RING-CH-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-variant domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AYR4_LEIMU

TriTrypDb:

LmxM.27.0120

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 2
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AYR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYR4

Function

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.581
CLV_NRD_NRD_1	440	442	PF00675	0.261
CLV_PCSK_KEX2_1	440	442	PF00082	0.261
CLV_PCSK_SKI1_1	190	194	PF00082	0.614
CLV_PCSK_SKI1_1	209	213	PF00082	0.438
CLV_PCSK_SKI1_1	267	271	PF00082	0.341
CLV_PCSK_SKI1_1	322	326	PF00082	0.345
CLV_PCSK_SKI1_1	377	381	PF00082	0.482
CLV_PCSK_SKI1_1	431	435	PF00082	0.284
CLV_PCSK_SKI1_1	499	503	PF00082	0.618
CLV_PCSK_SKI1_1	61	65	PF00082	0.707
DEG_APCC_DBOX_1	266	274	PF00400	0.393
DEG_COP1_1	297	306	PF00400	0.498
DEG_SCF_FBW7_1	140	145	PF00400	0.349
DEG_SCF_FBW7_2	464	471	PF00400	0.532
DEG_SPOP_SBC_1	142	146	PF00917	0.392
DEG_SPOP_SBC_1	20	24	PF00917	0.462
DOC_CYCLIN_RxL_1	475	487	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.355
DOC_MAPK_gen_1	294	303	PF00069	0.509
DOC_MAPK_gen_1	4	13	PF00069	0.389
DOC_MAPK_gen_1	544	553	PF00069	0.431
DOC_MAPK_MEF2A_6	267	275	PF00069	0.393
DOC_MAPK_MEF2A_6	31	38	PF00069	0.317
DOC_MAPK_MEF2A_6	547	555	PF00069	0.407
DOC_MAPK_MEF2A_6	6	15	PF00069	0.437
DOC_MAPK_MEF2A_6	67	76	PF00069	0.413
DOC_PP1_RVXF_1	353	359	PF00149	0.606
DOC_PP2B_LxvP_1	409	412	PF13499	0.484
DOC_PP2B_LxvP_1	96	99	PF13499	0.348
DOC_USP7_MATH_1	142	146	PF00917	0.392
DOC_USP7_MATH_1	177	181	PF00917	0.424
DOC_USP7_MATH_1	29	33	PF00917	0.358
DOC_USP7_MATH_1	327	331	PF00917	0.525
DOC_USP7_MATH_1	381	385	PF00917	0.606
DOC_USP7_MATH_1	70	74	PF00917	0.374
DOC_WW_Pin1_4	138	143	PF00397	0.348
DOC_WW_Pin1_4	25	30	PF00397	0.538
DOC_WW_Pin1_4	445	450	PF00397	0.497
DOC_WW_Pin1_4	464	469	PF00397	0.608
LIG_14-3-3_CanoR_1	190	195	PF00244	0.398
LIG_14-3-3_CanoR_1	227	233	PF00244	0.356
LIG_14-3-3_CanoR_1	401	405	PF00244	0.510
LIG_Actin_WH2_2	485	501	PF00022	0.341
LIG_BIR_II_1	1	5	PF00653	0.499
LIG_BRCT_BRCA1_1	206	210	PF00533	0.373
LIG_BRCT_BRCA1_1	383	387	PF00533	0.603
LIG_BRCT_BRCA1_1	417	421	PF00533	0.488
LIG_BRCT_BRCA1_1	558	562	PF00533	0.482
LIG_BRCT_BRCA1_1	575	579	PF00533	0.285
LIG_BRCT_BRCA1_1	77	81	PF00533	0.429
LIG_Clathr_ClatBox_1	560	564	PF01394	0.382
LIG_deltaCOP1_diTrp_1	513	516	PF00928	0.431
LIG_eIF4E_1	206	212	PF01652	0.386
LIG_FHA_1	263	269	PF00498	0.251
LIG_FHA_1	283	289	PF00498	0.314
LIG_FHA_1	33	39	PF00498	0.335
LIG_FHA_1	394	400	PF00498	0.453
LIG_FHA_1	465	471	PF00498	0.649
LIG_FHA_1	582	588	PF00498	0.411
LIG_FHA_2	128	134	PF00498	0.287
LIG_FHA_2	176	182	PF00498	0.441
LIG_FHA_2	236	242	PF00498	0.344
LIG_FHA_2	295	301	PF00498	0.553
LIG_FHA_2	423	429	PF00498	0.405
LIG_FHA_2	504	510	PF00498	0.365
LIG_LIR_Gen_1	129	140	PF02991	0.327
