LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania mexicana
UniProt:
E9AYR2_LEIMU
TriTrypDb:
LmxM.27.0100
Length:
660

Annotations

LeishMANIAdb annotations

Acyltransferase involved in GPI anchor remodelling (homologue of yeast GUP1)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AYR2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYR2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0004674 protein serine/threonine kinase activity 4 5
GO:0004707 MAP kinase activity 5 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 442 446 PF00656 0.482
CLV_NRD_NRD_1 147 149 PF00675 0.296
CLV_NRD_NRD_1 366 368 PF00675 0.654
CLV_NRD_NRD_1 438 440 PF00675 0.605
CLV_NRD_NRD_1 512 514 PF00675 0.695
CLV_NRD_NRD_1 55 57 PF00675 0.336
CLV_NRD_NRD_1 593 595 PF00675 0.656
CLV_NRD_NRD_1 618 620 PF00675 0.653
CLV_PCSK_FUR_1 591 595 PF00082 0.612
CLV_PCSK_KEX2_1 132 134 PF00082 0.288
CLV_PCSK_KEX2_1 326 328 PF00082 0.571
CLV_PCSK_KEX2_1 437 439 PF00082 0.664
CLV_PCSK_KEX2_1 512 514 PF00082 0.648
CLV_PCSK_KEX2_1 55 57 PF00082 0.336
CLV_PCSK_KEX2_1 593 595 PF00082 0.613
CLV_PCSK_KEX2_1 605 607 PF00082 0.526
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.288
CLV_PCSK_PC1ET2_1 326 328 PF00082 0.571
CLV_PCSK_PC1ET2_1 437 439 PF00082 0.664
CLV_PCSK_PC1ET2_1 605 607 PF00082 0.533
CLV_PCSK_SKI1_1 121 125 PF00082 0.381
CLV_PCSK_SKI1_1 138 142 PF00082 0.424
CLV_PCSK_SKI1_1 215 219 PF00082 0.389
CLV_PCSK_SKI1_1 247 251 PF00082 0.336
CLV_PCSK_SKI1_1 253 257 PF00082 0.283
CLV_PCSK_SKI1_1 281 285 PF00082 0.366
CLV_PCSK_SKI1_1 326 330 PF00082 0.694
CLV_PCSK_SKI1_1 33 37 PF00082 0.336
CLV_PCSK_SKI1_1 409 413 PF00082 0.600
CLV_PCSK_SKI1_1 518 522 PF00082 0.513
CLV_PCSK_SKI1_1 595 599 PF00082 0.501
CLV_PCSK_SKI1_1 646 650 PF00082 0.572
CLV_PCSK_SKI1_1 92 96 PF00082 0.336
DEG_APCC_DBOX_1 120 128 PF00400 0.336
DEG_Nend_UBRbox_2 1 3 PF02207 0.419
DEG_SPOP_SBC_1 388 392 PF00917 0.621
DEG_SPOP_SBC_1 520 524 PF00917 0.661
DOC_AGCK_PIF_2 77 82 PF00069 0.336
DOC_CYCLIN_RxL_1 212 221 PF00134 0.336
DOC_CYCLIN_yClb1_LxF_4 73 79 PF00134 0.336
DOC_MAPK_gen_1 138 147 PF00069 0.389
DOC_MAPK_gen_1 181 190 PF00069 0.389
DOC_MAPK_gen_1 24 32 PF00069 0.389
DOC_MAPK_gen_1 651 659 PF00069 0.600
DOC_MAPK_HePTP_8 178 190 PF00069 0.389
DOC_MAPK_JIP1_4 141 147 PF00069 0.389
DOC_MAPK_MEF2A_6 181 190 PF00069 0.389
DOC_MAPK_MEF2A_6 481 488 PF00069 0.588
DOC_PP2B_LxvP_1 380 383 PF13499 0.460
