Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYR9_LEIMU

TriTrypDb:

LmxM.27.0170

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.546
CLV_C14_Caspase3-7	97	101	PF00656	0.521
CLV_NRD_NRD_1	161	163	PF00675	0.686
CLV_NRD_NRD_1	17	19	PF00675	0.675
CLV_NRD_NRD_1	95	97	PF00675	0.683
CLV_PCSK_FUR_1	15	19	PF00082	0.723
CLV_PCSK_KEX2_1	17	19	PF00082	0.681
CLV_PCSK_KEX2_1	358	360	PF00082	0.749
CLV_PCSK_KEX2_1	95	97	PF00082	0.683
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.749
CLV_PCSK_SKI1_1	18	22	PF00082	0.671
CLV_PCSK_SKI1_1	23	27	PF00082	0.651
CLV_PCSK_SKI1_1	35	39	PF00082	0.545
CLV_PCSK_SKI1_1	443	447	PF00082	0.381
DEG_Nend_UBRbox_3	1	3	PF02207	0.546
DEG_SPOP_SBC_1	212	216	PF00917	0.411
DEG_SPOP_SBC_1	223	227	PF00917	0.252
DEG_SPOP_SBC_1	37	41	PF00917	0.445
DOC_CYCLIN_RxL_1	382	392	PF00134	0.433
DOC_MAPK_gen_1	358	368	PF00069	0.488
DOC_MAPK_MEF2A_6	361	370	PF00069	0.505
DOC_MAPK_RevD_3	149	164	PF00069	0.432
DOC_PP2B_LxvP_1	246	249	PF13499	0.450
DOC_PP2B_LxvP_1	425	428	PF13499	0.631
DOC_USP7_MATH_1	205	209	PF00917	0.338
DOC_USP7_MATH_1	212	216	PF00917	0.467
DOC_USP7_MATH_1	319	323	PF00917	0.495
DOC_USP7_MATH_1	60	64	PF00917	0.375
DOC_WW_Pin1_4	368	373	PF00397	0.417
LIG_14-3-3_CanoR_1	112	121	PF00244	0.519
LIG_14-3-3_CanoR_1	301	308	PF00244	0.340
LIG_14-3-3_CanoR_1	347	357	PF00244	0.551
LIG_14-3-3_CanoR_1	391	396	PF00244	0.430
LIG_14-3-3_CanoR_1	415	419	PF00244	0.698
LIG_BRCT_BRCA1_1	187	191	PF00533	0.370
LIG_BRCT_BRCA1_1	43	47	PF00533	0.450
LIG_BRCT_BRCA1_1	441	445	PF00533	0.457
LIG_Clathr_ClatBox_1	406	410	PF01394	0.342
LIG_Clathr_ClatBox_1	87	91	PF01394	0.450
LIG_CtBP_PxDLS_1	153	157	PF00389	0.422
LIG_deltaCOP1_diTrp_1	240	250	PF00928	0.276
LIG_eIF4E_1	433	439	PF01652	0.715
LIG_FHA_1	123	129	PF00498	0.434
LIG_FHA_1	212	218	PF00498	0.347
LIG_FHA_1	228	234	PF00498	0.438
LIG_FHA_1	24	30	PF00498	0.559
LIG_FHA_1	324	330	PF00498	0.308
LIG_FHA_1	365	371	PF00498	0.421
LIG_FHA_1	377	383	PF00498	0.389
LIG_FHA_1	394	400	PF00498	0.192
LIG_FHA_1	411	417	PF00498	0.421
LIG_FHA_1	461	467	PF00498	0.544
LIG_FHA_1	77	83	PF00498	0.416
LIG_FHA_2	236	242	PF00498	0.456
LIG_LIR_Gen_1	240	251	PF02991	0.391
LIG_LIR_Gen_1	341	350	PF02991	0.401
LIG_LIR_Gen_1	392	401	PF02991	0.362
LIG_LIR_Gen_1	444	454	PF02991	0.491
LIG_LIR_Nem_3	240	246	PF02991	0.378
LIG_LIR_Nem_3	341	346	PF02991	0.369
LIG_LIR_Nem_3	392	398	PF02991	0.298
LIG_LIR_Nem_3	442	448	PF02991	0.485
LIG_SH2_GRB2like	237	240	PF00017	0.266
LIG_SH2_PTP2	343	346	PF00017	0.369
LIG_SH2_STAT5	219	222	PF00017	0.313
LIG_SH2_STAT5	237	240	PF00017	0.310
LIG_SH2_STAT5	265	268	PF00017	0.335
LIG_SH2_STAT5	28	31	PF00017	0.526
LIG_SH2_STAT5	343	346	PF00017	0.373
LIG_SH2_STAT5	377	380	PF00017	0.353
LIG_SH2_STAT5	64	67	PF00017	0.320
LIG_SH2_STAT5	86	89	PF00017	0.344
LIG_SH3_3	254	260	PF00018	0.489
LIG_SH3_3	310	316	PF00018	0.410
LIG_SH3_3	415	421	PF00018	0.632
LIG_SH3_3	56	62	PF00018	0.449
LIG_SUMO_SIM_anti_2	396	403	PF11976	0.354
LIG_SUMO_SIM_par_1	119	125	PF11976	0.391
LIG_SUMO_SIM_par_1	225	235	PF11976	0.431
LIG_SUMO_SIM_par_1	363	369	PF11976	0.461
LIG_SUMO_SIM_par_1	396	403	PF11976	0.402
