Protein kinase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AYN8_LEIMU

TriTrypDb:

LmxM.26.2570

Length:

435

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYN8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	15
GO:0006793	phosphorus metabolic process	3	15
GO:0006796	phosphate-containing compound metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009987	cellular process	1	15
GO:0016310	phosphorylation	5	15
GO:0019538	protein metabolic process	3	15
GO:0036211	protein modification process	4	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043412	macromolecule modification	4	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003824	catalytic activity	1	15
GO:0004672	protein kinase activity	3	15
GO:0004674	protein serine/threonine kinase activity	4	11
GO:0005488	binding	1	15
GO:0005524	ATP binding	5	15
GO:0016301	kinase activity	4	15
GO:0016740	transferase activity	2	15
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	15
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	15
GO:0017076	purine nucleotide binding	4	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:0140096	catalytic activity, acting on a protein	2	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	195	201	PF00089	0.432
CLV_NRD_NRD_1	152	154	PF00675	0.307
CLV_NRD_NRD_1	363	365	PF00675	0.540
CLV_NRD_NRD_1	58	60	PF00675	0.355
CLV_PCSK_KEX2_1	152	154	PF00082	0.424
CLV_PCSK_KEX2_1	240	242	PF00082	0.409
CLV_PCSK_KEX2_1	58	60	PF00082	0.383
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.438
CLV_PCSK_PC7_1	236	242	PF00082	0.307
CLV_PCSK_SKI1_1	157	161	PF00082	0.313
CLV_PCSK_SKI1_1	241	245	PF00082	0.367
CLV_PCSK_SKI1_1	250	254	PF00082	0.379
CLV_PCSK_SKI1_1	317	321	PF00082	0.563
CLV_PCSK_SKI1_1	359	363	PF00082	0.552
CLV_PCSK_SKI1_1	37	41	PF00082	0.307
DEG_APCC_DBOX_1	353	361	PF00400	0.624
DEG_SPOP_SBC_1	263	267	PF00917	0.266
DOC_CKS1_1	1	6	PF01111	0.666
DOC_CKS1_1	199	204	PF01111	0.315
DOC_CYCLIN_RxL_1	10	19	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	298	304	PF00134	0.433
DOC_MAPK_DCC_7	125	134	PF00069	0.307
DOC_MAPK_FxFP_2	46	49	PF00069	0.261
DOC_MAPK_gen_1	125	134	PF00069	0.307
DOC_MAPK_gen_1	157	166	PF00069	0.315
DOC_MAPK_gen_1	354	362	PF00069	0.525
DOC_MAPK_MEF2A_6	125	134	PF00069	0.390
DOC_MAPK_MEF2A_6	160	168	PF00069	0.307
DOC_PP4_FxxP_1	46	49	PF00568	0.249
DOC_USP7_MATH_1	263	267	PF00917	0.459
DOC_USP7_MATH_1	329	333	PF00917	0.752
DOC_USP7_MATH_1	392	396	PF00917	0.496
DOC_WW_Pin1_4	198	203	PF00397	0.315
DOC_WW_Pin1_4	297	302	PF00397	0.479
DOC_WW_Pin1_4	321	326	PF00397	0.622
LIG_14-3-3_CanoR_1	241	249	PF00244	0.361
LIG_14-3-3_CanoR_1	262	269	PF00244	0.444
LIG_14-3-3_CanoR_1	288	296	PF00244	0.375
LIG_14-3-3_CanoR_1	375	384	PF00244	0.588
LIG_14-3-3_CanoR_1	59	67	PF00244	0.470
LIG_Actin_WH2_2	292	310	PF00022	0.220
LIG_APCC_ABBA_1	311	316	PF00400	0.488
LIG_APCC_ABBAyCdc20_2	152	158	PF00400	0.436
LIG_APCC_ABBAyCdc20_2	250	256	PF00400	0.404
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BIR_III_1	1	5	PF00653	0.582
LIG_BIR_III_3	1	5	PF00653	0.582
LIG_BIR_III_4	345	349	PF00653	0.685
LIG_BRCT_BRCA1_1	23	27	PF00533	0.357
LIG_deltaCOP1_diTrp_1	407	412	PF00928	0.430
LIG_EH1_1	384	392	PF00400	0.430
LIG_FHA_1	189	195	PF00498	0.276
LIG_FHA_1	263	269	PF00498	0.354
LIG_FHA_1	301	307	PF00498	0.319
LIG_FHA_1	372	378	PF00498	0.435
LIG_FHA_1	396	402	PF00498	0.592
LIG_FHA_2	215	221	PF00498	0.315
LIG_FHA_2	288	294	PF00498	0.241
LIG_FHA_2	61	67	PF00498	0.307
LIG_GBD_Chelix_1	273	281	PF00786	0.307
LIG_HCF-1_HBM_1	81	84	PF13415	0.307
LIG_LIR_Apic_2	201	207	PF02991	0.315
LIG_LIR_Apic_2	407	413	PF02991	0.436
LIG_LIR_Apic_2	81	87	PF02991	0.194
LIG_LIR_Gen_1	226	237	PF02991	0.277
LIG_LIR_Gen_1	29	39	PF02991	0.420
LIG_LIR_Gen_1	290	299	PF02991	0.261
LIG_LIR_Gen_1	416	427	PF02991	0.411
LIG_LIR_Nem_3	181	185	PF02991	0.399
LIG_LIR_Nem_3	226	232	PF02991	0.277
LIG_LIR_Nem_3	24	30	PF02991	0.442
LIG_LIR_Nem_3	290	295	PF02991	0.261
LIG_LIR_Nem_3	416	422	PF02991	0.423
LIG_LIR_Nem_3	428	433	PF02991	0.352
LIG_NRBOX	372	378	PF00104	0.407
LIG_NRBOX	404	410	PF00104	0.424
LIG_SH2_CRK	182	186	PF00017	0.307
LIG_SH2_CRK	292	296	PF00017	0.320
LIG_SH2_CRK	309	313	PF00017	0.203
LIG_SH2_CRK	430	434	PF00017	0.478
LIG_SH2_PTP2	204	207	PF00017	0.404
LIG_SH2_PTP2	84	87	PF00017	0.194
LIG_SH2_SRC	309	312	PF00017	0.379
LIG_SH2_STAP1	264	268	PF00017	0.352
LIG_SH2_STAP1	292	296	PF00017	0.320
LIG_SH2_STAT5	104	107	PF00017	0.132
LIG_SH2_STAT5	110	113	PF00017	0.364
LIG_SH2_STAT5	204	207	PF00017	0.309
LIG_SH2_STAT5	264	267	PF00017	0.431
LIG_SH2_STAT5	305	308	PF00017	0.328
LIG_SH2_STAT5	31	34	PF00017	0.373
LIG_SH2_STAT5	84	87	PF00017	0.325
LIG_SH2_STAT5	88	91	PF00017	0.266
LIG_SH3_1	309	315	PF00018	0.510
LIG_SH3_2	312	317	PF14604	0.423
LIG_SH3_3	196	202	PF00018	0.315
LIG_SH3_3	2	8	PF00018	0.564
LIG_SH3_3	309	315	PF00018	0.522
LIG_SH3_3	322	328	PF00018	0.623
LIG_SUMO_SIM_anti_2	421	429	PF11976	0.402
LIG_TRAF2_1	418	421	PF00917	0.421
LIG_WW_3	324	328	PF00397	0.738
MOD_CDC14_SPxK_1	324	327	PF00782	0.574
MOD_CDK_SPxK_1	321	327	PF00069	0.565
MOD_CK1_1	216	222	PF00069	0.341
MOD_CK1_1	223	229	PF00069	0.360
MOD_CK1_1	287	293	PF00069	0.397
MOD_CK1_1	300	306	PF00069	0.285
MOD_CK1_1	395	401	PF00069	0.466
MOD_DYRK1A_RPxSP_1	198	202	PF00069	0.315
MOD_GlcNHglycan	143	146	PF01048	0.261
