Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP92

Species:

Leishmania mexicana

UniProt:

E9AYP7_LEIMU

TriTrypDb:

LmxM.26.2660

Length:

827

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	1
GO:0005634	nucleus	5	1
GO:0005643	nuclear pore	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005816	spindle pole body	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0044615	nuclear pore nuclear basket	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AYP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYP7

Function

Biological processes
Term	Name	Level	Count
GO:0000278	mitotic cell cycle	3	1
GO:0007049	cell cycle	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	378	380	PF00675	0.650
CLV_NRD_NRD_1	417	419	PF00675	0.576
CLV_NRD_NRD_1	525	527	PF00675	0.572
CLV_NRD_NRD_1	565	567	PF00675	0.601
CLV_NRD_NRD_1	611	613	PF00675	0.522
CLV_PCSK_KEX2_1	118	120	PF00082	0.557
CLV_PCSK_KEX2_1	207	209	PF00082	0.548
CLV_PCSK_KEX2_1	378	380	PF00082	0.554
CLV_PCSK_KEX2_1	417	419	PF00082	0.535
CLV_PCSK_KEX2_1	564	566	PF00082	0.559
CLV_PCSK_KEX2_1	611	613	PF00082	0.544
CLV_PCSK_KEX2_1	659	661	PF00082	0.673
CLV_PCSK_KEX2_1	760	762	PF00082	0.492
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.557
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.583
CLV_PCSK_PC1ET2_1	659	661	PF00082	0.673
CLV_PCSK_PC1ET2_1	760	762	PF00082	0.492
CLV_PCSK_SKI1_1	119	123	PF00082	0.590
CLV_PCSK_SKI1_1	367	371	PF00082	0.589
CLV_PCSK_SKI1_1	385	389	PF00082	0.455
CLV_PCSK_SKI1_1	485	489	PF00082	0.563
CLV_PCSK_SKI1_1	5	9	PF00082	0.725
CLV_PCSK_SKI1_1	502	506	PF00082	0.451
CLV_PCSK_SKI1_1	70	74	PF00082	0.721
CLV_PCSK_SKI1_1	716	720	PF00082	0.364
CLV_PCSK_SKI1_1	761	765	PF00082	0.488
DEG_APCC_DBOX_1	384	392	PF00400	0.728
DEG_APCC_DBOX_1	416	424	PF00400	0.601
DEG_Nend_Nbox_1	1	3	PF02207	0.584
DOC_CYCLIN_RxL_1	113	126	PF00134	0.590
DOC_MAPK_DCC_7	19	28	PF00069	0.714
DOC_MAPK_DCC_7	816	826	PF00069	0.425
DOC_MAPK_gen_1	118	124	PF00069	0.592
DOC_MAPK_gen_1	168	176	PF00069	0.577
DOC_MAPK_gen_1	450	458	PF00069	0.521
DOC_MAPK_MEF2A_6	684	691	PF00069	0.557
DOC_PP1_RVXF_1	127	134	PF00149	0.500
DOC_PP2B_LxvP_1	50	53	PF13499	0.543
DOC_USP7_MATH_1	172	176	PF00917	0.605
DOC_USP7_MATH_1	402	406	PF00917	0.729
DOC_USP7_MATH_1	421	425	PF00917	0.605
DOC_USP7_MATH_1	622	626	PF00917	0.543
DOC_USP7_MATH_1	699	703	PF00917	0.488
DOC_USP7_MATH_1	767	771	PF00917	0.437
DOC_USP7_MATH_1	91	95	PF00917	0.619
