Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYN5_LEIMU

TriTrypDb:

LmxM.26.2540

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.383
CLV_C14_Caspase3-7	458	462	PF00656	0.514
CLV_NRD_NRD_1	102	104	PF00675	0.538
CLV_NRD_NRD_1	13	15	PF00675	0.619
CLV_NRD_NRD_1	137	139	PF00675	0.407
CLV_NRD_NRD_1	439	441	PF00675	0.441
CLV_NRD_NRD_1	682	684	PF00675	0.649
CLV_PCSK_KEX2_1	102	104	PF00082	0.538
CLV_PCSK_KEX2_1	13	15	PF00082	0.554
CLV_PCSK_KEX2_1	682	684	PF00082	0.680
CLV_PCSK_PC7_1	678	684	PF00082	0.648
CLV_PCSK_SKI1_1	175	179	PF00082	0.571
CLV_PCSK_SKI1_1	519	523	PF00082	0.534
CLV_PCSK_SKI1_1	540	544	PF00082	0.336
CLV_PCSK_SKI1_1	563	567	PF00082	0.687
DEG_APCC_DBOX_1	478	486	PF00400	0.410
DEG_Nend_UBRbox_1	1	4	PF02207	0.588
DOC_MAPK_gen_1	575	584	PF00069	0.586
DOC_MAPK_gen_1	618	627	PF00069	0.581
DOC_MAPK_MEF2A_6	205	213	PF00069	0.492
DOC_MAPK_MEF2A_6	395	404	PF00069	0.393
DOC_MAPK_MEF2A_6	528	536	PF00069	0.528
DOC_PP2B_LxvP_1	317	320	PF13499	0.454
DOC_PP2B_LxvP_1	532	535	PF13499	0.400
DOC_PP2B_LxvP_1	614	617	PF13499	0.407
DOC_PP4_FxxP_1	243	246	PF00568	0.572
DOC_USP7_MATH_1	142	146	PF00917	0.564
DOC_USP7_MATH_1	201	205	PF00917	0.565
DOC_USP7_MATH_1	246	250	PF00917	0.593
DOC_USP7_MATH_1	311	315	PF00917	0.625
DOC_USP7_MATH_1	328	332	PF00917	0.448
DOC_USP7_MATH_1	455	459	PF00917	0.466
DOC_USP7_MATH_1	462	466	PF00917	0.583
DOC_USP7_UBL2_3	413	417	PF12436	0.476
DOC_WW_Pin1_4	248	253	PF00397	0.570
DOC_WW_Pin1_4	41	46	PF00397	0.440
DOC_WW_Pin1_4	5	10	PF00397	0.509
DOC_WW_Pin1_4	639	644	PF00397	0.568
DOC_WW_Pin1_4	665	670	PF00397	0.570
DOC_WW_Pin1_4	80	85	PF00397	0.655
LIG_14-3-3_CanoR_1	110	115	PF00244	0.540
LIG_14-3-3_CanoR_1	138	147	PF00244	0.431
LIG_14-3-3_CanoR_1	281	287	PF00244	0.389
LIG_14-3-3_CanoR_1	4	9	PF00244	0.668
LIG_14-3-3_CanoR_1	519	526	PF00244	0.431
LIG_14-3-3_CanoR_1	528	536	PF00244	0.595
LIG_14-3-3_CanoR_1	682	690	PF00244	0.699
LIG_BIR_III_4	75	79	PF00653	0.469
LIG_BRCT_BRCA1_1	323	327	PF00533	0.369
LIG_Clathr_ClatBox_1	157	161	PF01394	0.331
LIG_deltaCOP1_diTrp_1	234	243	PF00928	0.377
LIG_FHA_1	197	203	PF00498	0.450
LIG_FHA_1	228	234	PF00498	0.315
LIG_FHA_1	576	582	PF00498	0.407
LIG_FHA_1	597	603	PF00498	0.491
LIG_FHA_1	640	646	PF00498	0.520
LIG_FHA_2	151	157	PF00498	0.403
LIG_FHA_2	176	182	PF00498	0.540
LIG_FHA_2	251	257	PF00498	0.468
LIG_FHA_2	45	51	PF00498	0.538
LIG_FHA_2	553	559	PF00498	0.610
LIG_FHA_2	586	592	PF00498	0.467
LIG_LIR_Apic_2	219	225	PF02991	0.525
LIG_LIR_Apic_2	241	246	PF02991	0.565
LIG_LIR_Gen_1	212	222	PF02991	0.434
LIG_LIR_Gen_1	256	265	PF02991	0.501
