Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYQ9_LEIMU

TriTrypDb:

LmxM.27.0070

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AYQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.381
CLV_C14_Caspase3-7	226	230	PF00656	0.443
CLV_NRD_NRD_1	210	212	PF00675	0.692
CLV_NRD_NRD_1	213	215	PF00675	0.703
CLV_NRD_NRD_1	244	246	PF00675	0.536
CLV_PCSK_FUR_1	211	215	PF00082	0.680
CLV_PCSK_KEX2_1	194	196	PF00082	0.739
CLV_PCSK_KEX2_1	208	210	PF00082	0.656
CLV_PCSK_KEX2_1	212	214	PF00082	0.670
CLV_PCSK_KEX2_1	244	246	PF00082	0.536
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.754
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.699
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.711
CLV_PCSK_PC7_1	209	215	PF00082	0.707
CLV_PCSK_SKI1_1	279	283	PF00082	0.494
CLV_PCSK_SKI1_1	3	7	PF00082	0.632
DEG_APCC_DBOX_1	2	10	PF00400	0.488
DEG_SPOP_SBC_1	134	138	PF00917	0.401
DOC_CKS1_1	111	116	PF01111	0.382
DOC_CKS1_1	157	162	PF01111	0.362
DOC_CKS1_1	256	261	PF01111	0.411
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.390
DOC_MAPK_HePTP_8	62	74	PF00069	0.249
DOC_MAPK_MEF2A_6	3	11	PF00069	0.344
DOC_MAPK_MEF2A_6	65	74	PF00069	0.254
DOC_PP2B_LxvP_1	23	26	PF13499	0.376
DOC_USP7_MATH_1	197	201	PF00917	0.498
DOC_USP7_MATH_1	280	284	PF00917	0.689
DOC_USP7_MATH_1	78	82	PF00917	0.417
DOC_USP7_UBL2_3	208	212	PF12436	0.579
DOC_WW_Pin1_4	110	115	PF00397	0.398
DOC_WW_Pin1_4	156	161	PF00397	0.446
DOC_WW_Pin1_4	255	260	PF00397	0.319
DOC_WW_Pin1_4	281	286	PF00397	0.713
DOC_WW_Pin1_4	44	49	PF00397	0.284
LIG_14-3-3_CanoR_1	214	220	PF00244	0.554
LIG_14-3-3_CanoR_1	244	252	PF00244	0.451
LIG_14-3-3_CanoR_1	270	276	PF00244	0.506
LIG_14-3-3_CanoR_1	279	285	PF00244	0.707
LIG_14-3-3_CanoR_1	77	83	PF00244	0.444
LIG_EH1_1	175	183	PF00400	0.306
LIG_FHA_1	123	129	PF00498	0.332
LIG_FHA_1	149	155	PF00498	0.444
LIG_FHA_1	182	188	PF00498	0.408
LIG_FHA_1	256	262	PF00498	0.392
LIG_FHA_1	56	62	PF00498	0.372
LIG_FHA_1	78	84	PF00498	0.419
LIG_FHA_2	100	106	PF00498	0.229
LIG_FHA_2	17	23	PF00498	0.553
LIG_LIR_Nem_3	264	269	PF02991	0.418
LIG_NRBOX	4	10	PF00104	0.552
LIG_Pex14_1	252	256	PF04695	0.457
LIG_Pex14_2	262	266	PF04695	0.470
LIG_SH2_CRK	131	135	PF00017	0.361
LIG_SH2_CRK	257	261	PF00017	0.406
LIG_SH2_NCK_1	277	281	PF00017	0.573
LIG_SH2_NCK_1	30	34	PF00017	0.388
LIG_SH2_SRC	30	33	PF00017	0.373
LIG_SH2_STAP1	176	180	PF00017	0.366
LIG_SH2_STAP1	277	281	PF00017	0.618
LIG_SH2_STAP1	30	34	PF00017	0.388
LIG_SH2_STAT5	101	104	PF00017	0.329
LIG_SH2_STAT5	110	113	PF00017	0.407
LIG_SH2_STAT5	127	130	PF00017	0.242
