Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYR0_LEIMU

TriTrypDb:

LmxM.27.0080

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.433
CLV_NRD_NRD_1	182	184	PF00675	0.392
CLV_NRD_NRD_1	220	222	PF00675	0.514
CLV_NRD_NRD_1	233	235	PF00675	0.496
CLV_NRD_NRD_1	242	244	PF00675	0.556
CLV_NRD_NRD_1	9	11	PF00675	0.658
CLV_PCSK_FUR_1	180	184	PF00082	0.419
CLV_PCSK_KEX2_1	182	184	PF00082	0.362
CLV_PCSK_KEX2_1	220	222	PF00082	0.542
CLV_PCSK_KEX2_1	232	234	PF00082	0.447
CLV_PCSK_KEX2_1	242	244	PF00082	0.546
CLV_PCSK_KEX2_1	9	11	PF00082	0.622
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.596
CLV_PCSK_SKI1_1	182	186	PF00082	0.383
CLV_PCSK_SKI1_1	264	268	PF00082	0.485
DEG_Nend_UBRbox_1	1	4	PF02207	0.468
DOC_MAPK_MEF2A_6	34	42	PF00069	0.431
DOC_PP1_RVXF_1	181	188	PF00149	0.347
DOC_USP7_MATH_1	102	106	PF00917	0.615
DOC_USP7_MATH_1	205	209	PF00917	0.369
DOC_USP7_MATH_1	63	67	PF00917	0.455
DOC_WW_Pin1_4	14	19	PF00397	0.650
DOC_WW_Pin1_4	170	175	PF00397	0.435
DOC_WW_Pin1_4	29	34	PF00397	0.610
DOC_WW_Pin1_4	65	70	PF00397	0.711
LIG_14-3-3_CanoR_1	188	196	PF00244	0.483
LIG_14-3-3_CanoR_1	268	272	PF00244	0.530
LIG_Clathr_ClatBox_1	137	141	PF01394	0.343
LIG_eIF4E_1	151	157	PF01652	0.371
LIG_FHA_1	108	114	PF00498	0.573
LIG_FHA_1	166	172	PF00498	0.446
LIG_FHA_1	54	60	PF00498	0.508
LIG_FHA_1	66	72	PF00498	0.412
LIG_FHA_1	73	79	PF00498	0.465
LIG_IBAR_NPY_1	239	241	PF08397	0.573
LIG_LIR_Apic_2	127	132	PF02991	0.471
LIG_LIR_Gen_1	55	63	PF02991	0.493
LIG_LIR_LC3C_4	168	172	PF02991	0.286
LIG_LIR_Nem_3	285	291	PF02991	0.441
LIG_LIR_Nem_3	55	61	PF02991	0.470
LIG_PTB_Apo_2	256	263	PF02174	0.482
LIG_SH2_CRK	129	133	PF00017	0.435
LIG_SH2_NCK_1	302	306	PF00017	0.551
LIG_SH2_STAT5	129	132	PF00017	0.528
LIG_SH2_STAT5	151	154	PF00017	0.472
LIG_SH3_3	168	174	PF00018	0.360
LIG_SH3_3	27	33	PF00018	0.614
LIG_SH3_3	37	43	PF00018	0.395
LIG_SH3_3	73	79	PF00018	0.527
LIG_SUMO_SIM_anti_2	136	141	PF11976	0.389
LIG_SUMO_SIM_anti_2	168	173	PF11976	0.346
LIG_SUMO_SIM_par_1	166	173	PF11976	0.442
LIG_SUMO_SIM_par_1	78	84	PF11976	0.403
LIG_WRC_WIRS_1	97	102	PF05994	0.429
MOD_CDK_SPK_2	29	34	PF00069	0.562
MOD_CK1_1	72	78	PF00069	0.468
MOD_CK2_1	121	127	PF00069	0.518
MOD_CK2_1	158	164	PF00069	0.449
MOD_Cter_Amidation	230	233	PF01082	0.605
MOD_DYRK1A_RPxSP_1	65	69	PF00069	0.500
MOD_GlcNHglycan	216	219	PF01048	0.582
MOD_GSK3_1	118	125	PF00069	0.580
MOD_GSK3_1	25	32	PF00069	0.600
MOD_GSK3_1	59	66	PF00069	0.664
MOD_NEK2_1	189	194	PF00069	0.336
MOD_NEK2_1	214	219	PF00069	0.441
MOD_NEK2_1	249	254	PF00069	0.601
MOD_NEK2_1	300	305	PF00069	0.467
MOD_PIKK_1	25	31	PF00454	0.611
MOD_PIKK_1	53	59	PF00454	0.509
MOD_PIKK_1	63	69	PF00454	0.466
MOD_PKA_1	9	15	PF00069	0.481
MOD_PKA_2	267	273	PF00069	0.489
MOD_PKA_2	9	15	PF00069	0.481
MOD_PKB_1	94	102	PF00069	0.606
MOD_Plk_1	118	124	PF00069	0.550
MOD_Plk_4	158	164	PF00069	0.460
MOD_Plk_4	165	171	PF00069	0.386
MOD_Plk_4	78	84	PF00069	0.428
MOD_ProDKin_1	14	20	PF00069	0.651
MOD_ProDKin_1	170	176	PF00069	0.440
MOD_ProDKin_1	29	35	PF00069	0.601
MOD_ProDKin_1	65	71	PF00069	0.548
TRG_AP2beta_CARGO_1	55	65	PF09066	0.384
TRG_DiLeu_BaEn_2	244	250	PF01217	0.497
TRG_ER_diArg_1	180	183	PF00400	0.424
TRG_ER_diArg_1	219	221	PF00400	0.494
TRG_ER_diArg_1	233	236	PF00400	0.509
TRG_ER_diArg_1	241	243	PF00400	0.578
TRG_ER_diArg_1	9	11	PF00400	0.499
TRG_NLS_Bipartite_1	220	236	PF00514	0.657
TRG_NLS_MonoExtC_3	231	236	PF00514	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUP8	Leptomonas seymouri	49%	89%
A0A1X0NLR8	Trypanosomatidae	28%	80%
A0A422N4S9	Trypanosoma rangeli	26%	80%
A4HFC7	Leishmania braziliensis	72%	100%
C9ZKU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	81%