DOC_USP7_UBL2_3	342	346	PF12436	0.602
DOC_USP7_UBL2_3	527	531	PF12436	0.592
DOC_WW_Pin1_4	21	26	PF00397	0.756
DOC_WW_Pin1_4	40	45	PF00397	0.787
DOC_WW_Pin1_4	618	623	PF00397	0.617
LIG_14-3-3_CanoR_1	111	121	PF00244	0.293
LIG_14-3-3_CanoR_1	173	177	PF00244	0.527
LIG_14-3-3_CanoR_1	223	228	PF00244	0.571
LIG_14-3-3_CanoR_1	303	309	PF00244	0.556
LIG_14-3-3_CanoR_1	344	352	PF00244	0.547
LIG_14-3-3_CanoR_1	356	366	PF00244	0.554
LIG_14-3-3_CanoR_1	598	606	PF00244	0.451
LIG_14-3-3_CanoR_1	642	650	PF00244	0.646
LIG_14-3-3_CanoR_1	660	669	PF00244	0.460
LIG_14-3-3_CanoR_1	761	769	PF00244	0.422
LIG_14-3-3_CanoR_1	80	88	PF00244	0.653
LIG_14-3-3_CanoR_1	93	97	PF00244	0.529
LIG_Actin_WH2_2	64	82	PF00022	0.757
LIG_BIR_III_2	46	50	PF00653	0.687
LIG_CaM_IQ_9	331	346	PF13499	0.427
LIG_CaM_IQ_9	359	375	PF13499	0.648
LIG_eIF4E_1	774	780	PF01652	0.424
LIG_EVH1_1	50	54	PF00568	0.539
LIG_FHA_1	186	192	PF00498	0.532
LIG_FHA_1	193	199	PF00498	0.484
LIG_FHA_1	22	28	PF00498	0.761
LIG_FHA_1	240	246	PF00498	0.407
LIG_FHA_1	258	264	PF00498	0.589
LIG_FHA_1	538	544	PF00498	0.561
LIG_FHA_1	67	73	PF00498	0.700
LIG_FHA_1	703	709	PF00498	0.407
LIG_FHA_1	712	718	PF00498	0.394
LIG_FHA_1	774	780	PF00498	0.390
LIG_FHA_2	184	190	PF00498	0.597
LIG_FHA_2	195	201	PF00498	0.558
LIG_FHA_2	262	268	PF00498	0.503
LIG_FHA_2	305	311	PF00498	0.538
LIG_FHA_2	345	351	PF00498	0.574
LIG_FHA_2	36	42	PF00498	0.792
LIG_FHA_2	405	411	PF00498	0.679
LIG_FHA_2	598	604	PF00498	0.519
LIG_FHA_2	6	12	PF00498	0.715
LIG_FHA_2	60	66	PF00498	0.602
LIG_FHA_2	799	805	PF00498	0.450
LIG_LIR_Gen_1	106	114	PF02991	0.535
LIG_LIR_Gen_1	130	138	PF02991	0.576
LIG_LIR_Nem_3	106	110	PF02991	0.536
LIG_LIR_Nem_3	130	136	PF02991	0.564
LIG_MYND_1	25	29	PF01753	0.774
LIG_PTB_Apo_2	95	102	PF02174	0.581
LIG_RPA_C_Fungi	247	259	PF08784	0.626
LIG_RPA_C_Fungi	351	363	PF08784	0.667
LIG_SH2_NCK_1	774	778	PF00017	0.481
LIG_SH2_STAP1	162	166	PF00017	0.595
LIG_SH2_STAT3	211	214	PF00017	0.550
LIG_SH2_STAT3	748	751	PF00017	0.551
LIG_SH2_STAT5	308	311	PF00017	0.623
LIG_SH2_STAT5	732	735	PF00017	0.397
LIG_SH3_3	23	29	PF00018	0.778
LIG_SH3_3	48	54	PF00018	0.779
LIG_SH3_3	786	792	PF00018	0.496
LIG_SH3_3	85	91	PF00018	0.674
LIG_TRAF2_1	103	106	PF00917	0.565
LIG_TRAF2_1	14	17	PF00917	0.761
LIG_TRAF2_1	141	144	PF00917	0.460
LIG_TRAF2_1	234	237	PF00917	0.572
LIG_TRAF2_1	348	351	PF00917	0.600
LIG_TRAF2_1	408	411	PF00917	0.597
LIG_TRAF2_1	444	447	PF00917	0.619
LIG_TRAF2_1	475	478	PF00917	0.564