LIG_SH2_STAT5	257	260	PF00017	0.382
LIG_SH3_2	160	165	PF14604	0.421
LIG_SH3_3	111	117	PF00018	0.390
LIG_SH3_3	157	163	PF00018	0.390
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.573
LIG_SUMO_SIM_par_1	4	10	PF11976	0.499
MOD_CDK_SPK_2	281	286	PF00069	0.671
MOD_CDK_SPxK_1	110	116	PF00069	0.378
MOD_CK1_1	136	142	PF00069	0.481
MOD_CK1_1	148	154	PF00069	0.433
MOD_CK1_1	284	290	PF00069	0.733
MOD_CK1_1	305	311	PF00069	0.562
MOD_CK1_1	44	50	PF00069	0.335
MOD_CK1_1	81	87	PF00069	0.393
MOD_CK2_1	16	22	PF00069	0.574
MOD_CK2_1	287	293	PF00069	0.763
MOD_CK2_1	99	105	PF00069	0.221
MOD_GlcNHglycan	131	134	PF01048	0.633
MOD_GlcNHglycan	220	223	PF01048	0.675
MOD_GlcNHglycan	245	248	PF01048	0.677
MOD_GlcNHglycan	288	292	PF01048	0.568
MOD_GlcNHglycan	74	77	PF01048	0.523
MOD_GSK3_1	129	136	PF00069	0.337
MOD_GSK3_1	140	147	PF00069	0.429
MOD_GSK3_1	280	287	PF00069	0.717
MOD_GSK3_1	301	308	PF00069	0.649
MOD_GSK3_1	40	47	PF00069	0.322
MOD_GSK3_1	51	58	PF00069	0.299
MOD_GSK3_1	72	79	PF00069	0.387
MOD_GSK3_1	86	93	PF00069	0.373
MOD_N-GLC_1	56	61	PF02516	0.584
MOD_NEK2_1	123	128	PF00069	0.360
MOD_NEK2_1	223	228	PF00069	0.525
MOD_NEK2_1	271	276	PF00069	0.539
MOD_NEK2_1	41	46	PF00069	0.391
MOD_NEK2_1	49	54	PF00069	0.354
MOD_NEK2_1	55	60	PF00069	0.361
MOD_NEK2_1	7	12	PF00069	0.489
MOD_NEK2_1	99	104	PF00069	0.215
MOD_NEK2_2	236	241	PF00069	0.382
MOD_PKA_2	243	249	PF00069	0.406
MOD_PKA_2	76	82	PF00069	0.432
MOD_Plk_1	148	154	PF00069	0.446
MOD_Plk_1	35	41	PF00069	0.394
MOD_Plk_1	56	62	PF00069	0.417
MOD_Plk_4	123	129	PF00069	0.413
MOD_Plk_4	261	267	PF00069	0.399
MOD_Plk_4	7	13	PF00069	0.583
MOD_Plk_4	78	84	PF00069	0.260
MOD_ProDKin_1	110	116	PF00069	0.395
MOD_ProDKin_1	156	162	PF00069	0.452
MOD_ProDKin_1	255	261	PF00069	0.319
MOD_ProDKin_1	281	287	PF00069	0.674
MOD_ProDKin_1	44	50	PF00069	0.285
MOD_SUMO_rev_2	66	75	PF00179	0.316
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.410
TRG_ENDOCYTIC_2	131	134	PF00928	0.340
TRG_ENDOCYTIC_2	257	260	PF00928	0.406
TRG_ER_diArg_1	211	214	PF00400	0.478
TRG_ER_diArg_1	243	245	PF00400	0.343
TRG_NLS_Bipartite_1	194	216	PF00514	0.504
TRG_NLS_MonoCore_2	210	215	PF00514	0.507
TRG_NLS_MonoExtN_4	208	215	PF00514	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD93	Leptomonas seymouri	52%	100%
A0A1X0NLP1	Trypanosomatidae	31%	100%
A0A3R7RDJ4	Trypanosoma rangeli	26%	100%
A0A3S7X0B8	Leishmania donovani	88%	100%
A4HFC6	Leishmania braziliensis	71%	100%
A4I2K3	Leishmania infantum	88%	100%
C9ZKU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ACY4	Leishmania major	87%	100%
V5BKS2	Trypanosoma cruzi	27%	100%