DOC_USP7_MATH_1 267 271 PF00917 0.430
DOC_USP7_MATH_1 353 357 PF00917 0.626
DOC_USP7_MATH_1 472 476 PF00917 0.673
DOC_USP7_MATH_1 625 629 PF00917 0.598
DOC_USP7_UBL2_3 20 24 PF12436 0.336
DOC_USP7_UBL2_3 34 38 PF12436 0.336
DOC_WW_Pin1_4 101 106 PF00397 0.330
DOC_WW_Pin1_4 233 238 PF00397 0.336
DOC_WW_Pin1_4 338 343 PF00397 0.615
DOC_WW_Pin1_4 389 394 PF00397 0.696
DOC_WW_Pin1_4 401 406 PF00397 0.656
DOC_WW_Pin1_4 410 415 PF00397 0.593
DOC_WW_Pin1_4 476 481 PF00397 0.704
DOC_WW_Pin1_4 507 512 PF00397 0.817
DOC_WW_Pin1_4 521 526 PF00397 0.521
DOC_WW_Pin1_4 606 611 PF00397 0.620
DOC_WW_Pin1_4 639 644 PF00397 0.589
LIG_14-3-3_CanoR_1 100 105 PF00244 0.278
LIG_14-3-3_CanoR_1 291 298 PF00244 0.481
LIG_14-3-3_CanoR_1 354 361 PF00244 0.615
LIG_14-3-3_CanoR_1 593 602 PF00244 0.612
LIG_BRCT_BRCA1_1 365 369 PF00533 0.565
LIG_eIF4E_1 183 189 PF01652 0.336
LIG_eIF4E_1 82 88 PF01652 0.336
LIG_FHA_1 105 111 PF00498 0.238
LIG_FHA_1 173 179 PF00498 0.330
LIG_FHA_1 219 225 PF00498 0.467
LIG_FHA_1 236 242 PF00498 0.233
LIG_FHA_1 24 30 PF00498 0.301
LIG_FHA_1 428 434 PF00498 0.682
LIG_FHA_1 611 617 PF00498 0.668
LIG_FHA_1 652 658 PF00498 0.714
LIG_FHA_2 39 45 PF00498 0.375
LIG_FHA_2 596 602 PF00498 0.616
LIG_IBAR_NPY_1 515 517 PF08397 0.606
LIG_LIR_Apic_2 180 186 PF02991 0.389
LIG_LIR_Apic_2 468 472 PF02991 0.708
LIG_LIR_Gen_1 2 10 PF02991 0.278
LIG_LIR_Nem_3 12 18 PF02991 0.335
LIG_LIR_Nem_3 161 165 PF02991 0.317
LIG_LIR_Nem_3 2 7 PF02991 0.284
LIG_LIR_Nem_3 366 372 PF02991 0.584
LIG_LIR_Nem_3 75 80 PF02991 0.389
LIG_LYPXL_yS_3 113 116 PF13949 0.336
LIG_MYND_1 576 580 PF01753 0.575
LIG_NRBOX 644 650 PF00104 0.578
LIG_PTB_Apo_2 586 593 PF02174 0.641
LIG_PTB_Phospho_1 586 592 PF10480 0.639
LIG_SH2_CRK 469 473 PF00017 0.729
LIG_SH2_NCK_1 469 473 PF00017 0.696
LIG_SH2_PTP2 254 257 PF00017 0.183
LIG_SH2_STAP1 4 8 PF00017 0.374
LIG_SH2_STAT3 119 122 PF00017 0.402
LIG_SH2_STAT3 572 575 PF00017 0.605
LIG_SH2_STAT5 129 132 PF00017 0.501
LIG_SH2_STAT5 135 138 PF00017 0.384
LIG_SH2_STAT5 177 180 PF00017 0.330
LIG_SH2_STAT5 254 257 PF00017 0.336
LIG_SH2_STAT5 370 373 PF00017 0.594
LIG_SH2_STAT5 40 43 PF00017 0.336
LIG_SH2_STAT5 572 575 PF00017 0.605
LIG_SH3_1 494 500 PF00018 0.573
LIG_SH3_3 106 112 PF00018 0.336
LIG_SH3_3 213 219 PF00018 0.378
LIG_SH3_3 282 288 PF00018 0.336
LIG_SH3_3 380 386 PF00018 0.607
LIG_SH3_3 43 49 PF00018 0.336
LIG_SH3_3 474 480 PF00018 0.579
LIG_SH3_3 489 495 PF00018 0.616