LIG_LIR_Gen_1	278	288	PF02991	0.392
LIG_LIR_Gen_1	448	458	PF02991	0.539
LIG_LIR_Gen_1	559	570	PF02991	0.396
LIG_LIR_Gen_1	572	582	PF02991	0.343
LIG_LIR_Gen_1	603	612	PF02991	0.576
LIG_LIR_Gen_1	90	100	PF02991	0.418
LIG_LIR_Nem_3	129	135	PF02991	0.336
LIG_LIR_Nem_3	195	201	PF02991	0.379
LIG_LIR_Nem_3	278	284	PF02991	0.377
LIG_LIR_Nem_3	448	453	PF02991	0.503
LIG_LIR_Nem_3	513	517	PF02991	0.404
LIG_LIR_Nem_3	559	565	PF02991	0.396
LIG_LIR_Nem_3	572	577	PF02991	0.317
LIG_LIR_Nem_3	603	608	PF02991	0.562
LIG_LIR_Nem_3	90	96	PF02991	0.370
LIG_LIR_Nem_3	97	103	PF02991	0.309
LIG_LYPXL_SIV_4	526	534	PF13949	0.341
LIG_NRBOX	553	559	PF00104	0.314
LIG_Pex14_1	585	589	PF04695	0.325
LIG_Pex14_2	477	481	PF04695	0.530
LIG_Pex14_2	579	583	PF04695	0.460
LIG_REV1ctd_RIR_1	317	326	PF16727	0.485
LIG_SH2_CRK	450	454	PF00017	0.536
LIG_SH2_STAP1	128	132	PF00017	0.344
LIG_SH2_STAP1	194	198	PF00017	0.396
LIG_SH2_STAP1	206	210	PF00017	0.322
LIG_SH2_STAP1	308	312	PF00017	0.554
LIG_SH2_STAP1	496	500	PF00017	0.447
LIG_SH2_STAP1	569	573	PF00017	0.335
LIG_SH2_STAT5	100	103	PF00017	0.305
LIG_SH2_STAT5	187	190	PF00017	0.398
LIG_SH2_STAT5	194	197	PF00017	0.362
LIG_SH2_STAT5	218	221	PF00017	0.379
LIG_SH2_STAT5	337	340	PF00017	0.661
LIG_SH2_STAT5	450	453	PF00017	0.523
LIG_SH2_STAT5	483	486	PF00017	0.349
LIG_SH2_STAT5	527	530	PF00017	0.312
LIG_SH3_2	364	369	PF14604	0.645
LIG_SH3_3	159	165	PF00018	0.377
LIG_SH3_3	298	304	PF00018	0.718
LIG_SH3_3	358	364	PF00018	0.665
LIG_SH3_3	452	458	PF00018	0.582
LIG_SUMO_SIM_anti_2	237	244	PF11976	0.289
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.527
LIG_SUMO_SIM_par_1	12	18	PF11976	0.543
LIG_SUMO_SIM_par_1	241	247	PF11976	0.269
LIG_SUMO_SIM_par_1	269	274	PF11976	0.341
LIG_SUMO_SIM_par_1	34	40	PF11976	0.396
LIG_TRAF2_1	388	391	PF00917	0.714
LIG_TRFH_1	17	21	PF08558	0.544
LIG_TYR_ITIM	98	103	PF00017	0.324
LIG_TYR_ITSM	446	453	PF00017	0.503
LIG_WRC_WIRS_1	276	281	PF05994	0.306
LIG_WRC_WIRS_1	602	607	PF05994	0.631
LIG_WRC_WIRS_1	612	617	PF05994	0.606
MOD_CDC14_SPxK_1	28	31	PF00782	0.380
MOD_CDK_SPxK_1	25	31	PF00069	0.480
MOD_CK1_1	105	111	PF00069	0.374
MOD_CK1_1	280	286	PF00069	0.387
MOD_CK1_1	32	38	PF00069	0.374
MOD_CK1_1	393	399	PF00069	0.601
MOD_CK1_1	75	81	PF00069	0.386
MOD_CK1_1	84	90	PF00069	0.336
MOD_CK2_1	194	200	PF00069	0.397
MOD_CK2_1	372	378	PF00069	0.648
MOD_CK2_1	385	391	PF00069	0.712
MOD_CK2_1	422	428	PF00069	0.383
MOD_CK2_1	534	540	PF00069	0.341
MOD_CK2_1	611	617	PF00069	0.592
MOD_GlcNHglycan	104	107	PF01048	0.606
MOD_GlcNHglycan	174	178	PF01048	0.602
MOD_GlcNHglycan	206	209	PF01048	0.584
MOD_GlcNHglycan	503	506	PF01048	0.504
MOD_GlcNHglycan	547	550	PF01048	0.281
MOD_GlcNHglycan	571	574	PF01048	0.577
MOD_GlcNHglycan	594	597	PF01048	0.297
MOD_GSK3_1	138	145	PF00069	0.370
MOD_GSK3_1	15	22	PF00069	0.549
MOD_GSK3_1	173	180	PF00069	0.402
