans	29%	91%
A0A1X0NLN1	Trypanosomatidae	41%	92%
A0A381MKM4	Leishmania infantum	94%	100%
A0A3S7X0D1	Leishmania donovani	94%	100%
A0A422NXN0	Trypanosoma rangeli	41%	94%
A4HFE0	Leishmania braziliensis	84%	100%
C9ZKW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	94%
E9ACZ9	Leishmania major	94%	100%
V5BBP3	Trypanosoma cruzi	40%	94%