LIG_SH3_3 505 511 PF00018 0.502
LIG_SH3_3 570 576 PF00018 0.654
LIG_SH3_5 173 177 PF00018 0.336
LIG_SUMO_SIM_anti_2 319 325 PF11976 0.521
LIG_SUMO_SIM_anti_2 50 55 PF11976 0.336
LIG_SUMO_SIM_par_1 385 392 PF11976 0.519
LIG_TRAF2_1 237 240 PF00917 0.336
LIG_TRAF2_1 41 44 PF00917 0.336
LIG_TRFH_1 370 374 PF08558 0.455
LIG_TRFH_1 496 500 PF08558 0.516
LIG_TYR_ITIM 111 116 PF00017 0.372
LIG_UBA3_1 123 132 PF00899 0.381
LIG_UBA3_1 371 376 PF00899 0.562
LIG_UBA3_1 87 95 PF00899 0.372
MOD_CDC14_SPxK_1 404 407 PF00782 0.612
MOD_CDC14_SPxK_1 510 513 PF00782 0.562
MOD_CDK_SPK_2 476 481 PF00069 0.632
MOD_CDK_SPK_2 507 512 PF00069 0.616
MOD_CDK_SPK_2 606 611 PF00069 0.620
MOD_CDK_SPxK_1 401 407 PF00069 0.618
MOD_CDK_SPxK_1 507 513 PF00069 0.562
MOD_CDK_SPxxK_3 639 646 PF00069 0.565
MOD_CK1_1 103 109 PF00069 0.281
MOD_CK1_1 23 29 PF00069 0.336
MOD_CK1_1 362 368 PF00069 0.694
MOD_CK1_1 392 398 PF00069 0.611
MOD_CK1_1 428 434 PF00069 0.701
MOD_CK1_1 440 446 PF00069 0.574
MOD_CK1_1 547 553 PF00069 0.596
MOD_CK1_1 561 567 PF00069 0.608
MOD_CK1_1 571 577 PF00069 0.577
MOD_CK1_1 596 602 PF00069 0.634
MOD_CK1_1 609 615 PF00069 0.634
MOD_CK2_1 149 155 PF00069 0.311
MOD_CK2_1 233 239 PF00069 0.340
MOD_CK2_1 38 44 PF00069 0.375
MOD_Cter_Amidation 435 438 PF01082 0.668
MOD_GlcNHglycan 150 154 PF01048 0.340
MOD_GlcNHglycan 261 264 PF01048 0.320
MOD_GlcNHglycan 313 316 PF01048 0.547
MOD_GlcNHglycan 474 477 PF01048 0.728
MOD_GlcNHglycan 488 491 PF01048 0.620
MOD_GlcNHglycan 528 531 PF01048 0.631
MOD_GlcNHglycan 560 563 PF01048 0.639
MOD_GlcNHglycan 595 598 PF01048 0.592
MOD_GlcNHglycan 634 638 PF01048 0.585
MOD_GlcNHglycan 654 657 PF01048 0.465
MOD_GSK3_1 100 107 PF00069 0.316
MOD_GSK3_1 172 179 PF00069 0.320
MOD_GSK3_1 229 236 PF00069 0.408
MOD_GSK3_1 353 360 PF00069 0.621
MOD_GSK3_1 388 395 PF00069 0.599
MOD_GSK3_1 425 432 PF00069 0.786
MOD_GSK3_1 472 479 PF00069 0.693
MOD_GSK3_1 519 526 PF00069 0.660
MOD_GSK3_1 544 551 PF00069 0.415
MOD_GSK3_1 606 613 PF00069 0.753
MOD_N-GLC_1 400 405 PF02516 0.570
MOD_N-GLC_1 587 592 PF02516 0.695
MOD_N-GLC_1 606 611 PF02516 0.708
MOD_NEK2_1 361 366 PF00069 0.650
MOD_NEK2_1 429 434 PF00069 0.795
MOD_NEK2_1 486 491 PF00069 0.631
MOD_NEK2_1 587 592 PF00069 0.645
MOD_PIKK_1 437 443 PF00454 0.601
MOD_PIKK_1 571 577 PF00454 0.643
MOD_PK_1 229 235 PF00069 0.336
MOD_PKA_1 437 443 PF00069 0.620
MOD_PKA_1 593 599 PF00069 0.612
MOD_PKA_2 290 296 PF00069 0.333