LIG_UBA3_1	820	825	PF00899	0.537
MOD_CK1_1	175	181	PF00069	0.433
MOD_CK1_1	257	263	PF00069	0.549
MOD_CK1_1	326	332	PF00069	0.595
MOD_CK1_1	37	43	PF00069	0.799
MOD_CK1_1	405	411	PF00069	0.720
MOD_CK1_1	625	631	PF00069	0.617
MOD_CK1_1	643	649	PF00069	0.624
MOD_CK1_1	702	708	PF00069	0.460
MOD_CK1_1	775	781	PF00069	0.503
MOD_CK1_1	92	98	PF00069	0.694
MOD_CK2_1	100	106	PF00069	0.551
MOD_CK2_1	138	144	PF00069	0.475
MOD_CK2_1	183	189	PF00069	0.597
MOD_CK2_1	194	200	PF00069	0.553
MOD_CK2_1	223	229	PF00069	0.553
MOD_CK2_1	261	267	PF00069	0.643
MOD_CK2_1	304	310	PF00069	0.520
MOD_CK2_1	344	350	PF00069	0.572
MOD_CK2_1	35	41	PF00069	0.782
MOD_CK2_1	404	410	PF00069	0.594
MOD_CK2_1	515	521	PF00069	0.517
MOD_CK2_1	59	65	PF00069	0.608
MOD_CK2_1	597	603	PF00069	0.477
MOD_CK2_1	733	739	PF00069	0.477
MOD_CK2_1	798	804	PF00069	0.456
MOD_GlcNHglycan	102	105	PF01048	0.585
MOD_GlcNHglycan	180	183	PF01048	0.558
MOD_GlcNHglycan	328	331	PF01048	0.581
MOD_GlcNHglycan	531	534	PF01048	0.490
MOD_GlcNHglycan	591	595	PF01048	0.526
MOD_GlcNHglycan	645	648	PF01048	0.646
MOD_GlcNHglycan	671	674	PF01048	0.399
MOD_GlcNHglycan	81	84	PF01048	0.669
MOD_GlcNHglycan	98	101	PF01048	0.544
MOD_GSK3_1	239	246	PF00069	0.560
MOD_GSK3_1	254	261	PF00069	0.616
MOD_GSK3_1	31	38	PF00069	0.710
MOD_GSK3_1	421	428	PF00069	0.514
MOD_GSK3_1	511	518	PF00069	0.527
MOD_GSK3_1	580	587	PF00069	0.585
MOD_GSK3_1	612	619	PF00069	0.626
MOD_GSK3_1	642	649	PF00069	0.658
MOD_GSK3_1	650	657	PF00069	0.609
MOD_GSK3_1	702	709	PF00069	0.441
MOD_GSK3_1	92	99	PF00069	0.652
MOD_LATS_1	638	644	PF00433	0.778
MOD_N-GLC_1	304	309	PF02516	0.620
MOD_N-GLC_1	628	633	PF02516	0.729
MOD_N-GLC_1	702	707	PF02516	0.465
MOD_NEK2_1	136	141	PF00069	0.510
MOD_NEK2_1	148	153	PF00069	0.493
MOD_NEK2_1	254	259	PF00069	0.627
MOD_NEK2_1	266	271	PF00069	0.523
MOD_NEK2_1	3	8	PF00069	0.611
MOD_NEK2_1	511	516	PF00069	0.572
MOD_NEK2_1	669	674	PF00069	0.451
MOD_NEK2_1	73	78	PF00069	0.667
MOD_NEK2_1	79	84	PF00069	0.669
MOD_NEK2_1	798	803	PF00069	0.487
MOD_NEK2_2	622	627	PF00069	0.760
MOD_NEK2_2	654	659	PF00069	0.767
MOD_NEK2_2	711	716	PF00069	0.410
MOD_NEK2_2	767	772	PF00069	0.387
MOD_PIKK_1	112	118	PF00454	0.524
MOD_PIKK_1	138	144	PF00454	0.507
MOD_PIKK_1	210	216	PF00454	0.633
MOD_PIKK_1	243	249	PF00454	0.556
MOD_PIKK_1	357	363	PF00454	0.606
MOD_PIKK_1	612	618	PF00454	0.621
MOD_PKA_1	58	64	PF00069	0.610
MOD_PKA_2	112	118	PF00069	0.502
MOD_PKA_2	148	154	PF00069	0.566
MOD_PKA_2	172	178	PF00069	0.533
