Putative CAAX prenyl protease 2 (Peptidase with unknown catalytic mechanism (Family u48))

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidase with unknown catalytic mechanism (family U48)

Species:

Leishmania mexicana

UniProt:

E9AYQ0_LEIMU

TriTrypDb:

LmxM.26.2690

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYQ0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0016485	protein processing	5	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071586	CAAX-box protein processing	6	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	88	90	PF00675	0.496
CLV_PCSK_KEX2_1	88	90	PF00082	0.496
CLV_PCSK_SKI1_1	79	83	PF00082	0.513
DEG_APCC_DBOX_1	78	86	PF00400	0.296
DEG_Nend_UBRbox_4	1	3	PF02207	0.648
DOC_PP1_RVXF_1	77	84	PF00149	0.384
DOC_PP4_FxxP_1	41	44	PF00568	0.447
DOC_PP4_FxxP_1	54	57	PF00568	0.419
DOC_WW_Pin1_4	56	61	PF00397	0.467
DOC_WW_Pin1_4	88	93	PF00397	0.303
LIG_14-3-3_CanoR_1	196	204	PF00244	0.630
LIG_14-3-3_CanoR_1	22	27	PF00244	0.626
LIG_14-3-3_CanoR_1	32	41	PF00244	0.500
LIG_14-3-3_CanoR_1	88	92	PF00244	0.297
LIG_14-3-3_CanoR_1	94	104	PF00244	0.325
LIG_FHA_1	35	41	PF00498	0.334
LIG_FHA_2	197	203	PF00498	0.651
LIG_LIR_Apic_2	53	57	PF02991	0.445
LIG_LIR_Gen_1	6	17	PF02991	0.649
LIG_LIR_Nem_3	153	159	PF02991	0.382
LIG_LIR_Nem_3	189	193	PF02991	0.578
LIG_LIR_Nem_3	6	12	PF02991	0.628
LIG_LIR_Nem_3	75	81	PF02991	0.299
LIG_NRBOX	154	160	PF00104	0.447
LIG_NRBOX	81	87	PF00104	0.313
LIG_Pex14_2	152	156	PF04695	0.418
LIG_Pex14_2	96	100	PF04695	0.463
LIG_SH2_CRK	78	82	PF00017	0.391
LIG_SH2_SRC	164	167	PF00017	0.362
LIG_SH2_STAT5	210	213	PF00017	0.358
LIG_SH2_STAT5	67	70	PF00017	0.324
LIG_SH2_STAT5	9	12	PF00017	0.671
LIG_SH3_3	54	60	PF00018	0.364
LIG_SH3_3	65	71	PF00018	0.357
LIG_TYR_ITIM	76	81	PF00017	0.391
LIG_WRC_WIRS_1	51	56	PF05994	0.441
MOD_CDC14_SPxK_1	91	94	PF00782	0.237
MOD_CDK_SPxK_1	88	94	PF00069	0.212
MOD_CK1_1	33	39	PF00069	0.466
MOD_CK2_1	196	202	PF00069	0.660
MOD_GlcNHglycan	140	143	PF01048	0.370
MOD_GlcNHglycan	159	162	PF01048	0.210
MOD_GlcNHglycan	205	208	PF01048	0.371
MOD_GlcNHglycan	5	8	PF01048	0.450
MOD_GlcNHglycan	97	100	PF01048	0.424
MOD_GSK3_1	138	145	PF00069	0.595
MOD_GSK3_1	188	195	PF00069	0.608
MOD_GSK3_1	30	37	PF00069	0.511
MOD_N-GLC_1	126	131	PF02516	0.345
MOD_NEK2_1	100	105	PF00069	0.351
MOD_NEK2_1	150	155	PF00069	0.430
MOD_PKA_2	21	27	PF00069	0.666
MOD_PKA_2	87	93	PF00069	0.347
MOD_PKB_1	194	202	PF00069	0.582
MOD_Plk_1	188	194	PF00069	0.587
MOD_Plk_4	168	174	PF00069	0.343
MOD_Plk_4	22	28	PF00069	0.624
MOD_Plk_4	34	40	PF00069	0.302
MOD_ProDKin_1	56	62	PF00069	0.463
MOD_ProDKin_1	88	94	PF00069	0.303
MOD_SUMO_rev_2	116	126	PF00179	0.597
TRG_DiLeu_BaEn_1	58	63	PF01217	0.344
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.252
TRG_ENDOCYTIC_2	164	167	PF00928	0.313
TRG_ENDOCYTIC_2	78	81	PF00928	0.391
TRG_ENDOCYTIC_2	9	12	PF00928	0.691
TRG_ER_diArg_1	193	196	PF00400	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYS3	Leptomonas seymouri	46%	79%
A0A0S4JSY4	Bodo saltans	33%	72%
A0A1X0NYX6	Trypanosomatidae	35%	74%
A0A3S7X0B2	Leishmania donovani	87%	100%
A4HFB3	Leishmania braziliensis	72%	100%
A4I2J5	Leishmania infantum	87%	100%
C9ZK27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	74%
Q4Q8S2	Leishmania major	88%	100%
V5BHT4	Trypanosoma cruzi	32%	93%