LIG_LIR_Gen_1	346	354	PF02991	0.406
LIG_LIR_Nem_3	212	217	PF02991	0.415
LIG_LIR_Nem_3	256	262	PF02991	0.503
LIG_LIR_Nem_3	30	35	PF02991	0.483
LIG_LIR_Nem_3	346	351	PF02991	0.385
LIG_LIR_Nem_3	499	505	PF02991	0.457
LIG_LIR_Nem_3	82	88	PF02991	0.510
LIG_PCNA_PIPBox_1	12	21	PF02747	0.544
LIG_PCNA_yPIPBox_3	6	19	PF02747	0.585
LIG_Rb_pABgroove_1	422	430	PF01858	0.404
LIG_SH2_CRK	214	218	PF00017	0.510
LIG_SH2_CRK	222	226	PF00017	0.473
LIG_SH2_CRK	502	506	PF00017	0.470
LIG_SH2_STAP1	173	177	PF00017	0.496
LIG_SH2_STAP1	214	218	PF00017	0.379
LIG_SH2_STAP1	69	73	PF00017	0.523
LIG_SH2_STAT3	517	520	PF00017	0.563
LIG_SH2_STAT5	171	174	PF00017	0.310
LIG_SH2_STAT5	18	21	PF00017	0.478
LIG_SH2_STAT5	352	355	PF00017	0.393
LIG_SH2_STAT5	365	368	PF00017	0.353
LIG_SH2_STAT5	481	484	PF00017	0.502
LIG_SH3_3	177	183	PF00018	0.468
LIG_SH3_3	431	437	PF00018	0.437
LIG_Sin3_3	606	613	PF02671	0.420
LIG_SUMO_SIM_anti_2	152	159	PF11976	0.371
LIG_SUMO_SIM_anti_2	578	583	PF11976	0.274
LIG_SUMO_SIM_par_1	128	134	PF11976	0.458
LIG_TRAF2_1	38	41	PF00917	0.456
LIG_TRAF2_1	555	558	PF00917	0.520
LIG_UBA3_1	190	198	PF00899	0.384
LIG_WRC_WIRS_1	345	350	PF05994	0.440
MOD_CDK_SPK_2	639	644	PF00069	0.568
MOD_CDK_SPxxK_3	248	255	PF00069	0.486
MOD_CDK_SPxxK_3	665	672	PF00069	0.349
MOD_CK1_1	150	156	PF00069	0.383
MOD_CK1_1	163	169	PF00069	0.424
MOD_CK1_1	239	245	PF00069	0.416
MOD_CK1_1	473	479	PF00069	0.376
MOD_CK1_1	49	55	PF00069	0.547
MOD_CK1_1	503	509	PF00069	0.483
MOD_CK1_1	639	645	PF00069	0.425
MOD_CK2_1	150	156	PF00069	0.292
MOD_CK2_1	21	27	PF00069	0.570
MOD_CK2_1	35	41	PF00069	0.458
MOD_CK2_1	44	50	PF00069	0.470
MOD_CK2_1	551	557	PF00069	0.530
MOD_CK2_1	585	591	PF00069	0.500
MOD_CK2_1	651	657	PF00069	0.404
MOD_GlcNHglycan	142	145	PF01048	0.572
MOD_GlcNHglycan	219	222	PF01048	0.388
MOD_GlcNHglycan	238	241	PF01048	0.369
MOD_GlcNHglycan	348	351	PF01048	0.469
MOD_GlcNHglycan	355	358	PF01048	0.424
MOD_GlcNHglycan	375	378	PF01048	0.277
MOD_GlcNHglycan	457	460	PF01048	0.498
MOD_GlcNHglycan	464	467	PF01048	0.655
MOD_GlcNHglycan	638	641	PF01048	0.424
MOD_GlcNHglycan	686	689	PF01048	0.624
MOD_GSK3_1	138	145	PF00069	0.353
MOD_GSK3_1	192	199	PF00069	0.379
MOD_GSK3_1	246	253	PF00069	0.486
MOD_GSK3_1	306	313	PF00069	0.509
MOD_GSK3_1	346	353	PF00069	0.491
MOD_GSK3_1	46	53	PF00069	0.386
MOD_GSK3_1	496	503	PF00069	0.440
MOD_LATS_1	681	687	PF00433	0.549
MOD_NEK2_1	160	165	PF00069	0.367
MOD_NEK2_1	19	24	PF00069	0.496
MOD_NEK2_1	217	222	PF00069	0.442
MOD_NEK2_1	306	311	PF00069	0.493
MOD_NEK2_1	344	349	PF00069	0.360
