C3H1-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYS2_LEIMU

TriTrypDb:

LmxM.27.0200

Length:

372

Annotations

LeishMANIAdb annotations

A Zn-finger protein with a TM segment on the C-terminus (2 paralogous lineages in Kinetoplastids: A4HSS9_LEIINvs. A4I356_LEIIN). Unlikely to be GPI-anchored due to reverse topology. Weakly similar to NLRC3/NOD3 intracellular immune receptor.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	13
GO:0016020	membrane	2	10
GO:0042995	cell projection	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0110165	cellular anatomical entity	1	13
GO:0120025	plasma membrane bounded cell projection	3	13
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AYS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYS2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3
GO:0003729	mRNA binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.503
CLV_NRD_NRD_1	313	315	PF00675	0.723
CLV_NRD_NRD_1	363	365	PF00675	0.525
CLV_PCSK_FUR_1	311	315	PF00082	0.653
CLV_PCSK_KEX2_1	28	30	PF00082	0.593
CLV_PCSK_KEX2_1	302	304	PF00082	0.723
CLV_PCSK_KEX2_1	311	313	PF00082	0.681
CLV_PCSK_KEX2_1	363	365	PF00082	0.503
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.740
CLV_PCSK_SKI1_1	82	86	PF00082	0.566
DEG_Nend_UBRbox_2	1	3	PF02207	0.534
DOC_MAPK_gen_1	136	144	PF00069	0.309
DOC_MAPK_gen_1	28	34	PF00069	0.293
DOC_USP7_MATH_1	126	130	PF00917	0.306
DOC_USP7_MATH_1	153	157	PF00917	0.306
DOC_USP7_MATH_1	327	331	PF00917	0.582
DOC_WW_Pin1_4	144	149	PF00397	0.292
DOC_WW_Pin1_4	301	306	PF00397	0.610
DOC_WW_Pin1_4	336	341	PF00397	0.567
DOC_WW_Pin1_4	367	372	PF00397	0.635
LIG_Actin_WH2_2	103	120	PF00022	0.304
LIG_Actin_WH2_2	153	170	PF00022	0.322
LIG_APCC_ABBA_1	84	89	PF00400	0.314
LIG_BRCT_BRCA1_1	102	106	PF00533	0.171
LIG_BRCT_BRCA1_1	270	274	PF00533	0.475
LIG_BRCT_BRCA1_1	90	94	PF00533	0.326
LIG_eIF4E_1	233	239	PF01652	0.356
LIG_FHA_1	167	173	PF00498	0.274
LIG_FHA_1	302	308	PF00498	0.448
LIG_FHA_2	11	17	PF00498	0.337
LIG_FHA_2	145	151	PF00498	0.306
LIG_IBAR_NPY_1	164	166	PF08397	0.277
LIG_LIR_Apic_2	293	297	PF02991	0.468
LIG_LIR_Gen_1	36	47	PF02991	0.248
LIG_LIR_Gen_1	59	69	PF02991	0.412
LIG_LIR_Nem_3	336	341	PF02991	0.491
LIG_LIR_Nem_3	36	42	PF02991	0.424
LIG_LIR_Nem_3	59	64	PF02991	0.401
LIG_LIR_Nem_3	66	72	PF02991	0.413
LIG_LIR_Nem_3	88	93	PF02991	0.362
LIG_MLH1_MIPbox_1	90	94	PF16413	0.406
LIG_Pex14_2	90	94	PF04695	0.313
LIG_SH2_CRK	61	65	PF00017	0.326
LIG_SH2_GRB2like	61	64	PF00017	0.388
LIG_SH2_PTP2	141	144	PF00017	0.312
LIG_SH2_STAP1	100	104	PF00017	0.283
LIG_SH2_STAP1	250	254	PF00017	0.371
LIG_SH2_STAT5	141	144	PF00017	0.377
LIG_SH2_STAT5	166	169	PF00017	0.271
