LPXTG cell wall anchor domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYQ8_LEIMU

TriTrypDb:

LmxM.27.0060

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AYQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYQ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.423
CLV_NRD_NRD_1	124	126	PF00675	0.433
CLV_NRD_NRD_1	143	145	PF00675	0.347
CLV_NRD_NRD_1	16	18	PF00675	0.628
CLV_PCSK_KEX2_1	121	123	PF00082	0.426
CLV_PCSK_KEX2_1	16	18	PF00082	0.628
CLV_PCSK_SKI1_1	125	129	PF00082	0.562
DEG_Nend_Nbox_1	1	3	PF02207	0.446
DOC_MAPK_HePTP_8	66	78	PF00069	0.430
DOC_MAPK_MEF2A_6	69	78	PF00069	0.597
DOC_MAPK_RevD_3	109	122	PF00069	0.651
DOC_USP7_MATH_1	87	91	PF00917	0.458
DOC_USP7_UBL2_3	141	145	PF12436	0.791
LIG_14-3-3_CanoR_1	35	39	PF00244	0.431
LIG_14-3-3_CanoR_1	42	50	PF00244	0.459
LIG_14-3-3_CanoR_1	63	73	PF00244	0.463
LIG_BRCT_BRCA1_1	88	92	PF00533	0.564
LIG_deltaCOP1_diTrp_1	97	103	PF00928	0.449
LIG_FHA_1	69	75	PF00498	0.426
LIG_GBD_Chelix_1	101	109	PF00786	0.316
LIG_LIR_Gen_1	71	79	PF02991	0.446
LIG_LIR_Gen_1	89	96	PF02991	0.476
LIG_LIR_Gen_1	97	108	PF02991	0.350
LIG_LIR_LC3C_4	71	76	PF02991	0.430
LIG_LIR_Nem_3	71	75	PF02991	0.448
LIG_LIR_Nem_3	89	95	PF02991	0.477
LIG_LIR_Nem_3	97	103	PF02991	0.350
LIG_SH2_PTP2	22	25	PF00017	0.415
LIG_SH2_PTP2	72	75	PF00017	0.430
LIG_SH2_STAT5	22	25	PF00017	0.415
LIG_SH2_STAT5	72	75	PF00017	0.430
LIG_SH3_3	73	79	PF00018	0.595
LIG_SUMO_SIM_anti_2	71	77	PF11976	0.429
LIG_UBA3_1	132	141	PF00899	0.710
MOD_CK1_1	140	146	PF00069	0.746
MOD_CK1_1	31	37	PF00069	0.498
MOD_CK1_1	46	52	PF00069	0.642
MOD_CK1_1	55	61	PF00069	0.492
MOD_CK1_1	90	96	PF00069	0.687
MOD_Cter_Amidation	14	17	PF01082	0.525
MOD_GlcNHglycan	30	33	PF01048	0.504
MOD_GSK3_1	34	41	PF00069	0.571
MOD_GSK3_1	48	55	PF00069	0.558
MOD_GSK3_1	64	71	PF00069	0.476
MOD_GSK3_1	86	93	PF00069	0.712
MOD_N-GLC_1	38	43	PF02516	0.539
MOD_NEK2_1	28	33	PF00069	0.502
MOD_NEK2_1	56	61	PF00069	0.603
MOD_NEK2_2	87	92	PF00069	0.712
MOD_PIKK_1	57	63	PF00454	0.778
MOD_PIKK_1	64	70	PF00454	0.639
MOD_PKA_2	34	40	PF00069	0.523
MOD_PKA_2	62	68	PF00069	0.695
MOD_Plk_1	46	52	PF00069	0.540
MOD_Plk_1	87	93	PF00069	0.707
MOD_Plk_4	68	74	PF00069	0.540
MOD_Plk_4	87	93	PF00069	0.596
TRG_ENDOCYTIC_2	72	75	PF00928	0.522
TRG_ER_diArg_1	16	18	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9ACY3	Leishmania major	80%	100%