MOD_GlcNHglycan	170	173	PF01048	0.382
MOD_GlcNHglycan	222	225	PF01048	0.268
MOD_GlcNHglycan	23	26	PF01048	0.276
MOD_GlcNHglycan	332	335	PF01048	0.628
MOD_GlcNHglycan	339	342	PF01048	0.570
MOD_GSK3_1	164	171	PF00069	0.359
MOD_GSK3_1	184	191	PF00069	0.339
MOD_GSK3_1	194	201	PF00069	0.296
MOD_GSK3_1	216	223	PF00069	0.265
MOD_GSK3_1	264	271	PF00069	0.266
MOD_GSK3_1	33	40	PF00069	0.341
MOD_GSK3_1	371	378	PF00069	0.423
MOD_N-GLC_1	146	151	PF02516	0.276
MOD_N-GLC_1	44	49	PF02516	0.463
MOD_NEK2_1	146	151	PF00069	0.276
MOD_NEK2_1	168	173	PF00069	0.438
MOD_NEK2_1	188	193	PF00069	0.307
MOD_NEK2_1	194	199	PF00069	0.247
MOD_NEK2_1	21	26	PF00069	0.291
MOD_NEK2_1	320	325	PF00069	0.751
MOD_NEK2_2	264	269	PF00069	0.266
MOD_PKA_2	287	293	PF00069	0.277
MOD_PKA_2	371	377	PF00069	0.422
MOD_Plk_1	44	50	PF00069	0.464
MOD_Plk_4	200	206	PF00069	0.401
MOD_Plk_4	223	229	PF00069	0.281
MOD_Plk_4	264	270	PF00069	0.458
MOD_ProDKin_1	198	204	PF00069	0.315
MOD_ProDKin_1	297	303	PF00069	0.475
MOD_ProDKin_1	321	327	PF00069	0.626
TRG_DiLeu_BaEn_1	358	363	PF01217	0.522
TRG_DiLeu_BaEn_1	421	426	PF01217	0.396
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.307
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.307
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.228
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.466
TRG_ENDOCYTIC_2	182	185	PF00928	0.442
TRG_ENDOCYTIC_2	229	232	PF00928	0.436
TRG_ENDOCYTIC_2	292	295	PF00928	0.276
TRG_ENDOCYTIC_2	31	34	PF00928	0.393
TRG_ENDOCYTIC_2	430	433	PF00928	0.471
TRG_ER_diArg_1	152	154	PF00400	0.430
TRG_ER_diArg_1	354	357	PF00400	0.696
TRG_ER_diArg_1	57	59	PF00400	0.367
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT76	Leptomonas seymouri	26%	97%
A0A0N1HZW6	Leptomonas seymouri	52%	98%
A0A0N1I9A0	Leptomonas seymouri	25%	67%
A0A0N1IM47	Leptomonas seymouri	27%	100%
A0A0S4IZ14	Bodo saltans	24%	73%
A0A0S4J6L4	Bodo saltans	26%	100%
A0A0S4JNA1	Bodo saltans	28%	88%
A0A0S4JP91	Bodo saltans	30%	72%
A0A1X0NIA0	Trypanosomatidae	26%	100%
A0A1X0NRZ9	Trypanosomatidae	28%	100%
A0A1X0P150	Trypanosomatidae	26%	70%
A0A1X0P1A2	Trypanosomatidae	25%	94%
A0A1X0P3P4	Trypanosomatidae	25%	89%
A0A1X0P765	Trypanosomatidae	46%	80%
A0A1X0P919	Trypanosomatidae	29%	100%
A0A3Q8IAQ1	Leishmania donovani	28%	100%
A0A3Q8IIG1	Leishmania donovani	33%	100%
A0A3Q8IPJ5	Leishmania donovani	95%	100%
A0A3R7M848	Trypanosoma rangeli	39%	93%
A0A3S5H4Z4	Leishmania donovani	26%	82%
A0A3S5IRC3	Trypanosoma rangeli	27%	100%
A0A3S7X7Y2	Leishmania donovani	28%	100%
A0A422NT89	Trypanosoma rangeli	22%	66%
A0A422NUF0	Trypanosoma rangeli	27%	100%
A0QNG1	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	29%	70%
