Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYP6_LEIMU

TriTrypDb:

LmxM.26.2650

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.610
CLV_C14_Caspase3-7	383	387	PF00656	0.571
CLV_NRD_NRD_1	366	368	PF00675	0.632
CLV_NRD_NRD_1	433	435	PF00675	0.554
CLV_NRD_NRD_1	546	548	PF00675	0.666
CLV_PCSK_KEX2_1	27	29	PF00082	0.595
CLV_PCSK_KEX2_1	366	368	PF00082	0.599
CLV_PCSK_KEX2_1	546	548	PF00082	0.666
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.588
CLV_PCSK_SKI1_1	211	215	PF00082	0.599
CLV_PCSK_SKI1_1	482	486	PF00082	0.511
CLV_PCSK_SKI1_1	95	99	PF00082	0.619
DEG_APCC_DBOX_1	546	554	PF00400	0.614
DEG_APCC_DBOX_1	94	102	PF00400	0.565
DEG_SPOP_SBC_1	56	60	PF00917	0.679
DOC_CKS1_1	540	545	PF01111	0.653
DOC_MAPK_MEF2A_6	68	75	PF00069	0.608
DOC_MAPK_MEF2A_6	77	84	PF00069	0.518
DOC_PP1_RVXF_1	565	571	PF00149	0.510
DOC_PP2B_LxvP_1	458	461	PF13499	0.656
DOC_PP4_FxxP_1	382	385	PF00568	0.421
DOC_PP4_FxxP_1	531	534	PF00568	0.398
DOC_USP7_MATH_1	136	140	PF00917	0.635
DOC_USP7_MATH_1	141	145	PF00917	0.822
DOC_USP7_MATH_1	269	273	PF00917	0.717
DOC_USP7_MATH_1	311	315	PF00917	0.642
DOC_USP7_MATH_1	369	373	PF00917	0.631
DOC_USP7_MATH_1	405	409	PF00917	0.557
DOC_USP7_MATH_1	465	469	PF00917	0.650
DOC_USP7_MATH_1	501	505	PF00917	0.612
DOC_USP7_MATH_1	56	60	PF00917	0.607
DOC_USP7_MATH_2	543	549	PF00917	0.571
DOC_USP7_UBL2_3	189	193	PF12436	0.518
DOC_WW_Pin1_4	143	148	PF00397	0.698
DOC_WW_Pin1_4	238	243	PF00397	0.739
DOC_WW_Pin1_4	295	300	PF00397	0.603
DOC_WW_Pin1_4	305	310	PF00397	0.606
DOC_WW_Pin1_4	447	452	PF00397	0.490
DOC_WW_Pin1_4	487	492	PF00397	0.694
DOC_WW_Pin1_4	539	544	PF00397	0.655
DOC_WW_Pin1_4	61	66	PF00397	0.542
LIG_14-3-3_CanoR_1	140	150	PF00244	0.645
LIG_14-3-3_CanoR_1	234	238	PF00244	0.696
LIG_14-3-3_CanoR_1	312	319	PF00244	0.764
LIG_14-3-3_CanoR_1	429	434	PF00244	0.664
LIG_14-3-3_CanoR_1	440	449	PF00244	0.616
LIG_14-3-3_CanoR_1	503	510	PF00244	0.567
LIG_Actin_WH2_2	90	108	PF00022	0.556
LIG_APCC_ABBA_1	459	464	PF00400	0.541
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_FHA_1	105	111	PF00498	0.662
LIG_FHA_1	246	252	PF00498	0.835
LIG_FHA_1	316	322	PF00498	0.741
LIG_FHA_1	379	385	PF00498	0.425
LIG_FHA_1	428	434	PF00498	0.661
LIG_FHA_1	464	470	PF00498	0.563
LIG_FHA_1	492	498	PF00498	0.579
LIG_FHA_1	528	534	PF00498	0.404
LIG_FHA_2	165	171	PF00498	0.708
LIG_FHA_2	200	206	PF00498	0.509