MOD_PKA_2 353 359 PF00069 0.654
MOD_PKA_2 437 443 PF00069 0.648
MOD_PKA_2 593 599 PF00069 0.655
MOD_PKA_2 610 616 PF00069 0.659
MOD_PKB_1 591 599 PF00069 0.557
MOD_Plk_1 357 363 PF00069 0.612
MOD_Plk_1 547 553 PF00069 0.666
MOD_Plk_1 587 593 PF00069 0.726
MOD_Plk_4 229 235 PF00069 0.288
MOD_Plk_4 568 574 PF00069 0.666
MOD_Plk_4 582 588 PF00069 0.596
MOD_ProDKin_1 101 107 PF00069 0.330
MOD_ProDKin_1 233 239 PF00069 0.336
MOD_ProDKin_1 338 344 PF00069 0.612
MOD_ProDKin_1 389 395 PF00069 0.696
MOD_ProDKin_1 401 407 PF00069 0.658
MOD_ProDKin_1 410 416 PF00069 0.595
MOD_ProDKin_1 476 482 PF00069 0.706
MOD_ProDKin_1 507 513 PF00069 0.819
MOD_ProDKin_1 521 527 PF00069 0.520
MOD_ProDKin_1 606 612 PF00069 0.619
MOD_ProDKin_1 639 645 PF00069 0.587
MOD_SUMO_for_1 140 143 PF00179 0.336
MOD_SUMO_for_1 532 535 PF00179 0.550
MOD_SUMO_for_1 567 570 PF00179 0.497
MOD_SUMO_rev_2 561 569 PF00179 0.597
TRG_DiLeu_BaEn_4 43 49 PF01217 0.336
TRG_DiLeu_BaLyEn_6 106 111 PF01217 0.336
TRG_ENDOCYTIC_2 113 116 PF00928 0.340
TRG_ENDOCYTIC_2 4 7 PF00928 0.278
TRG_ER_diArg_1 168 171 PF00400 0.281
TRG_ER_diArg_1 406 409 PF00400 0.582
TRG_ER_diArg_1 511 513 PF00400 0.639
TRG_ER_diArg_1 54 56 PF00400 0.336
TRG_ER_diArg_1 592 594 PF00400 0.559
TRG_NES_CRM1_1 296 309 PF08389 0.336
TRG_NLS_MonoExtC_3 436 442 PF00514 0.605
TRG_NLS_MonoExtN_4 247 254 PF00514 0.336
TRG_NLS_MonoExtN_4 435 441 PF00514 0.611

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4E3 Leptomonas seymouri 55% 98%
A0A3Q8IE25 Leishmania donovani 95% 100%
A0A3Q8IVR8 Leishmania donovani 34% 100%
A0A3S5H5U5 Leishmania donovani 25% 100%
A0A3S5H6C8 Leishmania donovani 25% 100%
A0A3S7WQK7 Leishmania donovani 25% 100%
A0A3S7X8Z8 Leishmania donovani 23% 100%
A4H4S9 Leishmania braziliensis 24% 100%
A4H5L7 Leishmania braziliensis 25% 100%
A4H9X1 Leishmania braziliensis 24% 100%
A4HFC9 Leishmania braziliensis 80% 100%
A4HFF3 Leishmania braziliensis 24% 100%
A4HNT2 Leishmania braziliensis 33% 100%
A4HTV4 Leishmania infantum 25% 100%
A4HTV5 Leishmania infantum 25% 100%
A4I2K6 Leishmania infantum 95% 100%
A4IB02 Leishmania infantum 23% 100%
A4ICR2 Leishmania infantum 34% 100%
E9ACY7 Leishmania major 94% 100%
E9AET0 Leishmania major 24% 100%
E9AG71 Leishmania infantum 25% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
P32581 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
Q4QIV8 Leishmania major 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS