Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYP5_LEIMU

TriTrypDb:

LmxM.26.2640

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYP5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.478
CLV_NRD_NRD_1	3	5	PF00675	0.588
CLV_NRD_NRD_1	320	322	PF00675	0.566
CLV_PCSK_KEX2_1	3	5	PF00082	0.573
CLV_PCSK_KEX2_1	361	363	PF00082	0.519
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.519
CLV_PCSK_SKI1_1	17	21	PF00082	0.507
CLV_PCSK_SKI1_1	248	252	PF00082	0.485
CLV_PCSK_SKI1_1	268	272	PF00082	0.803
CLV_PCSK_SKI1_1	55	59	PF00082	0.552
CLV_PCSK_SKI1_1	73	77	PF00082	0.384
CLV_PCSK_SKI1_1	78	82	PF00082	0.511
DEG_Nend_Nbox_1	1	3	PF02207	0.630
DEG_SPOP_SBC_1	262	266	PF00917	0.523
DOC_CKS1_1	125	130	PF01111	0.760
DOC_MAPK_gen_1	321	329	PF00069	0.630
DOC_PP1_RVXF_1	110	116	PF00149	0.469
DOC_PP1_RVXF_1	228	235	PF00149	0.485
DOC_PP4_FxxP_1	125	128	PF00568	0.671
DOC_PP4_FxxP_1	270	273	PF00568	0.789
DOC_USP7_MATH_1	154	158	PF00917	0.687
DOC_USP7_MATH_1	189	193	PF00917	0.735
DOC_USP7_MATH_1	262	266	PF00917	0.708
DOC_USP7_MATH_1	32	36	PF00917	0.548
DOC_USP7_MATH_2	129	135	PF00917	0.507
DOC_USP7_UBL2_3	37	41	PF12436	0.467
DOC_WW_Pin1_4	124	129	PF00397	0.659
DOC_WW_Pin1_4	132	137	PF00397	0.677
DOC_WW_Pin1_4	252	257	PF00397	0.477
LIG_14-3-3_CanoR_1	17	22	PF00244	0.466
LIG_14-3-3_CanoR_1	282	288	PF00244	0.494
LIG_BRCT_BRCA1_1	266	270	PF00533	0.796
LIG_FHA_1	199	205	PF00498	0.648
LIG_FHA_1	215	221	PF00498	0.529
LIG_FHA_1	222	228	PF00498	0.451
LIG_FHA_1	269	275	PF00498	0.763
LIG_FHA_1	28	34	PF00498	0.439
LIG_FHA_1	98	104	PF00498	0.518
LIG_FHA_2	133	139	PF00498	0.533
LIG_LIR_Apic_2	267	273	PF02991	0.764
LIG_LIR_Gen_1	58	69	PF02991	0.300
LIG_LIR_Nem_3	365	369	PF02991	0.453
LIG_LIR_Nem_3	58	64	PF02991	0.287
LIG_LYPXL_yS_3	366	369	PF13949	0.451
LIG_PDZ_Class_2	379	384	PF00595	0.676
LIG_PTB_Apo_2	310	317	PF02174	0.757
LIG_PTB_Phospho_1	310	316	PF10480	0.759
LIG_SH2_CRK	364	368	PF00017	0.456
LIG_SH2_SRC	364	367	PF00017	0.462
LIG_SH2_STAT3	294	297	PF00017	0.705
LIG_SH2_STAT3	59	62	PF00017	0.585
LIG_SH3_3	139	145	PF00018	0.646
LIG_SH3_3	203	209	PF00018	0.700
LIG_SH3_3	278	284	PF00018	0.630
LIG_SUMO_SIM_par_1	200	205	PF11976	0.657
LIG_TRAF2_1	192	195	PF00917	0.642
LIG_TRAF2_1	209	212	PF00917	0.676
MOD_CK1_1	134	140	PF00069	0.670
MOD_CK1_1	157	163	PF00069	0.802
MOD_CK1_1	252	258	PF00069	0.680
MOD_CK1_1	263	269	PF00069	0.612
MOD_CK1_1	275	281	PF00069	0.508
MOD_CK1_1	309	315	PF00069	0.741
MOD_CK1_1	368	374	PF00069	0.557
MOD_CK2_1	189	195	PF00069	0.712
MOD_CK2_1	32	38	PF00069	0.547
MOD_GlcNHglycan	156	159	PF01048	0.752
MOD_GlcNHglycan	160	163	PF01048	0.770
MOD_GlcNHglycan	187	190	PF01048	0.719
MOD_GlcNHglycan	21	24	PF01048	0.526
MOD_GlcNHglycan	251	254	PF01048	0.574
MOD_GlcNHglycan	308	311	PF01048	0.671
MOD_GlcNHglycan	351	354	PF01048	0.429
MOD_GlcNHglycan	67	70	PF01048	0.576
MOD_GlcNHglycan	82	85	PF01048	0.337
MOD_GSK3_1	152	159	PF00069	0.764
MOD_GSK3_1	185	192	PF00069	0.718
MOD_GSK3_1	214	221	PF00069	0.571
MOD_GSK3_1	260	267	PF00069	0.673
MOD_GSK3_1	268	275	PF00069	0.733
MOD_GSK3_1	27	34	PF00069	0.481
MOD_GSK3_1	78	85	PF00069	0.441
MOD_N-GLC_1	131	136	PF02516	0.650
MOD_N-GLC_1	232	237	PF02516	0.482
MOD_N-GLC_1	97	102	PF02516	0.559
MOD_NEK2_1	183	188	PF00069	0.801
MOD_NEK2_1	82	87	PF00069	0.429
MOD_NEK2_2	214	219	PF00069	0.564
MOD_NEK2_2	32	37	PF00069	0.561
MOD_PIKK_1	152	158	PF00454	0.501
MOD_Plk_2-3	198	204	PF00069	0.638
MOD_ProDKin_1	124	130	PF00069	0.660
MOD_ProDKin_1	132	138	PF00069	0.677
MOD_ProDKin_1	252	258	PF00069	0.487
MOD_SUMO_for_1	333	336	PF00179	0.424
MOD_SUMO_for_1	36	39	PF00179	0.461
MOD_SUMO_rev_2	358	363	PF00179	0.477
TRG_ENDOCYTIC_2	247	250	PF00928	0.459
TRG_ENDOCYTIC_2	366	369	PF00928	0.451
TRG_ER_diArg_1	2	4	PF00400	0.588
TRG_ER_diArg_1	243	246	PF00400	0.445
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.796
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1E9	Leptomonas seymouri	72%	100%
A0A0S4IIA8	Bodo saltans	48%	93%
A0A1X0P7H1	Trypanosomatidae	53%	100%
A0A3Q8IDW7	Leishmania donovani	94%	100%
A0A422N3I7	Trypanosoma rangeli	52%	100%
A4HFA8	Leishmania braziliensis	85%	100%
A4I2I5	Leishmania infantum	94%	100%
C9ZWZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	88%
Q4Q8S7	Leishmania major	93%	100%
V5BC49	Trypanosoma cruzi	54%	100%