LIG_FHA_2	540	546	PF00498	0.519
LIG_FHA_2	6	12	PF00498	0.623
LIG_FXI_DFP_1	217	221	PF00024	0.554
LIG_Integrin_isoDGR_2	118	120	PF01839	0.500
LIG_Integrin_isoDGR_2	209	211	PF01839	0.616
LIG_IRF3_LxIS_1	74	81	PF10401	0.551
LIG_LIR_Apic_2	191	197	PF02991	0.421
LIG_LIR_Apic_2	381	385	PF02991	0.419
LIG_LIR_Apic_2	530	534	PF02991	0.399
LIG_LIR_Apic_2	538	543	PF02991	0.495
LIG_LIR_Gen_1	408	418	PF02991	0.487
LIG_LIR_Gen_1	504	514	PF02991	0.426
LIG_LIR_Nem_3	20	26	PF02991	0.601
LIG_LIR_Nem_3	218	223	PF02991	0.527
LIG_LIR_Nem_3	305	310	PF02991	0.459
LIG_LIR_Nem_3	408	413	PF02991	0.456
LIG_LIR_Nem_3	467	473	PF02991	0.556
LIG_LIR_Nem_3	504	510	PF02991	0.517
LIG_LYPXL_yS_3	578	581	PF13949	0.581
LIG_PCNA_yPIPBox_3	193	207	PF02747	0.596
LIG_PROFILIN_1	147	153	PF00235	0.609
LIG_SH2_NCK_1	540	544	PF00017	0.602
LIG_SH2_SRC	462	465	PF00017	0.609
LIG_SH2_STAT5	100	103	PF00017	0.589
LIG_SH2_STAT5	223	226	PF00017	0.485
LIG_SH2_STAT5	470	473	PF00017	0.616
LIG_SH2_STAT5	483	486	PF00017	0.574
LIG_SH2_STAT5	498	501	PF00017	0.318
LIG_SH3_3	144	150	PF00018	0.820
LIG_SH3_3	160	166	PF00018	0.523
LIG_SH3_3	318	324	PF00018	0.681
LIG_SH3_3	558	564	PF00018	0.542
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.537
LIG_TRAF2_1	202	205	PF00917	0.531
LIG_TRAF2_1	461	464	PF00917	0.635
LIG_TRAF2_2	561	566	PF00917	0.500
LIG_WRC_WIRS_1	355	360	PF05994	0.631
MOD_CDK_SPxxK_3	305	312	PF00069	0.753
MOD_CDK_SPxxK_3	539	546	PF00069	0.570
MOD_CDK_SPxxK_3	61	68	PF00069	0.627
MOD_CK1_1	139	145	PF00069	0.717
MOD_CK1_1	241	247	PF00069	0.744
MOD_CK1_1	452	458	PF00069	0.634
MOD_CK1_1	522	528	PF00069	0.524
MOD_CK1_1	532	538	PF00069	0.474
MOD_CK1_1	59	65	PF00069	0.571
MOD_CK2_1	199	205	PF00069	0.578
MOD_CK2_1	5	11	PF00069	0.646
MOD_CK2_1	532	538	PF00069	0.458
MOD_CK2_1	539	545	PF00069	0.470
MOD_CK2_1	61	67	PF00069	0.505
MOD_GlcNHglycan	130	133	PF01048	0.713
MOD_GlcNHglycan	248	251	PF01048	0.591
MOD_GlcNHglycan	371	374	PF01048	0.588
MOD_GlcNHglycan	423	426	PF01048	0.716
MOD_GlcNHglycan	499	502	PF01048	0.587
MOD_GlcNHglycan	521	524	PF01048	0.434
MOD_GlcNHglycan	547	550	PF01048	0.614
MOD_GlcNHglycan	556	559	PF01048	0.567
MOD_GSK3_1	104	111	PF00069	0.568
MOD_GSK3_1	139	146	PF00069	0.616
MOD_GSK3_1	233	240	PF00069	0.669
MOD_GSK3_1	241	248	PF00069	0.712
MOD_GSK3_1	269	276	PF00069	0.697
MOD_GSK3_1	291	298	PF00069	0.633
MOD_GSK3_1	311	318	PF00069	0.688