MOD_GSK3_1	186	193	PF00069	0.353
MOD_GSK3_1	244	251	PF00069	0.372
MOD_GSK3_1	25	32	PF00069	0.649
MOD_GSK3_1	271	278	PF00069	0.418
MOD_GSK3_1	302	309	PF00069	0.637
MOD_GSK3_1	377	384	PF00069	0.605
MOD_GSK3_1	41	48	PF00069	0.326
MOD_GSK3_1	50	57	PF00069	0.378
MOD_GSK3_1	565	572	PF00069	0.445
MOD_GSK3_1	581	588	PF00069	0.309
MOD_GSK3_1	59	66	PF00069	0.332
MOD_GSK3_1	77	84	PF00069	0.229
MOD_N-GLC_1	157	162	PF02516	0.537
MOD_N-GLC_1	382	387	PF02516	0.443
MOD_N-GLC_1	41	46	PF02516	0.556
MOD_N-GLC_1	415	420	PF02516	0.383
MOD_N-GLC_1	534	539	PF02516	0.341
MOD_N-GLC_2	349	351	PF02516	0.382
MOD_NEK2_1	143	148	PF00069	0.389
MOD_NEK2_1	173	178	PF00069	0.285
MOD_NEK2_1	228	233	PF00069	0.296
MOD_NEK2_1	244	249	PF00069	0.308
MOD_NEK2_1	271	276	PF00069	0.389
MOD_NEK2_1	382	387	PF00069	0.720
MOD_NEK2_1	47	52	PF00069	0.375
MOD_NEK2_1	484	489	PF00069	0.489
MOD_NEK2_1	503	508	PF00069	0.301
MOD_NEK2_1	534	539	PF00069	0.409
MOD_NEK2_1	601	606	PF00069	0.478
MOD_NEK2_1	63	68	PF00069	0.361
MOD_NEK2_2	494	499	PF00069	0.177
MOD_NEK2_2	59	64	PF00069	0.407
MOD_NEK2_2	77	82	PF00069	0.225
MOD_PK_1	6	12	PF00069	0.337
MOD_PKA_2	400	406	PF00069	0.510
MOD_PKA_2	543	549	PF00069	0.523
MOD_PKB_1	125	133	PF00069	0.278
MOD_PKB_1	225	233	PF00069	0.316
MOD_Plk_1	377	383	PF00069	0.698
MOD_Plk_1	41	47	PF00069	0.355
MOD_Plk_1	534	540	PF00069	0.449
MOD_Plk_1	585	591	PF00069	0.259
MOD_Plk_1	84	90	PF00069	0.388
MOD_Plk_2-3	235	241	PF00069	0.339
MOD_Plk_2-3	613	619	PF00069	0.621
MOD_Plk_4	235	241	PF00069	0.371
MOD_Plk_4	271	277	PF00069	0.360
MOD_Plk_4	302	308	PF00069	0.585
MOD_Plk_4	448	454	PF00069	0.555
MOD_Plk_4	469	475	PF00069	0.681
MOD_Plk_4	484	490	PF00069	0.296
MOD_Plk_4	534	540	PF00069	0.360
MOD_Plk_4	556	562	PF00069	0.306
MOD_Plk_4	573	579	PF00069	0.253
MOD_Plk_4	6	12	PF00069	0.477
MOD_Plk_4	77	83	PF00069	0.450
MOD_ProDKin_1	138	144	PF00069	0.351
MOD_ProDKin_1	25	31	PF00069	0.534
MOD_ProDKin_1	445	451	PF00069	0.499
MOD_ProDKin_1	464	470	PF00069	0.607
MOD_SUMO_rev_2	151	155	PF00179	0.278
TRG_DiLeu_BaEn_1	287	292	PF01217	0.609
TRG_ENDOCYTIC_2	100	103	PF00928	0.330
TRG_ENDOCYTIC_2	119	122	PF00928	0.292
TRG_ENDOCYTIC_2	198	201	PF00928	0.409
TRG_ENDOCYTIC_2	450	453	PF00928	0.506
TRG_ENDOCYTIC_2	483	486	PF00928	0.380
TRG_ENDOCYTIC_2	520	523	PF00928	0.276
TRG_ER_diArg_1	124	127	PF00400	0.385
TRG_ER_diArg_1	224	227	PF00400	0.378
TRG_ER_diArg_1	355	358	PF00400	0.596
TRG_ER_diArg_1	440	442	PF00400	0.443
TRG_NES_CRM1_1	552	564	PF08389	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS2	Leptomonas seymouri	57%	99%
A0A3Q8IHD5	Leishmania donovani	92%	99%
A0A3R7MRQ1	Trypanosoma rangeli	33%	96%
A4HFD1	Leishmania braziliensis	75%	99%
A4I364	Leishmania infantum	92%	99%
C9ZKV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	86%
E9ACY9	Leishmania major	92%	100%
V5BGA4	Trypanosoma cruzi	33%	92%