A2ZMH2	Oryza sativa subsp. indica	30%	74%
A4H3C7	Leishmania braziliensis	26%	100%
A4HCE6	Leishmania braziliensis	27%	100%
A4HFA1	Leishmania braziliensis	91%	100%
A4HH03	Leishmania braziliensis	31%	100%
A4HNU6	Leishmania braziliensis	30%	83%
A4HRM6	Leishmania infantum	26%	82%
A4HZW8	Leishmania infantum	28%	100%
A4I2H8	Leishmania infantum	95%	100%
A4I435	Leishmania infantum	33%	100%
A4I9Y5	Leishmania infantum	28%	100%
B0LT89	Rattus norvegicus	27%	100%
C9ZIN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	87%
C9ZX04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	94%
C9ZX09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	94%
E9ACA4	Leishmania major	25%	82%
E9AJJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
G5EFM9	Caenorhabditis elegans	27%	100%
O00141	Homo sapiens	26%	100%
O00506	Homo sapiens	28%	100%
O01775	Caenorhabditis elegans	28%	100%
O61122	Dictyostelium discoideum	27%	91%
O61847	Caenorhabditis elegans	26%	100%
P08458	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	89%
P0A5S5	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	27%	69%
P22209	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P54744	Mycobacterium leprae (strain TN)	29%	70%
P62345	Plasmodium berghei (strain Anka)	29%	82%
P9WI80	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	69%
P9WI81	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	69%
Q06226	Rattus norvegicus	27%	100%
Q10GB1	Oryza sativa subsp. japonica	30%	73%
Q2QMH1	Oryza sativa subsp. japonica	30%	74%
Q3SWY6	Bos taurus	29%	100%
Q4Q2Z2	Leishmania major	28%	100%
Q4Q7W2	Leishmania major	32%	100%
Q4Q8T4	Leishmania major	96%	100%
Q4QBQ2	Leishmania major	28%	100%
Q4QCR2	Leishmania major	26%	100%
Q54EY4	Dictyostelium discoideum	30%	77%
Q54H05	Dictyostelium discoideum	24%	75%
Q54QD5	Dictyostelium discoideum	26%	90%
Q5Q0U5	Fundulus heteroclitus	25%	100%
Q5QNM6	Oryza sativa subsp. japonica	29%	85%
Q6YY75	Oryza sativa subsp. japonica	30%	81%
Q7RJG2	Plasmodium yoelii yoelii	29%	82%
Q86AD7	Dictyostelium discoideum	25%	100%
Q8C0Q4	Mus musculus	27%	69%
Q8RX66	Arabidopsis thaliana	31%	77%
Q8RXT4	Arabidopsis thaliana	28%	78%
Q8W490	Arabidopsis thaliana	29%	93%
Q99JT2	Mus musculus	27%	100%
Q9CAU7	Arabidopsis thaliana	30%	72%
Q9P289	Homo sapiens	27%	100%
Q9SN43	Arabidopsis thaliana	30%	89%
Q9TXJ0	Caenorhabditis elegans	26%	100%
Q9WVC6	Mus musculus	26%	100%
Q9Z2W1	Mus musculus	28%	100%
Q9ZV15	Arabidopsis thaliana	29%	75%
V5B8E0	Trypanosoma cruzi	26%	100%
V5BJT8	Trypanosoma cruzi	29%	100%
V5CI11	Trypanosoma cruzi	46%	91%
V5D179	Trypanosoma cruzi	25%	72%
V5D9M1	Trypanosoma cruzi	30%	100%