MOD_PKA_2	239	245	PF00069	0.621
MOD_PKA_2	402	408	PF00069	0.644
MOD_PKA_2	597	603	PF00069	0.453
MOD_PKA_2	79	85	PF00069	0.656
MOD_PKA_2	805	811	PF00069	0.525
MOD_PKA_2	92	98	PF00069	0.534
MOD_Plk_1	304	310	PF00069	0.623
MOD_Plk_1	425	431	PF00069	0.551
MOD_Plk_1	511	517	PF00069	0.540
MOD_Plk_1	520	526	PF00069	0.506
MOD_Plk_1	552	558	PF00069	0.595
MOD_Plk_1	66	72	PF00069	0.757
MOD_Plk_1	702	708	PF00069	0.456
MOD_Plk_1	73	79	PF00069	0.735
MOD_Plk_1	738	744	PF00069	0.521
MOD_Plk_4	304	310	PF00069	0.606
MOD_Plk_4	511	517	PF00069	0.551
MOD_Plk_4	728	734	PF00069	0.451
MOD_Plk_4	738	744	PF00069	0.476
MOD_Plk_4	74	80	PF00069	0.725
MOD_Plk_4	775	781	PF00069	0.503
MOD_ProDKin_1	21	27	PF00069	0.758
MOD_ProDKin_1	40	46	PF00069	0.789
MOD_ProDKin_1	618	624	PF00069	0.619
MOD_SUMO_for_1	117	120	PF00179	0.559
MOD_SUMO_for_1	155	158	PF00179	0.509
MOD_SUMO_for_1	442	445	PF00179	0.621
MOD_SUMO_for_1	604	607	PF00179	0.594
MOD_SUMO_rev_2	141	148	PF00179	0.524
MOD_SUMO_rev_2	167	172	PF00179	0.531
MOD_SUMO_rev_2	175	181	PF00179	0.556
MOD_SUMO_rev_2	253	260	PF00179	0.602
MOD_SUMO_rev_2	269	278	PF00179	0.612
MOD_SUMO_rev_2	310	315	PF00179	0.643
MOD_SUMO_rev_2	360	369	PF00179	0.547
MOD_SUMO_rev_2	597	606	PF00179	0.534
TRG_AP2beta_CARGO_1	130	140	PF09066	0.574
TRG_DiLeu_BaEn_1	143	148	PF01217	0.588
TRG_DiLeu_BaEn_2	188	194	PF01217	0.594
TRG_DiLeu_BaEn_4	143	149	PF01217	0.591
TRG_DiLeu_BaEn_4	189	195	PF01217	0.592
TRG_DiLeu_BaEn_4	236	242	PF01217	0.558
TRG_DiLeu_BaEn_4	310	316	PF01217	0.642
TRG_DiLeu_BaEn_4	411	417	PF01217	0.548
TRG_DiLeu_BaEn_4	552	558	PF01217	0.620
TRG_DiLeu_BaEn_4	753	759	PF01217	0.525
TRG_DiLeu_LyEn_5	753	758	PF01217	0.522
TRG_ENDOCYTIC_2	107	110	PF00928	0.603
TRG_ER_diArg_1	110	113	PF00400	0.501
TRG_ER_diArg_1	377	379	PF00400	0.648
TRG_ER_diArg_1	416	418	PF00400	0.587
TRG_ER_diArg_1	564	566	PF00400	0.611
TRG_ER_diArg_1	574	577	PF00400	0.563
TRG_ER_diArg_1	611	613	PF00400	0.536
TRG_NLS_MonoExtC_3	658	664	PF00514	0.659
TRG_NLS_MonoExtN_4	756	763	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9T1	Leptomonas seymouri	70%	100%
A0A0S4ILZ0	Bodo saltans	26%	100%
A0A1X0P756	Trypanosomatidae	41%	100%
A0A3Q8IE13	Leishmania donovani	92%	100%
A0A3S5IQG3	Trypanosoma rangeli	38%	100%
A4HFB0	Leishmania braziliensis	84%	100%
A4I2J2	Leishmania infantum	92%	100%
C9ZWZ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q8S5	Leishmania major	92%	100%
V5BGQ7	Trypanosoma cruzi	39%	100%