MOD_NEK2_1	404	409	PF00069	0.356
MOD_NEK2_1	427	432	PF00069	0.544
MOD_NEK2_1	504	509	PF00069	0.446
MOD_NEK2_1	51	56	PF00069	0.401
MOD_NEK2_1	543	548	PF00069	0.392
MOD_NEK2_2	350	355	PF00069	0.411
MOD_NEK2_2	365	370	PF00069	0.467
MOD_NEK2_2	481	486	PF00069	0.426
MOD_NEK2_2	512	517	PF00069	0.403
MOD_NEK2_2	585	590	PF00069	0.439
MOD_PIKK_1	404	410	PF00454	0.480
MOD_PIKK_1	519	525	PF00454	0.333
MOD_PKA_1	138	144	PF00069	0.345
MOD_PKA_2	109	115	PF00069	0.538
MOD_PKA_2	19	25	PF00069	0.476
MOD_PKA_2	280	286	PF00069	0.393
MOD_PKA_2	487	493	PF00069	0.463
MOD_PKA_2	527	533	PF00069	0.580
MOD_PKA_2	551	557	PF00069	0.537
MOD_PKA_2	684	690	PF00069	0.594
MOD_PKB_1	2	10	PF00069	0.545
MOD_Plk_1	160	166	PF00069	0.345
MOD_Plk_1	175	181	PF00069	0.399
MOD_Plk_1	306	312	PF00069	0.504
MOD_Plk_1	575	581	PF00069	0.301
MOD_Plk_4	150	156	PF00069	0.292
MOD_Plk_4	239	245	PF00069	0.489
MOD_Plk_4	321	327	PF00069	0.356
MOD_Plk_4	443	449	PF00069	0.331
MOD_Plk_4	470	476	PF00069	0.423
MOD_Plk_4	481	487	PF00069	0.483
MOD_Plk_4	500	506	PF00069	0.358
MOD_Plk_4	51	57	PF00069	0.384
MOD_Plk_4	512	518	PF00069	0.411
MOD_Plk_4	543	549	PF00069	0.414
MOD_Plk_4	659	665	PF00069	0.598
MOD_ProDKin_1	248	254	PF00069	0.566
MOD_ProDKin_1	41	47	PF00069	0.433
MOD_ProDKin_1	5	11	PF00069	0.502
MOD_ProDKin_1	639	645	PF00069	0.558
MOD_ProDKin_1	665	671	PF00069	0.568
MOD_ProDKin_1	80	86	PF00069	0.650
MOD_SUMO_rev_2	457	465	PF00179	0.561
TRG_AP2beta_CARGO_1	346	355	PF09066	0.439
TRG_DiLeu_BaEn_1	30	35	PF01217	0.453
TRG_DiLeu_BaEn_1	500	505	PF01217	0.474
TRG_DiLeu_BaEn_2	559	565	PF01217	0.491
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.302
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.584
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.301
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.446
TRG_ENDOCYTIC_2	214	217	PF00928	0.480
TRG_ENDOCYTIC_2	345	348	PF00928	0.424
TRG_ENDOCYTIC_2	502	505	PF00928	0.496
TRG_ER_diArg_1	102	104	PF00400	0.585
TRG_ER_diArg_1	13	15	PF00400	0.601
TRG_ER_diArg_1	263	266	PF00400	0.466
TRG_ER_diArg_1	617	620	PF00400	0.623
TRG_ER_diArg_1	682	685	PF00400	0.640
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K6	Leptomonas seymouri	66%	89%
A0A0S4JKX7	Bodo saltans	27%	84%
A0A1X0P8M4	Trypanosomatidae	38%	92%
A0A3Q8IG37	Leishmania donovani	94%	100%
A0A3S5ISN2	Trypanosoma rangeli	43%	89%
A4HF99	Leishmania braziliensis	84%	100%
A4I2H6	Leishmania infantum	94%	100%
C9ZX12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	95%
Q4Q8T7	Leishmania major	92%	100%
V5AS65	Trypanosoma cruzi	44%	89%