Queuine tRNA-ribosyltransferase accessory subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

queuine tRNA-ribosyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AYQ5_LEIMU

TriTrypDb:

LmxM.27.0030

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AYQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYQ5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006400	tRNA modification	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0101030	tRNA-guanine transglycosylation	7	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	9
GO:0008479	queuine tRNA-ribosyltransferase activity	5	9
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016763	pentosyltransferase activity	4	12
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140101	catalytic activity, acting on a tRNA	4	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.540
CLV_MEL_PAP_1	327	333	PF00089	0.248
CLV_NRD_NRD_1	135	137	PF00675	0.255
CLV_PCSK_KEX2_1	13	15	PF00082	0.254
CLV_PCSK_KEX2_1	133	135	PF00082	0.255
CLV_PCSK_KEX2_1	279	281	PF00082	0.295
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.315
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.255
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.297
CLV_PCSK_SKI1_1	136	140	PF00082	0.290
CLV_PCSK_SKI1_1	324	328	PF00082	0.423
CLV_PCSK_SKI1_1	67	71	PF00082	0.279
DEG_APCC_DBOX_1	282	290	PF00400	0.528
DEG_Nend_UBRbox_2	1	3	PF02207	0.617
DOC_MAPK_gen_1	198	204	PF00069	0.559
DOC_MAPK_gen_1	96	103	PF00069	0.497
DOC_MAPK_MEF2A_6	114	121	PF00069	0.495
DOC_MAPK_MEF2A_6	233	241	PF00069	0.515
DOC_PP2B_LxvP_1	237	240	PF13499	0.540
DOC_PP2B_LxvP_1	8	11	PF13499	0.465
DOC_PP4_FxxP_1	46	49	PF00568	0.515
DOC_USP7_MATH_1	214	218	PF00917	0.556
DOC_USP7_MATH_1	326	330	PF00917	0.507
DOC_USP7_MATH_1	81	85	PF00917	0.519
DOC_USP7_MATH_1	99	103	PF00917	0.367
DOC_WW_Pin1_4	18	23	PF00397	0.456
DOC_WW_Pin1_4	193	198	PF00397	0.551
LIG_14-3-3_CanoR_1	135	145	PF00244	0.477
LIG_14-3-3_CanoR_1	317	322	PF00244	0.441
LIG_14-3-3_CanoR_1	34	44	PF00244	0.454
LIG_14-3-3_CanoR_1	73	77	PF00244	0.506
LIG_14-3-3_CanoR_1	98	104	PF00244	0.464
LIG_BIR_III_2	175	179	PF00653	0.540
LIG_BIR_III_4	2	6	PF00653	0.540
LIG_BRCT_BRCA1_1	182	186	PF00533	0.564
LIG_Clathr_ClatBox_1	238	242	PF01394	0.500
LIG_FHA_1	199	205	PF00498	0.492
LIG_FHA_2	138	144	PF00498	0.487
LIG_FHA_2	227	233	PF00498	0.472
LIG_FHA_2	244	250	PF00498	0.514
LIG_FHA_2	289	295	PF00498	0.465
LIG_LIR_Apic_2	45	49	PF02991	0.497
LIG_LIR_Gen_1	181	192	PF02991	0.517
LIG_LIR_Gen_1	38	49	PF02991	0.516
LIG_LIR_Nem_3	104	109	PF02991	0.495
LIG_LIR_Nem_3	181	187	PF02991	0.528
LIG_LIR_Nem_3	58	63	PF02991	0.454
LIG_LIR_Nem_3	64	69	PF02991	0.457
LIG_LIR_Nem_3	74	79	PF02991	0.488
LIG_MYND_1	18	22	PF01753	0.465
LIG_NRBOX	285	291	PF00104	0.528
LIG_PDZ_Class_1	330	335	PF00595	0.523
LIG_SH2_CRK	60	64	PF00017	0.552
LIG_SH2_CRK	66	70	PF00017	0.527
LIG_SH2_SRC	173	176	PF00017	0.559
LIG_SH2_SRC	285	288	PF00017	0.454
LIG_SH2_STAT5	173	176	PF00017	0.492
LIG_SH2_STAT5	285	288	PF00017	0.476
LIG_SH2_STAT5	60	63	PF00017	0.552
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.522
LIG_SUMO_SIM_anti_2	297	304	PF11976	0.468
LIG_SUMO_SIM_par_1	253	259	PF11976	0.535
LIG_SUMO_SIM_par_1	288	294	PF11976	0.454
LIG_SUMO_SIM_par_1	68	75	PF11976	0.455
LIG_TRAF2_1	240	243	PF00917	0.500
LIG_TRAF2_1	291	294	PF00917	0.454
LIG_WRC_WIRS_1	100	105	PF05994	0.559
MOD_CDC14_SPxK_1	196	199	PF00782	0.559
MOD_CDK_SPK_2	193	198	PF00069	0.559