MOD_GSK3_1	34	41	PF00069	0.640
MOD_GSK3_1	445	452	PF00069	0.533
MOD_GSK3_1	487	494	PF00069	0.653
MOD_GSK3_1	497	504	PF00069	0.448
MOD_GSK3_1	51	58	PF00069	0.644
MOD_GSK3_1	529	536	PF00069	0.521
MOD_N-GLC_1	199	204	PF02516	0.662
MOD_N-GLC_1	405	410	PF02516	0.547
MOD_NEK2_1	127	132	PF00069	0.767
MOD_NEK2_1	378	383	PF00069	0.443
MOD_NEK2_1	497	502	PF00069	0.589
MOD_NEK2_1	55	60	PF00069	0.610
MOD_NEK2_1	78	83	PF00069	0.490
MOD_NEK2_2	465	470	PF00069	0.581
MOD_PIKK_1	108	114	PF00454	0.729
MOD_PIKK_1	233	239	PF00454	0.772
MOD_PIKK_1	242	248	PF00454	0.670
MOD_PK_1	429	435	PF00069	0.550
MOD_PKA_2	119	125	PF00069	0.631
MOD_PKA_2	139	145	PF00069	0.493
MOD_PKA_2	233	239	PF00069	0.685
MOD_PKA_2	29	35	PF00069	0.665
MOD_PKA_2	311	317	PF00069	0.761
MOD_PKA_2	339	345	PF00069	0.761
MOD_PKA_2	502	508	PF00069	0.609
MOD_PKA_2	545	551	PF00069	0.614
MOD_Plk_1	158	164	PF00069	0.669
MOD_Plk_1	292	298	PF00069	0.708
MOD_Plk_1	353	359	PF00069	0.630
MOD_Plk_1	38	44	PF00069	0.486
MOD_Plk_1	50	56	PF00069	0.515
MOD_Plk_1	69	75	PF00069	0.582
MOD_Plk_2-3	354	360	PF00069	0.643
MOD_Plk_2-3	506	512	PF00069	0.560
MOD_Plk_4	292	298	PF00069	0.671
MOD_Plk_4	317	323	PF00069	0.730
MOD_Plk_4	38	44	PF00069	0.507
MOD_Plk_4	465	471	PF00069	0.538
MOD_Plk_4	69	75	PF00069	0.615
MOD_ProDKin_1	143	149	PF00069	0.697
MOD_ProDKin_1	238	244	PF00069	0.740
MOD_ProDKin_1	295	301	PF00069	0.602
MOD_ProDKin_1	305	311	PF00069	0.606
MOD_ProDKin_1	447	453	PF00069	0.490
MOD_ProDKin_1	487	493	PF00069	0.688
MOD_ProDKin_1	539	545	PF00069	0.649
MOD_ProDKin_1	61	67	PF00069	0.536
MOD_SUMO_rev_2	185	195	PF00179	0.434
MOD_SUMO_rev_2	511	519	PF00179	0.552
MOD_SUMO_rev_2	9	15	PF00179	0.666
TRG_DiLeu_BaEn_1	409	414	PF01217	0.438
TRG_DiLeu_BaEn_1	70	75	PF01217	0.535
TRG_DiLeu_BaEn_2	167	173	PF01217	0.404
TRG_DiLeu_LyEn_5	409	414	PF01217	0.457
TRG_ENDOCYTIC_2	217	220	PF00928	0.448
TRG_ENDOCYTIC_2	507	510	PF00928	0.503
TRG_ENDOCYTIC_2	578	581	PF00928	0.581
TRG_ER_diArg_1	365	367	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I848	Leptomonas seymouri	56%	100%
A0A1X0P7D0	Trypanosomatidae	33%	100%
A0A3R7MCE3	Trypanosoma rangeli	35%	100%
A0A3S7X099	Leishmania donovani	89%	100%
A4HFA9	Leishmania braziliensis	79%	100%
A4I2J1	Leishmania infantum	90%	100%
C9ZWZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q8S6	Leishmania major	90%	100%
V5B7P2	Trypanosoma cruzi	35%	100%