Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYS0_LEIMU

TriTrypDb:

LmxM.27.0180

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYS0

PDB structure(s): 7ane_s

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.405
CLV_NRD_NRD_1	144	146	PF00675	0.447
CLV_PCSK_KEX2_1	102	104	PF00082	0.403
CLV_PCSK_KEX2_1	89	91	PF00082	0.407
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.607
DOC_PP2B_LxvP_1	21	24	PF13499	0.423
DOC_SPAK_OSR1_1	151	155	PF12202	0.434
DOC_USP7_UBL2_3	135	139	PF12436	0.394
DOC_WW_Pin1_4	159	164	PF00397	0.432
DOC_WW_Pin1_4	57	62	PF00397	0.380
LIG_14-3-3_CanoR_1	3	7	PF00244	0.544
LIG_APCC_ABBAyCdc20_2	35	41	PF00400	0.375
LIG_BRCT_BRCA1_1	59	63	PF00533	0.390
LIG_EVH1_2	163	167	PF00568	0.523
LIG_FHA_2	93	99	PF00498	0.383
LIG_LIR_Gen_1	165	174	PF02991	0.602
LIG_LIR_Gen_1	60	71	PF02991	0.522
LIG_LIR_Gen_1	95	105	PF02991	0.395
LIG_LIR_Nem_3	165	170	PF02991	0.464
LIG_LIR_Nem_3	60	66	PF02991	0.432
LIG_LIR_Nem_3	95	100	PF02991	0.388
LIG_SH2_CRK	113	117	PF00017	0.526
LIG_SH2_STAP1	118	122	PF00017	0.374
LIG_SH2_STAP1	97	101	PF00017	0.413
LIG_SH2_STAT5	15	18	PF00017	0.417
LIG_SH2_STAT5	42	45	PF00017	0.373
LIG_TRAF2_1	173	176	PF00917	0.500
LIG_WRC_WIRS_1	63	68	PF05994	0.396
MOD_CK1_1	126	132	PF00069	0.388
MOD_CK1_1	162	168	PF00069	0.452
MOD_CK2_1	162	168	PF00069	0.460
MOD_CK2_1	92	98	PF00069	0.379
MOD_GlcNHglycan	147	150	PF01048	0.451
MOD_GlcNHglycan	157	160	PF01048	0.420
MOD_GlcNHglycan	164	167	PF01048	0.523
MOD_GSK3_1	118	125	PF00069	0.401
MOD_GSK3_1	155	162	PF00069	0.435
MOD_N-GLC_1	155	160	PF02516	0.558
MOD_N-GLC_1	92	97	PF02516	0.381
MOD_NEK2_1	1	6	PF00069	0.581
MOD_NEK2_1	155	160	PF00069	0.447
MOD_NEK2_2	118	123	PF00069	0.359
MOD_PKA_1	145	151	PF00069	0.445
MOD_PKA_2	2	8	PF00069	0.645
MOD_Plk_1	118	124	PF00069	0.361
MOD_Plk_1	92	98	PF00069	0.395
MOD_Plk_4	126	132	PF00069	0.452
MOD_ProDKin_1	159	165	PF00069	0.439
MOD_ProDKin_1	57	63	PF00069	0.381
MOD_SUMO_rev_2	41	48	PF00179	0.391
TRG_ENDOCYTIC_2	113	116	PF00928	0.378
TRG_ENDOCYTIC_2	97	100	PF00928	0.392
TRG_ER_diArg_1	35	38	PF00400	0.367
TRG_NLS_MonoExtC_3	87	92	PF00514	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V0	Leptomonas seymouri	93%	100%
A0A0S4INE8	Bodo saltans	67%	100%
A0A1X0NLW0	Trypanosomatidae	89%	99%
A0A3Q8IPM9	Leishmania donovani	98%	100%
A0A3S5IS76	Trypanosoma rangeli	89%	99%
A4HFD6	Leishmania braziliensis	96%	100%
A4I358	Leishmania infantum	99%	100%
C9ZKV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	90%	99%
E9ACZ5	Leishmania major	99%	100%
V5BBN9	Trypanosoma cruzi	90%	72%