MOD_CDK_SPxK_1	193	199	PF00069	0.559
MOD_CK1_1	217	223	PF00069	0.531
MOD_CK1_1	320	326	PF00069	0.499
MOD_CK1_1	82	88	PF00069	0.528
MOD_CK2_1	137	143	PF00069	0.498
MOD_CK2_1	217	223	PF00069	0.492
MOD_CK2_1	226	232	PF00069	0.479
MOD_CK2_1	243	249	PF00069	0.520
MOD_CK2_1	288	294	PF00069	0.454
MOD_CK2_1	36	42	PF00069	0.559
MOD_GlcNHglycan	163	166	PF01048	0.333
MOD_GlcNHglycan	208	211	PF01048	0.253
MOD_GlcNHglycan	319	322	PF01048	0.417
MOD_GlcNHglycan	332	335	PF01048	0.471
MOD_GlcNHglycan	63	66	PF01048	0.348
MOD_GlcNHglycan	81	84	PF01048	0.273
MOD_GSK3_1	137	144	PF00069	0.521
MOD_GSK3_1	146	153	PF00069	0.472
MOD_GSK3_1	155	162	PF00069	0.439
MOD_GSK3_1	243	250	PF00069	0.422
MOD_GSK3_1	326	333	PF00069	0.537
MOD_GSK3_1	61	68	PF00069	0.511
MOD_GSK3_1	79	86	PF00069	0.462
MOD_N-GLC_1	217	222	PF02516	0.340
MOD_NEK2_1	155	160	PF00069	0.543
MOD_NEK2_1	186	191	PF00069	0.564
MOD_NEK2_1	241	246	PF00069	0.436
MOD_NEK2_1	36	41	PF00069	0.515
MOD_NEK2_1	72	77	PF00069	0.483
MOD_NEK2_1	79	84	PF00069	0.445
MOD_OFUCOSY	273	278	PF10250	0.254
MOD_PKA_1	198	204	PF00069	0.559
MOD_PKA_2	72	78	PF00069	0.540
MOD_PKB_1	134	142	PF00069	0.485
MOD_Plk_1	180	186	PF00069	0.463
MOD_Plk_1	217	223	PF00069	0.540
MOD_Plk_1	86	92	PF00069	0.523
MOD_Plk_4	141	147	PF00069	0.569
MOD_Plk_4	155	161	PF00069	0.524
MOD_Plk_4	217	223	PF00069	0.476
MOD_Plk_4	247	253	PF00069	0.353
MOD_Plk_4	36	42	PF00069	0.454
MOD_Plk_4	65	71	PF00069	0.471
MOD_ProDKin_1	18	24	PF00069	0.456
MOD_ProDKin_1	193	199	PF00069	0.551
MOD_SUMO_for_1	147	150	PF00179	0.528
TRG_DiLeu_BaEn_2	41	47	PF01217	0.559
TRG_DiLeu_BaEn_4	150	156	PF01217	0.559
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.540
TRG_ENDOCYTIC_2	184	187	PF00928	0.523
TRG_ENDOCYTIC_2	60	63	PF00928	0.554
TRG_ENDOCYTIC_2	66	69	PF00928	0.519
TRG_ER_diArg_1	134	136	PF00400	0.479
TRG_NLS_MonoCore_2	132	137	PF00514	0.455
TRG_NLS_MonoExtN_4	130	137	PF00514	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWE8	Leptomonas seymouri	67%	100%
A0A0S4IR14	Bodo saltans	37%	96%
A0A1X0NPI6	Trypanosomatidae	40%	100%
A0A3R7K861	Trypanosoma rangeli	40%	100%
A0A3S7X0A8	Leishmania donovani	93%	100%
A4HFC2	Leishmania braziliensis	84%	100%
A4I2J9	Leishmania infantum	94%	100%
A5D3G6	Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)	25%	91%
B0WAN0	Culex quinquefasciatus	23%	78%
B2USB2	Helicobacter pylori (strain Shi470)	28%	90%
B3NCH1	Drosophila erecta	23%	80%
B3RNT0	Trichoplax adhaerens	23%	91%
B4H1X9	Drosophila persimilis	25%	80%
B4HL48	Drosophila sechellia	24%	80%
B4IXD3	Drosophila grimshawi	23%	80%
B4KXI8	Drosophila mojavensis	23%	81%
B4LFW2	Drosophila virilis	23%	80%
B4N549	Drosophila willistoni	23%	78%
B4PEV9	Drosophila yakuba	23%	80%
B5ZA47	Helicobacter pylori (strain G27)	27%	90%
B6JKL0	Helicobacter pylori (strain P12)	28%	90%
C9ZPM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACY0	Leishmania major	93%	100%
O08314	Helicobacter pylori (strain ATCC 700392 / 26695)	28%	90%
Q16RF5	Aedes aegypti	22%	80%
Q17YB5	Helicobacter acinonychis (strain Sheeba)	28%	90%
Q1CUM2	Helicobacter pylori (strain HPAG1)	28%	90%
Q29EE9	Drosophila pseudoobscura pseudoobscura	26%	80%
Q5SLI7	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	27%	87%
Q7Q727	Anopheles gambiae	23%	78%
Q8YVT9	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	23%	90%
Q9VSZ6	Drosophila melanogaster	24%	80%
Q9ZMF4	Helicobacter pylori (strain J99 / ATCC 700824)	28%	90%
V5BCL2	Trypanosoma cruzi	40%	100%