LIG_SH2_STAT5	233	236	PF00017	0.311
LIG_SH2_STAT5	53	56	PF00017	0.321
LIG_SH2_STAT5	61	64	PF00017	0.325
LIG_SH3_3	282	288	PF00018	0.440
LIG_SH3_4	331	338	PF00018	0.386
LIG_SUMO_SIM_par_1	168	175	PF11976	0.285
LIG_TYR_ITIM	139	144	PF00017	0.369
LIG_WRC_WIRS_1	39	44	PF05994	0.404
LIG_WW_3	284	288	PF00397	0.658
MOD_CDK_SPK_2	301	306	PF00069	0.600
MOD_CK1_1	318	324	PF00069	0.700
MOD_CK1_1	38	44	PF00069	0.472
MOD_CK1_1	59	65	PF00069	0.395
MOD_CK1_1	80	86	PF00069	0.269
MOD_CK2_1	10	16	PF00069	0.491
MOD_CK2_1	126	132	PF00069	0.372
MOD_CK2_1	144	150	PF00069	0.360
MOD_CK2_1	191	197	PF00069	0.407
MOD_GlcNHglycan	18	21	PF01048	0.546
MOD_GlcNHglycan	256	259	PF01048	0.601
MOD_GlcNHglycan	266	269	PF01048	0.546
MOD_GlcNHglycan	342	345	PF01048	0.338
MOD_GlcNHglycan	35	38	PF01048	0.565
MOD_GlcNHglycan	88	93	PF01048	0.437
MOD_GSK3_1	12	19	PF00069	0.529
MOD_GSK3_1	250	257	PF00069	0.506
MOD_GSK3_1	264	271	PF00069	0.542
MOD_GSK3_1	286	293	PF00069	0.691
MOD_GSK3_1	315	322	PF00069	0.531
MOD_GSK3_1	336	343	PF00069	0.680
MOD_GSK3_1	52	59	PF00069	0.483
MOD_GSK3_1	73	80	PF00069	0.376
MOD_N-GLC_1	108	113	PF02516	0.364
MOD_N-GLC_1	120	125	PF02516	0.397
MOD_N-GLC_1	191	196	PF02516	0.391
MOD_N-GLC_1	318	323	PF02516	0.514
MOD_N-GLC_1	59	64	PF02516	0.414
MOD_N-GLC_1	77	82	PF02516	0.263
MOD_N-GLC_2	63	65	PF02516	0.329
MOD_NEK2_1	134	139	PF00069	0.359
MOD_NEK2_1	191	196	PF00069	0.391
MOD_NEK2_1	254	259	PF00069	0.538
MOD_NEK2_1	77	82	PF00069	0.328
MOD_PKA_2	286	292	PF00069	0.703
MOD_Plk_1	108	114	PF00069	0.363
MOD_Plk_1	172	178	PF00069	0.407
MOD_Plk_1	203	209	PF00069	0.473
MOD_Plk_1	262	268	PF00069	0.622
MOD_Plk_1	73	79	PF00069	0.483
MOD_Plk_4	172	178	PF00069	0.407
MOD_Plk_4	203	209	PF00069	0.473
MOD_ProDKin_1	144	150	PF00069	0.352
MOD_ProDKin_1	301	307	PF00069	0.789
MOD_ProDKin_1	336	342	PF00069	0.728
MOD_SUMO_rev_2	298	304	PF00179	0.635
TRG_ENDOCYTIC_2	141	144	PF00928	0.373
TRG_ENDOCYTIC_2	39	42	PF00928	0.446
TRG_ENDOCYTIC_2	61	64	PF00928	0.498
TRG_ENDOCYTIC_2	87	90	PF00928	0.509
TRG_ER_diArg_1	135	138	PF00400	0.468
TRG_ER_diArg_1	28	30	PF00400	0.361
TRG_ER_diArg_1	3	6	PF00400	0.533
TRG_ER_diArg_1	311	314	PF00400	0.701
TRG_ER_diArg_1	363	365	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T9	Leptomonas seymouri	75%	100%
A0A1X0NNG2	Trypanosomatidae	48%	100%
A0A3R7NQS8	Trypanosoma rangeli	55%	100%
A0A3S5H5P9	Leishmania donovani	21%	93%
A0A3S7X0C2	Leishmania donovani	94%	100%
A4HFD8	Leishmania braziliensis	84%	98%
A4HSS9	Leishmania infantum	21%	93%
A4I356	Leishmania infantum	93%	100%
C9ZKV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ACZ7	Leishmania major	92%	98%
V5DCE2	Trypanosoma cruzi	56%	100%