LIG_SUMO_SIM_par_1	436	442	PF11976	0.498
LIG_WRC_WIRS_1	390	395	PF05994	0.431
MOD_CK1_1	114	120	PF00069	0.294
MOD_CK1_1	129	135	PF00069	0.471
MOD_CK1_1	193	199	PF00069	0.396
MOD_CK1_1	227	233	PF00069	0.361
MOD_CK1_1	235	241	PF00069	0.351
MOD_CK1_1	270	276	PF00069	0.388
MOD_CK1_1	39	45	PF00069	0.425
MOD_CK1_1	49	55	PF00069	0.328
MOD_CK1_1	70	76	PF00069	0.367
MOD_CK1_1	80	86	PF00069	0.382
MOD_CK1_1	94	100	PF00069	0.457
MOD_CK2_1	223	229	PF00069	0.435
MOD_GlcNHglycan	114	117	PF01048	0.728
MOD_GlcNHglycan	128	131	PF01048	0.637
MOD_GlcNHglycan	195	198	PF01048	0.560
MOD_GlcNHglycan	207	210	PF01048	0.657
MOD_GlcNHglycan	269	272	PF01048	0.451
MOD_GlcNHglycan	280	283	PF01048	0.575
MOD_GlcNHglycan	326	329	PF01048	0.577
MOD_GlcNHglycan	348	351	PF01048	0.693
MOD_GlcNHglycan	402	405	PF01048	0.335
MOD_GlcNHglycan	449	452	PF01048	0.418
MOD_GlcNHglycan	454	457	PF01048	0.398
MOD_GSK3_1	122	129	PF00069	0.385
MOD_GSK3_1	223	230	PF00069	0.404
MOD_GSK3_1	302	309	PF00069	0.420
MOD_GSK3_1	319	326	PF00069	0.464
MOD_GSK3_1	338	345	PF00069	0.355
MOD_GSK3_1	35	42	PF00069	0.429
MOD_GSK3_1	364	371	PF00069	0.397
MOD_GSK3_1	389	396	PF00069	0.423
MOD_GSK3_1	410	417	PF00069	0.630
MOD_GSK3_1	76	83	PF00069	0.392
MOD_GSK3_1	94	101	PF00069	0.413
MOD_N-GLC_1	309	314	PF02516	0.589
MOD_N-GLC_1	70	75	PF02516	0.531
MOD_N-GLC_1	77	82	PF02516	0.514
MOD_NEK2_1	154	159	PF00069	0.419
MOD_NEK2_1	185	190	PF00069	0.403
MOD_NEK2_1	286	291	PF00069	0.295
MOD_NEK2_1	342	347	PF00069	0.352
MOD_NEK2_1	366	371	PF00069	0.412
MOD_NEK2_1	389	394	PF00069	0.390
MOD_NEK2_1	400	405	PF00069	0.227
MOD_NEK2_1	414	419	PF00069	0.572
MOD_NEK2_1	55	60	PF00069	0.433
MOD_NEK2_1	76	81	PF00069	0.336
MOD_NEK2_2	213	218	PF00069	0.478
MOD_PIKK_1	114	120	PF00454	0.375
MOD_PIKK_1	94	100	PF00454	0.544
MOD_PKA_1	163	169	PF00069	0.470
MOD_PKA_2	111	117	PF00069	0.345
MOD_PKA_2	346	352	PF00069	0.478
MOD_PKA_2	414	420	PF00069	0.678
MOD_PKA_2	91	97	PF00069	0.504
MOD_PKA_2	98	104	PF00069	0.516
MOD_Plk_1	154	160	PF00069	0.434
MOD_Plk_1	21	27	PF00069	0.520
MOD_Plk_1	227	233	PF00069	0.469
MOD_Plk_1	309	315	PF00069	0.407
MOD_Plk_1	49	55	PF00069	0.412
MOD_Plk_2-3	8	14	PF00069	0.476
MOD_Plk_4	136	142	PF00069	0.330
MOD_Plk_4	154	160	PF00069	0.354
MOD_Plk_4	270	276	PF00069	0.347
MOD_Plk_4	338	344	PF00069	0.355
MOD_Plk_4	42	48	PF00069	0.470
MOD_Plk_4	49	55	PF00069	0.398
MOD_Plk_4	60	66	PF00069	0.207
MOD_ProDKin_1	368	374	PF00069	0.426
MOD_SUMO_for_1	29	32	PF00179	0.572
MOD_SUMO_rev_2	155	165	PF00179	0.457
TRG_DiLeu_BaEn_1	402	407	PF01217	0.378
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.395
TRG_ENDOCYTIC_2	343	346	PF00928	0.374
TRG_ER_diArg_1	15	18	PF00400	0.481
TRG_NLS_MonoExtC_3	357	363	PF00514	0.545
TRG_NLS_MonoExtN_4	357	362	PF00514	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF2	Leptomonas seymouri	63%	99%
A0A1X0NLR9	Trypanosomatidae	27%	86%
A0A3Q8ID84	Leishmania donovani	94%	100%
A0A422NXM8	Trypanosoma rangeli	30%	86%
A4HFD5	Leishmania braziliensis	83%	100%
A4I359	Leishmania infantum	94%	100%
C9ZKV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	85%
E9ACZ4	Leishmania major	94%	100%
V5BKT2	Trypanosoma cruzi	27%	86%